CN105534745A - Emulsified composition and application of emulsified composition to preparation of oil-water mutual-dissolution type natural rosemary antioxidant - Google Patents
Emulsified composition and application of emulsified composition to preparation of oil-water mutual-dissolution type natural rosemary antioxidant Download PDFInfo
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- CN105534745A CN105534745A CN201510991135.3A CN201510991135A CN105534745A CN 105534745 A CN105534745 A CN 105534745A CN 201510991135 A CN201510991135 A CN 201510991135A CN 105534745 A CN105534745 A CN 105534745A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention provides an emulsified composition. The emulsified composition is prepared from the following raw materials in mass percent: 5 percent to 20 percent of a dispersant, 15 percent to 45 percent of an emulsifying agent, 20 percent to 35 percent of ethoxylated hydrogenated castor oil and 20 percent to 45 percent of propylene glycol, wherein the dispersant is triglycerol monostearate or polyglycerol-6-oleate; the emulsifying agent is Tween 20 or Span 80. After the emulsified composition provided by the invention is applied to treatment of the rosemary antioxidant, the rosemary antioxidant, which is mutually dissolved in an oil phase and a water phase randomly, is obtained, and layering and sediment are not caused; an anti-oxidization property of a previous antioxidant is also kept; the emulsified composition is easy to package and transport, and furthermore, the application of the rosemary antioxidant in cosmetics is enlarged.
Description
Technical field
The invention belongs to rosemary antioxidant embedding techniques field, more specifically, the application relating to a kind of emulsification composition and preparing profit and dissolve each other in the natural rosemary antioxidant of type.
Background technology
Herba Rosmarini Officinalis is a kind of spice berry with a long history, and it includes the phenols of multiple tool antioxidation.High-efficiency antioxidant material is wherein bisphenols diterpene, and scientific appraisal shows that carnosic acid and carnosol are main active component, and other also have rosmanol etc.
Along with everybody is to the attention of health, in cosmetics increasing insalubrious chemical composition progressively replace by natural effective ingredient.
Herba Rosmarini Officinalis is natural, safe as one, antibacterial, antioxidant efficiently, the fields such as food, health product, cosmetics are widely used in by people, antibacterial, antioxidant content main in Herba Rosmarini Officinalis are carnosic acid, ursolic acid, rosmarinic acid, and in these three kinds of materials antioxidant effect the best be carnosic acid, but carnosic acid is owing to being liposoluble constituent, all dispersing and dissolving is difficult to, so greatly limit its products application scope in cosmetics in Emulsion or water preparation.
At present there are no the process of oil formulation rosemary antioxidant being obtained product that profit dissolves each other and method.
Summary of the invention
The present invention, according to the deficiency of current oil formulation rosemary antioxidant range of application, provides a kind of emulsification composition.
The application that another object of the present invention is to provide above-mentioned emulsification composition preparing profit and dissolve each other in the natural rosemary antioxidant of type.
Technical purpose of the present invention is achieved through the following technical solutions:
The invention provides a kind of emulsification composition, comprise following raw material composition by mass percentage:
Described dispersant is trimerization glycerol monosterate or six polyglycerol monooleate; Described emulsifying agent is polysorbas20 or this Pan 80.
Because rosemary antioxidant is originally as fat-soluble product, if emulsifying is insufficient, unstable, can make this product in application process because oil-in-water is not thorough, disperse uneven, finally cause the outward appearance of product, effect and basic anti-oxidation efficacy etc. reduce even does not have effect, because carnosic acid oil formulation is carried out completely stable emulsifying, it will be embedded uniformly and be disperseed by reality exactly in end product, even if also its antioxidant effect will be caused to decline because of water mitigation in water liquid, stable embedding and dispersibility can ensure the antioxidant effect of excellence and equilibrium.
Therefore, emulsifying needs the composite factors such as stability, dispersibility, lyotropy, froth breaking jointly to play a role, and could realize optimum emulsifying effectiveness.
Preferably, described emulsification composition is made up of following raw material by mass percentage:
More preferably, described emulsification composition is made up of following raw material by mass percentage:
More preferably, described emulsification composition is made up of following raw material by mass percentage:
The present invention also provides a kind of profit two molten type rosemary antioxidant, and the raw material comprising following component is made:
Emulsification composition 65% ~ 70%
Carnosic acid oil formulation 30 ~ 35%;
Described emulsification composition comprises the raw material composition of following component:
Described dispersant is trimerization glycerol monosterate or six polyglycerol monooleate; Described emulsifying agent is polysorbas20 or this Pan 80.
Wherein, in carnosic acid oil formulation, carnosic acid content is 10 ~ 30%.
Preferably, described emulsification composition is made up of the raw material of following component:
Profit two of the present invention molten type rosemary antioxidant preparation process is: carnosic acid oil formulation and emulsification composition are dissolved in advance respectively, then by dissolved above-mentioned both materials mixing, homogenizing, obtain the molten type rosemary antioxidant of described profit two.
The property of the present invention is directed to screening excellence emulgate ingredient safely and effectively, by emulsifying technology, by fat-soluble Herba Rosmarini Officinalis extract carnosic acid oil formulation and the composite combination of food stage emulgate ingredient, be finally prepared into can be miscible arbitrarily in water preparation, oil preparation, Emulsion Natural antioxidant product.
Compared with prior art, the present invention has following beneficial effect:
Emulsification composition provided by the invention is applied in fat-soluble rosemary antioxidant product, prepare the system can dissolved each other arbitrarily in oil phase and aqueous phase, and there is not layering and precipitation in this system, also retains the antioxygenic property of former antioxidant, be beneficial to packaging and transport, expand the application of rosemary antioxidant in cosmetics further.
Detailed description of the invention
Below by embodiment, the present invention is specifically described; what be necessary to herein means out is that the present embodiment is only used to further illustrate the present invention; but can not be interpreted as limiting the scope of the invention, the person skilled in the art in this field can make some nonessential improvement and adjustment according to the content of the invention described above.
Unless stated otherwise, the present invention adopts reagent, method and apparatus are the art conventional reagent, method and apparatus.
Embodiment 1: the proportioning component following (by percentage to the quality) based on carnosic acid oil formulation being prepared into the molten type Natural antioxidant of the profit two being widely used in cosmetic product:
Adjuvant: 70%, carnosic acid oil formulation (10 ~ 30% content) 30%.
Wherein, adjunct ingredient is as follows: trimerization glycerol monosterate 5%, RH40 polyoxyethylene hydrogenated Oleum Ricini 15%, polysorbas20 (20%), propylene glycol 30%.
Preparation method is as follows: by carnosic acid content be 10%-30% carnosic acid oil formulation fully dissolve in 75 ~ 80 DEG C of water-baths.Then by hot miscible a little in 45 ~ 50 DEG C of water-baths for composite good above-mentioned adjuvant component.Finally, by above-mentioned both carry out whirlpool mixing, homogenizing becomes transparent mixed solution.
Embodiment 2: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant 65%, carnosic acid oil formulation: 30%
Wherein, trimerization glycerol monosterate 10%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 20%, polysorbas20 (10%), propylene glycol 25%,
Embodiment 3: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant: 65%, carnosic acid oil formulation: 35%
Wherein, six polyglycereol monostearates: 10%, this Pan 80:25%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 15%, propylene glycol: 15%
Embodiment 4: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant: 70%, carnosic acid oil formulation: 30%
Wherein, six polyglycereol monostearates: 5%, this Pan 80:30%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 20%, propylene glycol: 15%.
Comparative example 1: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant: 65%, carnosic acid oil formulation: 35%
Wherein, six polyglycereol monostearates: 20%, this Pan 80:35%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 5%, propylene glycol: 5%.
Comparative example 2: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant: 70%, carnosic acid oil formulation: 30%
Wherein, six polyglycereol monostearates: 25%, this Pan 80:5%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 10%, propylene glycol: 30%.
Comparative example 3: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant 65%, carnosic acid oil formulation: 35%
Wherein, trimerization glycerol monosterate 15%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 40%, polysorbas20 (5%), propylene glycol 5%.
Comparative example 4: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant 70%, carnosic acid oil formulation: 30%
Wherein, trimerization glycerol monosterate 5%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 5%, polysorbas20 (5%), propylene glycol 55%.
Comparative example 5:
Formulation ratio and preparation method, with embodiment 1, substitute polysorbas20 unlike employing Tween 80.
Comparative example 6
Formulation ratio and preparation method, with embodiment 2, substitute RH40 polyoxyethylene hydrogenated Oleum Ricini unlike employing polysorbate60.
Comparative example 7
Formulation ratio and preparation method, with embodiment 3, substitute six polyglycereol monostearates unlike employing poloxamer.
Comparative example 8
Formulation ratio and preparation method, with embodiment 4, substitute this Pan 80 unlike employing diacetyl tartarate list double glyceride.
Comparative example 9:
Formulation ratio and preparation method, with embodiment 4, substitute propylene glycol unlike employing PEG400.
Comparative example 10: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant: 70%, carnosic acid oil formulation: 30%
Wherein, six polyglycereol monostearates: 0%, this Pan 80:30%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 20%, propylene glycol: 20%.
Comparative example 11: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant: 70%, carnosic acid oil formulation: 30%
Wherein, six polyglycereol monostearates: 20%, this Pan 80:0%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 30%, propylene glycol: 20%.
Comparative example 12: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant: 70%, carnosic acid oil formulation: 30%
Wherein, six polyglycereol monostearates: 20%, this Pan 80:30%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 0%, propylene glycol: 20%.
Comparative example 13: preparation method is with embodiment 1, as follows based on proportioning component carnosic acid oil formulation being prepared into the profit two molten type Natural antioxidant being widely used in cosmetic product:
Adjuvant: 70%, carnosic acid oil formulation: 30%
Wherein, six polyglycereol monostearates: 20%, this Pan 80:30%, RH40 polyoxyethylene hydrogenated Oleum Ricini: 20%, propylene glycol: 0%.
Blank example:
Without emulsifying, it is the carnosic acid oil formulation of original 3%-10%.
1, dissolubility, dispersivity test:
Above-described embodiment and the formulated sample of comparative example are respectively got isodose, are added drop-wise to respectively in moisture retention water and carry out dissolubility, dispersivity test, by mixing, leave standstill more than 12h after observe its stability in water liquid.
2, Oxidation Resistance Test: utilize olive oil in cosmetics register to do the Oxidation Resistance Test of oils and fats, adds, under 45 DEG C of conditions by the relevant limitation of cosmetics register, do strenuous test, experimental period is two weeks, within every 3 days, detects a peroxide value change, using last numerical value as Appreciation gist.
The impact of performance of rosemary antioxidant in table 1 embodiment 1 ~ 4
The impact of performance of rosemary antioxidant in table 2 comparative example 1 ~ 9
Analysis of conclusion:
As can be seen from the above table, the basic recipe of comparative example 1 ~ 4 is consistent with embodiment, but has bigger difference due to the percentage ratio of each composition, its dispersibility finally in water and in oils and fats solubility to dispersion all poor, and oxidation resistance dies down.And the formulation ratio of comparative example 5 ~ 9 and preparation method are respectively with embodiment 1 ~ 4, but owing to substituted for different emulsifying agents, dispersant, its dispersibility finally in water and oils and fats dispersibility also very poor, and oxidation resistance dies down.Blank example this as oil formulation, so in water bad dispersibility, dissolubility good dispersion in oils and fats, and antioxidant effect in Vegetable oil lipoprotein is also fine.
In addition, comparative example 10 ~ 13 is owing to lacking the one in instant component, and its emulsifiability showed is not good yet.
Such as, comparative example 1 is that six polyglycereol monostearate ester contents increase, the increase of this material affects little on the emulsifying of emulsification composition and dispersion effect, but it is relatively poor at cold water stability, RH40 makes corresponding lyotropy and hydrophilic effect reduce and finally cause its emulsion stability to be deteriorated to the reduction of propylene glycol ratio simultaneously.
Comparative example 2 is that the proportion of this Pan 80 reduces, and because the content mainly as emulsifier component reduces, although do not affect its dispersibility, stability is not good, and levels also occurs aggregation, and its emulsifying is inabundant.
Comparative example 5 substitutes polysorbas20 for Tween 80, although Tween 80 emulsibility and lyotropy are all very similar to polysorbas20, but can not show a candle to polysorbas20 through its hydrophilic of oil preparation of Tween 80 emulsifying, thus with the carnosic acid oil formulation after Tween 80 emulsifying in water because hydrophilic is poor and not easily disperse.
From the interpretation of result of upper table, prepare a kind of molten type antioxidant of profit two being widely used in cosmetic product, the type selecting collocation of emulgate ingredient and ratio all play a part very crucial.
The molten type antioxidant of the profit two being widely used in cosmetics of the embodiment of the present invention 1 ~ 4 contains the composition of antibacterial anti-inflammatory, without the need to adding chemical antimicrobial antiphlogistic composition, and have passed human body skin patch test, safe and efficient.Method of testing and result as follows:
Tested material: the hydrosol that with the addition of the molten type antioxidant of profit two of embodiment 1 ~ 4.
Negative control: blank.
Experimenter: totally 30 people, male 15 people, female 15 people, at 18-35 years old ages, meets experimenter and volunteers inclusion criteria.
Speckle method for testing: select qualified speckle examination device, with closed patch test method, tested material being about 0.02ml ~ 0.025ml is applied in speckle examination device, external special adhesive tape sticks in the bent side of experimenter's forearm, tested material is removed after 24 hours, 30min after removal tested material speckle examination device, observes dermoreaction, by its result of dermoreaction grade scale record in " cosmetics health specification " (version in 2007) after impression disappears.
Evaluation of result: record reaction result by table 3 (skin adverse reaction grade scale).
Table 3 skin adverse reaction grade scale
Result of the test (seeing the following form 4)
Table 4
Analysis of conclusion:
Above result display: in embodiment 1,2,3,4,30 subjects skin are all negative reaction (grading system: 0 grade).According to " cosmetics health specification " (version in 2007) human body skin class paste test criterion, sample to human body without skin adverse reaction.
Claims (10)
1. an emulsification composition, is characterized in that, comprises following raw material composition by mass percentage:
Dispersant 5 ~ 20%
Emulsifying agent 15 ~ 45%
Polyoxyethylene hydrogenated Oleum Ricini 20 ~ 35%
Propylene glycol 20 ~ 45%;
Described dispersant is trimerization glycerol monosterate or six polyglycerol monooleate; Described emulsifying agent is polysorbas20 or this Pan 80.
2. emulsification composition according to claim 1, is characterized in that, is made up of following raw material by mass percentage:
Dispersant 7 ~ 16%
Emulsifying agent 15 ~ 43%
Polyoxyethylene hydrogenated Oleum Ricini 20 ~ 32%
Propylene glycol 20 ~ 43%.
3. an emulsification composition, is characterized in that, is made up of following raw material by mass percentage:
Trimerization glycerol monosterate 7 ~ 16%
Polyoxyethylene hydrogenated Oleum Ricini 20 ~ 32%
Polysorbas20 15 ~ 30%
Propylene glycol 20 ~ 43%.
4. an emulsification composition, is characterized in that, is made up of following raw material by mass percentage:
Six polyglycereol monostearates 5 ~ 10%
This Pan 8015 ~ 43%
Polyoxyethylene hydrogenated Oleum Ricini 20 ~ 32%
Propylene glycol 20 ~ 43%.
5. the emulsification composition described in a Claims 1-4 any one claim is preparing the application in the molten type rosemary antioxidant of profit two.
6. application according to claim 5, is characterized in that, described profit two molten type rosemary antioxidant comprises the raw material of following component:
Emulsification composition 65% ~ 70%
Carnosic acid oil formulation 30 ~ 35%
Wherein, in carnosic acid oil formulation, carnosic acid content is 10 ~ 30%.
7. application according to claim 5, is characterized in that, carnosic acid oil formulation and emulsification composition is dissolved in advance respectively, then by dissolved above-mentioned both materials mixing, homogenizing, obtain the molten type rosemary antioxidant of described profit two.
8. the molten type rosemary antioxidant of profit two, it is characterized in that, the raw material comprising following component is made:
Emulsification composition 65% ~ 70%
Carnosic acid oil formulation 30 ~ 35%;
Described emulsification composition is made up of the raw material of following component:
Dispersant 5 ~ 20%
Emulsifying agent 15 ~ 45%
Polyoxyethylene hydrogenated Oleum Ricini 20 ~ 35%
Propylene glycol 20 ~ 45%;
Described dispersant is trimerization glycerol monosterate or six polyglycerol monooleate; Described emulsifying agent is polysorbas20 or this Pan 80.
9. the molten type rosemary antioxidant of profit two according to claim 8, it is characterized in that, described emulsification composition is made up of the raw material of following component:
Dispersant 7 ~ 16%
Emulsifying agent 15 ~ 43%
Polyoxyethylene hydrogenated Oleum Ricini 20 ~ 32%
Propylene glycol 20 ~ 43%;
Described dispersant is trimerization glycerol monosterate or six polyglycerol monooleate; Described emulsifying agent is polysorbas20 or this Pan 80.
10. the application of the molten type rosemary antioxidant of the profit two described in claim 8 or 9 in cosmetic product.
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Cited By (5)
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|---|---|---|---|---|
| CN106036355A (en) * | 2016-08-20 | 2016-10-26 | 陈爱梅 | Preparation method of antioxidant |
| CN108635259A (en) * | 2018-05-16 | 2018-10-12 | 河南中大恒源生物科技股份有限公司 | A kind of grease and molten Rosmarinus officinalis extract and the preparation method and application thereof |
| CN110507611A (en) * | 2019-08-23 | 2019-11-29 | 中国医科大学 | A kind of carnosic acid nanometer emulsion oral liquid and preparation method thereof |
| CN113332443A (en) * | 2021-05-09 | 2021-09-03 | 湖北美田农业生物技术有限公司 | Water-soluble rosemary antioxidant and preparation method and application thereof |
| CN115043724A (en) * | 2022-07-21 | 2022-09-13 | 海南舒普生物科技有限公司 | Carnosic acid oil preparation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036355A (en) * | 2016-08-20 | 2016-10-26 | 陈爱梅 | Preparation method of antioxidant |
| CN108635259A (en) * | 2018-05-16 | 2018-10-12 | 河南中大恒源生物科技股份有限公司 | A kind of grease and molten Rosmarinus officinalis extract and the preparation method and application thereof |
| CN108635259B (en) * | 2018-05-16 | 2020-12-01 | 河南中大恒源生物科技股份有限公司 | Oil-water soluble rosemary extract and preparation method and application thereof |
| CN110507611A (en) * | 2019-08-23 | 2019-11-29 | 中国医科大学 | A kind of carnosic acid nanometer emulsion oral liquid and preparation method thereof |
| CN113332443A (en) * | 2021-05-09 | 2021-09-03 | 湖北美田农业生物技术有限公司 | Water-soluble rosemary antioxidant and preparation method and application thereof |
| CN115043724A (en) * | 2022-07-21 | 2022-09-13 | 海南舒普生物科技有限公司 | Carnosic acid oil preparation and preparation method thereof |
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| CN105534745B (en) | 2018-05-11 |
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