CN105509923A - Attached tumor cell thermometer - Google Patents
Attached tumor cell thermometer Download PDFInfo
- Publication number
- CN105509923A CN105509923A CN201510895989.1A CN201510895989A CN105509923A CN 105509923 A CN105509923 A CN 105509923A CN 201510895989 A CN201510895989 A CN 201510895989A CN 105509923 A CN105509923 A CN 105509923A
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- Prior art keywords
- temperature measuring
- measuring equipment
- sticking type
- type temperature
- flexible substrate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K7/00—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements
- G01K7/16—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements using resistive elements
- G01K7/22—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements using resistive elements the element being a non-linear resistance, e.g. thermistor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K1/00—Details of thermometers not specially adapted for particular types of thermometer
- G01K1/14—Supports; Fastening devices; Arrangements for mounting thermometers in particular locations
Abstract
The invention provides an attached temperature measuring device, and the device belongs to the technical field of human body temperature measurement. The device comprises a flexible substrate, wherein a first circuit is arranged in the flexible substrate; a temperature sensor, which is fixed to one side of the flexible substrate and is connected with the first circuit in a communication way; and an adhesion layer, which is arranged on the temperature-sensor-fixed side of the flexible substrate. According to the technical scheme provided by the embodiment of the invention, the device can closely attach the to-be-measured part, and the accuracy and sustainability of temperature measuring of the temperature measuring device are improved.
Description
Technical field
The invention belongs to human body temperature fields of measurement, particularly relate to a kind of sticking type tumour cell thermometer.
Background technology
Along with continuous advance and the development of wearable technology, more and more modish wearable device product is also following.Common wearable product, as earphone, socks, shoe-pad etc., sticking type temperature measuring equipment, as a kind of electronic equipment that is novel, that directly can be attached to human body surface, can be used for the temperature of long term monitoring human body, for medical diagnosis or healthy evaluation and test provide strong data supporting.
For sticking type temperature measuring equipment, important performance index are temperature measurement accuracies, and the factor affecting temperature measurement accuracy is a lot, such as, and temperature sensor etc.
In addition, the tightness degree that fit in sticking type temperature measuring equipment and human body thermometric position is also a very important influence factor.And there is temperature measuring equipment and human body thermometric position in prior art in sticking type temperature measuring equipment and to fit the problem of undertighten, therefore, need a kind of novel sticking type temperature measuring equipment badly.
Summary of the invention
The present invention proposes a kind of sticking type temperature measuring equipment, can be combined with thermometric position very closely, improve accuracy and the continuation of temperature measuring equipment measuring tempeature.
On the one hand, according to one embodiment of present invention, provide a kind of sticking type temperature measuring equipment, comprising:
Flexible substrate, is provided with conducting part in described flexible substrate;
Temperature sensor, described temperature sensor is fixed on the first side of described flexible substrate, and is electrically connected with described conducting part; And
Adhesion layer, described adhesion layer is arranged on described first side of described flexible substrate.
According to a kind of embodiment of the present invention, described adhesion layer corresponds to described temperature sensor and is provided with through hole.
According to a kind of embodiment of the present invention, described sticking type temperature measuring equipment also comprises: the heat-conducting layer being arranged at described temperature sensor, and the height of described heat-conducting layer is higher than described adhesion layer.
According to a kind of embodiment of the present invention, described heat-conducting layer is heat-conducting glue.
According to a kind of embodiment of the present invention, described heat-conducting glue is one or more in organosilicon heat-conducting glue, epoxy resin, polyurethane adhesive or heat-conducting silicone grease.
According to a kind of embodiment of the present invention, described heat-conducting glue comprises metal packing.
According to a kind of embodiment of the present invention, described sticking type temperature measuring equipment also comprises adherent layer, and described adherent layer is arranged on described adhesion layer.
According to a kind of embodiment of the present invention, described temperature sensor is at least one thermistor, and described conducting part is at least one P.e.c., and described at least one P.e.c. is electrically connected at least one thermistor described respectively.
According to a kind of embodiment of the present invention, described flexible substrate is provided with through hole, does not arrange adhered layer and temperature sensor at described lead to the hole site.
According to a kind of embodiment of the present invention, described flexible substrate is X-shaped, and four branches of X-shaped flexible substrate described in this radially distribute relative to described through hole; At least one thermistor described is arranged in described four branches.
According to a kind of embodiment of the present invention, described adhesion layer comprises hydrogel.
According to a kind of embodiment of the present invention, described hydrogel is temperature sensitive type water gel or photaesthesia type hydrogel or electric sensitive hydrogel.
By the sticking type temperature measuring equipment in above-described embodiment, by being arranged on the adhesion layer of the flexible substrate side being fixed with temperature sensor, the thermometric position described temperature measuring equipment being fixed on human body that can be stable.By continual and steady collection human body temperature data, the accuracy of temperature acquisition can be improve.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Figure 1A is the cross-sectional view of a kind of sticking type temperature measuring equipment according to an embodiment of the invention;
Figure 1B is the cross-sectional view of a kind of sticking type temperature measuring equipment according to another embodiment of the invention;
Fig. 2 is the cross-sectional view of a kind of sticking type temperature measuring equipment according to another embodiment of the invention;
Fig. 3 is the structural representation of a kind of sticking type temperature measuring equipment according to another embodiment of the invention.
Embodiment
Technical scheme in the embodiment of the present invention is understood better in order to make those skilled in the art, below in conjunction with the accompanying drawing in the embodiment of the present invention, technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
One embodiment of the invention provides a kind of sticking type temperature measuring equipment, and this temperature measuring equipment comprises flexible substrate 101, temperature sensor 102 and adhesion layer 103.Flexible substrate can be made by the material with flexible nature, and as an example, can adopt flexible PCB to realize, flexible PCB at least comprises following assembly:
(1), base material: the base material of flexible PCB can select polyimide.In order to ensure the comfort level of human body to base material, the base material that 25 μm thick can be selected.If need circuit board a little hard, the thickness of base material can be increased, such as select the base material of 50 μm.Otherwise, if need circuit board softness a bit, then can select the base material of 13 μm.
(2), the transparent adhesive tape of base material: be divided into epoxy resin and tygon two kinds, base material is thicker with the transparent adhesive tape on it, and circuit board is harder.If the region that circuit board has bending larger, then thinner base material and transparent adhesive tape can be selected to reduce the stress of copper foil surface, and such Copper Foil occurs that the chance of micro-crack is smaller.For such region, lamina can be selected as far as possible.
(3), Copper Foil: be divided into calendering copper and cathode copper two kinds.Calendering copper intensity is high, resistance to bending, but price is more expensive.Cathode copper low price many, but intensity difference, frangibility, is generally used in the occasion of seldom bending.The selection of copper thickness will be determined according to lead-in wire minimum widith and minimum spacing.Copper Foil is thinner, accessible minimum widith and spacing less.Select calendering copper in the embodiment of the present invention, and ensure that the rolling direction of Copper Foil is consistent with the main bending direction of circuit board.
(4), diaphragm and transparent adhesive tape thereof: for the scheme in the application, owing to there is the larger circuit board of bending, select the diaphragm of 13 μm.The material of transparent adhesive tape can select one of epoxy resin and tygon these two kinds, and the thickness arranging transparent adhesive tape is 13 μm.
(5), pad coating: adopt electronickelling+electroless plating layer gold, the THICKNESS CONTROL of electroless nickel layer is at 0.5-2 μm, and the THICKNESS CONTROL of electroless plating layer gold is at 0.05-0.1 μm.
Described flexible substrate 101 inside is provided with conducting part 106 (see Fig. 3), described conducting part is at least one P.e.c., the metal material that this P.e.c. can have Copper Foil etc. to have excellent conductive performance and bending resistance is made, can free bend, winding, folding, can require to arrange arbitrarily according to space layout, and move arbitrarily at three dimensions and stretch, thus reach components and parts (as temperature sensor) and assemble the integration be connected with wire.
In order to can from human body target collecting temperature data, need to be provided with temperature sensor 102 in sticking type temperature measuring equipment, these temperature sensors 102 from the surface of object to be measured according to predetermined time interval collecting temperature data, such as can arrange every five minutes and gather a temperature data, and continuous collecting a period of time (as 10 hours).The temperature data of all generations is all stored in a portable memory device.Sensor 102 is fixed on the side of flexible substrate, and is connected with the circuit in flexible substrate.
Temperature sensor 102 can adopt the sensor of multiplex pattern to realize, for example, temperature sensor 102 can be realized by thermistor, and based on the difference of thermo-sensitive material, thermistor can adopt semiconductor thermistor, metal thermo-sensitive resistance and alloy thermal responsive resistance again as required.
In addition, sticking type temperature measuring equipment also comprises adhesion layer 103, and the fundamental purpose of adhesion layer 103 is fixed on human body by temperature sensor, and see Figure 1A, Figure 1B, adhesion layer can adopt various ways to be arranged on flexible substrate.
As shown in Figure 1A, adhesion layer directly overlays on temperature sensor 102 and flexible substrate, and this mode implements more for convenience, is convenient to adhesion layer cutting in the preparation and batch production.
Except aforesaid way, see Figure 1B, adhesion layer 103 can also be arranged on other regions except temperature sensor 102, the position that adhesion layer 103 is provided with temperature sensor in installation is provided with through hole, can be arranged in through hole to make temperature sensor, other regions outside through hole, adhesion layer 103 is directly connected with flexible base, board 101.
Adhesion layer can be made by the sticking material of multiple tool, for example, can adopt and to have compared with strongly adherent skin and can the hydrogel of painless separation.
The fixed forms such as traditional adhesive tape are replaced with hydrogel layer, can make the temperature sensor of temperature measuring equipment more convenient, closely to fit human body surface, thus make more fully to carry out heat trnasfer contiguously between temperature sensor and the tested district of body surface, promote the measuring accuracy of temperature measuring equipment.
Based on the sticking type temperature measuring equipment of said structure design, good beneficial effect can be realized, to measure the temperature of chest region, use following three kinds of dissimilar temperature measuring equipments respectively: (1) ordinary electronic formula clinical thermometer (certain company's model is the thermometer product of MC-246); (2) temperature sensing device in the present embodiment; (3) intrusive mood blood heat measuring instrument.
By repetitive measurement, the body temperature for research object is followed successively by by the measurement result of above-mentioned three kinds of body temperature measuring devices: 1) 36.77 DEG C, 2) 36.86 DEG C, 3) 36.90 DEG C.
Using the temperature data measured by intrusive mood blood heat measuring instrument as standard reference data; According to the statistics of the axillaty temperature measurement result to 100 routine research objects, ordinary electronic clinical thermometer survey data be positioned at intrusive mood blood heat measuring instrument survey [-0.97% of temperature data, + 0.31%] within error burst, measurement data relative to the distribution center of standard reference data generally within-0.57%.And temperature sensing device in the present embodiment survey data be positioned at intrusive mood blood heat measuring instrument survey [-0.19% of temperature data, + 0.06%] within error burst, measurement data relative to the distribution center of standard reference data generally within-0.08%, the accuracy of its measurement data, is obviously better than ordinary electronic clinical thermometer and surveys data.
Except arranging adhesion layer, for the ease of fixing temperature measuring equipment, some stationary installations can be set.See Fig. 3, for testing human breast temperature, can through hole 105 be set on flexible substrate, adhered layer and temperature sensor are not set in through hole 105 position.Through hole 105, for being socketed nipple or other teats of health, is installed on health to help fixing this.Flexible substrate is set to X-shaped shape, and this shape is convenient to the breast portion being pasted onto human body, and the space taken is less, and certainly, except X-shaped shape, flexible substrate also can be set to other common shapes, such as Y shape shape etc.
In order to ensure accuracy and the validity of measuring tempeature, see Fig. 2, a heat-conducting part 104 is covered on temperature sensor 102, make heat-conducting part higher than adhered layer 103, thus can guarantee when temperature sensing device sticks on health, dry heat-conducting part fully fits on skin, strengthens the accuracy of heat-transfer effect and sensor senses body temperature.Concrete, heat-conducting part can adopt the multiple material with thermal conduction characteristic to be made, such as heat-conducting part can be heat-conducting glue, and for carrying out the conduction of heat, heat-conducting glue can be one or more in epoxy resin, organosilicon heat-conducting glue, polyurethane adhesive, heat-conducting silicone grease; Wherein more preferably, be mixed with the metal powders such as aluminium powder, copper powder, iron powder in heat-conducting glue, this can strengthen its temperature conductivity.
Add the temperature measuring equipment of said structure, its thermometric accuracy is improved further, for the temperature survey of chest region, uses following three kinds of dissimilar temperature measuring equipments respectively:
(1) ordinary electronic formula clinical thermometer (certain company's model is the thermometer product of MC-246); (2) temperature sensing device in the present embodiment; (3) intrusive mood blood heat measuring instrument.
By repetitive measurement, the body temperature for a certain routine research object is followed successively by by the measurement result of above-mentioned three kinds of body temperature measuring devices: 1) 36.77 DEG C, 2) 36.86 DEG C, 3) 36.90 DEG C.
Using the temperature data measured by intrusive mood blood heat measuring instrument as standard reference data; According to the statistics of the axillaty temperature measurement result to 100 routine research objects, ordinary electronic clinical thermometer survey data be positioned at intrusive mood blood heat measuring instrument survey [-0.97% of temperature data, + 0.31%] within error burst, measurement data relative to the distribution center of standard reference data generally within-0.57%.And temperature sensing device in the present embodiment survey data be positioned at intrusive mood blood heat measuring instrument survey [-0.10% of temperature data, + 0.02%] within error burst, measurement data relative to the distribution center of standard reference data generally within-0.04%, the accuracy of its measurement data, is obviously better than ordinary electronic clinical thermometer and surveys data.
For preventing adhesion layer covered with dust from reducing viscosity, adhesion layer is coated with adherent layer, adherent layer is specifically as follows a plastic paper.
As a concrete embodiment, adhesion layer 103 is made by hydrogel material.Hydrogel material is directly used in and contacts with tissue, can prevent the infection of micro-organisms in vitro, suppresses the loss of body fluid, and transmission oxygen, to wound, can promote the healing of wound in general.
When hydrogel is transplanted or after being expelled to biosome, hydrogel can maintain or be embedded in the medicine in hydrogel to body fluid Co ntrolled release, in general, there is the Co ntrolled release of two types, one discharges Small molecular as gel application thing, and another kind of situation is that the polymeric substrate containing medicine decomposes gradually, in this case, drug diffusion enters surrounding environment, is controlled by the biodegradation rate of material.Sometimes hydrogel is as micella drug loading, and the speed of insoluble drug release is realized by the chemical composition by adjustment degree of crosslinking and hydrogel, and since particularly progress in Intelligent Hydrogel is come out, the use of hydrogel is more extensive.
Specifically, hydrogel can adopt temperature sensitive type water gel, and common temperature sensitive type water gel comprises: Ionized polypropylene milling amine hydrogel, poly-(N, N mono-dihexyl) acrylamide gel and poly-(N-isopropyl) acrylamide gel etc.
In addition, hydrogel can also adopt photaesthesia type hydrogel and electric sensitive hydrogel.
Temperature measuring equipment in more above-mentioned embodiments, also as cancer cell thermometer, for detection, monitoring human body, especially body surface, because of the growth of cancer cell, canceration and issuable temperature anomaly, thus can from the index of Temperature changing, auxiliary examination, the health evaluating work carrying out disease (such as cancer).
The above; be only the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (12)
1. a sticking type temperature measuring equipment, is characterized in that, comprising:
Flexible substrate, is provided with conducting part in described flexible substrate;
Temperature sensor, described temperature sensor is fixed on the first side of described flexible substrate, and is electrically connected with described conducting part; And
Adhesion layer, described adhesion layer is arranged on described first side of described flexible substrate.
2. sticking type temperature measuring equipment according to claim 1, is characterized in that:
Preferably, described adhesion layer corresponds to described temperature sensor and is provided with through hole.
3. sticking type temperature measuring equipment according to claim 2, is characterized in that:
Described sticking type temperature measuring equipment also comprises: the heat-conducting layer being arranged at described temperature sensor, and the height of described heat-conducting layer is higher than described adhesion layer.
4. sticking type temperature measuring equipment according to claim 3, is characterized in that:
Described heat-conducting layer is heat-conducting glue.
5. sticking type temperature measuring equipment according to claim 4, is characterized in that:
Described heat-conducting glue is one or more in organosilicon heat-conducting glue, epoxy resin, polyurethane adhesive or heat-conducting silicone grease.
6. sticking type temperature measuring equipment according to claim 4, is characterized in that:
Described heat-conducting glue comprises metal packing.
7. sticking type temperature measuring equipment according to claim 1, is characterized in that:
Described sticking type temperature measuring equipment also comprises adherent layer, and described adherent layer is arranged on described adhesion layer.
8. sticking type temperature measuring equipment according to claim 1, is characterized in that:
Described temperature sensor is at least one thermistor, and described conducting part is at least one P.e.c., and described at least one P.e.c. is electrically connected at least one thermistor described respectively.
9. sticking type temperature measuring equipment according to claim 8, is characterized in that:
Described flexible substrate is provided with through hole, does not arrange adhered layer and temperature sensor at described lead to the hole site.
10. sticking type temperature measuring equipment according to claim 8, is characterized in that:
Described flexible substrate is X-shaped, and four branches of X-shaped flexible substrate described in this radially distribute relative to described through hole;
At least one thermistor described is arranged in described four branches.
11. sticking type temperature measuring equipments according to any one of claim 1-10, is characterized in that:
Described adhesion layer comprises hydrogel.
12. sticking type temperature measuring equipments according to claim 11, is characterized in that:
Described hydrogel is temperature sensitive type water gel or photaesthesia type hydrogel or electric sensitive hydrogel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510895989.1A CN105509923A (en) | 2015-12-07 | 2015-12-07 | Attached tumor cell thermometer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510895989.1A CN105509923A (en) | 2015-12-07 | 2015-12-07 | Attached tumor cell thermometer |
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| CN105509923A true CN105509923A (en) | 2016-04-20 |
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| CN201510895989.1A Pending CN105509923A (en) | 2015-12-07 | 2015-12-07 | Attached tumor cell thermometer |
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Cited By (2)
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| CN106556470A (en) * | 2016-11-22 | 2017-04-05 | 合肥舒实工贸有限公司 | Temperature sensor |
| CN109029759A (en) * | 2018-06-06 | 2018-12-18 | 东南大学 | A kind of high-precision unicellular temp measuring system in real time |
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