CN105596964A - Drug for treating acne - Google Patents

Drug for treating acne Download PDF

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Publication number
CN105596964A
CN105596964A CN201610101239.7A CN201610101239A CN105596964A CN 105596964 A CN105596964 A CN 105596964A CN 201610101239 A CN201610101239 A CN 201610101239A CN 105596964 A CN105596964 A CN 105596964A
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parts
acne
drug
treatment
medicine
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吴斌
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention relates to a drug for treating acne. The drug is prepared from, by weight, 9 parts of herbal carpesii cernui, 10 parts of snake gourd seeds, 1 part of entireleaf neoalsomitra, 4 parts of rhizome coptidis, 9 parts of herb of fanshaped umbrellasedge, 10 parts of spica prunellae, 5 parts of fruits of amomum cardamomum, 7 parts of pilea lomatogramma hand and 8 parts of streptopus simplex. According to the drug, herbal carpesii cernui is used for clearing away heat and toxic materials; snake gourd seeds are used for moistening the lungs and reducing phlegm; entireleaf neoalsomitra is used for restraining oneself and stopping pain; rhizome coptidis is used for purging fire and removing toxins; herb of fanshaped umbrellasedge is used for promoting qi circulation and activating blood circulation; spica prunellae is used for removing stasis and subsiding swelling; the fruits of amomum cardamomum are used for resolving dampness and promoting qi circulation; pilea lomatogramma hand is used for removing toxins and closing sores; streptopus simplex is used for removing heat from the lungs to relieve coughs. All the herbs are used in a combined mode to jointly achieve the effects of promoting blood circulation to remove meridian obstruction and reducing hardness to remove stasis. Clinical experiments prove that the drug can safely and effectively treat acne.

Description

A kind of medicine that is used for the treatment of acne
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine that is used for the treatment of acne.
Background technology
Acne is the chronic inflammation skin due to a kind of hair follicle that many factors causes, sebaceous glandsSick. The pilosebaceous follicle of the juvenile face of good pastiness and thoracic dorsal. Main pathogenic factor is that sebum too much dividesSecrete, pilosebaceous duct stops up, and bacterium infects, inflammatory reaction etc. Be recognized that at present acnePropionibacterium is a kind of key factor of morbidity. Be divided into papule according to fash form and state of an illness weightType, pustule type, nodular type, cyst type, atrophic type and poly-and type 6 classes.
Clinical manifestation
Acne lesions is apt to occur in face and upper chest and back. The non-inflammation skin of acne damages and shows as openingProperty and closed comedones. It is approximately 1 mm in size that the typical skin of closed comedones (claiming again hoary hair) damagesColour of skin papule, without obvious hair follicle opening. Open comedones (claiming again blackhead) shows as dome-shapedThe significantly hair follicle opening of expansion of papule companion. Acne further develop and can develop into various struvite skinsDamage, show as inflammatory papule, warts, tubercle and tumour. Inflammatory papule takes on a red color, diameter 1～5Millimeter is not etc.; Warts is in the same size, has wherein been full of white fester; Tubercle diameter is greater than 5 millimeters,Having of touching hardened and pain; The position of tumour is darker, has been full of the mixture of fester and blood.These skins damage also can merge and form large inflammatory patch and sinus etc. Struvite skin after damaging and disappearing usuallyLeave over pigmentation, erythema perstans, pitting or hypertrophic scar. Clinically according to acne skinDamage character and the order of severity acne is divided into 3 degree, 4 grades: 1 grade (slightly): only have acne; 2Level (moderate): except acne, also have some inflammatory papules; 3 grades (moderate): except acne,Also have more inflammatory papule or warts; 4 grades (severe): apart from acne, inflammatory papule and wartsGo back nodosity, tumour or scar outward.
The common method of acne treatment
(1) local topical medicine tretinoin (Tretinoin emulsifiable paste, adapalene gel, heZha Luoting gel), benzoyl peroxide, antibiotics (clindamycin, erythromycin, chloramphenicolDeng), azelaic acid, sulphur lotion etc.
(2) the first-selected Tetracyclines of oral antibiotic (minocycline, Doxycycline etc.), secondlyFor macrolides (erythromycin), avoid selecting the antibiotic that is usually used in therapy system infection as a left sideOfloxacin etc. Common 6～12 weeks of antibiotic regimen.
(3) oral isotretinoin is for serious acne, and oral isotretinoin is standard treatment,Also be the effective method of current Acne treatment. The course for the treatment of taking reach minimum intergal dose 60mg/kg asTarget.
(4) antiandrogen is treated as oral contraceptive Compound Cyproterone Acetate Tablets, is applicable to femaleIn property, severe acne patient, with the too high performance of androgen levels (as crinosity, seborrhea etc.)Or Stein-Leventhal syndrome. Delayed acne and female patient that before the menstrual period, acne significantly increases the weight of are alsoCan consider to apply oral contraceptive.
(5) oral glucocorticoid is mainly used in fulminant or acne conglobata, follow short-term,Low dose of, with the principle of additive method use in conjunction.
(6) other,, for the patient that can not tolerate or be reluctant to accept medicine treatment, also can consider thingReason treatment, as PDT (PDT), tartaric acid therapy, laser therapy etc.
Medicinal material involved in the present invention is all recorded in " China's book on Chinese herbal medicine " as seen.
Summary of the invention
The present invention aims to provide a kind of medicine that is used for the treatment of acne, by select suitable medicinal material andIts proportioning, reaches the object of safe and effective healing acne.
In order to achieve the above object, the present invention is by the following technical solutions:
A medicine that is used for the treatment of acne, is characterized in that, it is former by following weight proportionMaterial medicinal material is prepared from: 9 parts of spoon dishes, 10 parts of Chinese Drug Gualouzis, 1 part of henry hemsleya root, 4 parts of the coptiss,9 parts of umbrella plants, 10 parts of selfheals, 5 parts of Amomum cardamomums, 7 parts of Pilea lomatogramma Hand.-Mazzs, 8 parts of twisted-stalks.
Below in conjunction with theories of Chinese materia medica, beneficial effect of the present invention is described:
Inventor thinks, the basic pathogenesis of acne is that lung machine silts up, and stomach accumulated heat is loose. Damp and hotly accumulate for a long time,Cause smegma to cross Sheng, the raw illness of fur. Therefore should focus on eliminating heat from the lung, strong taste in treatment.Reach effect promoting blood circulation and removing obstruction in channels, light hard dissipating bind.
The present invention uses: spoon dish is clearing heat and detoxicating; Chinese Drug Gualouzi moistening lung for removing phlegm; Henry hemsleya root convergencePain relieving; Coptis purging intense heat and detonicating; The umbrella plant promoting flow of qi and blood circulation; Selfheal mass dissipating and swelling eliminating; Amomum cardamomumizationWet promoting the circulation of qi; Pilea lomatogramma Hand.-Mazz removing toxic substances sore; Twisted-stalk removing heat from the lung to relieve cough. All medicines share, play altogether invigorate blood circulation logicalThe merit of network, light hard dissipating bind.
Below in conjunction with clinical trial data declaration beneficial effect of the present invention:
1, physical data
70 routine patients with acne are collected between year May altogether in inventor in May, 2012-2014. Random pointFor: treatment group 40 examples, control group 30 examples. Wherein treatment group man 15 examples, female's 25 examples, the age18～34 years old, the course of disease 1 month～12 years; Control group man 13 examples, female's 17 examples, the age 18～Between 30 years old, the course of disease 1 month～10 years. The data such as two groups of sexes, age, the course of disease are without conspicuousnessDifference, has comparativity.
Western medicine diagnose standard
Distinguish work " clinical dermatology " Western medicine diagnose mark Huaihe River with reference to Zhao. Pubarche morbidity is goodSend out in the flourishing position of the sebaceous glands such as face, upper chest and back, symmetrical. Skin damages as hair follicle moundRash, blackhead, warts, tubercle, tumour and scar, with seborrhea, be chronic process.
1. the people's standard of receiving distinguishes work " clinical dermatology " Western medicine diagnose standard according to Zhao, meets ordinaryThe diagnosis of type acne; 2. meet above-mentioned Syndrome Differentiation of Traditional Chinese Medicine standard person; 3. the age more than 18 years old,Male or female. 4. sign voluntarily Informed Consent Form.
Exclusion standard: 1) gestation or women breast-feeding their children; 2) patient other may affect the treatment observeSkin disease, as psoriasis, lupus erythematosus; 3) Drug that occupational acne or iodine, bromine etc. causeAcne; 4) there are severe cardiac, lung, kidney and disease of hematopoietic system person; 5) treatment the last fortnight is once localOr system is used the medicine of other Acne treatment; 6) do not complete the course for the treatment of or because of serious adverse reaction endOnly curer.
2, methods for the treatment of
The capsule that the oral the present invention for the treatment of group makes according to specific embodiment 3, every day 3 times. Treatment2 months.
The oral Te Weisi of control group (isotretinoin capsules, the accurate word H0055201 of traditional Chinese medicines, the East Sea, ShanghaiEast Sea pharmaceutical factory of Pharmacy stock Co., Ltd) 10mg every day. Treat 2 months.
3, criterion of therapeutical effect and treatment results
3.1 criterion of therapeutical effect
Cure: skin damages and substantially disappears, restrain pain and disappear, skin damages sum minimizing and is more than or equal to 90%;
Effective: skin damages and obviously disappears, the pain of itching obviously alleviates, and skin damages sum minimizing and is more than or equal to 60%But be less than 90%;
Effective: skin damage disappear to some extent, itching pain alleviates, skin damage sum reduce be more than or equal to 20% butBe less than 60%;
Invalid: skin damages and disappears seldom, or skin damages without obviously changing or increasing the weight of, itching pain do not alleviate orAggravation, skin damages sum minimizing and is less than 20%.
3.2 treatment statisticses are in table 1.
Table 1 liang group curative effect comparison
Group n Cure Effective Effectively Invalid Total effective rate (%) Obvious adverse reaction example
Treatment group 40 19 10 8 3 92.5％ Nothing
Control group 30 10 5 3 12 60％ Allergic 3 examples;
Visible, the medicine that the present invention makes can safe and effective Acne treatment, and cure rate is high.
Detailed description of the invention
In order to understand better and to implement the present invention, further illustrate this below in conjunction with specific embodimentInvention.
Embodiment 1
Take: 9 grams of spoon dishes, 10 grams of Chinese Drug Gualouzis, 1 gram of henry hemsleya root, 4 grams of the coptiss, umbrella Sha9 grams of grass, 10 grams of selfheals, 5 grams of roud cardamon seeds, 7 grams of Pilea lomatogramma Hand.-Mazzs, 8 grams of twisted-stalks; Add 8Times water gaging, decocts 1.5 hours, filters; Filter residue adds 6 times of water gagings, decocts 1 hour, filters;Merging filtrate, is concentrated into 120 grams, must meet the decoction of one day consumption of normal adult.
Be used for the treatment of acne. Oral, take once every day.
Embodiment 2
Take: 9 grams of spoon dishes, 10 grams of Chinese Drug Gualouzis, 1 gram of henry hemsleya root, 4 grams of the coptiss, umbrella Sha9 grams of grass, 10 grams of selfheals, 5 grams of roud cardamon seeds, 7 grams of Pilea lomatogramma Hand.-Mazzs, 8 grams of twisted-stalks; Add 10Times water gaging, decocts 2 hours, filters; Filter residue adds 8 times of water gagings, decocts 1.5 hours, filters;Merging filtrate, concentrated, dry, pack, must meet the powder of one day consumption of normal adult.
Be used for the treatment of acne. Oral, every bu is taken for twice sooner or later.
Embodiment 3
Take: 9 grams of spoon dishes, 10 grams of Chinese Drug Gualouzis, 1 gram of henry hemsleya root, 4 grams of the coptiss, umbrella Sha9 grams of grass, 10 grams of selfheals, 5 grams of roud cardamon seeds, 7 grams of Pilea lomatogramma Hand.-Mazzs, 8 grams of twisted-stalks; Add 6Times water gaging, decocts 3 times, decocts 1 hour at every turn, merges decoction liquor, concentrated, dry, packs intoCapsule shells, must meet the capsule of one day consumption of normal adult.
Be used for the treatment of acne. Oral, every bu morning, noon and afternoon take for three times.

Claims (4)

1. a medicine that is used for the treatment of acne, is characterized in that, it is by following weight proportionRaw medicinal material is prepared from: 9 parts of spoon dishes, 10 parts of Chinese Drug Gualouzis, 1 part of henry hemsleya root, the coptis4 parts, 9 parts of umbrella plants, 10 parts of selfheals, 5 parts of Amomum cardamomums, 7 parts of Pilea lomatogramma Hand.-Mazzs, abacus78 parts.
2. the medicine that is used for the treatment of acne as claimed in claim 1, is characterized in that, its preparationMethod is: take: 9 parts of spoon dishes, 10 parts of Chinese Drug Gualouzis, 1 part of henry hemsleya root, 4 parts of the coptiss,9 parts of umbrella plants, 10 parts of selfheals, 5 parts of Amomum cardamomums, 7 parts of Pilea lomatogramma Hand.-Mazzs, 8 parts of twisted-stalks;Add 8 times of water gagings, decoct 1.5 hours, filter; Filter residue adds 6 times of water gagings, decocts 1 hour,Filter; Merging filtrate, is concentrated into 120 parts, obtains decoction; Above-mentioned part all refers to weight portion.
3. the medicine that is used for the treatment of acne as claimed in claim 1, is characterized in that, its preparationMethod is: take: 9 parts of spoon dishes, 10 parts of Chinese Drug Gualouzis, 1 part of henry hemsleya root, 4 parts of the coptiss,9 parts of umbrella plants, 10 parts of selfheals, 5 parts of Amomum cardamomums, 7 parts of Pilea lomatogramma Hand.-Mazzs, 8 parts of twisted-stalks;Add 10 times of water gagings, decoct 2 hours, filter; Filter residue adds 8 times of water gagings, decocts 1.5 hours,Filter; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weightPart.
4. the medicine that is used for the treatment of acne as claimed in claim 1, is characterized in that, its preparationMethod is: take: 9 parts of spoon dishes, 10 parts of Chinese Drug Gualouzis, 1 part of henry hemsleya root, 4 parts of the coptiss,9 parts of umbrella plants, 10 parts of selfheals, 5 parts of Amomum cardamomums, 7 parts of Pilea lomatogramma Hand.-Mazzs, 8 parts of twisted-stalks;Add 6 times of water gagings, decoct 3 times, decoct 1 hour at every turn, merge decoction liquor, concentrated, dry,Incapsulate shell, obtain capsule; Above-mentioned part all refers to weight portion.
CN201610101239.7A 2016-02-24 2016-02-24 Drug for treating acne Pending CN105596964A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105267482A (en) * 2014-06-26 2016-01-27 应丽红 Formula for treating acne

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105267482A (en) * 2014-06-26 2016-01-27 应丽红 Formula for treating acne

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