CN105561474B - A kind of device for treating epilepsy by stimulation human body vagus nerve - Google Patents
A kind of device for treating epilepsy by stimulation human body vagus nerve Download PDFInfo
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- CN105561474B CN105561474B CN201610078975.5A CN201610078975A CN105561474B CN 105561474 B CN105561474 B CN 105561474B CN 201610078975 A CN201610078975 A CN 201610078975A CN 105561474 B CN105561474 B CN 105561474B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36064—Epilepsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
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- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
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- Electrotherapy Devices (AREA)
Abstract
A kind of device for treating epilepsy by stimulation human body vagus nerve, including for absorbing aggregation human body brain exception electric energy receiving module, for stimulating the vagal stimulating module of human body and the control module that is connected with receiving module and stimulating module respectively, the signal that receiving module will start to absorb the abnormal electric energy of aggregation feeds back to control module, and control module controls stimulating module according to the signal of feedback and stimulates stimulation human body vagus nerve.When receiving module senses brain paradoxical discharge, it is likely to be the very subtle electric discharge for not causing clinical symptoms, the information that brain starts paradoxical discharge is fed back to control device by receiving module, and control device then starts control stimulating module and carries out electric discharge stimulation to human body vagus nerve.
Description
Technical field
The invention belongs to the field of medical instrument technology, more particularly, to one kind for being treated by stimulation human body vagus nerve
The device of epilepsy.
Background technique
Epilepsy is the electric discharge of cerebral neuron paroxysmal abnormality, causes one kind of of short duration cerebral disorder common, anti-
The chronic neurological condition made is recurred, disease incidence is high, has become the second largest common disease that neurology department is only second to headache.
At present both at home and abroad for the treatment of epilepsy mainly based on drug therapy, but still having about 20%-30% patient is drug
Intractable epilepsy, and drug therapy will appear serious drug side-effect.Operative treatment mode has epileptogenic focus resection, brain
Outside cortex resection, temporal lobe excision art, hemispherectomy, selective amygdaloid nucleus and hippocampalectomies, stereo directional radiative
Section's treatment etc., but these operations have very big traumatic, and and for partial epilepsy, the positioning of epilepsy source region is indefinite, disease
The not single patient's discomfort of stove shares operative treatment, furthermore operative treatment may lead important afunction.
Vagus nerve is stroke longest in cranial nerve, and the most wide nerve of distribution is main between human body and brain
, good access.Vagal nerve stimulation (VNS) is a kind of new method for being not required to out cranium, non-drug therapy intractable epilepsy,
VNS reduces the degree and frequency of insane pain breaking-out by intermittent stimulation patient left neck vagus nerve, and stimulates on the left of patient
Vagus nerve it is also smaller to the side effect of heart.VNS passes through parameter (intensity, time, frequency such as stimulation for accurately controlling stimulation
Rate etc.) it can achieve a variety of effects, and also the electro photoluminescence of appropriateness will not make tissue be damaged being repeated as many times.Due to it
It is curative for effect, safely and effectively and be easy to be resistant to, it is commonly used.End more than 10,000 patients in January, 2013 global range to connect
It is treated by VNS, and (Liu Aihua etc. " clinical progress of the Vagal nerve stimulation in intractable epilepsy field " China mind curative for effect
Through medical journal 2013:12(1)).
But the current progress of Vagal nerve stimulation on the market is interval sexual stimulus, is predicted according to the disease cycle of patient
Possible disease time, and setting program carrys out timing and stimulated, but epileptic irregularly falls ill, can not Accurate Prediction,
Many stimulations are ineffective stimulation, not only cause unnecessary injury to the body of patient, but also can not be when patient really falls ill
Accurately and effectively stimulated.
Summary of the invention
For overcome the deficiencies in the prior art, the present invention provide it is a kind of can clinical symptoms each time generation before to fan walk
The device for the treatment epilepsy that nerve is accurately stimulated.
The technical solution adopted by the present invention to solve the technical problems is: one kind is treated insane by stimulation human body vagus nerve
The device of epilepsy, including assembling the receiving module of human body brain exception electric energy, for stimulating the vagal thorn of human body for absorbing
The control module for swashing module and being connected respectively with receiving module and stimulating module, receiving module, which will start to absorb, assembles abnormal electric energy
Signal feed back to control module, control module controls stimulating module according to the signal of feedback and carries out to stimulation human body vagus nerve
Stimulation.When receiving module senses brain paradoxical discharge, it may be possible to which the very subtle electric discharge for not causing clinical symptoms connects
It receives module and the information that brain starts paradoxical discharge is fed back into control device, control device then starts to control stimulating module to people
Body vagus nerve carries out electric discharge stimulation.The present apparatus is by the way that (i.e. brain exception electric energy goes out before there are the clinical symptoms of epilepsy
The first existing moment) vagus nerve is stimulated, and vagal stimulation can inhibit the appearance of clinical symptoms, rise
Reduce the damage to human body to the effect worked along both lines so that the stimulation each time of stimulating module is all effectively to stimulate；Together
When, the present apparatus is just stimulated vagus nerve before clinical symptoms generation, it is suppressed that brain exception electric energy is persistently released
It puts, effectively prevents the appearance of clinical symptoms.
Further, the control module controls the receiving module to stimulating module continued conduction electric energy.Control module
The electric energy that receiving module is received is converted to be used to stimulating module, saves electric energy.
It further, further include for the receiving module to be absorbed the storage mould that the abnormal electric energy gathered stores
Block.In the brain exception electric energy release higher situation of frequency, it can will absorb the electric energy gathered and store.
Further, further include power module that stimulating module is powered；When brain exception electric energy release frequency is lower
In the case where, the electric energy that receiving module absorbs aggregation is unable to satisfy the normal work in stimulating module, and electric power source pair of module stimulates mould
Block is powered.
Further, further include frequency adjustment module for controlling the frequency of stimulation of stimulating module.Frequency adjustment module
Setting, the length of time that stimulating module discharges each time can be defined；The frequency of either brain paradoxical discharge is prominent
When so increasing, need that the number of stimulating module is adjusted.
The beneficial effects of the present invention are: carrying out absorption aggregation to abnormal electric energy by being provided in brain paradoxical discharge region
Receiving module, can clinical symptoms each time generation before vagus nerve is stimulated, the electricity that brain is released extremely
Lead the release for also effectively inhibiting new abnormal electric energy while letting out, to effectively treat epilepsy.
Detailed description of the invention
Fig. 1 is the principle of the present invention schematic block diagram.
Specific embodiment
In order to make those skilled in the art better understand the present invention program, below in conjunction in the embodiment of the present invention
Attached drawing, the technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is only
A part of the embodiments of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill people
The model that the present invention protects all should belong in member's every other embodiment obtained without making creative work
It encloses.
As shown in Figure 1, a kind of device that epilepsy is treated by stimulation human body vagus nerve, including for absorbing aggregation human body
The receiving module 1 of brain exception electric energy, for stimulate the vagal stimulating module 2 of human body and respectively with receiving module and stimulation
The connected control module 3 of module,
When paradoxical discharge occurs in patient's brain (may be very subtle electric discharge, do not cause clinical symptoms), receive
Module senses the paradoxical discharge, starts to absorb the exception electric energy, while the signal for starting to absorb is fed back to control device, control
After device processed receives signal, control stimulating module to vagus nerve carry out electric discharge stimulation movement (stimulating module can be adopted
With the stimulating module of any one vns device in the prior art, electric discharge thorn is carried out to vagus nerve as long as being able to achieve
Swash)；Not only inhibit brain to carry out new paradoxical discharge, also the brain exception electric energy released lead let out to
Outside brain, the generation of clinical symptoms is effectively prevented or reduced, achievees the purpose that treat epilepsy.
As a further improvement, the control module controls the receiving module to stimulating module continued conduction electric energy；
The abnormal electric energy that receiving module absorbs aggregation can lead and let out outside, can also be by the effect of control module by these abnormal electric energy
Switch to the inputing power of stimulating module, is powered for the normal work of stimulating module；Continued conduction electric energy mentioned here is
As long as can all carry out transmitting electric energy to stimulating module after referring to that receiving module absorption has accumulated the paradoxical discharge of brain, and when reception
Module is not absorbed into the paradoxical discharge of brain, and receiving module receives abnormal electric energy and all led to let out and finishes, and connects at this time
It receives module and then carries out electric energy conduction without normal direction stimulating module.
The present apparatus is additionally provided with for the receiving module to be absorbed the electricity storage module that the abnormal electric energy gathered stores
5, which is connected with control module, when the frequency of brain paradoxical discharge is higher, when such as duration electric discharge, and receiving module
It is more to absorb the electric energy gathered, and the electricity of stimulating module is also more enough at this time, control module can then pass through the storage
Module is stored to by electric energy；
It further include the power module 6 that stimulating module is powered, which is connected with control module, when brain exception
When the frequency of electric discharge is lower, the electric energy that absorption module is conducted to stimulating module is less, and control module can then pass through the power module
Stimulating module is powered, to guarantee the normal work of stimulating module.
It further, further include frequency adjustment module 7 for controlling the frequency of stimulation of stimulating module, which adjusts mould
Block is connected with control module, can control daily discharge frequency (including conventional stimulation and unconventional stimulation), can also control
The length of each stimulation time.
Above-mentioned specific embodiment is used to illustrate the present invention, rather than limits the invention, of the invention
In spirit and scope of protection of the claims, to any modifications and changes that the present invention makes, protection model of the invention is both fallen within
It encloses.
Claims (3)
1. a kind of device for treating epilepsy by stimulation human body vagus nerve, it is characterised in that: including for absorbing aggregation human body
The receiving module of brain exception electric energy, for stimulate the vagal stimulating module of human body, respectively with receiving module and stimulation mould
The control module that block is connected and the electricity storage module that the abnormal electric energy for gathering receiving module absorption stores, connect
The signal that receipts module will start to absorb the abnormal electric energy of aggregation feeds back to control module, and control module controls thorn according to the signal of feedback
Swashing module stimulates stimulation human body vagus nerve；The control module controls the receiving module and persistently passes to stimulating module
Conductive energy.
2. a kind of device for treating epilepsy by stimulation human body vagus nerve according to claim 1, it is characterised in that: also
Including the power module being powered to stimulating module.
3. a kind of device for treating epilepsy by stimulation human body vagus nerve according to claim 1, it is characterised in that: also
Frequency adjustment module including the frequency of stimulation for controlling stimulating module.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610078975.5A CN105561474B (en) | 2015-02-20 | 2016-02-03 | A kind of device for treating epilepsy by stimulation human body vagus nerve |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510085851 | 2015-02-20 | ||
| CN2015100858515 | 2015-02-20 | ||
| CN201610078975.5A CN105561474B (en) | 2015-02-20 | 2016-02-03 | A kind of device for treating epilepsy by stimulation human body vagus nerve |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105561474A CN105561474A (en) | 2016-05-11 |
| CN105561474B true CN105561474B (en) | 2019-05-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610078975.5A Active CN105561474B (en) | 2015-02-20 | 2016-02-03 | A kind of device for treating epilepsy by stimulation human body vagus nerve |
| CN201620110930.7U Expired - Fee Related CN205516003U (en) | 2015-02-20 | 2016-02-03 | Device of treatment epilepsy |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620110930.7U Expired - Fee Related CN205516003U (en) | 2015-02-20 | 2016-02-03 | Device of treatment epilepsy |
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| CN (2) | CN105561474B (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116138784B (en) * | 2023-02-27 | 2024-03-15 | 海南大学 | Signal acquisition device of brain-computer interface and brain-computer interface system |
| CN116251295A (en) * | 2023-03-09 | 2023-06-13 | 北京工业大学 | Focal epileptic electric guidance-nerve electric regulation and control system and method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2516176Y (en) * | 2002-01-21 | 2002-10-16 | 姜炜 | Vagus nerve stimulation instrument |
| CN102613971A (en) * | 2012-03-30 | 2012-08-01 | 北京品驰医疗设备有限公司 | Electroencephalograph (EEG)-based epilepsy detection and intervention device |
| CN103446673A (en) * | 2013-09-09 | 2013-12-18 | 中国科学院深圳先进技术研究院 | Epilepsy treatment system |
| CN205516002U (en) * | 2016-02-03 | 2016-08-31 | 邵志辉 | Device through amazing human vagus nerve treatment epilepsy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322866A (en) * | 2008-01-11 | 2008-12-17 | 梁树立 | Deep brain epileptic discharge induction treatment method and equipment |
-
2016
- 2016-02-03 CN CN201610078975.5A patent/CN105561474B/en active Active
- 2016-02-03 CN CN201620110930.7U patent/CN205516003U/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2516176Y (en) * | 2002-01-21 | 2002-10-16 | 姜炜 | Vagus nerve stimulation instrument |
| CN102613971A (en) * | 2012-03-30 | 2012-08-01 | 北京品驰医疗设备有限公司 | Electroencephalograph (EEG)-based epilepsy detection and intervention device |
| CN103446673A (en) * | 2013-09-09 | 2013-12-18 | 中国科学院深圳先进技术研究院 | Epilepsy treatment system |
| CN205516002U (en) * | 2016-02-03 | 2016-08-31 | 邵志辉 | Device through amazing human vagus nerve treatment epilepsy |
Also Published As
| Publication number | Publication date |
|---|---|
| CN205516003U (en) | 2016-08-31 |
| CN105561474A (en) | 2016-05-11 |
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Effective date of registration: 20190419 Address after: 225300 366 Taihu Road, hi tech Zone, Taizhou, Jiangsu Applicant after: JIANGSU TAIZHOU PEOPLE'S HOSPITAL Address before: 310015 No. 126 Wenzhou Road, Gongshu District, Hangzhou City, Zhejiang Province Applicant before: Shao Zhihui |
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