CN105535058A - Medicine composition for preventing and treating pancreatic cancer - Google Patents
Medicine composition for preventing and treating pancreatic cancer Download PDFInfo
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Abstract
The invention discloses a medicine composition for preventing and treating a pancreatic cancer and a preparation method thereof. The medicine composition uses lysimachia hemsleyana, Grewia lantsangensis Hu, glepidotin C, bilobetin and ligularia virgaurea as medicinal raw materials, is prepared in proportion, can be prepared into various preparations by adopting a conventional preparation process and has the remarkable effect of preventing and treating the pancreatic cancer.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition preventing and treating cancer of pancreas and preparation method thereof.
Background technology
The cause of disease of cancer of pancreas is still not fully aware of.Its morbidity is relevant with six factors, smoking, drink, diet, coffee, chronic pancreatitis and inherited genetic factors.Cancer of pancreas can betide any position of pancreas, but is common with head of pancreas, and infiltrates for metastasis and extension approach with lymphatic metastasis and cancer.Also have that many factors are sick therewith has certain relation, as occupation, environment, geography etc. in addition.Along with the sharply change of people life style and dietary structure, the sickness rate of cancer of pancreas is obvious ascendant trend and rejuvenation day by day.Because it has the fast feature with lacking specific symptoms of disease progression, its early diagnosis is quite difficult to a great extent, and therapeutic effect is poor, prognosis mala.Therefore chemotherapy becomes its treatment major measure, and in view of current clinical institute treatment with chemotherapy drug effect is limited and side effect brings great pain to patient, the chemotherapeutic efficacy how improving cancer of pancreas is still the clinical difficult problem needing solution badly at present.
Lysimachia hemsleyana: this product is the herb of Primulaceae Lysimachia plant Lysimachia hemsleyana LysimachiahemsleyanaMaxim..Summer gathers, and dries.[nature and flavor] micro-hardship; Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Stimulate the menstrual flow.Main hepatitis; Pyelonephritis; Cystitis; Amenorrhea.Isolate potassium chloride and mixing saccharide in [chemical analysis] herb, preliminary examination still has the reactions such as flavonoid, Saponin, glycoside, lactone and organic acid.[pharmacological action] choleretic effect rat oral 100% Lysimachia hemsleyana decoct 5m1 every day, in continuous 6 weeks, in general anesthesia acute experiment situation, compares with matched group, has the effect promoting bile excretion.As lower in dosage or eye is short with the phase, then act on not obvious, continuous eye decoct is after 2-3 days, and animal feces is thinning, and color becomes sepia, but does not find intoxicating phenomenon.Rat without gallbladder, therefore promotes that the excretion of bile is not caused by enhancing gallbladder contraction.Record in Chinese medicine voluminous dictionary.
Prairie fire rope: this product is the root white skin of Tiliaceae load bar platymiscium comospore bilobed grewia GrewiaeriocarpaJuss. ［ G.lantsangensisHu ］.Autumn, winter take root, strip root bark, and removing cork, cutting, dries.[nature and flavor] are puckery; Micro-hardship; Cool.[function cures mainly] stops blooding; Synthetism; Granulation promoting; Removing toxic substances.Main traumatic hemorrhage; Weapons damage; Fracture; Furuncle is red and swollen.[original shape state] comospore bilobed grewia shrub or dungarunga, up to 8m.Twig is by the starlike soft fine hair of taupe.Leaf alternate; Time handle long 5-10mm; Stipule wire lanceolar, long 5-10mm; Blade papery, tiltedly avette to ovum shape Long Circle, long 6-13cm, wide 3-6cm, tip is point or anxious point gradually, base portion deflection, tiltedly circular or bevel shape, above scattered stellate hair, blackening brown after dry, below by the starlike soft fine hair of Lycoperdon polymorphum Vitt, there is serration at edge; Trinervious two lateral veins rise and reach 3/4 of leaf length, and the middle arteries and veins first half has lateral vein 3-4 couple.Cyme 1-3 branch axil is raw, long 1.5-3cm, the long 3-8mm of common peduncle; The long 3-5mm of anthocaulus; Bract lanceolar; Flower both sexes; The long and narrow circle of sepal, long 6-8mm, inside and outside two sides is all without hair; The long 3mm of petal; Body of gland is short and small; Androgynophore is by hair; Stamen is from life, different in size, shorter than sepal; Ovary is by hair, and style has pubescence, stigma peltate, and 4 shallowly split or do not divide.Drupe is subsphaeroidal, diameter 6-8mm, by stellate hair, has shallow ridges.Record in Chinese medicine voluminous dictionary.
Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski: this product is the dry herb of feverfew Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski Ligulariavirgaurea (Maxim.) Mactf..6 ~ July gathers herb, cleans and dries.[nature and flavor] sweet, bitter, cold.[function with cure mainly] clear place heat, the skin ulcer that heals of detoxify, yellow fluid reducing, emetic.For dyspepsia, " Baconic " and " red bar " complication, stomach " dragon " is sick, outmoded epidemic disease, grasserie, skin infection, nosotoxicosis.[character] this product root is most, strip, pitchy, and rhizome is close is deposited petiole by brown threadiness is withered.Stem hollow, tool vertical wrinkle ditch is smooth or by white arachnoid hair.How broken blade is, and in oval shape lanceolar after complete person launches, the lower portion of the stem leaf downward one-tenth wing handle, the little stockless of upper leaf, embraces stem.Head inflorescence composition raceme, obstructs short sagging; Brightly yellowish color, pappus white, coarse wool shape, achene Long Circle.Gas is different, mildly bitter flavor, micro-cool.Record in health Tibetan medicine standard promulgated by the ministries or commissions of the Central Government (first), standard number: WS3-BC-0091-95.
Bilobetin (Bilobetin): CAS 521-32-4, molecular formula C
31h
20o
10, molecular weight 552.50.[pharmacological action] has the effect reducing serum cholesterol, the ratio of phospholipid and cholesterol can be made to be tending towards normal, be used for the treatment of angina pectoris.[purposes] antilipemics.[ingredient origin] Ginkgoaceae plant Ginkgo biloba GinkgobilobaL. leaf, Podocarpaceae plant long Semen Podocarpi Macrophylli PodocarpuselongatusL'Herit. leaf.
Scale leaf glycyrrhizin C(GlepidotinC): CAS 87440-56-0, molecular formula C
20h
20o
5, molecular weight 340.38.[pharmacological action] is antibacterial.[ingredient origin] pulse family American licorice Glycyrrhizalepidota.
2 crude drug chemical constitutions:
Bilobetin (Bilobetin) scale leaf glycyrrhizin C(GlepidotinC).
Summary of the invention
The object of the invention is the deficiency overcoming background technology, pharmaceutical composition of a kind of effective control cancer of pancreas and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the crude drug of the pharmaceutical composition of this control cancer of pancreas are:
Lysimachia hemsleyana 5200-5300 weight portion prairie fire rope 4200-4300 weight portion scale leaf glycyrrhizin C230-260 weight portion bilobetin 150-160 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2700-2900 weight portion.
Preferred for preventing and treating the pharmaceutical composition of cancer of pancreas, be made up of the crude drug of following weight portion:
Lysimachia hemsleyana 5250 weight portion prairie fire rope 4250 weight portion scale leaf glycyrrhizin C245 weight portion bilobetin 155 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2800 weight portion.
Prevent and treat a pharmaceutical composition for cancer of pancreas, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
Prevent and treat a pharmaceutical composition for cancer of pancreas, what it is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form prevents and treats pancreatic cancer drug.
Prevent and treat a preparation method for the pharmaceutical composition of cancer of pancreas, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Lysimachia hemsleyana 5200-5300 weight portion prairie fire rope 4200-4300 weight portion scale leaf glycyrrhizin C230-260 weight portion bilobetin 150-160 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2700-2900 weight portion;
Preparation method:
(1) Lysimachia hemsleyana is got by crude drug proportioning, prairie fire rope, scale leaf glycyrrhizin C, bilobetin, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, mixing, with weight percent concentration 22% ethanol as solvent, 32 DEG C of warm macerating extract, extraction time is 8 times, each extraction time is 15 hours, each solvent load is 21 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.15, filter, medicinal liquid is by SIP1300 macroporous adsorptive resins, first wash with water, use weight percent concentration 92% alcoholic solution eluting SIP1300 macroporous adsorptive resins again, collect weight percent concentration 92% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 48% ethanol as solvent, heating and refluxing extraction 20 times, each extraction time is 0.7 hour, each solvent load is 13 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by GDX-401 macroporous adsorptive resins, first wash with water, use weight percent concentration 89% alcoholic solution eluting GDX-401 macroporous adsorptive resins again, collect weight percent concentration 89% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Preferred a kind of preparation method of preventing and treating the pharmaceutical composition of cancer of pancreas, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Lysimachia hemsleyana 5250 weight portion prairie fire rope 4250 weight portion scale leaf glycyrrhizin C245 weight portion bilobetin 155 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2800 weight portion;
Preparation method:
(1) Lysimachia hemsleyana is got by crude drug proportioning, prairie fire rope, scale leaf glycyrrhizin C, bilobetin, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, mixing, with weight percent concentration 22% ethanol as solvent, 32 DEG C of warm macerating extract, extraction time is 8 times, each extraction time is 15 hours, each solvent load is 21 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.15, filter, medicinal liquid is by SIP1300 macroporous adsorptive resins, first wash with water, use weight percent concentration 92% alcoholic solution eluting SIP1300 macroporous adsorptive resins again, collect weight percent concentration 92% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 48% ethanol as solvent, heating and refluxing extraction 20 times, each extraction time is 0.7 hour, each solvent load is 13 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by GDX-401 macroporous adsorptive resins, first wash with water, use weight percent concentration 89% alcoholic solution eluting GDX-401 macroporous adsorptive resins again, collect weight percent concentration 89% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Prevent and treat a preparation method for the pharmaceutical composition of cancer of pancreas, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
Prevent and treat a preparation method for the pharmaceutical composition of cancer of pancreas, it is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and prevent and treat pancreatic cancer drug.
Pharmaceutical composition control cancer of pancreas is evident in efficacy.
Detailed description of the invention
Embodiment 1: pharmaceutical composition of control cancer of pancreas and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition of control cancer of pancreas are: Lysimachia hemsleyana 5250g prairie fire rope 4250g scale leaf glycyrrhizin C245g bilobetin 155g Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2800g;
Preparation method:
(1) Lysimachia hemsleyana is got by crude drug proportioning, prairie fire rope, scale leaf glycyrrhizin C, bilobetin, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, mixing, with weight percent concentration 22% ethanol as solvent, 32 DEG C of warm macerating extract, extraction time is 8 times, each extraction time is 15 hours, each solvent load is 21 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.15, filter, medicinal liquid is by SIP1300 macroporous adsorptive resins, first wash with water, use weight percent concentration 92% alcoholic solution eluting SIP1300 macroporous adsorptive resins again, collect weight percent concentration 92% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 48% ethanol as solvent, heating and refluxing extraction 20 times, each extraction time is 0.7 hour, each solvent load is 13 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by GDX-401 macroporous adsorptive resins, first wash with water, use weight percent concentration 89% alcoholic solution eluting GDX-401 macroporous adsorptive resins again, collect weight percent concentration 89% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Embodiment 2: pharmaceutical composition of control cancer of pancreas and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition of control cancer of pancreas are: Lysimachia hemsleyana 5200g prairie fire rope 4300g scale leaf glycyrrhizin C230g bilobetin 160g Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2700g;
Preparation method:
(1) Lysimachia hemsleyana is got by crude drug proportioning, prairie fire rope, scale leaf glycyrrhizin C, bilobetin, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, mixing, with weight percent concentration 22% ethanol as solvent, 32 DEG C of warm macerating extract, extraction time is 8 times, each extraction time is 15 hours, each solvent load is 21 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.15, filter, medicinal liquid is by SIP1300 macroporous adsorptive resins, first wash with water, use weight percent concentration 92% alcoholic solution eluting SIP1300 macroporous adsorptive resins again, collect weight percent concentration 92% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 48% ethanol as solvent, heating and refluxing extraction 20 times, each extraction time is 0.7 hour, each solvent load is 13 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by GDX-401 macroporous adsorptive resins, first wash with water, use weight percent concentration 89% alcoholic solution eluting GDX-401 macroporous adsorptive resins again, collect weight percent concentration 89% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Embodiment 3: pharmaceutical composition of control cancer of pancreas and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition of control cancer of pancreas are: Lysimachia hemsleyana 5300g prairie fire rope 4200g scale leaf glycyrrhizin C260g bilobetin 150g Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2900g;
Preparation method:
(1) Lysimachia hemsleyana is got by crude drug proportioning, prairie fire rope, scale leaf glycyrrhizin C, bilobetin, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, mixing, with weight percent concentration 22% ethanol as solvent, 32 DEG C of warm macerating extract, extraction time is 8 times, each extraction time is 15 hours, each solvent load is 21 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.15, filter, medicinal liquid is by SIP1300 macroporous adsorptive resins, first wash with water, use weight percent concentration 92% alcoholic solution eluting SIP1300 macroporous adsorptive resins again, collect weight percent concentration 92% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 48% ethanol as solvent, heating and refluxing extraction 20 times, each extraction time is 0.7 hour, each solvent load is 13 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by GDX-401 macroporous adsorptive resins, first wash with water, use weight percent concentration 89% alcoholic solution eluting GDX-401 macroporous adsorptive resins again, collect weight percent concentration 89% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 445g, adds starch 382g, mixing, granulates, dry, adds microcrystalline Cellulose 169g, magnesium stearate 7g, and mixing, is pressed into 1500, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 348g, adds starch 270g, mixing, granulates, and dry, granulate, adds appropriate magnesium stearate, and mixing, obtains medicament composition capsule by encapsulated 1300.
Embodiment 6: the preparation of drop pill
Taking polyethylene glycol 6000 370g water-bath (80 DEG C) heating boils molten, add embodiment 3 pharmaceutical composition 18.4g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 8 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 2.8cm apart from liquid level, drips speed with per minute 60 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 7: the pharmaceutical composition of control cancer of pancreas
Composition and the weight portion of the crude drug of the pharmaceutical composition of control cancer of pancreas are:
Prairie fire rope 5080 weight portion bilobetin 260 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 3460 weight portion.
Embodiment 8: the pharmaceutical composition of control cancer of pancreas
Composition and the weight portion of the crude drug of the pharmaceutical composition of control cancer of pancreas are:
Scale leaf glycyrrhizin C230 weight portion bilobetin 270 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 3050 weight portion.
Embodiment 9: the pharmaceutical composition of control cancer of pancreas
Composition and the weight portion of the crude drug of the pharmaceutical composition of control cancer of pancreas are:
Scale leaf glycyrrhizin C320 weight portion bilobetin 100 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 3250 weight portion.
Experimental example 1: the experimental study of control cancer of pancreas
1 data and method
1.1 basic document
That chooses this city hospital in February, 2011 ~ in April, 2012 accepts 29 routine Pancreas cancer patients for medical treatment, wherein, and male patient 19 example, female patient 10 example, 35 ~ 68 years old age, 45.5 years old mean age.
1.2 method
The equal drug of choice compositions of all patients of 29 routine cancer of pancreas (embodiment 1 pharmaceutical composition lot number 20110106) is treated, oral, a 1.2g, every day 3 times.The all single employing aforementioned pharmaceutical compositions treatment of this 29 routine Pancreas cancer patients, do not adopt other drug to treat, treatments period carries out fluid infusion auxiliary treatment according to needs of patients.
2 results
2.1 cancer of pancreas clinical manifestations
This 29 routine Pancreas cancer patients all has the performance such as distension and fullness of the chest and abdomen, inappetence, jaundice ascites, sharp ache, constipation in various degree, in conjunction with the diagnosis of clinical Chinese medicine and each patient's own characteristic is dialectical treats, above-mentioned patient is summarized as epigastric region pain endlessly person or distension and fullness of the chest and abdomen, nausea and vomiting, the indigestion and loss of appetite person of lack of appetite or dry mouth with bitter taste, emaciated physique person, patient's body of the tongue is light red dark red or livid purple or have ecchymosis, pulse condition or string thin or puckery.With jaundice person 15 example in this 29 routine Pancreas cancer patients; With swollen person 12 example of breast abdominal distention; With inappetence person 13; With digestive tract hemorrhage hold concurrently constipation person 10 example; Merge other internal organs of transfer person 6 example in addition.Above patient is put inspection-free survey by CT or tumor and is added clinical experience and make a definite diagnosis.
2.2 therapeutic outcomes with lapse to and make a definite diagnosis after, 29 routine Pancreas cancer patients time-to-live after tcm diagnosis and treatment all exceeded half a year more than, wherein, time-to-live has 12 examples in half a year to the patient of 1 year, accounts for 41.38%, and there are 10 examples the time-to-live the patient of 1 to 2 years, account for 34.48%, and time-to-live having more than 2 years be 3 routine, account for 10.34%, up to the present, in these patients surviving have 4 example, account for 13.79%, patient recovers orthobiosis substantially as ordinary person, and body weight increases to some extent.
Claims (8)
1. prevent and treat a pharmaceutical composition for cancer of pancreas, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Lysimachia hemsleyana 5200-5300 weight portion prairie fire rope 4200-4300 weight portion scale leaf glycyrrhizin C230-260 weight portion bilobetin 150-160 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2700-2900 weight portion.
2. a kind of pharmaceutical composition preventing and treating cancer of pancreas according to claim 1, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Lysimachia hemsleyana 5250 weight portion prairie fire rope 4250 weight portion scale leaf glycyrrhizin C245 weight portion bilobetin 155 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2800 weight portion.
3. a kind of pharmaceutical composition preventing and treating cancer of pancreas according to claim 1, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
4. a kind of pharmaceutical composition preventing and treating cancer of pancreas according to claim 1, what it is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form prevents and treats pancreatic cancer drug.
5. prevent and treat a preparation method for the pharmaceutical composition of cancer of pancreas, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Lysimachia hemsleyana 5200-5300 weight portion prairie fire rope 4200-4300 weight portion scale leaf glycyrrhizin C230-260 weight portion bilobetin 150-160 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2700-2900 weight portion;
Preparation method:
(1) Lysimachia hemsleyana is got by crude drug proportioning, prairie fire rope, scale leaf glycyrrhizin C, bilobetin, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, mixing, with weight percent concentration 22% ethanol as solvent, 32 DEG C of warm macerating extract, extraction time is 8 times, each extraction time is 15 hours, each solvent load is 21 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.15, filter, medicinal liquid is by SIP1300 macroporous adsorptive resins, first wash with water, use weight percent concentration 92% alcoholic solution eluting SIP1300 macroporous adsorptive resins again, collect weight percent concentration 92% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 48% ethanol as solvent, heating and refluxing extraction 20 times, each extraction time is 0.7 hour, each solvent load is 13 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by GDX-401 macroporous adsorptive resins, first wash with water, use weight percent concentration 89% alcoholic solution eluting GDX-401 macroporous adsorptive resins again, collect weight percent concentration 89% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
6. a kind of preparation method of preventing and treating the pharmaceutical composition of cancer of pancreas according to claim 5, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Lysimachia hemsleyana 5250 weight portion prairie fire rope 4250 weight portion scale leaf glycyrrhizin C245 weight portion bilobetin 155 weight portion Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski 2800 weight portion;
Preparation method:
(1) Lysimachia hemsleyana is got by crude drug proportioning, prairie fire rope, scale leaf glycyrrhizin C, bilobetin, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, mixing, with weight percent concentration 22% ethanol as solvent, 32 DEG C of warm macerating extract, extraction time is 8 times, each extraction time is 15 hours, each solvent load is 21 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.15, filter, medicinal liquid is by SIP1300 macroporous adsorptive resins, first wash with water, use weight percent concentration 92% alcoholic solution eluting SIP1300 macroporous adsorptive resins again, collect weight percent concentration 92% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 48% ethanol as solvent, heating and refluxing extraction 20 times, each extraction time is 0.7 hour, each solvent load is 13 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by GDX-401 macroporous adsorptive resins, first wash with water, use weight percent concentration 89% alcoholic solution eluting GDX-401 macroporous adsorptive resins again, collect weight percent concentration 89% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
7. a kind of preparation method of preventing and treating the pharmaceutical composition of cancer of pancreas according to claim 5, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
8. a kind of preparation method of preventing and treating the pharmaceutical composition of cancer of pancreas according to claim 5, is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and prevents and treats pancreatic cancer drug.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610047050.4A CN105535058A (en) | 2016-01-25 | 2016-01-25 | Medicine composition for preventing and treating pancreatic cancer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610047050.4A CN105535058A (en) | 2016-01-25 | 2016-01-25 | Medicine composition for preventing and treating pancreatic cancer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116159094A (en) * | 2023-03-13 | 2023-05-26 | 重庆市人民医院 | Pharmaceutical composition for preventing or treating pancreatic cancer and kit for detecting pancreatic cancer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116159094A (en) * | 2023-03-13 | 2023-05-26 | 重庆市人民医院 | Pharmaceutical composition for preventing or treating pancreatic cancer and kit for detecting pancreatic cancer |
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