CN105596902A - Traditional Chinese medicine oral liquid for preventing and treating avian influenza and preparation method thereof - Google Patents

Traditional Chinese medicine oral liquid for preventing and treating avian influenza and preparation method thereof Download PDF

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CN105596902A
CN105596902A CN201610008179.4A CN201610008179A CN105596902A CN 105596902 A CN105596902 A CN 105596902A CN 201610008179 A CN201610008179 A CN 201610008179A CN 105596902 A CN105596902 A CN 105596902A
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agent
weight portion
oral liquid
fruit
parts
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CN105596902B (en
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孙茹茹
闫晓玉
童耀阳
黄洁
金志敏
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Zhejiang University of Technology ZJUT
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A61K36/126—Drynaria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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Abstract

The invention provides traditional Chinese medicine oral liquid for preventing and treating avian influenza. The oral liquid is composed of an agent A and an agent B, wherein the mass ratio of the agent A to the agent B is 1: (0.17-2.5). The agent A is composed of, by weight, 5-30 parts of fructus gardeniae, 10-50 parts of radix astragali, 10-40 parts of radix glycyrrhizae, 5-25 parts of fructus aurantii immaturus, and 3-10 parts of drynaria roosii. The agent B is composed of, by weight, one or several of plant fruit buds including 10-120 parts of barley malt, 10-120 parts of sorghum shoot, 10-120 parts of rice bud, 10-140 parts of soybean sprout and 10-120 parts of buckwheat sprout. The traditional Chinese medicine oral liquid has the effects of clearing away heat and toxic materials, diminishing inflammation, easing pain, relieving cough, reducing sputum, soothing the nerves, tonifying qi, resisting bacteria and viruses, enhancing immunity of the organism and the like, and can prevent and treat avian influenza well. By means of elaborate and reasonable compatibility, mutual combination can be achieved to enhance the medicine effect; the traditional Chinese medicine oral liquid for preventing and treating avian influenza has the advantages that the preparing technology is simple, the oral liquid can be absorbed by the organism easily, the material range is wide, cost is low, the cure rate is high, no medicine residue is caused, and no toxic or side effect is achieved.

Description

Traditional Chinese medicine oral liquid of a kind of prophylactic treatment bird flu and preparation method thereof
Technical field
The invention belongs to Chinese medicine preparation technical field, relate in particular to a kind of traditional Chinese medicine oral liquid of prophylactic treatment bird fluAnd preparation method thereof.
Background technology
Bird flu (BirdFlu or AvianInfluenza) is the abbreviation of Bird Flu, and it is a kind ofThe communicable disease being caused by a kind of hypotype (also claiming avian influenza virus) of influenza A virus, by international epizootic diseaseOffice is decided to be category A infectious disease, claims again fowl plague or European checken pest. Also can infect the mankind and cause morbidity, become fowlInfluenza infection or avian flu, the metainfective symptom main manifestations of people is high heat, cough, runny nose, myalgiaDeng, most with serious pneumonia, the multiple organ failures such as the severe patient heart, kidney cause death.
Anti-influenza virus medicament is mainly M2 inhibitors of ion channels (amantadine and Rimantadine) or disease at presentPoison neuraminidase inhibitor (Oseltamivir and zanamivir), but all due to its inherent toxicity and prolonged applicationDrug resistance and limited its clinical practice. Find according to up-to-date antiviral study on monitoring, be active in Asia, Australia is largeThe amantadine resistance to the action of a drug influenza virus A type H3N2 strain in Leah, North America and Europe significantly increases, and people is pathogenicThe avian influenza virus of H5N1 avian influenza virus and other hypotypes is also to amantadine resistance. And for neuraminic acid, also there is recently seasonal current Influenza Virus Oseltamivir persister, or even do not had in enzyme inhibitor class medicineIn the patient of medication. Therefore find new anti-influenza virus medicament extremely urgent.
China's traditional Chinese medicine has the advantages such as medicine source is extensive, and toxic and side effect is little, low price, therefore utilizes Chinese medicinePrevention and treatment bird flu a kind of good method of can yet be regarded as. The general principle of Traditional Chinese Medicine Anti influenza virus is " eliminating evil "With " righting ". From modern pharmacology angle analysis, the antiviral approach of Chinese medicine mainly comprises direct inhibition virusWith indirect inhibition virus, directly suppressing virus is that medicine directly acts on virus, the suction of blocking virus reproductive processAttached, penetrate, copy, a certain link in maturation, kill virus or suppress virus replication then, thus reachAntiviral object, indirectly suppresses virus and is medicine by improving the immunologic function of body, by promotion bodySpecificity and non-specific immune function and reach and suppress viral object, besides by inducing, promote to induceThe effect of interferon (IFN) etc. reaches antiviral object.
Summary of the invention
In order to solve the existing problem of existing Anti-avian influenza virus drugs, the invention provides a kind of pre-controlTreat the pure traditional Chinese medicine oral liquid of human avian influenza, by the humidification of mutually promoting between plurality of Chinese, to prevention andQuality bird flu has remarkable efficacy.
The technical scheme that technical solution problem of the present invention adopts is:
A agent and B that a traditional Chinese medicine oral liquid for prophylactic treatment bird flu is 1:0.17-2.5 by mass ratioAgent composition, described A agent is water decoction, is made up of the component of following weight portion: 5-30 weight portion cape jasmine, 10-50The weight portion root of large-flowered skullcap, 10-40 weight portion Radix Glycyrrhizae, the 5-25 weight portion dried immature fruit of citron orange and 3-10 weight portion Mongolian oak fern, described BAgent, for squeezing agent, is made up of one or more in the fresh bud of fruit of following weight portion: 10-120 weightPart fructus hordei germinatus, 10-120 weight portion Chinese sorghum bud, 10-120 weight portion Fructus Oryzae Germinatus, the large bean sprouts of 10-140 weight portionWith 10-120 weight portion buckwheat bud.
As preferably, A agent and B agent that described oral liquid is 1:2 by mass ratio form, and described A agent is by followingThe component composition of weight portion: 20 weight portion cape jasmines, the 30 weight portion roots of large-flowered skullcap, 20 weight portion Radix Glycyrrhizaes, 22 weightPart dried immature fruit of citron orange and 8 weight portion Mongolian oak ferns, described B agent is by one or more in the fresh bud of fruit of following weight portionComposition: 60 weight portion fructus hordei germinatus, 80 weight portion Chinese sorghum buds, 90 weight portion Fructus Oryzae Germinatus, the 80 large bean sprouts of weight portionWith 30 weight portion buckwheat buds.
As preferably, the preparation method of the fresh bud of described fruit is: it is its quality that fruit is added to qualityIn 1-3 10-20 DEG C of clear water doubly, soak 6-24 hour, drain away the water, in 15-30% humidity and 20-25 DEG CLower placement was germinateed after 1-3 days, germinates and obtain the fresh bud of fruit after 1-3 days, and described fruit is largeWheat, Chinese sorghum, paddy, soybean or buckwheat.
Cape jasmine: there is the effects such as the liver of protecting, cholagogic, step-down, calmness, hemostasis, detumescence. Cape jasmine in Chinese medicine cape jasmineSub-glycosides, can antagonism influenza A virus H3N2 infection cell center transcription factor NF-KB in the cell of mediationThe activation of signal transduction pathway, and can suppress its downstream target gene TNF-a and interleukin-6 (IL-6) mRNAHigh level expression, thereby performance viral infection resisting function.
The root of large-flowered skullcap: hardship, cold. Return lung, courage, spleen, stomach, large intestine, small intestinl channel. The root of large-flowered skullcap is that labiate is with rootBe used as medicine. Have heat-clearing and damp-drying drug, cool blood is antiabortive, detoxicating functions. Curing mainly warm heat disease, the infection of the upper respiratory tract, lung heat coughsCough, the disease such as the swollen furuncle sore of jaundice with damp-heat pathogen, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle.The clinical practice of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs. The total cyclenes of Scullcap total-flavonoid and cape jasmineEther terpene glycoside composition has obvious antiviral effect, and its mechanism of action may be to suppress virus in intracellular increasingGrow and direct killing action to virus.
Radix Glycyrrhizae: taste is sweet, property is flat, nontoxic. There are anti-inflammatory, antiviral and protecting liver and detoxication and enhancing immunologic function etc.Effect. Radix Glycyrrhizae crude extract and mono-ammonium glycyrrhizinate all can significantly suppress H9N2 subtype influenza virus mouse lung adapted strainThe mouse pneumonia sudden change causing, Radix Glycyrrhizae crude extract can obviously extend the life span of influenza infection mouse. SweetGrass glucin infected by influenza has inhibitory action. Licorice polysaccharide has humidification to mouse immunity of organism.
The dried immature fruit of citron orange: hardship, pungent, cold. Return spleen, stomach, liver, the heart channel of Hang-Shaoyin. Cure mainly in stagnant and stop; The full distending pain of ruffian; StoolConstipated; After rushing down dysentery, weigh; Accumulation of pathogens in chest; Gastroptosis; The prolapse of uterus; Prolapse of the anus. Be recovered with the cape jasmine coupling cold serious disease that can cure the woundThe multiple person of rear labor.
Mongolian oak fern: bitter, temperature is nontoxic. To the marrow, use with mend connect wound broken the most refreshing. Treat the long-pending pain of wind blood, broken bloodMeritorious, hemostasis is effect also. That uses with antianaemics is especially good, and its function really has inconceivable wonderful; With kidney-reinforcing drug with it,Can permanent tooth; With lose blood medicinal it, can fill out key, the exclusive outstanding service of the synthetism of incessantly dispeling the wind also. In addition, Mongolian oak fern rootStem is starch-containing, glucose and naringin etc.
Fructus hordei germinatus: taste is sweet, property is flat. Return spleen, stomach warp. Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn dissipate-swelling. Fructus Hordei GerminatusAmylase-containing, conversion carbohydrase, protein, protease, Cobastab, lecithin, maltose, grapeThe compositions such as sugar.
Large bean sprouts: taste is sweet, property is flat. Energy invigorating spleen to remove dampness, beneficial blood qi-restoratives, removing toxic substances. For deficiency of the spleen causing weakness of QI, become thinFood, or anaemia less, malnutrition; Arthritis with fixed pain caused by dampness contraction, or oedema, difficult urination; Verruca vulgaris etc. In large bean sproutsContain a large amount of enzymes, especially contain glucose glycosidase.
The present invention has passed through a kind of preparation method of traditional Chinese medicine oral liquid of prophylactic treatment bird flu simultaneously, comprises as followsStep:
(1) take the each component of A agent claimed in claim 1, mix and pulverize;
(2) mixture step (1) Suo Shu is put into container, add quality be its quality 6-10 doubly10-20 DEG C of clear water, soaks 15-60 minute,, after 60-120 minute, obtains after filtering in 90-100 DEG C of decoctionFiltrate, then concentrate to obtain A agent, for subsequent use;
(3) the fresh bud of one or more fruits claimed in claim 1 is mixed, add clear water to pressSqueeze into juice, filter, filtrate is B agent;
(4) take the step that mass ratio is 1:0.17-2.5 (2) gained A agent and step (3) gained BAgent, mixes latter standing 0-15 minute and obtains described traditional Chinese medicine oral liquid.
As preferably, described in step (3), the preparation method of the fresh bud of fruit is: fruit is addedQuality is in its quality 1-3 10-20 DEG C of clear water doubly, soaks 6-24 hour, drains away the water, in 15-30%At humidity and 20-25 DEG C, place after 1-3 days and germinate, obtain the fresh bud of fruit, described fruit be barley,Chinese sorghum, paddy, soybean or buckwheat.
As preferably, clear water quality described in step (3) be the fresh bud quality of fruit 0-2 doubly. Due toIn the fresh bud of fruit, itself just contain compared with high-moisture, therefore, in the time of the real fresh bud large usage quantity of plant fresh fruit, needAdd clear water; In the time that the real fresh bud consumption of plant fresh fruit is less, do not need to add clear water.
Beneficial effect of the present invention is:
1, traditional Chinese medicine oral liquid of the present invention by plurality of Chinese component and the fresh bud of fruit mutually promote andSynergy, directly suppresses avian influenza virus in cell internal breeding, and kill virus, increases exempting from of body simultaneouslyEpidemic disease power, promotes the specificity of body and non-specific immune function and reaches the object that suppresses viral.
2, traditional Chinese medicine oral liquid medicine of the present invention source is extensive, and toxic and side effect is little, and drug resistance is low, low price.
3, the preparation method of traditional Chinese medicine oral liquid medicine of the present invention is simple, is applicable to suitability for industrialized production.
Detailed description of the invention
Further explain the present invention below in conjunction with embodiment, but that embodiment does not do the present invention is any type ofLimit.
Embodiment 1
(1) take cape jasmine 5g, root of large-flowered skullcap 50g, Radix Glycyrrhizae 10g, dried immature fruit of citron orange 25g, Mongolian oak fern 10g, mix alsoPulverize;
(2) mixture step (1) Suo Shu is put into container, add 10 DEG C of clear water of 600g, soak15 minutes, decoct after 60 minutes in 100 DEG C, after filtering filtrate, more concentratedly to obtain A agent, for subsequent use;
(3) fructus hordei germinatus 60g and large bean sprouts 80g are mixed, add 50g clear water to squeeze into juice, filter,Filtrate is B agent;
(4) take 60g (2) gained A agent and 60g step (3) gained B agent, after mixing and get final productDescribed traditional Chinese medicine oral liquid.
Embodiment 2
(1) take cape jasmine 30g, root of large-flowered skullcap 10g, Radix Glycyrrhizae 40g, dried immature fruit of citron orange 12g, Mongolian oak fern 8g, mix alsoPulverize;
(2) mixture step (1) Suo Shu is put into container, add 15 DEG C of clear water of 800g, soak30 minutes, decoct after 100 minutes in 90 DEG C, after filtering filtrate, more concentratedly to obtain A agent, for subsequent use;
(3) 10g fructus hordei germinatus, 10g Chinese sorghum bud, 10g Fructus Oryzae Germinatus, the large bean sprouts of 10g and 10g buckwheat bud is mixedClose evenly, add 100g clear water to squeeze into juice, filter, filtrate is B agent;
(4) take 60g (2) gained A agent and 10g step (3) gained B agent, mix rear leaving standstillWithin 10 minutes, obtain described traditional Chinese medicine oral liquid.
Embodiment 3
(1) take cape jasmine 20g, root of large-flowered skullcap 30g, Radix Glycyrrhizae 20g, dried immature fruit of citron orange 22g, Mongolian oak fern 8g, mix alsoPulverize;
(2) mixture step (1) Suo Shu is put into container, add 20 DEG C of clear water of 1000g, soakSteep 60 minutes, decoct after 120 minutes in 100 DEG C, after filtering filtrate, more concentratedly to obtain A agent, for subsequent use;
(3) 80g Chinese sorghum bud, 90g Fructus Oryzae Germinatus and 30g buckwheat bud are mixed, add 40g clear water to pressSqueeze into juice, filter, filtrate is B agent;
(4) take 100g (2) gained A agent and 200g step (3) gained B agent, mix rear quietPut and within 15 minutes, obtain described traditional Chinese medicine oral liquid.
Embodiment 4
(1) take cape jasmine 30g, root of large-flowered skullcap 50g, Radix Glycyrrhizae 12g, dried immature fruit of citron orange 5g, Mongolian oak fern 3g, mix alsoPulverize;
(2) mixture step (1) Suo Shu is put into container, add 12 DEG C of clear water of 700g, soak40 minutes, decoct after 90 minutes in 95 DEG C, after filtering filtrate, more concentratedly to obtain A agent, for subsequent use;
(3) by 120g fructus hordei germinatus, 120g Chinese sorghum bud, 120g Fructus Oryzae Germinatus, the large bean sprouts of 140g and 120g buckwheatFructus Hordei Germinatus mixes, and does not add clear water and directly squeezes into juice, filters, and filtrate is B agent;
(4) take 100g (2) gained A agent and 250g step (3) gained B agent, mix rear quietPut and within 15 minutes, obtain described traditional Chinese medicine oral liquid.
Comparative example 1A agent group
Take cape jasmine 20g, root of large-flowered skullcap 30g, Radix Glycyrrhizae 20g, dried immature fruit of citron orange 22g, Mongolian oak fern 8g, mix and pulverize,Gained mixture is put into container, add 20 DEG C of clear water of 1000g, soak 60 minutes, decoct in 100 DEG CBoil after 120 minutes, after filtering filtrate, more concentrated to obtain A agent.
Comparative example 2B agent group
80g Chinese sorghum bud, 90g Fructus Oryzae Germinatus and 30g buckwheat bud are mixed, add 40g clear water to squeeze into juice,Filter, filtrate is B agent.
Drug test
Below trying by experiment example further illustrates traditional Chinese medicine oral liquid of the present invention and compares that A agent is used separately, BAgent is used and has more effective effect separately.
Taking 40 mouse that infected bird flu as example, be divided at random 4 groups. Be respectively embodiment 3 oral liquidsGroup, comparative example 1A agent group, comparative example 2B agent group and blank group. Embodiment 3 oral liquid groups are pressed 10ml/kgOral liquid gavage; Comparative example 1A agent group is pressed 10ml/kgA agent gavage; Comparative example 2B agent group is pressed 10ml/kgB agent gavage; Blank group is pressed 10ml/kg physiological saline gavage; Successive administration 7 days, observes each mouse feelingsCondition.
Note: effectively refer to that the state of an illness is clearly better, body temperature is normal, pulmonary rale reduces; Effectively refer to that sb.'s illness took a favorable turn,Body temperature is normal, and pulmonary rale reduces; Invalidly refer to that body temperature is higher than normal value, the state of an illness is without taking a turn for the better or increasing the weight of.
Can be found out by above-mentioned test effect, A agent and B agent meet and traditional Chinese medicine oral liquid (be embodiment 3Oral liquid) to infecting mouse result for the treatment of the best of bird flu, than A agent use separately, B agent makes separately apparatusThere is more effective effect.
Below only enumerate the preferred embodiments of the invention, protection scope of the present invention is not restricted to this, abilityAny change that field technique personnel do within the scope of the claims in the present invention all falls in protection domain of the present invention.

Claims (6)

1. the traditional Chinese medicine oral liquid of a prophylactic treatment bird flu, it is characterized in that, A agent and B agent that described oral liquid is 1:0.17-2.5 by mass ratio form, described A agent is water decoction, formed by following parts by weight of component: 5-30 weight portion cape jasmine, the 10-50 weight portion root of large-flowered skullcap, 10-40 weight portion Radix Glycyrrhizae, the 5-25 weight portion dried immature fruit of citron orange and 3-10 weight portion Mongolian oak fern, described B agent is squeezing agent, formed by one or more in the fresh bud of fruit of following weight portion: 10-120 weight portion fructus hordei germinatus, 10-120 weight portion Chinese sorghum bud, 10-120 weight portion Fructus Oryzae Germinatus, the large bean sprouts of 10-140 weight portion and 10-120 weight portion buckwheat bud.
2. traditional Chinese medicine oral liquid as claimed in claim 1, it is characterized in that, A agent and B agent that described oral liquid is 1:2 by mass ratio form, described A agent is made up of the component of following weight portion: 20 weight portion cape jasmines, the 30 weight portion roots of large-flowered skullcap, 20 weight portion Radix Glycyrrhizaes, the 22 weight portion dried immature fruit of citron oranges and 8 weight portion Mongolian oak ferns, described B agent is made up of one or more in the fresh bud of fruit of following weight portion: 60 weight portion fructus hordei germinatus, 80 weight portion Chinese sorghum buds, 90 weight portion Fructus Oryzae Germinatus, the 80 large bean sprouts of weight portion and 30 weight portion buckwheat buds.
3. traditional Chinese medicine oral liquid as claimed in claim 1 or 2, it is characterized in that, the preparation method of the fresh bud of described fruit is: it is in its quality 1-3 10-20 DEG C of clear water doubly that fruit is added to quality, soak 6-24 hour, drain away the water, place 1-3 days at 15-30% humidity and 20-25 DEG C after, germinate, obtain the fresh bud of fruit, described fruit is barley, Chinese sorghum, paddy, soybean or buckwheat.
4. a method of preparing traditional Chinese medicine oral liquid described in claim 1, is characterized in that, described preparation method comprises the steps:
(1) take the each component of A agent claimed in claim 1, mix and pulverize;
(2) mixture step (1) Suo Shu is put into container, adding quality is its quality 6-10 10-20 DEG C of clear water doubly, soaks 15-60 minute, decoct after 60-120 minute in 90-100 DEG C, after filtering filtrate, more concentratedly to obtain A agent, for subsequent use;
(3) the fresh bud of one or more fruits claimed in claim 1 is mixed, add clear water to squeeze into juice, filter, filtrate is B agent;
(4) take the step that mass ratio is 1:0.17-2.5 (2) gained A agent and step (3) gained B agent, mix latter standing 0-15 minute and obtain described traditional Chinese medicine oral liquid.
5. preparation method as claimed in claim 4, it is characterized in that, described in step (3), the preparation method of the fresh bud of fruit is: it is in its quality 1-3 10-20 DEG C of clear water doubly that fruit is added to quality, soak 6-24 hour, drain away the water, place 1-3 days at 15-30% humidity and 20-25 DEG C after, germinate, obtain the fresh bud of fruit, described fruit is barley, Chinese sorghum, paddy, soybean or buckwheat.
6. preparation method as claimed in claim 4, is characterized in that, clear water quality described in step (3) is 0-2 times of the fresh bud quality of fruit.
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