CN105616857A - Traditional Chinese medicine composition for treating gout and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating gout. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 10-12 parts of astragalus, 5-6 parts of pseudostellaria heterophylla, 5-6 parts of caulis lonicerae, 5-6 parts of kelp, 5-6 parts of alga, 1-2 parts of stir-fried earthworm, 5-6 parts of caulis piperis futokadsurae, 1-2 parts of little multibanded krait, 5-6 parts of dried rehmannia root, 2-3 parts of cortex moutan, 2-3 parts of achyranthes bidentata, 1-2 parts of centipede, 1-2 parts of scorpion, 5-6 parts of fish poison yam and 5-6 parts of gypsum. The traditional Chinese medicine composition can treat both symptoms and root causes, has the advantages of wide therapeutic range, good curative effect, short taking time, no side effect and no sequela, can be called as a 'green medicine', is simple to manufacture, can be produced on a large scale and can be prepared into a patent medicine so as to be convenient to carry and take.

Description

A kind of Chinese medicine composition treating gout and preparation method

Technical field

The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating gout and preparation method.

Background technology

Chinese medicine is thought: damp and hot turbid poison, and root is in taste, and passages through which vital energy circulates of being detained, heap soil or fertilizer over and around the roots amenorrhea network, multiple abscess joint, if deficient vital QI leading to lingering of pathogen, noxious dampness does not go, and follows through altering network, invests joint, forms sucutaneous nodule, as hard as flint. So damp and hot turbid poison is to form tophaceous main cause. Eating and drinking without temperance, impairing the spleen and stomach, transporting imbalance in addition that ferritic is insufficiency of the spleen, makes raw turbid damp, outer note skin and flesh joint, inside stays internal organs, send out as primary disease. Exopathogen is detained, and to cause QI and blood smooth for muscle arthrosis, blockage of main and collateral channels, and stagnation of QI and blood may bring about pain then can cause deficiency of both QI and blood for a long time, and heat in blood causes the stasis of blood, and network road blocks, and causes arthroncus, lopsided and stiff. It is main for treating with " invigorating the spleen and benefiting QI dehumidifies, heat-clearing and toxic substances removing ", is auxiliary with " promoting blood circulation to remove blood stasis, removing obstruction in the collateral to relieve pain ".

Doctor trained in Western medicine thinks that gout is the crystal dependency arthrosis caused by monosodium urate salt (MSU) deposition, directly related with the hyperuricemia caused by purine metabolic disturbance and (or) underexcretion, refer in particular to acute characteristic arthritis and chronic gout stone disease, mainly including acute attack arthritis, tophus formation, tophaceous chronic arthritis, urate nephropathy and uric acid lithangiuria, severe one may occur in which joint deformity and renal insufficiency.

Treatment gout is mainly had to the treatments by Chinese herbs such as TONGFENGDING capsule or application Western medicine allopurinol and nonsteroidal anti inflammatory analgesic, unsatisfactory curative effect, and western medicine and medical practitioners class purine alcohol and nonsteroidal anti inflammatory analgesic side effect big, especially the surgical skin such as erythra, skin pruritus or urticaria can be caused sick, in addition can also cause nausea, vomit, suffer from abdominal pain, the digestive tract disease such as diarrhoea, somewhat expensive, and application for a long time can cause the vitals such as Drug Liver and kidney.

Treatment gout Chinese patent medicine is mainly based on TONGFENGDING capsule now, and composition is Radix Gentianae Macrophyllae, Cortex Phellodendri, Rhizoma Corydalis, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Alismatis, Semen Plantaginis, Rhizoma Smilacis Glabrae. Oral, one time 4,3 times on the one. One after each meal.

TONGFENGDING capsule pays attention to have clearing away heat and expelling wind dehumidifying, effect of promoting blood circulation, dredging meridian and relieving pain, only pays attention to clearing heat and expelling damp, strengthens the surface action of pain relieving. Do not focus on inherent invigorating the spleen and regulating the stomach, strengthening vital QI to eliminate pathogenic factors, cure the symptoms, not the disease, fail to solve root problem. Additionally, TONGFENGDING capsule pharmacopeia is merely provided to the numbness disease caused by dampness and heat stasis, disease sees redness and swelling of joints burning pain, with heating, no relieving of symptom after perspiration, thirsty vexed, yellow urine, red tongue with yellowish and greasy fur, slippery and rapid pulse; Gout is shown in above-mentioned disease person. Limitation is too narrow, it is impossible to serve all kinds of patient with gout that transporting and transforming function of the spleen and stomach imbalance causes.

Summary of the invention

It is an object of the invention to overcome above-mentioned technical problem and provide a kind of curative effect better, have no side effect, the Chinese medicine composition of no sequel, treatment time is short, expense is relatively low treatment gout and preparation method.

For achieving the above object, the present invention adopts the following technical scheme that a kind of Chinese medicine composition treating gout, including following component by weight: Radix Astragali 10-12 weight portion, Radix Pseudostellariae 5-6 weight portion, Caulis Lonicerae 5-6 weight portion, Thallus Laminariae (Thallus Eckloniae) 5-6 weight portion, Sargassum 5-6 weight portion, Pheretima (parched) 1-2 weight portion, Caulis Piperis Kadsurae 5-6 weight portion, money Elaphe moellendorffi 1-2 weight portion, Radix Rehmanniae 5-6 weight portion, Cortex Moutan 2-3 weight portion, Radix Achyranthis Bidentatae 2-3 weight portion, Scolopendra 1-2 weight portion, Scorpio 1-2 weight portion, Bi 5-6 weight portion, Gypsum Fibrosum 5-6 weight portion.

The preparation method of a kind of Chinese medicine composition treating gout, comprises the following steps:

(1) weighing each medicine by prescription, it is standby that the Radix Astragali, Radix Pseudostellariae, Pheretima, Bungarus Parvus, Radix Achyranthis Bidentatae, Scolopendra, scorpion powder are broken into fine powder mixing of sieving;

(2) take Caulis Lonicerae, Cortex Moutan, the Radix Rehmanniae are ground into coarse powder, according to fluid extract and the percolation under extractum item, use 70% ethanol as solvent, after impregnate 4 hours, and slowly percolation, collect liquid of filtering, recovery ethanol, filtration, filtrate and medicinal residues are standby;

(3) by the medicinal residues in step 2 and Thallus Laminariae (Thallus Eckloniae), Sargassum, Caulis Piperis Kadsurae, Gypsum Fibrosum, Bi boiling twice, each 2 hours, collecting decoction, filter, filtrate merges with the filtrate in step 2, is concentrated into paste;

(4) poultice in step 3 adding the fine powder of step 1, loads No. 0 capsule, every, containing medicated powder 0.3g, obtains 1000. After ethane via epoxyethane sterilizing, place 7-10 days, subpackage, 60/bottle.

Beneficial effect: treating both the principal and secondary aspects of a disease of the present invention, therapeutic domain is wide, and curative effect is good, and Time of Administration is short, has no side effect, no sequel, can be rated as " green medicine ", makes simple, disposable can produce in enormous quantities, make patent medicine taking convenience easy to carry.

Controlling according to differential diagnosis in tcm opinion, the controlled disease of we, damp and hot poison wets, root in taste, passages through which vital energy circulates of being detained, cause that body is insufficiency of the spleen damp and hot, transporting is lacked of proper care, and outer note skin and flesh joint causes joint QI and blood not smooth, blockage of main and collateral channels, stagnation of QI and blood may bring about pain, then can cause deficiency of both QI and blood for a long time, and heat in blood causes the stasis of blood, network road blocks, and causes arthroncus, lopsided and stiff; Therefore treatment heat-clearing and toxic substances removing dehumidifying, invigorating the spleen and benefiting QI. Side reuses the Radix Astragali, Radix Pseudostellariae invigorating the spleen and benefiting QI; Thallus Laminariae (Thallus Eckloniae), Sargassum, Bi eliminating stagnation expectorant dampness removing, for the meter of removing burning wood away under the boiler; Use the removing heat from blood and promoting blood circulation such as the Radix Rehmanniae, Cortex Moutan, Caulis Lonicerae, Caulis Piperis Kadsurae, Gypsum Fibrosum, heat-clearing and toxic substances removing; Using Scorpio to search wind diaphoresis, make poison from cure by diaphoresis, with the Scolopendra compatibility walking the power steepest altered, then all skin ulcers are hindered toxic swelling and all can be disappeared it; Bungarus Parvus can declare purging FU-organs dirty, implements meridians, thoroughly reaches pass key, Pheretima energy heat-clearing and toxic substances removing, dredging collateral; Radix Achyranthis Bidentatae draws the descending through sick institute of all medicines. Gather invigorating the spleen and benefiting QI altogether, promoting blood circulation, dredging meridian and relieving pain, the merit of heat-clearing and toxic substances removing.

We's medication principle and modern pharmacological research are as follows:

The Radix Astragali: sweet, temperature. Return lung, spleen channel; Tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promote the production of body fluid and nourish blood, the stagnant arthralgia aggravated by cold of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency dull yellowish colored skin, hemiplegia, and arthralgia pain is numb, and carbuncle difficulty is burst, and bursts for a long time and does not hold back; There is enhancing immunity, strengthen energy, resisting fatigue, mutation, protect the liver, it is suppressed that the effect of osteoclast; Astragalus polysaccharides has blood fat reducing, namely reduces the effect of cholesterol and triglyceride, high density lipoprotein increasing; Can prevent and treat cardiovascular and cerebrovascular disease, such as atherosclerosis, coronary artery pathological changes, peripheral angiopathy and hyperlipemia etc. Astragaloside has the effect significantly reducing blood glucose, glycolated hemoglobin and urine protein, the AGEs in renal cortex and serum can be reduced, display astragaloside has antioxidation, and aldose reductase is had inhibitory action, also suppresses proliferation of mesangial cells, alleviates the effect of renal hypertrophy; Adding suitable adjuvant in astragaloside, can be made into oral formulations, it is used for preventing and treating diabetic nephropathy;

" Bencao Jingshu ": " function reality table, person does not use pathogenic factor in the exterior; Helping gas, QI excess person does not use; Interior filling in, tonifying for the deficiency, chest and diaphragm is gas-tight asks, the intestines and stomach has stagnant person not use; Energy YANG invigorating, overabundance of YANG leading to deficiency of YIN person avoids it; Part of the body cavity above the diaphragm housing the heart and lungs intenseness of heat, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness person avoids it; The many anger of patient, disharmony in liver-QI person do not take; Variola blood system heat notably disables. " return lung, spleen, liver, kidney channel; Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation; Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and bursts for a long time and does not hold back, blood deficiency dull yellowish colored skin, and interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Radix Pseudostellariae: hardship sweet, micro-is flat. Return spleen, lung meridian; Replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung. Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough; Radix Pseudostellariae can improve immunologic function, improves cardiac function; Containing Pseudostellaria Polysaccharide, several amino acids and trace element. The phagocytic function of reticuloendothelial system can be significantly improved, increase cyclophosphamide and cause the body weight of immunologic hypofunction mice and the weight etc. of spleen, thymus; The immunologic function of body can be significantly improved. " Shaanxi Chinese herbal medicine " is said: invigorating qi and benefiting blood, spleen invigorating is promoted the production of body fluid. After curing the disease, body is empty, cough due to deficiency of the lung, insufficiency of the spleen diarrhoea, children's's sweating due to debility, cardiopalmus, xerostomia, anorexia.

Caulis Lonicerae: sweet, cold; Attach to the lung and stomach meridians; Heat-clearing and toxic substances removing, dispelling wind dredging collateral. Generate heat for epidemic febrile disease, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain; Having and have significant anti-inflammatory activity, intramuscular injection can significantly inhibit rat paw edema and pleura oozes out; Luteolin is oral can make children's Mus atrophy of thymus gland, it was shown that it can strengthen hard adrenal cortex function, and its antiinflammatory action is relevant with this; Drum allergy is had significant inhibitory action by antianaphylaxis and immunomodulating; The mechanism of antianaphylaxis can suppress Anaphylactic mediator to discharge with it, the effect causing convulsion effect and histamine of competitive antagonism SRS-A (slow reacting substance), and directly makes smooth muscle spasmolysis relevant.

Thallus Laminariae (Thallus Eckloniae): salty, cold; Return liver, stomach, kidney channel; Eliminating phlegm and softening indurated mass eliminating stagnation, inducing diuresis to remove edema; For goiter, scrofula, painful and swollen testis, phlegm retention edema; [attention] should not with Radix Glycyrrhizae with using; Modern study is to thyroid effect, hypotensive effect, antiasthmatic effect effect; Return liver, stomach, kidney channel; Hard masses softening and resolving, expectorant, diuretic; For goiter, scrofula, painful and swollen testis, phlegm retention edema.

Sargassum: bitter, salty, cold. Return liver, stomach, kidney channel; Eliminating phlegm and softening indurated mass eliminating stagnation, inducing diuresis to remove edema; For goiter, scrofula, painful and swollen testis, phlegm retention edema; [attention] should not with Radix Glycyrrhizae with using. Containing the substantial amounts of iodine that can substantially reduce blood cholesterol level in Sargassum, often food is conducive to maintaining the function of cardiovascular system, makes blood vessel high resilience, thus ensureing the regular supply of skin-nourishing; Methionine, cystine in Sargassum are enriched, and can prevent xerosis cutis, and normal food also can make dry skin be rich in gloss, and oily skin can improve fat secretion; Bitter in the mouth, salty, cold in nature, nontoxic. Effect: softening the hard mass; Expectorant; Diuretic; Detumescent. Thyromegaly, item submental lymph nodes tuberculosis. Eliminating stagnation gas carbuncle, abdomen inner product block, distending pain, abdomen hollow are rung. Also can descend 12 kinds of edema, treat and between skin, gather sudden and violent bursting, stay depressed heat, diuresis. " herbal classic " (Shennong's Herbal): main goiter gas, core under neck, broken eliminating stagnation gas, carbuncle lump in the abdomen heavily fortified point gas, abdomen rings up and down, lower 12 edema.

Pheretima: salty, cold; Return liver, spleen, bladder warp; Heat clearing away is calmed the frightened, and dredging collateral is relievingd asthma, diuresis; For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema. Heat clearing away is calmed the frightened, and dredging collateral is relievingd asthma, diuresis; For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension. We's Pheretima parch is mainly used in the effects such as arthralgia, numb limbs and tense tendons, hemiplegia.

Caulis Piperis Kadsurae: pungent, bitter, tepor. Return Liver Channel. Wind-damp dispelling, the meridian dredging, stopping numbness pain; For anemofrigid-damp arthralgia, arthrodynia of extremities, muscle arteries and veins contracture, joint stuffiness. For anemofrigid-damp arthralgia, arthrodynia of extremities, muscle arteries and veins contracture, joint stuffiness; " book on Chinese herbal medicine is new again ": " network of passing through, and blood vessels, alleviating distention in middle-JIAO is regulated the flow of vital energy, lower wet except wind, manages waist beriberi, controls hernia, antiabortive.

Bungarus Parvus: sweet, salty, temperature; Poisonous; Return Liver Channel. Dispel the wind, dredging collateral, relieving convulsion; For rheumatoid arthritis stubborn, numbness contracture, middle air port eye is oblique, hemiplegia, tic spasm, tetanus, leprosy, scabies; Dispelling wind and removing obstruction in the collateral; Arresting convulsion relieving convulsion; Main air pain of dampness syndrome; Spasm of muscles and vessels; Middle air port eye is oblique; Hemiplegia; Infantile convulsion; Tetanus; Leprosy; Scabies; Prunus mume (sieb.) sieb.et zucc. poison; Malignant boil. For rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil. For rheumatoid arthritis stubborn, numbness contracture, middle air port, hemiplegia, tic spasm, tetanus disease, leprosy scabies, scrofula malignant boil.

The Radix Rehmanniae: sweet, cold. GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Entering nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, consumption of YIN caused by febrile disease, crimson tongue excessive thirst for heat, constipation, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever are hindered in Tianjin, and interior-heat is quenched one's thirst; Removing heat from blood YIN nourishing, Radix Rehmanniae is scrophulariaceae rehmannia glutinosa plant or the rhizome of bosom celebrating Radix Rehmanniae, is dried people's medicine and is called the Radix Rehmanniae; The Radix Rehmanniae is cool in nature, sweet in the mouth, enters the heart, liver, kidney channel, can removing heat from blood, again can YIN nourishing, tool heat clearing away YIN nourishing, cooling blood for hemostasis, promoting the production of body fluid to quench thirst effect; Modern pharmacological research shows, Radix Rehmanniae has radioprotective, protects the liver, reduces blood glucose, heart tonifying, hemostasis, diuresis, antifungal effect.

Cortex Moutan: bitter, pungent, is slightly cold; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling. Enter nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea for heat, fall and flutter the pain of injury, carbuncle sore tumefacting virus; Compendium of Material Medica: " nourishing YIN to lower pathogenic fire solves speckle poison, throat, diuresis stasis. Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also. Red colored person profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it. " modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has suppression Platelet; Paeonol has the effects such as central inhibitory action and atherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolytic.

Radix Achyranthis Bidentatae: bitter, sour is flat; Return liver, kidney channel; Eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards; For amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, stranguria, edema, headache, dizziness, toothache, and aphtha is spitted blood, epistaxis; Eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards; " not Lu ": few gas in curing the wound, man's the moon disappears, and old man loses excessive, and invigorating middle warmer is continuous absolutely, benefit essence Li Yin gas, fills out bone marrow, only turns white, and except pain and pain along the spinal column in brain, married woman's moon water is obstructed, blood agglomeration.

Scolopendra: pungent, temperature; Poisonous; Return Liver Channel; Endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation; For liver-wind stirring up internally, spasm is twitched, infantile convulsion, middle air port fish sticking its mouth out of the water, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula, snake bite and insect sting; Scolopendra is medicinal herbs most in use, warm in nature, and acrid in the mouth is poisonous; There is the function of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; For infantile convulsion, tic spasm, apoplexy facial hemiparalysis, hemiplegia, tetanus disease, rheumatoid arthritis stubborn, skin infection, scrofula, venom. " Records of Tradition Chinese and Western Medicine in Combination ": " Scolopendra, Zou Cuan main force steepest, interior and internal organs, outer and meridians, all QI and blood cohesion part all can open it; Property have micro-poison, and turn kind removing toxic substances, all poison of all skin infection all can disappear it; Its property is especially kind searches wind, and treatment by oral administration of medicines liver-wind is sprouted, epilepsy dizziness, takes out and pulls, infantile neonatal tetanus; External treatment meridians apoplexy, facial hemiparalysis, numb hand and foot. For its performance Serpentis, therefore control again Serpentis disease and ophidism; Skin ulcer first (popular name clavus) is controlled in external application; With appropriate to the occasion foot of taking the lead, the then power gone subtracts, and its former nothing of property is malicious greatly, therefore might as well entirely with also. " " ill dysphagic person, the medicine does no good to, even thinks to drink, and drinks off a kettle and recovers. Backsight kettle has Scolopendra one, realize that it recovers all of a sudden by not at wine, tangible wine having Scolopendra also. Covering dysphagic card, how because of blood stasis Shangwan, for tangible obstruct, Scolopendra is good at out the stasis of blood, is healing. Seeing in this, then control dysphagic person, Scolopendra is when the product for urgent need. "

Scorpio: pungent, flat; Poisonous. Return Liver Channel; Endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation; For liver-wind stirring up internally, spasm is twitched, infantile convulsion, middle air port fish sticking its mouth out of the water, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula; Scorpio is classified as medicine for calming liver and calming endopathic wind, its acrid in the mouth, and property is put down, poisonous, returns Liver Channel; There is effect of endogenous wind stopping relieving convulsion, removing obstruction in the collateral to relieve pain, detoxicating and resolving stagnation of pathogens; The effect of Scorpio is in that pungent to dissipate, string thoroughly, counteracting toxic substances, for controlling the key medicine of exogenous wind; It is usually used in apoplexy, infantile convulsion, tetanus, arthromyodynia, can be used for carbuncle sore, tuberculosis, venom; Scorpio is edible, medicinal history is long; According to Compendium of Material Medica and " Chinese Pharmacopoeia " load, Scorpio has " spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain " function; Cure mainly diseases such as " infantile convulsion, tic spasm, dermatosis, cardiovascular and cerebrovascular disease, inflammation, hepatitis B, tumors ".

Bi: bitter is flat; Return kidney, stomach warp; Dampness removing goes turbid, wind expelling stagnation removing. For stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain; For stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain. The merit of Compendium of Material Medica: Bi, is longer than rheumatism, so controlling slow weak insensitive impediment, losing genus rheumatism person turbid, all diseases of malignant boil.

Gypsum Fibrosum: sweet, pungent, Great Cold; Attach to the lung and stomach meridians; Clearing away heat-fire, relieving restlessness is quenched the thirst; For fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache; Gypsum Fibrosum cures mainly apoplexy cold and heat, and heart subinverse gas is frightened to be breathed heavily, xerostomia scorching tongue, it is impossible to breath, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound; Except seasonal epidemic pathogens headache fever of the body, three burnt big heat, skin heat, stagnation of QI in the intestines and stomach, expelling pathogenic factors from muscles by diaphoresis, restlessness accompanied by ascending of QI of only quenching one's thirst, the sudden and violent gas of abdominal distention, pant and swallow heat, also can do bath soup; Cure the wound cold headache as split; Simmer tea with Herba Alii fistulosi, pain of decaptitating; Controlling sky row fanatic, wind syndrome of head revolves, and stimulating milk secretion wipes tooth benefit tooth; Except gastric heat lung-heat, dissipate YIN pathogen, slow spleen QI invigorating; Only Yangming Channel headache, fever with chills, day feeds hectic fever, drinking a large amount of water due to extreme thirst, heatstroke hectic fever, has a toothache; From Compendium of Material Medica. Gypsum Fibrosum is mainly composed of hydrous calcium sulfate; Additionally, still have the ferrum of a small amount of silicic acid, aluminium hydroxide, sulfide and trace, magnesium etc.; Gypsum Fibrosum Preparatum be mainly composed of dehydrated calcium sulfate; For oral administration through gastric acid effect, a part becomes soluble calcium salt, can increase the concentration of calcium ion in serum after entering blood to intestinal absorption, can suppress thermotaxic centre, alleviates the irritability of skeletal muscle, reduce vascular permeability, therefore has the effects such as antipyretic, spasmolytic, antiinflammatory.

Detailed description of the invention

Below, it is further described in conjunction with the example substantive distinguishing features to the present invention and advantage, but the invention is not limited in listed embodiment.

Embodiment 1

A kind of Chinese medicine composition treating gout, including following component by weight: Radix Astragali 10-12 weight portion, Radix Pseudostellariae 5 weight portion, Caulis Lonicerae 5 weight portion, Thallus Laminariae (Thallus Eckloniae) 5 weight portion, Sargassum 5 weight portion, Pheretima (parched) 1 weight portion, Caulis Piperis Kadsurae 5 weight portion, money Elaphe moellendorffi 1 weight portion, the Radix Rehmanniae 5 weight portion, Cortex Moutan 2 weight portion, Radix Achyranthis Bidentatae 2 weight portion, Scolopendra 1 weight portion, Scorpio 1 weight portion, Bi 5 weight portion, Gypsum Fibrosum 5 weight portion.

The preparation method of a kind of Chinese medicine composition treating gout, comprises the following steps:

(1) weighing each medicine by prescription, it is standby that the Radix Astragali, Radix Pseudostellariae, Pheretima, Bungarus Parvus, Radix Achyranthis Bidentatae, Scolopendra, scorpion powder are broken into fine powder mixing of sieving;

(2) take Caulis Lonicerae, Cortex Moutan, the Radix Rehmanniae are ground into coarse powder, according to fluid extract and the percolation under extractum item, use 70% ethanol as solvent, after impregnate 4 hours, and slowly percolation, collect liquid of filtering, recovery ethanol, filtration, filtrate and medicinal residues are standby;

(3) by the medicinal residues in step 2 and Thallus Laminariae (Thallus Eckloniae), Sargassum, Caulis Piperis Kadsurae, Gypsum Fibrosum, Bi boiling twice, each 2 hours, collecting decoction, filter, filtrate merges with the filtrate in step 2, is concentrated into paste;

(4) poultice in step 3 adding the fine powder of step 1, loads No. 0 capsule, every, containing medicated powder 0.3g, obtains 1000. After ethane via epoxyethane sterilizing, place 7-10 days, subpackage, 60/bottle.

Usage and dosage: oral, each 4-6 grain, every day 2-3 time; Anemia of pregnant woman disables.

Embodiment 2

A kind of Chinese medicine composition treating gout, including following component by weight: Radix Astragali 10-12 weight portion, Radix Pseudostellariae 6 weight portion, Caulis Lonicerae 6 weight portion, Thallus Laminariae (Thallus Eckloniae) 6 weight portion, Sargassum 6 weight portion, Pheretima (parched) 2 weight portion, Caulis Piperis Kadsurae 6 weight portion, money Elaphe moellendorffi 2 weight portion, the Radix Rehmanniae 6 weight portion, Cortex Moutan 3 weight portion, Radix Achyranthis Bidentatae 3 weight portion, Scolopendra 2 weight portion, Scorpio 2 weight portion, Bi 6 weight portion, Gypsum Fibrosum 6 weight portion.

The preparation method of a kind of Chinese medicine composition treating gout, comprises the following steps:

(1) weighing each medicine by prescription, it is standby that the Radix Astragali, Radix Pseudostellariae, Pheretima, Bungarus Parvus, Radix Achyranthis Bidentatae, Scolopendra, scorpion powder are broken into fine powder mixing of sieving;

(2) take Caulis Lonicerae, Cortex Moutan, the Radix Rehmanniae are ground into coarse powder, according to fluid extract and the percolation under extractum item, use 70% ethanol as solvent, after impregnate 4 hours, and slowly percolation, collect liquid of filtering, recovery ethanol, filtration, filtrate and medicinal residues are standby;

(3) by the medicinal residues in step 2 and Thallus Laminariae (Thallus Eckloniae), Sargassum, Caulis Piperis Kadsurae, Gypsum Fibrosum, Bi boiling twice, each 2 hours, collecting decoction, filter, filtrate merges with the filtrate in step 2, is concentrated into paste;

(4) poultice in step 3 adding the fine powder of step 1, loads No. 0 capsule, every, containing medicated powder 0.3g, obtains 1000. After ethane via epoxyethane sterilizing, place 7-10 days, subpackage, 60/bottle.

Usage and dosage: oral, each 4-6 grain, every day 2-3 time; Anemia of pregnant woman disables.

My seminar of hospital of institute is according to important dialectical theory, in conjunction with pharmacological research in modern age, use the medicine composition prescriptions such as the Radix Astragali, Radix Pseudostellariae, Caulis Lonicerae, Pheretima, Radix Achyranthis Bidentatae, Scorpio, there is heat-clearing and toxic substances removing dehumidifying significantly, invigorating the spleen and benefiting QI, a surname's spleen dampness removing, the curative effect of promoting blood circulation, dredging meridian and relieving pain, effect is obvious by clinic application.

100 example gout patients are given this preparation for treating 3 courses for the treatment of (10 days) relatively matched group (gout application allopurinol and indomethacin) evident in efficacy. And follow the tracks of and look for after three courses for the treatment of of patient's medication 15 days. Adding up every untoward reaction, relatively matched group (gout application allopurinol and indomethacin) untoward reaction significantly reduces.

Treatment this preparation medicine of gout and allopurinol, indomethacin comparitive study

Through statistical procedures P < 0.05, there is notable difference

Through statistical procedures P < 0.05, there is notable difference

The above is only the preferred embodiment of the present invention; it should be pointed out that, for those skilled in the art, under the premise without departing from the principles of the invention; can also making some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention.

Claims (2)

1. the Chinese medicine composition treating gout, it is characterized in that, including following component by weight: Radix Astragali 10-12 weight portion, Radix Pseudostellariae 5-6 weight portion, Caulis Lonicerae 5-6 weight portion, Thallus Laminariae (Thallus Eckloniae) 5-6 weight portion, Sargassum 5-6 weight portion, Pheretima (parched) 1-2 weight portion, Caulis Piperis Kadsurae 5-6 weight portion, money Elaphe moellendorffi 1-2 weight portion, Radix Rehmanniae 5-6 weight portion, Cortex Moutan 2-3 weight portion, Radix Achyranthis Bidentatae 2-3 weight portion, Scolopendra 1-2 weight portion, Scorpio 1-2 weight portion, Bi 5-6 weight portion, Gypsum Fibrosum 5-6 weight portion.

2. the preparation method treating the Chinese medicine composition of gout described in a claim 1, it is characterised in that comprise the following steps:

(1) weighing each medicine by prescription, it is standby that the Radix Astragali, Radix Pseudostellariae, Pheretima, Bungarus Parvus, Radix Achyranthis Bidentatae, Scolopendra, scorpion powder are broken into fine powder mixing of sieving;

(2) take Caulis Lonicerae, Cortex Moutan, the Radix Rehmanniae are ground into coarse powder, according to fluid extract and the percolation under extractum item, use 70% ethanol as solvent, after impregnate 4 hours, and slowly percolation, collect liquid of filtering, recovery ethanol, filtration, filtrate and medicinal residues are standby;

(3) by the medicinal residues in step 2 and Thallus Laminariae (Thallus Eckloniae), Sargassum, Caulis Piperis Kadsurae, Gypsum Fibrosum, Bi boiling twice, each 2 hours, collecting decoction, filter, filtrate merges with the filtrate in step 2, is concentrated into paste;

(4) poultice in step 3 adding the fine powder of step 1, loads No. 0 capsule, every, containing medicated powder 0.3g, obtains 1000; After ethane via epoxyethane sterilizing, place 7-10 days, subpackage, 60/bottle.