CN105596289A - Drug sustained release hydrogel carrier and preparing method and application thereof - Google Patents
Drug sustained release hydrogel carrier and preparing method and application thereof Download PDFInfo
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- CN105596289A CN105596289A CN201511025688.XA CN201511025688A CN105596289A CN 105596289 A CN105596289 A CN 105596289A CN 201511025688 A CN201511025688 A CN 201511025688A CN 105596289 A CN105596289 A CN 105596289A
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- slow release
- xylan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
Abstract
The invention belongs to the technical field of medical materials, and discloses a drug sustained release hydrogel carrier and a preparing method and application thereof. The preparing method includes the steps that xylan is dissolved in hot water, and a xylan solution is obtained; n-isopropyl-acrylamide and acrylic acid are added into the xylan solution, then a cross-linking agent is added, nitrogen leading and deoxygenization are carried out, a photoinitiator is added, the mixture is mixed to be even, then subjected to ultraviolet radiation for reacting at the room temperature and subjected to closed standing for reacting at the room temperature, a reaction product is washed, swelled, sliced and dried, and the drug sustained release hydrogel carrier is obtained. The prepared efficient drug sustained release hydrogel carrier has good stimulation responses to the temperature and the pH, good drug sustained releasing behaviors are achieved, the drug sustained releasing rate in the intestinal tract can be 90%, and the drug sustained release hydrogel carrier can be used for preparing a drug sustained releasing agent.
Description
Technical field
The invention belongs to medical material tech field, be specifically related to a kind of medicament slow release hydrogel carrier and system thereofPreparation Method and application.
Background technology
In recent years, the development and utilization of renewable lignocellulose-like biomass resource has obtained the very big of peoplePay attention to and pay close attention to, being considered to solve the effective way of the day by day exhausted and environmental problem of petrochemical industry resource. Half fiberElement is one of key component of agricultural-forestry biomass, and its content is only second to cellulose, is the abundantest on the earth,One of cheap renewable resource. Xylan is the main version of hemicellulose, is mainly present in broad-leavedIn wood and grass. It is reported, xylan class hemicellulose not only has biodegradability, compatibleProperty etc. feature, can also produce cell mutation and suppress, have removing toxic substances, anti-inflammatory, promotion MA,Effect such as anticancer grade. Especially allow people interested, xylan has chemically stable in the stomach of human body and small intestineProperty, not degrade, this characteristic makes xylan be suitable as very much intestinal-specific pharmaceutical carrier, can haveEffect improves curative effect of medication and reduces side effects of pharmaceutical drugs, realizes the concentrated release of lesion. Low xylan can alsoRegulate stomach, the intestines function of humans and animals by the beneficial bacterium in selective proliferative enteron aisle, inhibition harmful bacteria,Correct and treatment because of micro-ecological disturbance produce diseases related. Xylan itself has certain gelation,It is the good raw material of preparing intelligent aqueous gel capable. The special physico-chemical performance of xylan makes it at biomedicine fieldHave huge application prospect.
The enviromental sensitive hydrogel intelligent aqueous gel capable that is otherwise known as, refer to self can sensing external environment (as temperatureDegree, pH value, optical, electrical, pressure etc.) minor variations or stimulation, and produce respective physical structure and chemistryOne family macromolecule hydrogel of qualitative change. The characteristic of this environmental stimulus response makes it to become new function materialThe focus of research, is widely used in the biomedicine fields such as cell cultivation, organizational project, medicine control release.This wherein, the hydrogel of temperature and pH response is easy to operate because of it, controllability is strong, applying the feature such as wide becomes intelligenceThe focus direction of energy hydrogel research. NIPA hydrogel is because of its lower critical solution temperature(LCST, 33 DEG C) approach human body temperature and become the temperature-sensitive hydrogel of broad research. Acrylic acid is onePlant important function monomer, acrylic acid is introduced in polymer and is cross-linked into network-like hydrogel and can give waterThe carboxyl that gel is a large amount of, not only makes hydrogel have higher water imbibition, and the existence of a large amount of carboxyls makes hydrogelThe various external environment conditions such as acid-base value, salt are changed and produce corresponding stimuli responsive, as human body different parts: stomach,The pH value of enteron aisle and blood vessel is different, and therefore, this hydrogel can be realized the control of human body medicine targetDischarge. And for the application of the biological medicine classes such as medicament slow release, (cellulose, shell is poly-for natural polymerSugar, starch etc.) to introduce intelligent aqueous gel capable and improve its biocompatibility, the speciality of degradability has caused scientific research workAuthors are interest widely. Up to the present, prepare efficient medicine about the hemicellulose of xylan type slowThe report of releasing hydrogel carrier and application thereof is very limited.
Summary of the invention
Based on above prior art, primary and foremost purpose of the present invention is to provide a kind of medicament slow release hydrogel carrierPreparation method.
Another object of the present invention is to provide a kind of medicament slow release hydrogel preparing by said methodCarrier.
A further object of the present invention is to provide said medicine slowly-releasing hydrogel carrier preparing in medicinal slow release agentApplication.
The object of the invention is achieved through the following technical solutions:
A preparation method for medicament slow release hydrogel carrier, comprises following preparation process:
Xylan, with hot water dissolving, is obtained to xylan solution; In xylan solution, add N-isopropyl thirdAlkene acid amides and acrylic acid, then add crosslinking agent, after letting nitrogen in and deoxidizing, add light trigger to mix, thenAt room temperature ultraviolet irradiation reaction, then seal placing response under room temperature, product through washing, swollen,Section, dry, obtains described medicament slow release hydrogel carrier.
Preferably, described hot water dissolving refers to that it is in the hot water of 60～90 DEG C that xylan is added to temperature, stirsDissolve 15～40min.
Preferably, the mass concentration of described xylan solution is 4%～6%.
Preferably, described crosslinking agent is N, N '-methylene-bisacrylamide; Described light trigger is for resting in peaceFragrant dimethyl ether.
Preferably, the consumption of described NIPA is 4%～16% of xylan quality; Described thirdThe mass ratio of olefin(e) acid and xylan is (6～12): 1; The consumption of described crosslinking agent be 6% of xylan quality～16%; The consumption of described light trigger is 5% of xylan quality.
Preferably, described light trigger, adding before xylan solution, is first used 1-METHYLPYRROLIDONE (NMP)Be dissolved into mass concentration and be 2.5% photoinitiator solution.
Preferably, described letting nitrogen in and deoxidizing refers to logical nitrogen bubble 10～30min.
Preferably, described ultraviolet irradiation reaction refers to that at wavelength be the ultraviolet that 365nm, power are 400WUnder radiation, react 4～8h.
Preferably, the time of described sealing placing response is 8～20h.
Preferably, described washing and swollen refer to and wash with water and swollen; Described dryly refer to that vacuum is dryDry, common freeze drying or liquid-nitrogen freeze drying.
A kind of medicament slow release hydrogel carrier, prepares by above method.
Said medicine slowly-releasing hydrogel carrier is in the application of preparing in medicinal slow release agent, and concrete application process is as follows:Medicine is dissolved in ethanol, and preparation obtains medicine-ethanolic solution, by described medicament slow release hydrogel carrier impregnationIn medicine-ethanolic solution, sealing, is placed in dark place and places 20～28h, takes out, and is placed in vacuum drying chamber dryDry, obtain having the medicinal slow release agent of slow release effect.
Preferably, described medicine is acetylsalicylic acid; The mass concentration of described medicine-ethanolic solution is 8～15%;In described vacuum tank, dry temperature is 40～60 DEG C, and be 20～28h drying time.
The medicine hydrogel carrier with slow release effect of gained can delay Slow release in stomach environment.
Preparation method of the present invention and the product tool obtaining have the following advantages and beneficial effect:
(1) raw material that preparation method of the present invention uses is living beings, because of xylan itself has can be biologicalDegraded, biocompatibility and special physicochemical property, be to prepare the desirable raw material of medical aquogel, thisThe bright commercial Application that can expand xylan type hemicellulose, for the higher value application of hemicellulose provides heavyThe effective way of wanting;
(2) the efficient medicament slow release hydrogel carrier that prepared by the present invention has good stimulation to ring to temperature and pHShould, medicine is had to good medicament slow release behavior, reach 90% in enteron aisle Chinese traditional medicine slowly-releasing efficiency;
(3) preparation method of the present invention is simple to operate, easily realizes industrialization, has environment friendly.
Brief description of the drawings
Fig. 1 is the embodiment of the present invention 1 (a), embodiment 2 (b) and the efficient medicine of embodiment 3 (c) gainedThe SEM figure of slowly-releasing hydrogel carrier;
Fig. 2 is the embodiment of the present invention 1 (a), embodiment 2 (b) and the efficient medicine of embodiment 3 (c) gainedThe DSC figure of slowly-releasing hydrogel carrier;
Fig. 3 is that the medicine aqueogel that embodiment 3 gained have a slow release effect is 7.4 simulated intestinal fluids at pHWith pH be the medicament slow release figure under the gastric juice physiological liquid environment of 1.5 simulations.
Detailed description of the invention
Below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail, but enforcement side of the present inventionFormula is not limited to this.
Embodiment 1
The efficient medicament slow release hydrogel of the one carrier of the present embodiment, its preparation process is as follows:
Take 3.0g xylan (xylan) and be placed in there-necked flask, add 75mL deionized water 70 DEG C of heating15min stirring are dissolved it completely; Be cooled to 50 DEG C, then add respectively the N-isopropyl acrylamide of 0.48gAmine (NIPA), 36g acrylic acid (AA) and 0.48gN, N '-methylene-bisacrylamide (MBA), uses nitrogenGas bell 10min, to remove dissolved oxygen and the interior air of bottle in solution; Then add light trigger styrax twoMethyl ether 0.15g (first dimethoxybenzoin 0.15g is dissolved in 1-METHYLPYRROLIDONE, mass concentration is 2.5%);After mixed liquor is even, be down to room temperature, pour silica dish into and be placed in ultra-violet radiation reactor, set and irradiate barPart is: wavelength is that 365nm, power are 400W, under room temperature, irradiates 4h; Reach after the reaction time at room temperature8h is placed in sealing, makes its abundant polymerization and crosslinked; After having reacted, the hydrogel of gained is taken out with excessiveDeionized water washs to remove reaction reagent remaining in hydrogel, and balance swollen final vacuum is dry, obtains instituteState efficient medicament slow release xylan hydrogel carrier.
Efficient medicament slow release xylan hydrogel carrier to the present embodiment gained carries out scanning electron microscope analysis, instituteThe SEM of the dried hydrogel obtaining schemes as shown in Fig. 1 (a).
The efficient medicament slow release xylan hydrogel carrier of gained is carried out to heat analysis, gained thermal analysis curue spectrum(DSC figure), as shown in Fig. 2 (a), can find out at the thermal analysis curve of 10～60 DEG C temperature from hydrogel,There is a thin and sharp-pointed absworption peak at 33.2 DEG C in the efficient medicament slow release hydrogel of gained carrier, has illustrated33.2 DEG C have occurred to change mutually.
The efficient medicament slow release xylan hydrogel carrier of gained is used for to drug encapsulation and slowly-releasing, concrete stepsFor: acetylsalicylic acid-ethanolic solution that preparation mass concentration is 15%; By efficient gained medicament slow release hydrogelCarrier uniformly slicing, then vacuum drying 24 hours, then impregnated in acetylsalicylic acid-ethanolic solution, sealing,Be placed in dark place and place 28h, take out, be put under room temperature and in vacuum drying chamber, be dried 28h, obtain having slowly-releasing effectThe medicine aqueogel of fruit.
The medicine aqueogel that gained is had to a slow release effect be placed in simulation human gastric juice (pH is 1.5) andIn the different physiological environment of intestinal juice (pH is 7.4), level concussion (50r/min), got 5ml every 1 hourSolution, and the buffer solution of getting same amount is put back to wherein to maintain total liquor capacity constant. Buffer solution will now be joinedNow use. Measure the concentration of medium Chinese traditional medicine by ultraviolet spectrophotometer method.
Calculate medicament slow release rate according to following formula:
Medicament slow release rate (%)=Wt/W0×100％(WtFor hydrogel Chinese traditional medicine quality g after t hour, W0ForIn hydrogel, total drug encapsulation amount g).
Calculate by analysis the efficient medicament slow release xylan hydrogel of the present embodiment gained carrier low critical moltenSeparating temperature (LCST) is 33.2 DEG C; Medicine acetylsalicylic acid 7h medicament slow release rate in simulated intestinal fluid reaches 85%,In SGF, 5h slowly-releasing rate is 38%.
Embodiment 2
The efficient medicament slow release hydrogel of the one carrier of the present embodiment, its preparation process is as follows:
Take 3.0g xylan and be placed in there-necked flask, add 50mL deionized water at 60 DEG C of heating 40min and stirMix it is dissolved completely; Be cooled to 50 DEG C, then add respectively 0.12g NIPA (NIPA),18g acrylic acid (AA) and 0.18gN, N '-methylene-bisacrylamide (MBA), uses nitrogen bubble 30min,To remove dissolved oxygen and the interior air of bottle in solution; Then add light trigger dimethoxybenzoin 0.15g (firstDimethoxybenzoin 0.15g is dissolved in 1-METHYLPYRROLIDONE, and mass concentration is 2.5%); After mixed liquor is even,Be down to room temperature, pour silica dish into and be placed in ultra-violet radiation reactor, setting illuminate condition is: wavelength is365nm, power are 400W, under room temperature, irradiate 8h; After reaching the reaction time, 20h is placed at room temperature sealing,Make its abundant polymerization and crosslinked; After having reacted, the hydrogel of gained is taken out with excessive deionized water washingTo remove reaction reagent remaining in hydrogel, common freeze drying after balance swollen, obtains described efficient medicineThing slowly-releasing xylan hydrogel carrier.
Efficient medicament slow release xylan hydrogel carrier to the present embodiment gained carries out scanning electron microscope analysis, instituteThe SEM of the dried hydrogel obtaining schemes as shown in Fig. 1 (b).
The efficient medicament slow release xylan hydrogel carrier of gained is carried out to heat analysis, gained thermal analysis curue spectrum(DSC figure), as shown in Fig. 2 (b), can find out at the thermal analysis curve of 10～60 DEG C temperature from hydrogel,There is a thin and sharp-pointed absworption peak at 34.5 DEG C in the efficient medicament slow release hydrogel of gained carrier, has illustrated33.5 DEG C have occurred to change mutually.
The efficient medicament slow release xylan hydrogel carrier of gained is used for to drug encapsulation and slowly-releasing, concrete stepsFor: acetylsalicylic acid-ethanolic solution that preparation mass concentration is 8%; By efficient gained medicament slow release xylan waterGel carrier uniformly slicing, at-50 DEG C, freeze drying 24 hours, then impregnated in acetylsalicylic acid-ethanol moltenLiquid, sealing, is placed in dark place and places 20h, takes out, and is put in dry 20h in 60 DEG C of vacuum drying chambers, obtains toolThere is the medicine aqueogel of slow release effect.
The medicine aqueogel that gained is had to a slow release effect be placed in simulation human gastric juice (pH is 1.5) andIn the different physiological environment of intestinal juice (pH is 7.4), level concussion (50r/min), got 5ml every 1 hourSolution, and the buffer solution of getting same amount is put back to wherein to maintain total liquor capacity constant. Buffer solution will now be joinedNow use. Measure the concentration of medium Chinese traditional medicine by ultraviolet spectrophotometer method.
Calculate by analysis the efficient medicament slow release xylan hydrogel of the present embodiment gained carrier low critical moltenSeparating temperature (LCST) is 33.5 DEG C; Medicine acetylsalicylic acid 6h medicament slow release rate in simulated intestinal fluid reaches 82%,In SGF, 4h slowly-releasing rate is 35%.
Embodiment 3
The efficient medicament slow release hydrogel of the one carrier of the present embodiment, its preparation process is as follows:
Take 2.5g xylan (xylan) and be placed in there-necked flask, add 50mL deionized water 80 DEG C of heating30min stirring are dissolved it completely; Be cooled to 50 DEG C, then add respectively the N-isopropyl acrylamide of 0.25gAmine (NIPA), 25g acrylic acid (AA) and 0.25gN, N '-methylene-bisacrylamide (MBA), uses nitrogenGas bell 15min, to remove dissolved oxygen and the interior air of bottle in solution; Then add light trigger styrax two(first dimethoxybenzoin 0.125g is dissolved in 1-METHYLPYRROLIDONE, mass concentration is methyl ether 0.125g2.5%); After mixed liquor is even, be down to room temperature, pour silica dish into and be placed in ultra-violet radiation reactor, setIlluminate condition is: wavelength is that 365nm, power are 400W, under room temperature, irradiates 6h; Reach after the reaction timeUnder room temperature, 12h is placed in sealing, makes its abundant polymerization and crosslinked; After having reacted, the hydrogel of gained is taken outWash to remove reaction reagent remaining in hydrogel by excessive deionized water, after balance swollen, liquid nitrogen frozen is dryDry, obtain described efficient medicament slow release xylan hydrogel carrier.
Efficient medicament slow release xylan hydrogel carrier to the present embodiment gained carries out scanning electron microscope analysis, instituteThe SEM of the dried hydrogel obtaining schemes as shown in Fig. 1 (c).
The efficient medicament slow release xylan hydrogel carrier of gained is carried out to heat analysis, gained thermal analysis curue spectrum(DSC figure), as shown in Fig. 2 (c), can find out at the thermal analysis curve of 10～60 DEG C temperature from hydrogel,There is a thin and sharp-pointed absworption peak at 34.1 DEG C in the efficient medicament slow release hydrogel of gained carrier, has illustrated34.1 DEG C have occurred to change mutually.
By efficient gained medicament slow release xylan hydrogel carrier, for drug encapsulation and slowly-releasing, concrete steps are:Acetylsalicylic acid-ethanolic solution that preparation mass concentration is 10%; By efficient gained medicament slow release xylan water-settingGlue carrier uniformly slicing, at-50 DEG C, freeze drying 24 hours, then impregnated in acetylsalicylic acid-ethanolic solution,Sealing, is placed in dark place and places 24h, takes out, and is put in dry 24h in 40 DEG C of vacuum drying chambers, obtains having slowRelease the medicine aqueogel of effect.
The medicine aqueogel that gained is had to a slow release effect be placed in simulation human gastric juice (pH is 1.5) andIn the different physiological environment of intestinal juice (pH is 7.4), level concussion (50r/min), got 5ml every 1 hourSolution, and the buffer solution of getting same amount is put back to wherein to maintain total liquor capacity constant. Buffer solution will now be joinedNow use. Measure the concentration of medium Chinese traditional medicine by ultraviolet spectrophotometer method.
Calculate by analysis the efficient medicament slow release xylan of the present embodiment gained based aquagel carrier low criticalSolution temperature (LCST) is 34.1 DEG C; Medicine acetylsalicylic acid is 8h slowly-releasing balance in simulated intestinal fluid, slowThe rate of releasing reaches 90%, 4 hours slowly-releasing balances in SGF, and slowly-releasing rate is 26%. Gained has slowly-releasing effectThe medicine aqueogel of fruit is that 7.4 simulated intestinal fluids and pH are the gastric juice physiological liquid environment of 1.5 simulations at pHUnder medicament slow release figure as shown in Figure 3.
Medicament slow release figure and Fig. 3 of above-described embodiment 1 and embodiment 2 are basic identical, not explanation one by one.
Above-described embodiment is preferably embodiment of the present invention, but embodiments of the present invention are not subject to above-mentioned realityExecute routine restriction, other any do not deviate from the change done under Spirit Essence of the present invention and principle, modification,Substitute, combine, simplify, all should be equivalent substitute mode, within being included in protection scope of the present invention.
Claims (10)
1. a preparation method for medicament slow release hydrogel carrier, is characterized in that comprising following preparation process:
Xylan, with hot water dissolving, is obtained to xylan solution; In xylan solution, add N-isopropyl thirdAlkene acid amides and acrylic acid, then add crosslinking agent, after letting nitrogen in and deoxidizing, add light trigger to mix, thenAt room temperature ultraviolet irradiation reaction, then seal placing response under room temperature, product through washing, swollen,Section, dry, obtains described medicament slow release hydrogel carrier.
2. the preparation method of a kind of medicament slow release hydrogel carrier according to claim 1, its feature existsRefer to that in: described hot water dissolving xylan being added to temperature is in the hot water of 60～90 DEG C, stirring and dissolving15～40min。
3. the preparation method of a kind of medicament slow release hydrogel carrier according to claim 1, its feature existsIn: the mass concentration of described xylan solution is 4%～6%.
4. the preparation method of a kind of medicament slow release hydrogel carrier according to claim 1, its feature existsIn: described crosslinking agent is N, N '-methylene-bisacrylamide; Described light trigger is dimethoxybenzoin.
5. the preparation method of a kind of medicament slow release hydrogel carrier according to claim 1, its feature existsIn: the consumption of described NIPA is 4%～16% of xylan quality; Described acrylic acid and woodThe mass ratio of glycan is (6～12): 1; The consumption of described crosslinking agent is 6%～16% of xylan quality; InstituteThe consumption of stating light trigger is 5% of xylan quality.
6. the preparation method of a kind of medicament slow release hydrogel carrier according to claim 1, its feature existsIn: described light trigger is adding before xylan solution, is first dissolved into quality with 1-METHYLPYRROLIDONEConcentration is 2.5% photoinitiator solution.
7. the preparation method of a kind of medicament slow release hydrogel carrier according to claim 1, its feature existsIn: described letting nitrogen in and deoxidizing refers to logical nitrogen bubble 10～30min; Described ultraviolet irradiation reaction refers at wavelengthFor reacting 4～8h under 365nm, the power ultra-violet radiation that is 400W; The time of described sealing placing response is8～20h; Described washing and swollen refer to and wash with water and swollen; The described dry vacuum drying, general that refers toLogical freeze drying or liquid-nitrogen freeze drying.
8. a medicament slow release hydrogel carrier, is prepared into by the method described in claim 1～7 any oneArrive.
9. medicament slow release hydrogel carrier claimed in claim 8 is in the application of preparing in medicinal slow release agent, itsBe characterised in that described application process is as follows: medicine is dissolved in ethanol, and preparation obtains medicine-ethanolic solution, willDescribed medicament slow release hydrogel carrier impregnation is in medicine-ethanolic solution, and sealing, is placed in dark place and places 20～28h,Take out, be placed in vacuum drying chamber dry, obtain having the medicinal slow release agent of slow release effect.
Medicament slow release hydrogel carrier according to claim 9 prepare in medicinal slow release agent shouldWith, it is characterized in that: described medicine is acetylsalicylic acid; The mass concentration of described medicine-ethanolic solution is8～15%; In described vacuum tank, dry temperature is 40～60 DEG C, and be 20～28h drying time.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106821963A (en) * | 2016-12-28 | 2017-06-13 | 浙江理工大学 | A kind of method of utilization cellulose base temperature and the load of pH sensitive hydrogels and slow releasing pharmaceutical |
| CN108467464A (en) * | 2018-04-02 | 2018-08-31 | 常熟理工学院 | Hydrogel of visible-light curing containing azelaic acid and preparation method thereof |
| CN108976443A (en) * | 2018-06-26 | 2018-12-11 | 华南理工大学 | A kind of carbon nanotube enhancing carboxymethyl xylan/polyacrylic acid composite hydrogel and preparation method thereof |
| CN111548454A (en) * | 2020-05-25 | 2020-08-18 | 湖北工业大学 | Preparation method of printable and formable high-strength body temperature release drug hydrogel |
| CN111592679A (en) * | 2020-05-08 | 2020-08-28 | 丽水学院 | Novel nano hydrogel for promoting growth of lactic acid bacteria and preparation method thereof |
| CN113398273A (en) * | 2021-05-14 | 2021-09-17 | 广西壮族自治区中国科学院广西植物研究所 | Application of xylan derivative as hydrophilic sustained-release material in preparation of drug sustained-release tablets |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821963A (en) * | 2016-12-28 | 2017-06-13 | 浙江理工大学 | A kind of method of utilization cellulose base temperature and the load of pH sensitive hydrogels and slow releasing pharmaceutical |
| CN108467464A (en) * | 2018-04-02 | 2018-08-31 | 常熟理工学院 | Hydrogel of visible-light curing containing azelaic acid and preparation method thereof |
| CN108976443A (en) * | 2018-06-26 | 2018-12-11 | 华南理工大学 | A kind of carbon nanotube enhancing carboxymethyl xylan/polyacrylic acid composite hydrogel and preparation method thereof |
| CN111592679A (en) * | 2020-05-08 | 2020-08-28 | 丽水学院 | Novel nano hydrogel for promoting growth of lactic acid bacteria and preparation method thereof |
| CN111592679B (en) * | 2020-05-08 | 2022-11-08 | 丽水学院 | Novel nano hydrogel for promoting growth of lactic acid bacteria and preparation method thereof |
| CN111548454A (en) * | 2020-05-25 | 2020-08-18 | 湖北工业大学 | Preparation method of printable and formable high-strength body temperature release drug hydrogel |
| CN111548454B (en) * | 2020-05-25 | 2023-01-20 | 湖北工业大学 | Preparation method of printable and formable high-strength body temperature release drug hydrogel |
| CN113398273A (en) * | 2021-05-14 | 2021-09-17 | 广西壮族自治区中国科学院广西植物研究所 | Application of xylan derivative as hydrophilic sustained-release material in preparation of drug sustained-release tablets |
| CN113398273B (en) * | 2021-05-14 | 2022-07-19 | 广西壮族自治区中国科学院广西植物研究所 | Application of xylan derivative as hydrophilic sustained-release material in preparation of drug sustained-release tablets |
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