CN105534618B - The manufacture method of multifocal intraocular lenses - Google Patents
The manufacture method of multifocal intraocular lenses Download PDFInfo
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- CN105534618B CN105534618B CN201511011145.2A CN201511011145A CN105534618B CN 105534618 B CN105534618 B CN 105534618B CN 201511011145 A CN201511011145 A CN 201511011145A CN 105534618 B CN105534618 B CN 105534618B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
- A61F2/1618—Multifocal lenses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0053—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in optical properties
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Abstract
The present invention proposes a kind of method for manufacturing multifocal intraocular lenses, and it includes step：Determine the physiological parameter of the art eye of patient；Determine one or more sighting distances of art eye；One or more additional optical focal powers of the multifocal intraocular lenses for art eye are determined according to the physiological parameter of art eye and one or more sighting distances, wherein, one or more additional optical focal powers correspond respectively to one or more sighting distances；And multifocal intraocular lenses of the manufacture with one or more additional optical focal powers so that the multifocal intraocular lenses provide one or more sighting distances after implantation art eye.
Description
Technical field
The present invention relates to the manufacture method of multifocal intraocular lenses, relate more specifically to accurately realize the art of patient
Eye（It is one or more）The manufacture method of the multifocal intraocular lenses of personalized sighting distance.
Background technology
The eyes of normal person have the parallel rays of infinity by refracting media Refractive focusing to retina, seeing clearly
The function of Chu's distant objects.Before presbyopia generation, eyes change lenticular diopter by adjusting to see clearly
Object closely and read.After cataract operation, human eye adjusting means is changed, and regulatory function accordingly disappears,
It is implanted into after monofocal intraocular lens, sees that remote ability is recovered, but sees that near ability does not improve, postoperative near vision
Being necessarily dependent upon presbyopia glasses could recover.The purpose of phototropism cataract operation is can while being surgically removed cataract
Implantable artificial crystalline lens recovers the physiological visual function of postoperative patient, including see it is remote, see near, photopic vision power, scotopia etc..And it is many
The implantation of multifocal intraocular lens is exactly to solve the postoperative effective measures read to the dependence of presbyopia glasses of patient.
The design principle of multifocal intraocular lenses is by the way of while watching attentively, by the light belt structure of different focal planes
Build on the optical surface of intraocular lens's about 6mm diameters, regarded so as to realize for the clear of other sighting distances beyond infinity
The function of power.When seeing that near image is focused on retina, see that then defocus, in retina, sees that remote image is focused on to remote image
When retina, see near image then defocus in retina, that is to say, that distance vision acuity only focuses on remote object, dipped beam
Focal power only focuses on closer object, and its imaging schematic diagram is as shown in Figure 1.
It is manually brilliant that multifocal intraocular lenses include Bifocal intraocular lenses, three multifocal intraocular lens and big depth of focus
Shape body.Bifocal intraocular lenses have two focal powers, depending on distance vision acuity with that regarding near optical power, can be provided well for patient
Remote, near vision.Three multifocal intraocular lens have three focal powers, depending on distance vision acuity, regarding middle focal power and burnt regarding dipped beam
Degree, can provide well remote, intermediate range and near vision for patient.Big depth of focus intraocular lens also has three focal powers, its
Characteristic be the difference of adjacent focal power numerical value within 1.5D, the difference of maximum focal power and minimum power is controlled within 2.5D,
From infinitely in a certain distance range, there is no vision blind spot.More generally, multifocal intraocular lenses include providing regarding
The intraocular lens of distance vision acuity and one or more sighting distance focal powers.
Relative to monofocal intraocular lens, the function of multifocal intraocular lenses is to be provided for patient outside distant vision
Clear eyesight at other sighting distances.Clear eyesight at different sighting distances is real by the additional optical focal power of multifocal intraocular lenses
Existing, the additional optical focal power of the multifocal intraocular lenses of prior art is to regard the work of near and intermediate range according to what patients with presbyopia was commonly used
Distance determination, such as the distance reading, read newspaper, writing with operating computer, the single fixation of its numerical value, such as AMO TECNIS
The stereoscopic near addition focal power of Multifocal intraocular implants is+4.0D；Alcon AcrySof RESTOR multifocal intraocular implants
Stereoscopic near addition focal power is+3.0D；Zeiss Acri.Lisa multifocal intraocular lenses regard near addition focal power as+
3.75D；The Zeiss multifocal intraocular lens' of AT Lisa tri 839M tri- regards middle additional optical focal power as+1.66D, depending near attached
Plus focal power is+3.33D.The multifocal intraocular lenses of the additional optical focal power of this single fixation be only patient realize it is single
Sighting distance, the unmatched patient of sighting distance that can be provided for the sighting distance under nature and additional optical focal power, after implantation crystal
Need to change in the past usual sighting distance to be accustomed to by long-term training, provided so as to adapt to multifocal intraocular lenses for human eye
Specific sighting distance；Meanwhile, different eye's physiological parameters is different, such as corneal diopter, anterior chamber depth, axiallength
Multifocal intraocular lenses can be implanted into the sighting distance after human eye produce influence Deng, these parameters, that is to say, that even if implantation is identical
The intraocular lens of additional optical focal power, the sighting distance that different patients obtain is also different, and prior art can not be accurately in the preoperative
The estimated postoperative sighting distance of patient, is that doctor and patient bring puzzlement.
The selection of multifocal intraocular lenses is based on facing, and the number of degrees of intraocular lens are to be conducive to postoperative intermediate range and near
Eyesight is calculated.The postoperative refractive status of patient should can be only achieved good distant vision and sighting distance eyesight with 0 degree of long sight.
The accuracy that intraocular lens are calculated is influenceed by several factors：The measurements such as axiallength, corneal diopter it is accurate
Property, the selection of IOL calculation formula, the prediction of postoperative anterior chamber depth is also to influence the key factor of intraocular lens selection.
With eye measuring instrument measure the human eyes structure physiological parameter degree of accuracy raising, intraocular lens's power calculation formula it is continuous
Perfect, doctor can accurately provide the stereoscopic distance vision acuity of intraocular implants of patient's art eye, but can not determine at sighting distance distance
Realize the additional optical focal power needed for good vision.
The content of the invention
The present invention proposes a kind of method for manufacturing multifocal intraocular lenses, and it includes step：Determine the art eye of patient
Physiological parameter；Determine one or more sighting distances of the art eye；According to the physiological parameter of the art eye and the art eye
One or more sighting distances determine one or more additional optical focal powers of the multifocal intraocular lenses for the art eye, wherein,
One or more of additional optical focal powers correspond respectively to one or more of sighting distances；And manufacture is with one or many
The multifocal intraocular lenses of individual additional optical focal power so that the multifocal intraocular lenses provide institute after the art eye is implanted into
State one or more sighting distances.
Compared with prior art, advantageous effects of the invention are at least that according to the different sighting distance need of the art eye of patient
Ask, the physiological parameter of art eye determines one or more additional optical focal powers of multifocal intraocular lenses, rather than by existing many
The intrinsic property of multifocal intraocular lens determines the sighting distance of the art eye of patient.The manufacturer of the multifocal intraocular lenses of the present invention
Method is a kind of personalized method, can according to one of the customized art eye for meeting the patient of actual demand of the art eye of patient or
The multifocal intraocular lenses of multiple sighting distances, eliminate the postoperative worry for needing to adapt to new sighting distance of art eye and the puzzlement of patient.
Brief description of the drawings
Consider by referring to the following detailed description and claim and simultaneously accompanying drawing, can have more complete to the disclosure
Understand and can appreciate that other advantages that the disclosure has.In whole accompanying drawings, identical reference represents identical
Element.In the accompanying drawings：
Fig. 1 shows the imaging schematic diagram of multifocal intraocular lenses；
Fig. 2 a show the schematic diagram of refractive multifocal intraocular lenses；
Fig. 2 b show the imaging schematic diagram of refractive multifocal intraocular lenses；
Fig. 3 a show the schematic diagram of diffractive multifocal intraocular lenses；
Fig. 3 b show the imaging schematic diagram of diffractive multifocal intraocular lenses；
Fig. 4 shows the design flow diagram of personalized multifocal intraocular lenses；
Fig. 5 shows the principle index path regarding distance vision acuity and art eye parameters relationship, and the light direction of propagation is from left to right；
Fig. 6 shows the principle index path for determining additional optical focal power, and the light direction of propagation is from left to right.
Embodiment
Realizing the optical principle of multifocal intraocular lenses has two kinds：Refraction principle and diffraction principle.Utilize refraction principle
The multifocal intraocular lenses of manufacture are referred to as refractive multifocal intraocular lenses, and the multifocal manufactured using diffraction principle is artificial
Crystalline lens is referred to as diffractive multifocal intraocular lenses.Either refractive multifocal intraocular lenses or diffractive multifocal
Intraocular lens, determine its critical manufacturing parameters is additional optical focal power.
Refractive multifocal intraocular lenses are to construct the refraction light belt with different curvature radius in optical surface, annulus
There is provided and regard remote and sighting distance apart from clear eyesight, structural representation is shown in Fig. 2 a, and imaging schematic diagram is shown in Fig. 2 b.Depending on far field and sighting distance distance regions
It is alternately distributed, provides clearly distant vision depending on far field, its radius of curvature depending on distance vision acuity by determining；Sighting distance distance regions provide clear
Sighting distance eyesight, its radius of curvature determines by sighting distance focal power, sighting distance focal power and regards the difference of distance vision acuity as additional optical focal power.
Diffractive multifocal intraocular lenses are to etch the diffraction ring band with one fixed width and height in intraocular implants
On the optical surface of body, its structural representation is shown in Fig. 3 a, using the different diffraction level of diffraction ring band by incident ray with diffraction side
Formula is assigned to regarding at a distance and at sighting distance distance, and its imaging schematic diagram is shown in Fig. 3 b.Diffractive multifocal intraocular lenses optical surface
Radius of curvature by being determined depending on distance vision acuity, the width of diffraction ring is determined by additional optical focal power, and the height of diffraction ring is by regarding at a distance
Determined with the luminous energy allocation proportion at sighting distance distance.
The manufacture method of the multifocal intraocular lenses of the present invention includes：Determine the physiological parameter of the art eye of patient；It is determined that
One or more sighting distances of art eye；Determined to be used for art eye according to one or more sighting distances of the physiological parameter of art eye and art eye
Multifocal intraocular lenses one or more additional optical focal powers, wherein, one or more additional optical focal powers are corresponded respectively to
One or more sighting distances；Multifocal intraocular lenses are manufactured according to identified one or more additional optical focal powers.Specifically,
The process for determining one or more additional optical focal powers of the method according to the invention comprises the following steps：It is incident in directional light
Under conditions of, determine the pass regarded between distance vision acuity of the multifocal intraocular lenses of the physiological parameter of art eye and the art eye of patient
System；Under conditions of spot light is incident, art eye is determined according to one or more sighting distances of the art eye of patient, the physiological parameter of art eye
Multifocal intraocular lenses one or more additional optical focal powers.The schematic flow sheet of the process is shown in Fig. 4.
The physiological parameter of art eye includes corneal parameters, aqueous humor refractive index, anterior chamber depth, vitreum refractive index.
In one embodiment, corneal parameters can be corneal diopter.In another embodiment, corneal parameters can be with
The data for calculating corneal diopter, the data for being used to calculating corneal diopter include the refractive index of cornea and including
The curvature or radius of curvature of cornea.
The sighting distance of the above-mentioned art eye for patient determines that the process of additional optical focal power is carried out in human-eye model.People
The basic structure of phantom eye includes the optical system that cornea, aqueous humor, intraocular lens, vitreum and retina are constituted.Incident light
Line is located in air, and air refraction is labeled as, aqueous humor refractive index is labeled as, the refractive index of vitreum is labeled as, angle
Film diopter is labeled as, human eye's anterior chamber depth value is labeled as, the distance between intraocular lens and retina are labeled as
, multifocal intraocular lenses are labeled as depending on distance vision acuity, sighting distance focal power is labeled as, sighting distance is labeled as, and it is attached
Plus focal power is labeled as。
Under conditions of directional light is incident, the light in air incides cornea table with the direction perpendicular to cornea principal plane
On face, cornea, aqueous humor, intraocular lens, vitreum are sequentially passed through, is finally imaged on the retina.The purpose of this step be
In the case of art eye physiological parameter and multifocal intraocular lens are regarded known to distance vision acuity, determine multifocal intraocular lenses regards distance light
The anterior chamber depth of focal power and art eyeThe distance between with intraocular lens and retinaRelation, light path schematic diagram is shown in Fig. 5.
Under conditions of spot light is incident, the spot light in air determines to incide cornea under conditions of sighting distance with a certain
On surface, cornea, aqueous humor, intraocular lens, vitreum are sequentially passed through, is finally imaged on the retina.The purpose of this step is
In the case of known to sighting distance and art eye parameter, the sighting distance focal power and additional optical focal power of multifocal intraocular lenses are determined,
Light path schematic diagram is shown in Fig. 6.
Sighting distance focal power and difference depending on distance vision acuity are additional optical focal power.
The sighting distance of the above-mentioned art eye for patient determines that the process of sighting distance focal power and additional optical focal power can be in people
Carried out in phantom eye, required parameter is corneal diopter, anterior chamber depth, between intraocular lens and retina away from
From, air refraction, aqueous humor refractive index, vitreum refractive index, sighting distance, these parameters can pass through this area
Known mode measurement is obtained.
Under conditions of directional light is incident（As shown in Figure 5）, it is divided into cornea imaging and is imaged two parts with intraocular lens.
During cornea is imaged, the object distance of incident light is labeled as, image distance is labeled as, according to saturating
Mirror image-forming principle has
So as to obtain
（1）
In the imaging process of intraocular lens, object distance is, image distance is（Intraocular lens and retina
The distance between）, had according to lens imaging principle
So as to obtain
（2）
Under conditions of spot light is incident（As shown in Figure 6）, still it is divided into cornea imaging and intraocular lens is imaged two parts.
During cornea is imaged, object distance（Sighting distance）For, image distance is labeled as, had according to lens imaging principle
So as to obtain
（3）
In the imaging process of intraocular lens, object distance is, image distance is, had according to lens imaging principle
So as to obtain
（4）
According to（1）-（4）Formula, obtains additional optical focal powerExpression formula be
（5）.
According to the manufacture method of the multifocal intraocular lenses of the present invention, the additional light focus of the multifocal intraocular lenses
Degree has relation with the sighting distance of art eye, corneal diopter, anterior chamber depth, aqueous humor refractive index, vitreum refractive index, air refraction,
Specific relational expression is shown in formula（5）.
Condition involved in the present invention, such as art eye corneal parameters, aqueous humor refractive index, anterior chamber depth, vitreum refractive index,
These conditions are not limited to, are this as long as making patient reach desired, accurate sighting distance according to art eye parameter, sighting distance
Invent the protection content included.
In corneal parameters, aqueous humor refractive index, anterior chamber depth, vitreum refractive index involved by heretofore described art eye
One or more parameters can not use the measured value that prior art means measurement is obtained in practice, but use this area
Assembly average or approximation.In one embodiment, anterior chamber depth can use the measured value of art eye, and cornea is joined
Number, aqueous humor refractive index and vitreum refractive index can use the assembly average either approximation of this area.In an implementation
In example, corneal parameters and anterior chamber depth can use the measured value of art eye, and aqueous humor refractive index and vitreum refractive index can be with
Using the assembly average or approximation of this area.In one embodiment, corneal parameters, anterior chamber depth and aqueous humor refractive index
The measured value of art eye can be used, and vitreum refractive index can use the assembly average or approximation of this area.
In one embodiment, corneal parameters, anterior chamber depth, aqueous humor refractive index and vitreum refractive index can use the measurement of art eye
Value.Moreover, vitreum refractive index can be replaced or approximate with aqueous humor refractive index.
Those skilled in the art can appreciate that, patient is obtained good distant vision, while having resulted in
The near vision of effect and middle apart from eyesight, reaches the visual quality of postoperative satisfaction.It is special according to the daily life demand of patient and occupation
Point is, it is necessary to which crystal type and parameter to patient's art eye carry out personalized design.
For monocular cataract patient, art eye can also select diffraction with selective refraction type multifocal intraocular lenses
Type multifocal intraocular lenses, additional optical focal power is determined by the physiological parameter and sighting distance of art eye.
, can be with eyes while implantation refractive multifocal intraocular lenses, or eyes are same for eyes cataract patient
When be implanted into diffractive multifocal intraocular lenses, or art eye implantation refractive multifocal intraocular lenses, another eye
It is implanted into diffractive multifocal intraocular lenses.Under different lighting conditions, diffraction and refractive multifocal intraocular lenses tool
There is complementation, diffractive multifocal intraocular lenses closely act on strong under strong light, and refractive multifocal intraocular implants
Closely effect of the body under half-light is strong.Two distinct types of multifocal intraocular lenses joint implantation can improve patient's
There is provided high-quality whole eyesight for postoperative visual range.
For eyes cataract patient, can be simultaneously implanted into eyes identical additional optical focal power multifocal intraocular lenses or
Person's eyes are implanted into the multifocal intraocular lenses of different additional optical focal powers.Alternatively, it is also possible to being the single multifocal intraocular of eye implantation
Crystalline lens and another eye implantation multifocal intraocular lenses.Alternatively, it is also possible to being eye implantation multifocal intraocular lenses
And another eye not implantable artificial crystalline lens.For some patients, the multifocal that an eye is implanted into low additional optical focal power is manually brilliant
Shape body, the multifocal intraocular lenses of the high additional optical focal power of another eye implantation, the postoperative art eye of patient, which has, sees remote clear
Vision, and another art eye sees that near vision is satisfied with, and the collaboration of postoperative eyes results in fairly good depth of focus.It is few for reading
Patient, can be implanted into the multifocal intraocular lenses of low additional optical focal power with eyes, it is postoperative to obtain satisfied distant vision, and
Near vision also disclosure satisfy that the demand of daily near work；If patient's reading demands are more, eyes can be selected to be implanted into
The multifocal intraocular lenses of high additional optical focal power, postoperative provide good sees near vision.
Those skilled in the art will appreciate that, for multiple sighting distances, can respectively it be calculated according to above-mentioned formula pair
Should be in the sighting distance focal power and additional optical focal power of each sighting distance.
It is above-mentioned according to the physiological parameter of art eye and the sighting distance of art eye determine the sighting distance focal power of multifocal intraocular lenses with
And the process of additional optical focal power can be realized in human-eye model by the way of ray tracing.Parallel rays sequentially passes through angle
Film, aqueous humor, intraocular lens, vitreum, are imaged on the retina, and when the aberration of picture point is minimum, corresponding multifocal is artificial
Lenticular focal power is defined as regarding distance vision acuity；Point-source light ray sequentially passes through cornea, aqueous humor, intraocular lens, vitreum,
It is imaged on the retina, when the aberration of picture point is minimum, the focal power of corresponding multifocal intraocular lenses is sighting distance focal power.
Sighting distance focal power and the difference of distance vision acuity is regarded as additional optical focal power.
Some specific embodiments in accordance with the principles of the present invention are given below
Bifocal intraocular lenses' embodiment
1. sighting distance is determined, the Fabrication parameter of Bifocal intraocular lenses under the conditions of different art eye structure physiological parameters
The Fabrication parameter of multifocal intraocular lens under the conditions of 1.1 corneal diopters and anterior chamber depth determination, different axiallengths
Embodiment 1：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 28.40mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is identified additional when sighting distance is 43cm
Focal power is+2.85D.
Embodiment 2：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is identified additional when sighting distance is 43cm
Focal power is+2.85D.
Embodiment 3：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 20.50mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is identified additional when sighting distance is 43cm
Focal power is+2.85D.
The Fabrication parameter of multifocal intraocular lens under the conditions of 1.2 anterior chamber depths and axiallength determination, different corneal diopters
Embodiment 4：
Corneal diopter is 35.0D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air refraction
Rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.When sighting distance is 43cm, identified additional optical
Focal power is+2.75D.
Embodiment 5：
Corneal diopter is 44.0D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air refraction
Rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.When sighting distance is 43cm, additional light focus is determined
Spend for+2.88D.
Embodiment 6：
Corneal diopter is 50.0D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air refraction
Rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.When sighting distance is 43cm, identified additional optical
Focal power is+2.97D.
Under 1.3 corneal diopters and axiallength are determined, the Fabrication parameter of multifocal intraocular lens under the conditions of different anterior chamber depths
Embodiment 7：
Corneal diopter is 42.25D, and anterior chamber depth value L2=0.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.When sighting distance is 43cm, additional optical is determined
Focal power is+2.37D.
Embodiment 8：
Corneal diopter is 42.25D, and anterior chamber depth value L2=2.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.When sighting distance is 43cm, additional optical is determined
Focal power is+2.69D.
Embodiment 9：
Corneal diopter is 42.25D, and anterior chamber depth value L2=4.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.When sighting distance is 43cm, additional optical is determined
Focal power is+3.09D.
Embodiment 10：
Corneal diopter is 42.25D, and anterior chamber depth value L2=6.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is identified additional when sighting distance is 43cm
Focal power is+3.58D.
2. art eye physiological structure parameter is determined, the Fabrication parameter of Bifocal intraocular lenses under the conditions of the different apparent distances
Embodiment 11：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.When sighting distance is 30cm, additional optical is determined
Focal power is+4.08D.
Embodiment 12：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is identified additional when sighting distance is 38cm
Focal power is+3.20D.
Embodiment 13：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is identified additional when sighting distance is 53cm
Focal power is+2.32D.
Embodiment 14：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.When sighting distance is 68cm, additional optical is determined
Focal power is+1.81D.
The Data Summary of above example is shown in Table 1.
Three multifocal intraocular lens' embodiments
1. sighting distance is determined, the Fabrication parameter of three multifocal intraocular lens under the conditions of different art eye structure physiological parameters
The Fabrication parameter of multifocal intraocular lens under the conditions of 1.1 corneal diopters and anterior chamber depth determination, different axiallengths
Embodiment 1：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 28.40mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, sighting distance 2 is 100cm
When, it is+2.85D to determine additional optical focal power 1, and additional optical focal power 2 is+1.23D.
Embodiment 2：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, sighting distance 2 is 100cm
When, identified additional optical focal power 1 is+2.85D, and additional optical focal power 2 is+1.23D.
Embodiment 3：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 20.50mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, sighting distance 2 is 100cm
When, it is+2.85D to determine additional optical focal power 1, and additional optical focal power 2 is+1.23D.
The Fabrication parameter of multifocal intraocular lens under the conditions of 1.2 anterior chamber depths and axiallength determination, different corneal diopters
Embodiment 4：
Corneal diopter is 35.0D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air refraction
Rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, when sighting distance 2 is 100cm,
Identified additional optical focal power 1 is+2.75D, and additional optical focal power 2 is+1.19D.
Embodiment 5：
Corneal diopter is 44.0D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air refraction
Rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, when sighting distance 2 is 100cm,
Identified additional optical focal power 1 is+2.88D, and additional optical focal power 2 is+1.24D.
Embodiment 6：
Corneal diopter is 50.0D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air refraction
Rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, when sighting distance 2 is 100cm,
Determined additional optical focal power 1 is+2.97D, and additional optical focal power 2 is+1.28D.
Under 1.3 corneal diopters and axiallength are determined, the Fabrication parameter of multifocal intraocular lens under the conditions of different anterior chamber depths
Embodiment 7：
Corneal diopter is 42.25D, and anterior chamber depth value L2=0.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, sighting distance 2 is 100cm
When, it is+2.37D to determine additional optical focal power 1, and additional optical focal power 2 is+1.02D.
Embodiment 8：
Corneal diopter is 42.25D, and anterior chamber depth value L2=2.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, sighting distance 2 is 100cm
When, identified additional optical focal power 1 is+2.69D, and additional optical focal power 2 is+1.16D.
Embodiment 9：
Corneal diopter is 42.25D, and anterior chamber depth value L2=4.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, sighting distance 2 is 100cm
When, identified additional optical focal power 1 is+3.09D, and additional optical focal power 2 is+1.33D.
Embodiment 10：
Corneal diopter is 42.25D, and anterior chamber depth value L2=6.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 43cm in sighting distance 1, sighting distance 2 is 100cm
When, identified additional optical focal power 1 is+3.58D, and additional optical focal power 2 is+1.55D.
2. art eye physiological structure parameter is determined, the Fabrication parameter of three multifocal intraocular lens under different line of sight conditions
Embodiment 11：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 30cm in sighting distance 1, when sighting distance 2 is 80cm,
Determined additional optical focal power 1 is+4.08D, and additional optical focal power 2 is+1.54D.
Embodiment 12：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 38cm in sighting distance 1, when sighting distance 2 is 90cm,
Determined additional optical focal power 1 is+3.2D, and additional optical focal power 2 is+1.37D.
Embodiment 13：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 53cm in sighting distance 1, sighting distance 2 is 110cm
When, identified additional optical focal power 1 is+2.32D, and additional optical focal power 2 is+1.12D.
Embodiment 14：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 68cm in sighting distance 1, sighting distance 2 is 120cm
When, identified additional optical focal power 1 is+1.81D, and additional optical focal power 2 is+1.03D.
The Data Summary of above example is shown in Table 2.
Big depth of focus intraocular lens's embodiment
1. sighting distance is determined, the Fabrication parameter of big depth of focus intraocular lens under the conditions of different art eye structure physiological parameters
The Fabrication parameter of big depth of focus intraocular lens under the conditions of 1.1 corneal diopters and anterior chamber depth determination, different axiallengths
Embodiment 1：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 28.40mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, sighting distance 2 is 120cm
When, identified additional optical focal power 1 is+2.05D, and additional optical focal power 2 is+1.03D.
Embodiment 2：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, sighting distance 2 is 120cm
When, identified additional optical focal power 1 is+2.05D, and additional optical focal power 2 is+1.03D.
Embodiment 3：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 20.50mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, sighting distance 2 is 120cm
When, identified additional optical focal power 1 is+2.05D, and additional optical focal power 2 is+1.03D.
The Fabrication parameter of big depth of focus intraocular lens under the conditions of 1.2 anterior chamber depths and axiallength determination, different corneal diopters
Embodiment 4：
Corneal diopter is 35.0D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air refraction
Rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, when sighting distance 2 is 120cm,
Identified additional optical focal power 1 is+1.97D, and additional optical focal power 2 is+0.99D.
Embodiment 5：
Corneal diopter is 44.0D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air refraction
Rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, when sighting distance 2 is 120cm,
Identified additional optical focal power 1 is+2.07D, and additional optical focal power 2 is+1.04D.
Embodiment 6：
Corneal diopter is 50.0D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air refraction
Rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, when sighting distance 2 is 120cm,
Identified additional optical focal power 1 is+2.13D, and additional optical focal power 2 is+1.07D.
Under 1.3 corneal diopters and axiallength are determined, the system of big depth of focus intraocular lens under the conditions of different anterior chamber depths
Make parameter
Embodiment 7：
Corneal diopter is 42.25D, and anterior chamber depth value L2=0.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, sighting distance 2 is 120cm
When, identified additional optical focal power 1 is+1.70D, and additional optical focal power 2 is+0.85D.
Embodiment 8：
Corneal diopter is 42.25D, and anterior chamber depth value L2=2.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, sighting distance 2 is 120cm
When, identified additional optical focal power 1 is+1.93D, and additional optical focal power 2 is+0.97D.
Embodiment 9：
Corneal diopter is 42.25D, and anterior chamber depth value L2=4.30mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, sighting distance 2 is 120cm
When, identified additional optical focal power 1 is+2.22D, and additional optical focal power 2 is+1.11D.
Embodiment 10：
Corneal diopter is 42.25D, and anterior chamber depth value L2=5.80mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 60cm in sighting distance 1, sighting distance 2 is 120cm
When, identified additional optical focal power 1 is+2.48D, and additional optical focal power 2 is+1.24D.
2. art eye physiological structure parameter is determined, the Fabrication parameter of big depth of focus intraocular lens under different line of sight conditions
Embodiment 11：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 50cm in sighting distance 1, sighting distance 2 is 100cm
When, identified additional optical focal power 1 is+2.46D, and additional optical focal power 2 is+1.23D.
Embodiment 12：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 70cm in sighting distance 1, sighting distance 2 is 110cm
When, identified additional optical focal power 1 is+1.76D, and additional optical focal power 2 is+1.12D.
Embodiment 13：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 80cm in sighting distance 1, sighting distance 2 is 120cm
When, identified additional optical focal power 1 is+1.54D, and additional optical focal power 2 is+1.03D.
Embodiment 14：
Corneal diopter is 42.25D, and anterior chamber depth value L2=3.16mm, axiallength L2+L3 is 23.10mm.Air is rolled over
Penetrate rate n1=1, aqueous humor refractive index n2=1.336, vitreum refractive index n3=1.336.It is 90cm in sighting distance 1, sighting distance 2 is 130cm
When, identified additional optical focal power 1 is+1.37D, and additional optical focal power 2 is+0.95D.
The Data Summary of above example is shown in Table 3.
Term：
Sighting distance：The distance between spot light and cornea, other distances of this patent middle finger in addition to infinite distance.
Anterior chamber depth：Corneal endothelium is the distance between to crystalline body front surface, in Fig. 5 with being used in the schematic diagram shown in Fig. 6Represent.
Sighting distance focal power：Under line of sight conditions, the focal power required for clear eyesight is obtained.
Additional optical focal power：Sighting distance focal power and the difference regarding distance vision acuity.
。
Claims (10)
1. a kind of method for manufacturing multifocal intraocular lenses, including step：
Determine the physiological parameter of the art eye of patient；
Determine one or more sighting distances of the art eye；
Determined according to one or more sighting distances of the physiological parameter of the art eye and the art eye for the multifocal of the art eye
One or more additional optical focal powers of point intraocular lens, wherein, one or more of additional optical focal powers correspond respectively to institute
One or more sighting distances are stated, wherein, additional optical focal power is sighting distance focal power and the difference regarding distance vision acuity；And
Multifocal intraocular lenses of the manufacture with one or more of additional optical focal powers so that the multifocal intraocular implants
Body provides one or more of sighting distances after the art eye is implanted into.
2. according to the method described in claim 1, the physiological parameter of the art eye includes corneal parameters, anterior chamber depth, aqueous humor folding
Penetrate rate and vitreum refractive index.
3. method according to claim 2, wherein, anterior chamber depth uses the measured value of the art eye, and corneal parameters,
Aqueous humor refractive index and vitreum refractive index use assembly average or approximation.
4. method according to claim 2, wherein, corneal parameters and anterior chamber depth use the measured value of the art eye, and
And aqueous humor refractive index and vitreum refractive index use assembly average or approximation.
5. method according to claim 2, wherein, corneal parameters, anterior chamber depth and aqueous humor refractive index use the art eye
Measured value, and vitreum refractive index use assembly average or approximation.
6. method according to claim 2, wherein, corneal parameters, anterior chamber depth, aqueous humor refractive index and vitreum refractive index
Use the measured value of the art eye.
7. the method according to any one of claim 2-6, wherein, corneal parameters are corneal diopters.
8. the method according to any one of claim 2-6, wherein, corneal parameters are the numbers for calculating corneal diopter
According to the data for being used to calculate corneal diopter include the refractive index of cornea and curvature or radius of curvature including cornea.
9. according to the method described in claim 1, wherein, the additional of the multifocal intraocular lenses is determined according to equation below
Focal power：,
Wherein,For additional optical focal power,For corneal diopter,For anterior chamber depth,For sighting distance,For air refraction
Rate,For aqueous humor refractive index, andFor vitreum refractive index.
10. according to the method described in claim 1, wherein it is determined that one of multifocal intraocular lenses for the art eye
Or the step of multiple additional optical focal powers are to use the method for ray tracing to carry out in human-eye model.
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