CN105559960A - Intrauterine device made of degradable composite material with layered nano-structure - Google Patents
Intrauterine device made of degradable composite material with layered nano-structure Download PDFInfo
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- CN105559960A CN105559960A CN201510953887.0A CN201510953887A CN105559960A CN 105559960 A CN105559960 A CN 105559960A CN 201510953887 A CN201510953887 A CN 201510953887A CN 105559960 A CN105559960 A CN 105559960A
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- composite material
- copper
- layered nano
- intrauterine device
- degradable composite
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- 239000002131 composite material Substances 0.000 title claims abstract description 110
- 239000002086 nanomaterial Substances 0.000 title claims abstract description 71
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 94
- 239000010949 copper Substances 0.000 claims abstract description 76
- 229910052802 copper Inorganic materials 0.000 claims abstract description 76
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 70
- 239000000463 material Substances 0.000 claims abstract description 40
- 229910052742 iron Inorganic materials 0.000 claims abstract description 28
- 238000005096 rolling process Methods 0.000 claims description 20
- 238000005097 cold rolling Methods 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 230000009467 reduction Effects 0.000 claims description 10
- 239000000741 silica gel Substances 0.000 claims description 10
- 229910002027 silica gel Inorganic materials 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- 230000000903 blocking effect Effects 0.000 claims description 4
- 238000004513 sizing Methods 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229910001431 copper ion Inorganic materials 0.000 abstract description 12
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract description 11
- 230000006378 damage Effects 0.000 abstract description 6
- 230000007797 corrosion Effects 0.000 abstract description 5
- 238000005260 corrosion Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 208000027418 Wounds and injury Diseases 0.000 abstract description 3
- 210000004696 endometrium Anatomy 0.000 abstract description 3
- 208000014674 injury Diseases 0.000 abstract description 3
- 210000004291 uterus Anatomy 0.000 abstract description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000002254 contraceptive effect Effects 0.000 description 10
- 238000000137 annealing Methods 0.000 description 6
- 239000003433 contraceptive agent Substances 0.000 description 5
- 239000003984 copper intrauterine device Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000010622 cold drawing Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229910000521 B alloy Inorganic materials 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229910004337 Ti-Ni Inorganic materials 0.000 description 1
- 229910011209 Ti—Ni Inorganic materials 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- IYRDVAUFQZOLSB-UHFFFAOYSA-N copper iron Chemical compound [Fe].[Cu] IYRDVAUFQZOLSB-UHFFFAOYSA-N 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- ALKZAGKDWUSJED-UHFFFAOYSA-N dinuclear copper ion Chemical compound [Cu].[Cu] ALKZAGKDWUSJED-UHFFFAOYSA-N 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- KHYBPSFKEHXSLX-UHFFFAOYSA-N iminotitanium Chemical compound [Ti]=N KHYBPSFKEHXSLX-UHFFFAOYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000000754 myometrium Anatomy 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000005554 pickling Methods 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 238000005488 sandblasting Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000004901 spalling Methods 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
- A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
Landscapes
- Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to an intrauterine device made of a degradable composite material with a layered nano-structure. The intrauterine device is made of the degradable composite material with the layered nano-structure, wherein the degradable composite material is of a layered nano-structure with alternate arrangement of copper layers and iron layers, the weight percentage of copper is 40-70%, and the elasticity modulus of the composite material is 80-120 GPa. For the nano-scale layered iron/copper degradable material, the nano-scale alternate distribution of the copper layers and the iron layers is formed in the internal structure, thus the large-area direct contact between copper and the endometrium is avoided, and further, the injury to the inner conditions of the uterus caused by abundant reactive oxygen generated by excessively fast corrosion of copper is alleviated. Meanwhile, along with the degradation of iron, new copper layers are continuously exposed out, and the copper layers exposed out in the composite material are of nano-structures, so that the release of copper ions is guaranteed, and further, the contraception effect is guaranteed; good contraception effect is achieved, and meanwhile, the injury to the body is reduced.
Description
Technical field
The present invention relates to a kind of female contraception contraceptive device, specifically refer to a kind of intrauterine device with the degradable composite material of layered nano-structure.
Background technology
Intrauterine device (IntrauterineDeviceIUD) is a kind of safe, effective, economic and easy women's contraceptive device, is also one of current global most widely used contraceptive device.The research of many decades and clinically all to show, why cupric IUD has quite excellent contraceptive effect, reacts and to discharge the copper ion that can strengthen contraceptive effect closely related with it in uterine cavity with uterine fluid.And the minimum copper ion concentration of motility of sperm in uterine fluid can be suppressed should to be not less than 0.5 μ g/ml, and the copper ion that cupric IUD discharges has 50% will be absorbed by endometrium.Research shows simultaneously, and the amount of human body uterine fluid, at below 1ml, considers that cupric IUD guarantees the safety coefficient of contraceptive effect, and the minimum copper ion rate of release of cupric IUD in uterine fluid must maintain 2.0 μ g/ days; Existing copper intrauterine devices is contained is all copper wire or copper pipe, there is amount of copper ions released uncontrollable and produce problems such as " burst releases ", bring the uncomfortable side effect such as dysmenorrhea to patient clinically, and also can bring great misery to women in the process of taking off intrauterine device.And, existing cupric IUD, for preventing from making the too fast corrosion of copper because copper ion acutely discharges and the IUD caused comes off, usually first the materials such as polyethylene are prepared into skeleton, then residual around copper wire or inlay copper sheathing on skeleton, or on support, be set with the release pipe of hormonal contraceptive again, make complicated.
Ferrum is indispensable trace element in organism; there is good biocompatibility, excellent comprehensive mechanical property and shape performance; because the standard equilibration electrode potential of iron oxidation reaction is relatively low; and the loose porous of the oxide-film in human body fluid, iron surface formed; can not play a good protection to matrix; especially, in the human body environment's corrosive medium containing chloride ion, higher chemistry and electro-chemical activity is presented.Therefore ferrum can corrode faster in human body environment, is called biodegradation.Due to iron rot degraded, can by absorption degraded after implant into body.
Summary of the invention
The invention provides a kind of intrauterine device with the degradable composite material of layered nano-structure, to solve the problems of the technologies described above.
In order to achieve the above object, technical scheme of the present invention is achieved in that a kind of intrauterine device with the degradable composite material of layered nano-structure, this intrauterine device is made up of a kind of degradable composite material with layered nano-structure, degradable composite material is the layered nano-structure that layers of copper and iron layer are alternately arranged, wherein the mass percentage content of copper is 40-70%, and the elastic modelling quantity of degradable composite material is between 80-120GPa.
In above-mentioned technical characteristic, the purity of the copper used in degradable composite material is 99.999%, and the purity of the ferrum of use is 99.999%.
In above-mentioned technical characteristic, the preparation process of degradable composite material is as follows:
(1) at room temperature by copper coin base with the superimposed employing of iron plate base is cold rolling is prepared into the ferrum with layered nano-structure/copper composite board that thickness is 5 ~ 10mm.;
(2) ferrum with the layered nano-structure/copper composite board obtained in step (1) be processed into bar and carry out ferrum/carbon/carbon-copper composite material wire rod that multi pass drawing preparation has layered nano-structure.
In above-mentioned technical characteristic, the standby method of cold rolling comprises the following steps:
(1) be that the copper coin base of 0.5 ~ 2mm and iron plate base interlock superimposed by the thickness with clean surface, after superimposed, ground floor and last one deck are respectively copper coin base and iron plate base;
(2) undertaken cold rolling by superimposed good copper coin base and iron plate base, cold rolling strain rate scope control is 10
-2~ 10s
-1, rolling temperature≤100 DEG C, rolling reduction is 40 ~ 60% of superimposed sheet material gross thickness; Obtain cold rolled sheet;
(3) cold rolled sheet obtained in step (2) is blocked, and by superimposed for the sheet material after blocking, time superimposed the copper side of one piece of cold rolled sheet and the ferrum contacts side surfaces of another block cold rolled sheet superimposed, superimposed rear repetition step (2) is rolled;
(4) repeat step (2)-(3) and obtain the ferrum/copper composite board with layered nano-structure 15-40 time.
In above-mentioned technical characteristic, method prepared by drawing comprises the following steps:
(1) ferrum with the layered nano-structure/copper composite board obtained after cold rolling is standby is processed into the ferrum with layered nano-structure/carbon/carbon-copper composite material bar that diameter is 5-10mm;
(2) ferrum with the layered nano-structure/carbon/carbon-copper composite material bar of preparation in step (1) is carried out multi pass drawing, passage sizing reduction is within 5-~ 15%, and drawing strain rate scope is 10
-2~ 10s
-1, after multi pass drawing, obtain the ferrum with layered nano-structure/carbon/carbon-copper composite material wire rod that diameter is 1 ~ 2mm.
In above-mentioned technical characteristic, at cold rolling for front, first by copper coin base and iron plate base surface mechanical grinding cleaning with acetone.
In above-mentioned technical characteristic, this intrauterine device comprises the many sections of composite joints be made up of the degradable composite material with layered nano-structure, multiple composite joint is serially connected with on an abiotic suture, and arranges a composite knot be made up of the degradable composite material with layered nano-structure in one end of abiotic suture.
In above-mentioned technical characteristic, this intrauterine device comprises V-type support, silica gel sheath and has the corrugated tubing of degradable composite material of layered nano-structure, and the both sides of V-type support alternately suit silica gel sheath and corrugated tubing respectively, corrugated tubing is held on the centre of two-section silica gel sheath.
In above-mentioned technical characteristic, this intrauterine device comprises transverse arm and support ring; Support ring is droplet-shaped; Transverse arm is two, and the end of each transverse arm self-supporting ring respectively is upwards outwards bent to form again.
In above-mentioned technical characteristic, the support that this intrauterine device comprises core bar and is connected with core bar one end; Support is arc, and the opening of support is consistent with the extending direction of core bar, and stent outer is provided with multiple protuberance for this intrauterine device is fixed on intrauterine.
In above-mentioned technical characteristic, this intrauterine device comprises V-type main body and head composition, and head connects the free end of V-type main body, and head is ring-type or hooks shape.
Compared with prior art, the invention has the advantages that: (1) nano lamellar ferrum/copper degradable composite material owing to having the ferrum of nanoscale in its internal structure, layers of copper is staggered, avoid larger areas of copper directly to contact with uterus inwall, thus alleviate a large amount of active oxygens of producing because of the too fast corrosion of copper to the injury of intrauterine environment.Meanwhile, along with the degraded of ferrum, constantly have new layers of copper to expose, in degradable composite material, exposed layers of copper is nanostructured, ensure that the release of copper ion, thus ensure that contraceptive effect.(2) IUD of the present invention is after inserting uterus, its operation principle is: surperficial layers of copper copper ion releasing and be corroded gradually, peel off, expose iron layer, ferrum exposes again new layers of copper and continues copper ion releasing after degrading gradually ... so repeatedly carry out, and avoids simple substance fine copper IUD because its copper surface corrosion is roughening and calcium carbonate forms abnormal inflammatory that calculus etc. aggravates to cause stimulation and the damage of endometrial tissue and the side-effect problem such as hemorrhage at its surface aggregation.In addition, after IUD reaches design length of service, IUD of the present invention occurs to rupture because of the corrosion spalling of copper, ferrum and degraded and is excreted, and eliminates and manually wins IUD and having an intense pain of causing.Good contraceptive effect can be reached, can reduce that again human body is damaged.(3) adopt Nanoscale Iron copper composite wire material prepared by the present invention disposable machine-shaping can obtain the copper IUD of various form, compare existing manufacture method easier.
Accompanying drawing explanation
In order to be illustrated more clearly in the specific embodiment of the invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in detailed description of the invention or description of the prior art below, apparently, accompanying drawing in the following describes is some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the embodiment of the present invention 1 nanometer laminated structure composite preparation process schematic diagram;
Fig. 2 is the embodiment of the present invention 2 nanometer laminated structure composite preparation process schematic diagram;
Fig. 3 is the heterogeneous microstructure figure of embodiment of the present invention composite; In figure, black represents iron layer, and white represents layers of copper;
Fig. 4 is the structural representation of the intrauterine device of the embodiment of the present invention 3;
Fig. 5 is the structural representation of the intrauterine device of the embodiment of the present invention 4;
Fig. 6 is the structural representation of the intrauterine device of the embodiment of the present invention 5;
Fig. 7 is the structural representation of the intrauterine device of the embodiment of the present invention 6;
Fig. 8 is the structural representation of the intrauterine device of the embodiment of the present invention 7.
In figure: 11, composite joint; 12, abiotic suture; 13, composite knot; 21, V-type support; 22, silica gel sheath; 23, corrugated tubing; 24, termination; 31 transverse arms; 32 support rings; 41, core bar; 42, support; 43, protuberance; 431, nose bar; 432, convex ball; 51, V-type main body; 52 heads.
Detailed description of the invention
Carry out clear, complete description below with reference to accompanying drawing to the technical scheme of various embodiments of the present invention, obviously, described embodiment is only a part of embodiment of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, other embodiments all that those of ordinary skill in the art obtain under the prerequisite not making creative work, all belong to the scope that the present invention protects.
Also by reference to the accompanying drawings the present invention is described in further detail below by specific embodiment.
The present invention relates to a kind of intrauterine device with the degradable composite material of layered nano-structure, be made up of ferrum, copper bi-material, degradable composite material is the layered nano-structure that layers of copper and iron layer are alternately arranged, wherein the mass percentage content of copper is 40-70%, the composite wire rod that diameter is 1 ~ 2mm is prepared by cold rolling and drawing, when specifically practicing, the percentage by weight of copper and gauge or diameter of wire are the key factors of control IUD military service phase.The elastic modelling quantity of degradable composite material is between 80-120GPa.
Consider that the real active substance playing contraceptive efficacy is copper ion, after the intrauterine device of the ferrum/copper degradable composite material with nanometer laminated structure is inserted uterine cavity, along with the iron layer in degradable composite material is degraded gradually, constantly there is new layers of copper exposing surface copper ion releasing, this procedure avoids continuous print larger areas of copper directly to contact with inner membrane of uterine cavity and to the stimulation of Endometrium tissue and damage, simultaneously due to the successively stripping of degradable composite material, can Automatic-falling after intrauterine device is completed the term of service, avoid or reduce artificial take out intrauterine device and having an intense pain of causing.Thisly can reach good contraceptive effect, the nanometer degradable composite material that can reduce again human body damages will become the ideal substitute of existing naked copper IUD.
Embodiment 1
The preparation method of the degradable composite material of the layered nano-structure of the present embodiment comprises the following steps:
Step one, choose fine copper sheet material and each one piece of pure iron sheet material that thickness is respectively 4mm;
Step 2, the fine copper sheet material chosen in step one and pure iron plate surface to be cleaned out by sandblasting and polishing;
Step 3, the fine copper sheet material handled well in step 2, pure iron sheet material are superimposed together, carry out room temperature rolling, rolling reduction is 50% of superimposed sheet material gross thickness, obtains cold rolling composite plate material;
Step 4, inserted in vacuum heat treatment furnace and carry out annealing heat treatment by the cold rolling composite plate material that step 3 obtains, annealing temperature is 800 DEG C, annealing time 3 hours, obtains annealed state Rolling compund sheet material;
Step 5, by the annealed state Rolling compund sheet material in step 4 therefrom between block, and to process by the surface of method to annealed state Rolling compund sheet material of step 2;
Step 6, by the copper side surface of one block of sheet material in step 5 and the ferrum side surface of another block sheet material superimposed after carry out room temperature rolling, rolling reduction is 50% of superimposed sheet material gross thickness;
Step 7, repetition step 3 ~ step 6 36 times, final acquisition thickness of slab is the layered nano-structure composite board of 2.7mm;
Step 8, the layered nano-structure composite board of gained in step 7 is cut into the layered nano-structure composite wire of diameter 2.5mm by the method for Linear cut;
Step 9, the layered nano-structure composite wire of step 8 gained is carried out the 2 passage cold drawings that passage sizing reduction is 0.5mm, finally obtain layered nano-structure ferrum/copper composite wire material that diameter is 1.5mm;
Step 10, the techniques such as layered nano-structure ferrum/copper composite wire material that step 9 obtains carries out blocking, bend are prepared into the IUD of various shape.
Embodiment 2
The preparation method of the degradable composite material of the layered nano-structure of the present embodiment comprises the following steps:
Step one, choose fine copper sheet material and each 10 pieces of pure iron sheet material that thickness is respectively 0.5mm;
Step 2, the fine copper sheet material chosen in step one and pure iron plate surface to be cleaned out by pickling and polishing;
Step 3, to be superimposed together by the sheet material handled well to carry out room temperature rolling in step 2 by the compound mode that copper, ferrum, copper, ferrum interlock successively, rolling reduction is 50% of superimposed sheet material gross thickness, obtains cold rolling composite plate material;
Step 4, inserted in vacuum heat treatment furnace and carry out annealing heat treatment by the cold rolling composite plate material that step 3 obtains, annealing temperature is 800 DEG C, annealing time 3 hours, obtains annealed state Rolling compund sheet material;
Step 5, by the annealed state Rolling compund sheet material in step 4 therefrom between block, and by step 2 method process annealed state Rolling compund sheet material surface;
Step 6, to be superimposed together by the ferrum side surface of the copper side surface of one block of annealed state Rolling compund sheet material in step 5 and another block annealed state Rolling compund sheet material and to carry out room temperature rolling, rolling reduction is 50% of superimposed sheet material gross thickness;
Step 7, repetition step 3 ~ step 6 20 times, final acquisition thickness of slab is the layered nano-structure composite board of 4.2mm;
Step 8, the layered nano-structure composite board obtained in step 7 is cut into the layered nano-structure composite wire of diameter 2.5mm by the method for Linear cut;
Step 9, step 8 gained layered nano-structure composite wire is carried out the 2 passage cold drawings that passage sizing reduction is 0.5mm, finally obtain layered nano-structure ferrum/copper composite wire material that diameter is 1.5mm;
Step 10, the techniques such as layered nano-structure ferrum/copper composite wire material that step 9 obtains carries out blocking, bend are prepared into the IUD of various shape.
Embodiment 3
As shown in Figure 4, the present embodiment relates to a kind of intrauterine device with the degradable composite material of layered nano-structure, this intrauterine device comprises the many sections of composite joints 11 be made up of the degradable composite material with layered nano-structure, multiple composite joint 11 is serially connected with on an abiotic suture 12, and arranges a composite knot 13 be made up of the degradable composite material with layered nano-structure in one end of abiotic suture 12.
This intrauterine device saves 11 by 6 composites and forms, each composite saves 11 long 5mm, diameter is about 2.2mm, string is on the abiotic suture 12 of a root polypropylene, then the end of the abiotic suture 12 of polypropylene adds that a composite knot 13 be made up of the degradable composite material with layered nano-structure forms; During placement, composite knot 13 is fixed on myometrium 1cm place.
Embodiment 4
As shown in Figure 5, the present embodiment relates to a kind of intrauterine device with the degradable composite material of layered nano-structure, this intrauterine device comprises V-type support 21, silica gel sheath 22 and has the corrugated tubing 23 of degradable composite material of layered nano-structure, the both sides of V-type support 21 are alternately set with silica gel sheath 22 and corrugated tubing 23 respectively, and corrugated tubing 23 is held on the centre of two-section silica gel sheath 22.Two free ends of V-type support 21 are respectively arranged with termination 24, and termination 24 is ring-type or hooks shape.V-type support 21 be B alloy wire with memory function, optional material is Ti-Ni alloy, and the surface area of this intrauterine device is 380mm
2.
Embodiment 5
As shown in Figure 6, the present embodiment relates to a kind of intrauterine device with the degradable composite material of layered nano-structure, and this intrauterine device comprises transverse arm 31 and support ring 32; Support ring 32 is droplet-shaped; Transverse arm 31 is two, and the end of each transverse arm 31 self-supporting ring 32 respectively is upwards outwards bent to form again.
Be provided with in support ring 32 and the junction of each transverse arm 31 between curved portions 33, two curved portions 33 bent to the inside and have gap, support ring 32 is non-close ring.
Embodiment 6
As shown in Figure 7, the present embodiment relates to a kind of intrauterine device with the degradable composite material of layered nano-structure, the support 42 that this intrauterine device comprises core bar 41 and is connected with core bar 41 one end; Support 42 is arc, and the opening of support 42 is consistent with the extending direction of core bar 41, and support 42 arranged outside has multiple protuberance 43 for this intrauterine device is fixed on intrauterine.
Protuberance 43 comprises from the nose bar 431 of support 42 surface convex and the convex ball 432 being arranged at nose bar 431 end, and the diameter of convex ball 432 is greater than the diameter of nose bar 431.
Embodiment 7
As shown in Figure 8, the present embodiment relates to a kind of intrauterine device with the degradable composite material of layered nano-structure, and this intrauterine device comprises V-type main body 51 and head 52 forms, and head 52 connects the free end of V-type main body 51, and head 52 is ring-type or hooks shape.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, any those skilled in the art, do not departing within the scope of technical solution of the present invention, make a little change when the technology contents of above-mentioned announcement can be utilized or be modified to the Equivalent embodiments of equivalent variations, in every case be the content not departing from technical solution of the present invention, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (11)
1. one kind has the intrauterine device of the degradable composite material of layered nano-structure, it is characterized in that, this intrauterine device is made up of a kind of degradable composite material with layered nano-structure, described degradable composite material comprises copper and ferrum, described degradable composite material is the layered nano-structure that layers of copper and iron layer are alternately arranged, wherein the mass percentage content of copper is 40-70%, and the elastic modelling quantity of described degradable composite material is between 80-120GPa.
2. have the intrauterine device of the degradable composite material of layered nano-structure as claimed in claim 1, it is characterized in that: the purity of the copper used in described degradable composite material is 99.999%, the purity of the ferrum of use is 99.999%.
3. there is the intrauterine device of the degradable composite material of layered nano-structure as claimed in claim 1, it is characterized in that: the preparation process of described degradable composite material is as follows:
(1) at room temperature by copper coin base with the superimposed employing of iron plate base is cold rolling is prepared into the ferrum with layered nano-structure/copper composite board that thickness is 5 ~ 10mm.;
(2) ferrum with the layered nano-structure/copper composite board obtained in step (1) be processed into bar and carry out ferrum/carbon/carbon-copper composite material wire rod that multi pass drawing preparation has layered nano-structure.
4. there is the intrauterine device of the degradable composite material of layered nano-structure as claimed in claim 3, it is characterized in that: the standby method of described cold rolling comprises the following steps:
(1) be that the copper coin base of 0.5 ~ 2mm and iron plate base interlock superimposed by the thickness with clean surface, after superimposed, ground floor and last one deck are respectively copper coin base and iron plate base;
(2) undertaken cold rolling by superimposed good copper coin base and iron plate base, cold rolling strain rate scope control is 10
-2~ 10s
-1, rolling temperature≤100 DEG C, rolling reduction is 40 ~ 60% of superimposed sheet material gross thickness; Obtain cold rolled sheet;
(3) cold rolled sheet obtained in step (2) is blocked, and by superimposed for the sheet material after blocking, time superimposed the copper side of one piece of cold rolled sheet and the ferrum contacts side surfaces of another block cold rolled sheet superimposed, superimposed rear repetition step (2) is rolled;
(4) repeat step (2)-(3) and obtain the ferrum/copper composite board with layered nano-structure 15-40 time.
5. there is the intrauterine device of the degradable composite material of layered nano-structure as claimed in claim 3, it is characterized in that: method prepared by described drawing comprises the following steps:
(1) ferrum with the layered nano-structure/copper composite board obtained after cold rolling is standby is processed into the ferrum with layered nano-structure/carbon/carbon-copper composite material bar that diameter is 5-10mm;
(2) ferrum with the layered nano-structure/carbon/carbon-copper composite material bar of preparation in step (1) is carried out multi pass drawing, passage sizing reduction is within 5-~ 15%, and drawing strain rate scope is 10
-2~ 10s
-1, after multi pass drawing, obtain the ferrum with layered nano-structure/carbon/carbon-copper composite material wire rod that diameter is 1 ~ 2mm.
6. there is the intrauterine device of the degradable composite material of layered nano-structure as claimed in claim 3, it is characterized in that: at cold rolling for front, first by copper coin base and iron plate base surface mechanical grinding cleaning with acetone.
7. there is the intrauterine device of the degradable composite material of layered nano-structure as claimed in claim 1, it is characterized in that: this intrauterine device comprises the many sections of composite joints be made up of the degradable composite material with layered nano-structure, multiple described composite joint is serially connected with on an abiotic suture, and arranges a composite knot be made up of the degradable composite material with layered nano-structure in one end of described abiotic suture.
8. there is the intrauterine device of the degradable composite material of layered nano-structure as claimed in claim 1, it is characterized in that: this intrauterine device comprises V-type support, silica gel sheath and has the corrugated tubing of degradable composite material of layered nano-structure, the both sides of described V-type support are alternately set with described silica gel sheath and described corrugated tubing respectively, and described corrugated tubing is held on the centre of silica gel sheath described in two-section.
9. there is the intrauterine device of the degradable composite material of layered nano-structure as claimed in claim 1, it is characterized in that: this intrauterine device comprises transverse arm and support ring; Described support ring is droplet-shaped; Described transverse arm is two, and transverse arm described in each is upwards outwards bent to form from the end of described support ring respectively again.
10. there is the intrauterine device of the degradable composite material of layered nano-structure as claimed in claim 1, it is characterized in that: the support that this intrauterine device comprises core bar and is connected with described core bar one end; Described support is arc, and the opening of described support is consistent with the extending direction of described core bar, and described stent outer is provided with multiple protuberance for this intrauterine device is fixed on intrauterine.
11. intrauterine device as claimed in claim 1 with the degradable composite material of layered nano-structure, it is characterized in that: this intrauterine device comprises V-type main body and head composition, described head connects the free end of described V-type main body, and described head is ring-type or hooks shape.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106473859A (en) * | 2016-11-04 | 2017-03-08 | 郑州莉迪亚医药科技有限公司 | A kind of adjustable intrauterine device |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN2073736U (en) * | 1990-08-11 | 1991-03-27 | 河南省商丘市医疗器械厂 | Active anchor shape intra-uterine contraceptive device |
CN1273081A (en) * | 1999-05-10 | 2000-11-15 | 吴裕浩 | Magnetic intrauterine contraceptive |
WO2004078081A1 (en) * | 2003-03-05 | 2004-09-16 | Iakov Grigorevich Joukovski | Intrauterine contraceptive means |
CN2790436Y (en) * | 2005-04-06 | 2006-06-28 | 华中科技大学 | Nano composite material stein-free intrauterine device |
CN101019791A (en) * | 2007-03-21 | 2007-08-22 | 唐文祥 | Intrauterine device with slow released medicine |
CN101234052A (en) * | 2007-02-01 | 2008-08-06 | 柳葆光 | Magnetic contraceptive ring and contraceptive ring taking device |
CN101278872A (en) * | 2007-04-05 | 2008-10-08 | 辽宁爱母医疗科技有限公司 | Nano memory alloy intrauterine device |
CN101695589A (en) * | 2009-10-22 | 2010-04-21 | 华中科技大学 | Sandwich layer slow-release birth control material |
-
2015
- 2015-12-17 CN CN201510953887.0A patent/CN105559960B/en active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN2073736U (en) * | 1990-08-11 | 1991-03-27 | 河南省商丘市医疗器械厂 | Active anchor shape intra-uterine contraceptive device |
CN1273081A (en) * | 1999-05-10 | 2000-11-15 | 吴裕浩 | Magnetic intrauterine contraceptive |
WO2004078081A1 (en) * | 2003-03-05 | 2004-09-16 | Iakov Grigorevich Joukovski | Intrauterine contraceptive means |
CN2790436Y (en) * | 2005-04-06 | 2006-06-28 | 华中科技大学 | Nano composite material stein-free intrauterine device |
CN101234052A (en) * | 2007-02-01 | 2008-08-06 | 柳葆光 | Magnetic contraceptive ring and contraceptive ring taking device |
CN101019791A (en) * | 2007-03-21 | 2007-08-22 | 唐文祥 | Intrauterine device with slow released medicine |
CN101278872A (en) * | 2007-04-05 | 2008-10-08 | 辽宁爱母医疗科技有限公司 | Nano memory alloy intrauterine device |
CN101695589A (en) * | 2009-10-22 | 2010-04-21 | 华中科技大学 | Sandwich layer slow-release birth control material |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106473859A (en) * | 2016-11-04 | 2017-03-08 | 郑州莉迪亚医药科技有限公司 | A kind of adjustable intrauterine device |
CN106473859B (en) * | 2016-11-04 | 2018-10-30 | 张美娟 | A kind of adjustable intrauterine device |
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