CN105534618A - Manufacturing method for multi-focus artificial lens - Google Patents
Manufacturing method for multi-focus artificial lens Download PDFInfo
- Publication number
- CN105534618A CN105534618A CN201511011145.2A CN201511011145A CN105534618A CN 105534618 A CN105534618 A CN 105534618A CN 201511011145 A CN201511011145 A CN 201511011145A CN 105534618 A CN105534618 A CN 105534618A
- Authority
- CN
- China
- Prior art keywords
- refractive index
- focal power
- additional optical
- optical focal
- sighting distance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
- A61F2/1618—Multifocal lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0053—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in optical properties
Abstract
The invention provides a manufacturing method for a multi-focus artificial lens. The manufacturing method includes the steps that physiological parameters of an operative eye of a patient are determined; one or more sight distances of the operative eye are determined; one or more kinds of additive focal power of the multi-focus artificial lens used for the operative eye are determined according to the physiological parameters and the one or more sight distances of the operative eye; the multi-focus artificial lens with one or more kinds of additive focal power is manufactured so that the multi-focus artificial lens can provide one or more sight distances after being implanted into the operative eye.
Description
Technical field
The present invention relates to the manufacture method of multifocal intraocular lenses, relate more specifically to the manufacture method of the multifocal intraocular lenses of (one or more) the personalized sighting distance of the art eye that accurately can realize patient.
Background technology
The eyes of normal person to have the parallel rays of infinity by refracting media Refractive focusing on retina, see the function of distant objects clearly.Before presbyopia occurs, eyes change lenticular diopter by regulating thus can see in-plant object clearly and read.After cataract operation, human eye adjusting device there occurs change, the corresponding disappearance of regulatory function, after implanting monofocal intraocular lens, sees that ability far away obtains recovery, but sees that near ability is not improved, and postoperative near vision must depend on presbyopia glasses and could recover.The object of refrangibility cataract operation can recover the physiological visual function of postoperative patient by implantable artificial crystalline lens while of being surgically removed cataractous, comprise see far away, see near, photopic vision power, scotopia etc.And the implantation of multifocal intraocular lenses is exactly read the effective measures relied on presbyopia glasses after solving operation in patients.
The design principle of multifocal intraocular lenses adopts the mode of simultaneously watching attentively, constructed by the light belt of different focal plane on the optical surface of the about 6mm diameter of intraocular lens, thus realize the function for the clear vision of other sighting distance beyond infinity.When seeing that near image focuses on retina, see image far away then out of focus in retina, when seeing that image far away focuses on retina, see near image then out of focus in retina, that is distance vision acuity only focuses on remote object, near optical power only focuses on closer object, and its imaging schematic diagram as shown in Figure 1.
Multifocal intraocular lenses comprises Bifocal intraocular lenses, three multifocal intraocular lens and large depth of focus intraocular lens.Bifocal intraocular lenses has two focal powers, depending on distance vision acuity with look near optical power, good far away, near vision can be provided for patient.Three multifocal intraocular lens have three focal powers, depending on distance vision acuity, depending on middle focal power and look near optical power, can provide good far away, intermediate range and near vision for patient.Large depth of focus intraocular lens also has three focal powers, its characteristic be the difference of adjacent focal power numerical value within 1.5D, the difference of maximum focal power and minimum power controls within 2.5D, from unlimited in a certain distance range, does not have vision blind spot.More generally, multifocal intraocular lenses comprises the intraocular lens that can provide and look distance vision acuity and one or more sighting distance focal power.
Relative to monofocal intraocular lens, the function of multifocal intraocular lenses is for patient provides the clear vision at other sighting distance place outside distant vision.The clear vision at different sighting distance place relies on the additional optical focal power of multifocal intraocular lenses to realize, the additional optical focal power of the multifocal intraocular lenses of prior art is determining depending near and intermediate range operating distance of commonly using according to patients with presbyopia, such as read, read newspaper, write and the distance of operating computer, its numerical value is single fixing, and the stereoscopic near addition focal power of the TECNISMultifocal intraocular implants as AMO is+4.0D; The AcrySofRESTOR multifocal intraocular lenses of Alcon looks near addition focal power for+3.0D; The Acri.Lisa multifocal intraocular lenses of Zeiss looks near addition focal power for+3.75D; The additional optical focal power of looking middle of ATLisatri839M tri-multifocal intraocular lens of Zeiss is+1.66D, is+3.33D depending near addition focal power.The multifocal intraocular lenses of this single fixing additional optical focal power can only realize single sighting distance for patient, for the unmatched patient of sighting distance that the sighting distance under naturalness and additional optical focal power can provide, need after implanting crystal by long-term training to change in the past usual sighting distance custom, thus the specific sighting distance that adaptation multifocal intraocular lenses provides for human eye; Simultaneously, different eye's physiological parameters is different, such as corneal diopter, anterior chamber depth, axiallength etc., these parameters can be implanted the sighting distance after human eye to multifocal intraocular lenses and have an impact, that is, even if implant the intraocular lens of identical additional optical focal power, the sighting distance that different patient obtains also is different, prior art cannot in the preoperative accurately for patient estimates postoperative sighting distance, for doctor and patient bring puzzlement.
The selection of multifocal intraocular lenses is main to be just considered as, and the number of degrees of intraocular lens are to be conducive to postoperative intermediate range and near vision calculates.Refractive status after operation in patients with 0 degree of hypermetropia, just should can reach good distant vision and sighting distance vision.The accuracy that intraocular lens calculates is subject to the impact of several factors: the accuracy that axiallength, corneal diopter etc. are measured, the selection of IOL computing formula, and the prediction of postoperative anterior chamber depth is also the key factor affecting intraocular lens selection.Along with the raising of human eyes structure physiological parameter accuracy measured by eye measuring instrument, intraocular lens's power calculation formula constantly perfect, doctor can provide the stereoscopic distance vision acuity of intraocular implants of operation in patients eye accurately, but cannot determine that sighting distance distance realizes the additional optical focal power needed for good vision.
Summary of the invention
The present invention proposes a kind of method manufacturing multifocal intraocular lenses, it comprises step: the physiological parameter determining the art eye of patient; Determine one or more sighting distances of described art eye; One or more additional optical focal powers of the multifocal intraocular lenses of described art eye are determined according to the physiological parameter of described art eye and one or more sighting distances of described art eye, wherein, described one or more additional optical focal power corresponds respectively to described one or more sighting distance; And manufacture the multifocal intraocular lenses with described one or more additional optical focal power, make described multifocal intraocular lenses provide described one or more sighting distance after the described art eye of implantation.
Compared with prior art, one or more additional optical focal powers that Advantageous Effects of the present invention is at least the different sighting distance demands of the art eye according to patient, the physiological parameter of art eye determines multifocal intraocular lenses, instead of the sighting distance of art eye being decided patient by the intrinsic property of existing multifocal intraocular lenses.The manufacture method of multifocal intraocular lenses of the present invention is a kind of personalized method, according to the customized multifocal intraocular lenses meeting one or more sighting distances of the art eye of this patient of the actual demand of the art eye of patient, postoperative worry and the puzzlement needing to adapt to new sighting distance of art eye of patient can be eliminated.
Accompanying drawing explanation
Also consider accompanying drawing by referring to the following detailed description and claim simultaneously, more complete understanding can be had to the disclosure and other advantages that the disclosure has can be recognized.In whole accompanying drawing, identical Reference numeral represents identical element.In the accompanying drawings:
Fig. 1 shows the imaging schematic diagram of multifocal intraocular lenses;
Fig. 2 a shows the schematic diagram of refractive multifocal intraocular lenses;
Fig. 2 b shows the imaging schematic diagram of refractive multifocal intraocular lenses;
Fig. 3 a shows the schematic diagram of diffractive multifocal intraocular lenses;
Fig. 3 b shows the imaging schematic diagram of diffractive multifocal intraocular lenses;
Fig. 4 shows the design flow diagram of personalized multifocal intraocular lenses;
Fig. 5 shows the principle index path looking distance vision acuity and art eye parameters relationship, and light transmition direction is from left to right;
Fig. 6 shows the principle index path for determining additional optical focal power, and light transmition direction is from left to right.
Detailed description of the invention
The optical principle realizing multifocal intraocular lenses has two kinds: refraction principle and diffraction principle.Utilize the multifocal intraocular lenses of refraction principle manufacture to be called refractive multifocal intraocular lenses, utilize the multifocal intraocular lenses of diffraction principle manufacture to be called diffractive multifocal intraocular lenses.No matter be refractive multifocal intraocular lenses or diffractive multifocal intraocular lenses, what determine its critical manufacturing parameters is additional optical focal power.
Refractive multifocal intraocular lenses constructs at optical surface by the refraction light belt with different curvature radius, and endless belt provides looks far away and sighting distance apart from clear vision, and structural representation is shown in Fig. 2 a, and Fig. 2 b is shown in by imaging schematic diagram.Be alternately distributed depending on far field and sighting distance distance regions, provide distant vision clearly depending on far field, its radius of curvature determines by looking distance vision acuity; Sighting distance distance regions provides sighting distance vision clearly, and its radius of curvature is determined by sighting distance focal power, and sighting distance focal power is additional optical focal power with the difference depending on distance vision acuity.
Diffractive multifocal intraocular lenses is etched on the optical surface of intraocular lens by the diffraction endless belt with one fixed width and height, its structural representation is shown in Fig. 3 a, utilize the different diffraction level of diffraction endless belt to be assigned to diffraction mode by incident ray to look at a distance and sighting distance distance, Fig. 3 b is shown in by its imaging schematic diagram.The radius of curvature of diffractive multifocal intraocular lenses optical surface determines by looking distance vision acuity, and the width of diffraction ring is determined by additional optical focal power, and the height of diffraction ring is determined by the luminous energy allocation proportion of looking distant place and sighting distance distance.
The manufacture method of multifocal intraocular lenses of the present invention comprises: the physiological parameter determining the art eye of patient; Determine one or more sighting distances of art eye; Determine one or more additional optical focal powers of the multifocal intraocular lenses of art eye according to the physiological parameter of art eye and one or more sighting distances of art eye, wherein, one or more additional optical focal power corresponds respectively to one or more sighting distance; Multifocal intraocular lenses is manufactured according to determined one or more additional optical focal power.Particularly, according to method of the present invention for determining that the process of one or more additional optical focal power comprises the steps: under the condition of directional light incidence, determine the relation of looking between distance vision acuity of the multifocal intraocular lenses of the physiological parameter of art eye and the art eye of patient; Under the condition of point source incidence, according to one or more additional optical focal powers of the multifocal intraocular lenses of one or more sighting distances of the art eye of patient, the physiological parameter determination art eye of art eye.The schematic flow sheet of this process is shown in Fig. 4.
The physiological parameter of art eye comprises corneal parameters, aqueous humor refractive index, anterior chamber depth, vitreous body refractive index.
In one embodiment, corneal parameters can be corneal diopter.In another embodiment, corneal parameters can be the data for calculating corneal diopter, and these data being used for calculating corneal diopter comprise the refractive index of cornea and comprise curvature or the radius of curvature of cornea.
The sighting distance of the above-mentioned art eye for patient determines that the process of additional optical focal power is carried out in human-eye model.The basic structure of human-eye model comprises the optical system that cornea, aqueous humor, intraocular lens, vitreous body and retina are formed.Incident ray is arranged in air, and air refraction is labeled as
, aqueous humor refractive index is labeled as
, Vitrea refractive index is labeled as
, corneal diopter is labeled as
, human eye's anterior chamber depth value is labeled as
, the range mark between intraocular lens and retina is
, multifocal intraocular lenses is labeled as depending on distance vision acuity
, sighting distance focal power is labeled as
, sighting distance is labeled as
, and additional optical focal power is labeled as
.
Under the condition of directional light incidence, the light in air, to incide on anterior corneal surface perpendicular to the direction of cornea principal plane, sequentially passes through cornea, aqueous humor, intraocular lens, vitreous body, finally imaging on the retina.The object of this step be when art physiology of eye parameter and the stereoscopic distance vision acuity of multifocal intraocular implants known, determine the anterior chamber depth of looking distance vision acuity and art eye of multifocal intraocular lenses
and the distance between intraocular lens and retina
relation, Fig. 5 is shown in by light path schematic diagram.
Under the condition of point source incidence, the point source in air with a certain determine the condition of sighting distance under incide on the surface of cornea, sequentially pass through cornea, aqueous humor, intraocular lens, vitreous body, finally imaging on the retina.The object of this step be when sighting distance and art eye parameter known, determine sighting distance focal power and the additional optical focal power of multifocal intraocular lenses, Fig. 6 is shown in by light path schematic diagram.
Sighting distance focal power is additional optical focal power with the difference depending on distance vision acuity.
The sighting distance of the above-mentioned art eye for patient determines that the process of sighting distance focal power and additional optical focal power can be carried out in human-eye model, and required parameter is corneal diopter
, anterior chamber depth
, the distance between intraocular lens and retina
, air refraction
, aqueous humor refractive index
, vitreous body refractive index
, sighting distance
, these parameters can be obtained by manner known in the art measurement.
Under the condition of directional light incidence (as shown in Figure 5), be divided into cornea imaging and intraocular lens's imaging two parts.
In the process of cornea imaging, the object distance of incident illumination is labeled as
, image distance is labeled as
, have according to lens imaging principle
Thus obtain
（1）
In the imaging process of intraocular lens, object distance is
, image distance is
(distance between intraocular lens and retina), has according to lens imaging principle
Thus obtain
（2）
Under the condition of point source incidence (as shown in Figure 6), be still divided into cornea imaging and intraocular lens's imaging two parts.
In the process of cornea imaging, object distance (sighting distance) is
, image distance is labeled as
, have according to lens imaging principle
Thus obtain
（3）
In the imaging process of intraocular lens, object distance is
, image distance is
, have according to lens imaging principle
Thus obtain
（4）
According to (1)-(4) formula, obtain additional optical focal power
expression formula be
（5）。
According to the manufacture method of multifocal intraocular lenses of the present invention, the additional optical focal power of described multifocal intraocular lenses and the sighting distance of art eye, corneal diopter, anterior chamber depth, aqueous humor refractive index, vitreous body refractive index, air refraction have relation, and concrete relational expression is shown in formula (5).
Condition involved in the present invention; such as art cornea parameter, aqueous humor refractive index, anterior chamber depth, vitreous body refractive index, be not limited to these conditions; as long as according to art eye parameter, sighting distance and make patient reach to want, accurate sighting distance, be the protection content that the present invention comprises.
The measured value that one or more parameters in the corneal parameters involved by art eye described in the present invention, aqueous humor refractive index, anterior chamber depth, vitreous body refractive index can not adopt the measurement of prior art means to obtain in practice, but the assembly average or the approximation that adopt this area.In one embodiment, anterior chamber depth can adopt the measured value of art eye, and corneal parameters, aqueous humor refractive index and vitreous body refractive index can adopt assembly average or the approximation of this area.In one embodiment, corneal parameters and anterior chamber depth can adopt the measured value of art eye, and aqueous humor refractive index and vitreous body refractive index can adopt assembly average or the approximation of this area.In one embodiment, corneal parameters, anterior chamber depth and aqueous humor refractive index can adopt the measured value of art eye, and vitreous body refractive index can adopt assembly average or the approximation of this area.In one embodiment, corneal parameters, anterior chamber depth, aqueous humor refractive index and vitreous body refractive index all can adopt the measured value of art eye.And vitreous body refractive index can replace by aqueous humor refractive index or be similar to.
Those skilled in the art will appreciate that, make patient obtain good distant vision, effective near vision and middle distance vision can be obtained simultaneously, reach the visual quality of postoperative satisfaction.According to daily life demand and the occupational characteristic of patient, need to carry out personalized design to the crystal type of operation in patients eye and parameter.
For monocular cataract patient, art eye can selective refraction type multifocal intraocular lenses, also can select diffractive multifocal intraocular lenses, and additional optical focal power is determined by the physiological parameter of art eye and sighting distance.
For eyes cataract patient, refractive multifocal intraocular lenses can be implanted by eyes simultaneously, or eyes implant diffractive multifocal intraocular lenses simultaneously, or an art eye implants refractive multifocal intraocular lenses, and another eye implants diffractive multifocal intraocular lenses.Under different lighting conditions, diffraction and refractive multifocal intraocular lenses have complementary action, and closely effect is strong under high light for diffractive multifocal intraocular lenses, and the closely effect of refractive multifocal intraocular lenses under half-light is strong.Two kinds of dissimilar multifocal intraocular lenses combine the postoperative visual range implanted and can improve patient, provide high-quality omnidistance vision.
For eyes cataract patient, the multifocal intraocular lenses that the multifocal intraocular lenses of identical additional optical focal power or eyes implant different additional optical focal power can be implanted by eyes simultaneously.In addition, also can be an eye implantation monofocal intraocular lens and another eye implants multifocal intraocular lenses.In addition, also can be that eye implants multifocal intraocular lenses and another eye not implantable artificial crystalline lens.For some patient, an eye implants the multifocal intraocular lenses of low additional optical focal power, another eye implants the multifocal intraocular lenses of high additional optical focal power, after operation in patients, art eye has and sees vision clearly far away, and the near vision satisfaction soon of another art, postoperative eyes are collaborative can obtain goodish depth of focus.For reading few patient, the multifocal intraocular lenses of low additional optical focal power can be implanted by eyes, postoperatively can obtain satisfied distant vision, and near vision also can meet the demand of daily near work; If patient's reading demands is more, then eyes can be selected to implant the multifocal intraocular lenses of high additional optical focal power, postoperatively provide good and see near vision.
Those skilled in the art will appreciate that, for multiple sighting distance, sighting distance focal power corresponding to each sighting distance and additional optical focal power can be calculated respectively according to above-mentioned formula.
The sighting distance focal power of the sighting distance determination multifocal intraocular lenses of the above-mentioned physiological parameter according to art eye and art eye and the process of additional optical focal power can adopt the mode of ray tracing to realize in human-eye model.Parallel rays sequentially passes through cornea, aqueous humor, intraocular lens, vitreous body, on the retina imaging, and when the aberration of picture point is minimum, the focal power of corresponding multifocal intraocular lenses is defined as looking distance vision acuity; Point-source light ray sequentially passes through cornea, aqueous humor, intraocular lens, vitreous body, on the retina imaging, and when the aberration of picture point is minimum, the focal power of corresponding multifocal intraocular lenses is sighting distance focal power.Sighting distance focal power is additional optical focal power with the difference depending on distance vision acuity.
Provide some specific embodiments in accordance with the principles of the present invention below
Bifocal intraocular lenses's embodiment
1. sighting distance is determined, the Fabrication parameter of Bifocal intraocular lenses under different art ocular structure physiological parameter condition
1.1 corneal diopters and anterior chamber depth are determined, the Fabrication parameter of multifocal intraocular lens under different axiallength condition
Embodiment 1:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 28.40mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, determined additional optical focal power is+2.85D.
Embodiment 2:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, determined additional optical focal power is+2.85D.
Embodiment 3:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 20.50mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, determined additional optical focal power is+2.85D.
1.2 anterior chamber depth and axiallength are determined, the Fabrication parameter of multifocal intraocular lens under different corneal diopter condition
Embodiment 4:
Corneal diopter is 35.0D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, determined additional optical focal power is+2.75D.
Embodiment 5:
Corneal diopter is 44.0D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, institute determines that additional optical focal power is for+2.88D.
Embodiment 6:
Corneal diopter is 50.0D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, determined additional optical focal power is+2.97D.
Under 1.3 corneal diopters and axiallength are determined, the Fabrication parameter of multifocal intraocular lens under different anterior chamber depth condition
Embodiment 7:
Corneal diopter is 42.25D, anterior chamber depth value L2=0.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, institute determines that additional optical focal power is for+2.37D.
Embodiment 8:
Corneal diopter is 42.25D, anterior chamber depth value L2=2.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, institute determines that additional optical focal power is for+2.69D.
Embodiment 9:
Corneal diopter is 42.25D, anterior chamber depth value L2=4.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, institute determines that additional optical focal power is for+3.09D.
Embodiment 10:
Corneal diopter is 42.25D, anterior chamber depth value L2=6.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 43cm, determined additional optical focal power is+3.58D.
2. art physiology of eye structural parameters are determined, the Fabrication parameter of Bifocal intraocular lenses under different apparent distance condition
Embodiment 11:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 30cm, institute determines that additional optical focal power is for+4.08D.
Embodiment 12:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 38cm, determined additional optical focal power is+3.20D.
Embodiment 13:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 53cm, determined additional optical focal power is+2.32D.
Embodiment 14:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.When sighting distance is 68cm, institute determines that additional optical focal power is for+1.81D.
The Data Summary of above embodiment is in table 1.
Three multifocal intraocular lens's embodiments
1. sighting distance is determined, the Fabrication parameter of three multifocal intraocular lens under different art ocular structure physiological parameter condition
1.1 corneal diopters and anterior chamber depth are determined, the Fabrication parameter of multifocal intraocular lens under different axiallength condition
Embodiment 1:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 28.40mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, institute determines that additional optical focal power 1 is for+2.85D, and additional optical focal power 2 is+1.23D.
Embodiment 2:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, determined additional optical focal power 1 is+2.85D, and additional optical focal power 2 is+1.23D.
Embodiment 3:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 20.50mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, institute determines that additional optical focal power 1 is for+2.85D, and additional optical focal power 2 is+1.23D.
1.2 anterior chamber depth and axiallength are determined, the Fabrication parameter of multifocal intraocular lens under different corneal diopter condition
Embodiment 4:
Corneal diopter is 35.0D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, determined additional optical focal power 1 is+2.75D, and additional optical focal power 2 is+1.19D.
Embodiment 5:
Corneal diopter is 44.0D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, determined additional optical focal power 1 is+2.88D, and additional optical focal power 2 is+1.24D.
Embodiment 6:
Corneal diopter is 50.0D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, institute determines that additional optical focal power 1 is for+2.97D, and additional optical focal power 2 is+1.28D.
Under 1.3 corneal diopters and axiallength are determined, the Fabrication parameter of multifocal intraocular lens under different anterior chamber depth condition
Embodiment 7:
Corneal diopter is 42.25D, anterior chamber depth value L2=0.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, institute determines that additional optical focal power 1 is for+2.37D, and additional optical focal power 2 is+1.02D.
Embodiment 8:
Corneal diopter is 42.25D, anterior chamber depth value L2=2.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, determined additional optical focal power 1 is+2.69D, and additional optical focal power 2 is+1.16D.
Embodiment 9:
Corneal diopter is 42.25D, anterior chamber depth value L2=4.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, determined additional optical focal power 1 is+3.09D, and additional optical focal power 2 is+1.33D.
Embodiment 10:
Corneal diopter is 42.25D, anterior chamber depth value L2=6.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 43cm in sighting distance 1, when sighting distance 2 is 100cm, determined additional optical focal power 1 is+3.58D, and additional optical focal power 2 is+1.55D.
2. art physiology of eye structural parameters are determined, the Fabrication parameter of three multifocal intraocular lens under different line of sight conditions
Embodiment 11:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 30cm in sighting distance 1, when sighting distance 2 is 80cm, institute determines that additional optical focal power 1 is for+4.08D, and additional optical focal power 2 is+1.54D.
Embodiment 12:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 38cm in sighting distance 1, when sighting distance 2 is 90cm, institute determines that additional optical focal power 1 is for+3.2D, and additional optical focal power 2 is+1.37D.
Embodiment 13:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 53cm in sighting distance 1, when sighting distance 2 is 110cm, determined additional optical focal power 1 is+2.32D, and additional optical focal power 2 is+1.12D.
Embodiment 14:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 68cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+1.81D, and additional optical focal power 2 is+1.03D.
The Data Summary of above embodiment is in table 2.
Large depth of focus intraocular lens embodiment
1. sighting distance is determined, the Fabrication parameter of large depth of focus intraocular lens under different art ocular structure physiological parameter condition
1.1 corneal diopters and anterior chamber depth are determined, the Fabrication parameter of large depth of focus intraocular lens under different axiallength condition
Embodiment 1:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 28.40mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+2.05D, and additional optical focal power 2 is+1.03D.
Embodiment 2:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+2.05D, and additional optical focal power 2 is+1.03D.
Embodiment 3:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 20.50mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+2.05D, and additional optical focal power 2 is+1.03D.
1.2 anterior chamber depth and axiallength are determined, the Fabrication parameter of large depth of focus intraocular lens under different corneal diopter condition
Embodiment 4:
Corneal diopter is 35.0D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+1.97D, and additional optical focal power 2 is+0.99D.
Embodiment 5:
Corneal diopter is 44.0D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+2.07D, and additional optical focal power 2 is+1.04D.
Embodiment 6:
Corneal diopter is 50.0D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+2.13D, and additional optical focal power 2 is+1.07D.
Under 1.3 corneal diopters and axiallength are determined, the Fabrication parameter of large depth of focus intraocular lens under different anterior chamber depth condition
Embodiment 7:
Corneal diopter is 42.25D, anterior chamber depth value L2=0.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+1.70D, and additional optical focal power 2 is+0.85D.
Embodiment 8:
Corneal diopter is 42.25D, anterior chamber depth value L2=2.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+1.93D, and additional optical focal power 2 is+0.97D.
Embodiment 9:
Corneal diopter is 42.25D, anterior chamber depth value L2=4.30mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+2.22D, and additional optical focal power 2 is+1.11D.
Embodiment 10:
Corneal diopter is 42.25D, anterior chamber depth value L2=5.80mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 60cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+2.48D, and additional optical focal power 2 is+1.24D.
2. art physiology of eye structural parameters are determined, the Fabrication parameter of large depth of focus intraocular lens under different line of sight conditions
Embodiment 11:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 50cm in sighting distance 1, when sighting distance 2 is 100cm, determined additional optical focal power 1 is+2.46D, and additional optical focal power 2 is+1.23D.
Embodiment 12:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 70cm in sighting distance 1, when sighting distance 2 is 110cm, determined additional optical focal power 1 is+1.76D, and additional optical focal power 2 is+1.12D.
Embodiment 13:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 80cm in sighting distance 1, when sighting distance 2 is 120cm, determined additional optical focal power 1 is+1.54D, and additional optical focal power 2 is+1.03D.
Embodiment 14:
Corneal diopter is 42.25D, anterior chamber depth value L2=3.16mm, and axiallength L2+L3 is 23.10mm.Air refraction n1=1, aqueous humor refractive index n2=1.336, vitreous body refractive index n3=1.336.Be 90cm in sighting distance 1, when sighting distance 2 is 130cm, determined additional optical focal power 1 is+1.37D, and additional optical focal power 2 is+0.95D.
The Data Summary of above embodiment is in table 3.
Term:
Sighting distance: the distance between point source and cornea, this patent middle finger other distance except infinite distance.
Anterior chamber depth: the distance between corneal endothelium to crystalline lens front surface, uses in the schematic diagram shown in Fig. 5 and Fig. 6
represent.
Sighting distance focal power: under line of sight conditions, obtains the focal power required for clear vision.
Additional optical focal power: sighting distance focal power and the difference of looking distance vision acuity.
。
Claims (10)
1. manufacture a method for multifocal intraocular lenses, comprise step:
Determine the physiological parameter of the art eye of patient;
Determine one or more sighting distances of described art eye;
One or more additional optical focal powers of the multifocal intraocular lenses of described art eye are determined according to the physiological parameter of described art eye and one or more sighting distances of described art eye, wherein, described one or more additional optical focal power corresponds respectively to described one or more sighting distance; And
Manufacture the multifocal intraocular lenses with described one or more additional optical focal power, make described multifocal intraocular lenses provide described one or more sighting distance after the described art eye of implantation.
2. method according to claim 1, the physiological parameter of described art eye comprises corneal parameters, anterior chamber depth, aqueous humor refractive index and vitreous body refractive index.
3. method according to claim 2, wherein, anterior chamber depth adopts the measured value of described art eye, and corneal parameters, aqueous humor refractive index and vitreous body refractive index adopt assembly average or approximation.
4. method according to claim 2, wherein, corneal parameters and anterior chamber depth adopt the measured value of described art eye, and aqueous humor refractive index and vitreous body refractive index adopt assembly average or approximation.
5. method according to claim 2, wherein, corneal parameters, anterior chamber depth and aqueous humor refractive index adopt the measured value of described art eye, and vitreous body refractive index adopts assembly average or approximation.
6. method according to claim 2, wherein, corneal parameters, anterior chamber depth, aqueous humor refractive index and vitreous body refractive index all adopt the measured value of described art eye.
7. the method according to any one of claim 2-6, wherein, corneal parameters is corneal diopter.
8. the method according to any one of claim 2-6, wherein, corneal parameters is the data for calculating corneal diopter, and the described data for calculating corneal diopter comprise the refractive index of cornea and comprise curvature or the radius of curvature of cornea.
9. method according to claim 1, wherein, determine the additional optical focal power of described multifocal intraocular lenses according to following formula:
,
Wherein,
for additional optical focal power,
for corneal diopter,
for anterior chamber depth,
for sighting distance,
for air refraction,
for aqueous humor refractive index, and
for vitreous body refractive index.
10. method according to claim 1, wherein, the step determining one or more additional optical focal powers of the multifocal intraocular lenses of described art eye is in human-eye model, adopt the method for ray tracing to carry out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511011145.2A CN105534618B (en) | 2015-12-30 | 2015-12-30 | The manufacture method of multifocal intraocular lenses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511011145.2A CN105534618B (en) | 2015-12-30 | 2015-12-30 | The manufacture method of multifocal intraocular lenses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105534618A true CN105534618A (en) | 2016-05-04 |
| CN105534618B CN105534618B (en) | 2017-10-03 |
Family
ID=55814558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511011145.2A Active CN105534618B (en) | 2015-12-30 | 2015-12-30 | The manufacture method of multifocal intraocular lenses |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105534618B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420110A (en) * | 2016-08-24 | 2017-02-22 | 滕植鑫 | Pediatric intraocular lens degree prediction method |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1582408A (en) * | 2000-09-08 | 2005-02-16 | 佛罗里达光学工程公司 | Multifocal ophthalmic lens with induced aperture |
| WO2007128423A1 (en) * | 2006-05-05 | 2007-11-15 | Carl Zeiss Meditec Ag | Aspheric intraocular lens and method for designing such iol |
| CN101422392A (en) * | 2007-10-02 | 2009-05-06 | 爱尔康公司 | Zonal diffractive multifocal intraocular lenses |
| CN101636683A (en) * | 2007-01-11 | 2010-01-27 | 爱尔康研究有限公司 | Alternating optical system: mixing and matching optics to maximize binocular visual benefits |
| US20100225014A1 (en) * | 2009-03-04 | 2010-09-09 | Aaren Scientific Inc. | System for characterizing a cornea and obtaining an opthalmic lens |
| CN101842225A (en) * | 2007-12-21 | 2010-09-22 | 爱尔康公司 | The manufacture method of customized intraocular lenses |
| CN102421352A (en) * | 2009-03-26 | 2012-04-18 | 国家数据研究中心公司 | Ocular modeling methods and apparatus |
| JP2012075647A (en) * | 2010-09-30 | 2012-04-19 | Nidek Co Ltd | Ophthalmologic measuring apparatus |
| CN102460274A (en) * | 2009-06-09 | 2012-05-16 | 诺华公司 | Zonal diffractive multifocal intraocular lens with central monofocal diffractive region |
| WO2014152017A1 (en) * | 2013-03-21 | 2014-09-25 | Shifamed Holdings, Llc | Accommodating intraocular lens |
-
2015
- 2015-12-30 CN CN201511011145.2A patent/CN105534618B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1582408A (en) * | 2000-09-08 | 2005-02-16 | 佛罗里达光学工程公司 | Multifocal ophthalmic lens with induced aperture |
| WO2007128423A1 (en) * | 2006-05-05 | 2007-11-15 | Carl Zeiss Meditec Ag | Aspheric intraocular lens and method for designing such iol |
| CN101636683A (en) * | 2007-01-11 | 2010-01-27 | 爱尔康研究有限公司 | Alternating optical system: mixing and matching optics to maximize binocular visual benefits |
| CN101422392A (en) * | 2007-10-02 | 2009-05-06 | 爱尔康公司 | Zonal diffractive multifocal intraocular lenses |
| CN101842225A (en) * | 2007-12-21 | 2010-09-22 | 爱尔康公司 | The manufacture method of customized intraocular lenses |
| US20100225014A1 (en) * | 2009-03-04 | 2010-09-09 | Aaren Scientific Inc. | System for characterizing a cornea and obtaining an opthalmic lens |
| CN102421352A (en) * | 2009-03-26 | 2012-04-18 | 国家数据研究中心公司 | Ocular modeling methods and apparatus |
| CN102460274A (en) * | 2009-06-09 | 2012-05-16 | 诺华公司 | Zonal diffractive multifocal intraocular lens with central monofocal diffractive region |
| JP2012075647A (en) * | 2010-09-30 | 2012-04-19 | Nidek Co Ltd | Ophthalmologic measuring apparatus |
| WO2014152017A1 (en) * | 2013-03-21 | 2014-09-25 | Shifamed Holdings, Llc | Accommodating intraocular lens |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420110A (en) * | 2016-08-24 | 2017-02-22 | 滕植鑫 | Pediatric intraocular lens degree prediction method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105534618B (en) | 2017-10-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104755012B (en) | Polycyclic crystalline lens, system and method for extended focal depth | |
| US8430508B2 (en) | Single microstructure lens, systems and methods | |
| CN101636683B (en) | Lens set | |
| AU2020203170B2 (en) | High definition and extended depth of field intraocular lens | |
| CN105659152B (en) | For correcting the eyeglass of astigmatism | |
| AU2017383107B2 (en) | Contact lens | |
| JP2013514833A5 (en) | ||
| JP2013515284A5 (en) | ||
| CN101460114A (en) | Corneal implant and method for correction of impaired vision in the human eye | |
| KR20170056675A (en) | Multifocal intraocular lens with extended depth of field | |
| CN109426007A (en) | Optical lens for correcting eyesight | |
| JPH0926559A (en) | Multifocal lens for opthalmology and its manufacture | |
| AU2004269510B2 (en) | Optical accommodative compensation system | |
| US20240118563A1 (en) | Multi-region refractive lenses for vision treatment | |
| CN114010371A (en) | Posterior chamber type progressive multifocal intraocular lens for crystalline eye | |
| CN105534618B (en) | The manufacture method of multifocal intraocular lenses | |
| JP2763293B2 (en) | Intraocular bifocal lens | |
| ES2947815T3 (en) | Procedure for manufacturing an ocular implant | |
| KR20220103913A (en) | Intraocular lenses with extended depth of focus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 102200 No. 9 Xingchang Road, Changping District Science and Technology Park, Beijing Patentee after: Abbott (Beijing) Medical Technology Co., Ltd. Address before: 102200, Changping District Beijing science and Technology Park, super Road, No. 37, building 1, 6 North Zone Patentee before: Eponode (Beijing) Medical Technology Co., Ltd. |