CN105502459A - Preparing method of nanometer calcium hydroxide for antacid - Google Patents
Preparing method of nanometer calcium hydroxide for antacid Download PDFInfo
- Publication number
- CN105502459A CN105502459A CN201510994823.5A CN201510994823A CN105502459A CN 105502459 A CN105502459 A CN 105502459A CN 201510994823 A CN201510994823 A CN 201510994823A CN 105502459 A CN105502459 A CN 105502459A
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- antacid
- calcium hydroxide
- preparation
- nano calcium
- nanometer calcium
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F11/00—Compounds of calcium, strontium, or barium
- C01F11/02—Oxides or hydroxides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
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- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Geology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a preparing method of nanometer calcium hydroxide for an antacid. The preparing method includes the following steps that 1, a mixed solution is prepared from, by mass, calcium chloride, organic solvent and deionized water; 2, a dispersing agent is added; 3, a calcium hydroxide mixture slurry is prepared; 4, suction filtration, washing and drying are carried out, and the nanometer calcium hydroxide for the antacid is obtained. The specific surface area of the nanometer calcium hydroxide obtained with the method ranges from 83 m<2>/g to 86 m<2>/g. The preparing method of the nanometer calcium hydroxide for the antacid is easy and convenient to operate and easy to achieve, and particles of the obtained nanometer calcium hydroxide are even in particle size, large in specific surface area and high in activity, have the advantages of being small in use quantity and high in neutralizing performance, and are suitable for the antacid.
Description
Technical field
The present invention relates to calcium hydroxide field, particularly relate to a kind of preparation method of antacid nano calcium hydroxide.
Background technology
Antacid is the medicine being applied to illness such as treatment peptide ulceration, hyperchlorhydria etc.Traditional antacid, in and while hydrochloric acid in gastric juice, also there is release magnalium ion (easily causing constipation diarrhoea), release of carbon dioxide or cause osteoporosis and vitamins B
12the untoward reaction of the side effects such as malabsorption.
Montmorillonite is natural aluminosilicate mineral, has mucosa, can be used as pharmaceutical carrier.Calcium hydroxide has potential using value in neutralizing acid, and does not produce the side effects such as carbonic acid gas, load can make antacid on montmorillonite.But calcium hydroxide is a kind of highly basic, can corrode muscle and mucous membrane, therefore strictly must control its adsorptive capacity, but lower adsorptive capacity does not reach again good neutralization.
Summary of the invention
The technical problem that the present invention mainly solves is to provide a kind of preparation method of antacid nano calcium hydroxide, effectively can improve activity and the specific surface area of calcium hydroxide, thus under the condition of low adsorptive capacity, play efficient antacid effect.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: the preparation method providing a kind of antacid nano calcium hydroxide, comprises the steps:
(1) calcium chloride, organic solvent and deionized water are mixed with mixing solutions by certain mass ratio, and ultrasonic disperse is even;
(2) a certain amount of dispersion agent is added, stirring and dissolving in the mixing solutions obtained in step (1);
(3) mixture obtained in step (2) is placed in water-bath, and mixed solution is maintained at a constant temperature, then dripping sodium hydroxide solution wherein to producing without new throw out with given pace while stirring, continuing stirring 1 ~ 2h, obtaining mixture slurry;
(4) by obtain in step (2) slurry suction filtration, washing, drying, obtain described antacid nano calcium hydroxide.
In a preferred embodiment of the present invention, in described step (1), the mass ratio of described calcium chloride, organic solvent and deionized water is 1:3 ~ 5:5 ~ 15.
In a preferred embodiment of the present invention, in described step (2), described dispersion agent is polyvinyl alcohol, and its mass ratio adding calcium chloride in quality and step (1) is 1 ~ 1.5:10.
In a preferred embodiment of the present invention, in described step (3), the temperature of described mixed solution is 15 ~ 20 DEG C.
In a preferred embodiment of the present invention, in described step (3), the concentration of described sodium hydroxide solution is 0.25 ~ 0.4mol/L, and its drop rate is 1 ~ 3ml/min.
In a preferred embodiment of the present invention, described organic solvent is ethanol, propyl alcohol or butanols.
The invention has the beneficial effects as follows: the preparation method of a kind of antacid nano calcium hydroxide of the present invention, easy and simple to handle, easily realize, gained nano calcium hydroxide grain diameter is even, and specific surface area is large, active high, there is consumption low, in and the high advantage of performance, be suitable for the use of antacid.
Embodiment
Below preferred embodiment of the present invention is described in detail, can be easier to make advantages and features of the invention be readily appreciated by one skilled in the art, thus more explicit defining is made to protection scope of the present invention.
The embodiment of the present invention comprises:
Embodiment 1
A preparation method for antacid nano calcium hydroxide, comprises the steps:
(1) proportions of calcium chloride, ethanol and deionized water 1:3:5 is in mass ratio become mixing solutions, and more than ultrasonic disperse 30min is to evenly;
(2) add a certain amount of polyvinyl alcohol dispersion agent in the mixing solutions obtained in step (1), make the mass ratio of polyvinyl alcohol and calcium chloride be 1:10, stirring and dissolving;
(3) mixture obtained in step (2) is placed in water-bath, and make the homo(io)thermism of mixed solution at 15 DEG C, then dripping volumetric molar concentration for 0.25mol/L sodium hydroxide solution is to producing without new throw out with the speed of 1ml/min while stirring, continuing to stir 2h, obtaining mixture slurry;
(4) by obtain in step (2) slurry suction filtration, washing, drying, obtain described antacid nano calcium hydroxide.
Embodiment 2
A preparation method for antacid nano calcium hydroxide, comprises the steps:
(1) proportions of calcium chloride, propyl alcohol and deionized water 1:5:15 is in mass ratio become mixing solutions, and more than ultrasonic disperse 30min is to evenly;
(2) add a certain amount of polyvinyl alcohol dispersion agent in the mixing solutions obtained in step (1), make the mass ratio of polyvinyl alcohol and calcium chloride be 1.5:10, stirring and dissolving;
(3) mixture obtained in step (2) is placed in water-bath, and make the homo(io)thermism of mixed solution at 20 DEG C, then dripping volumetric molar concentration for 0.4mol/L sodium hydroxide solution is to producing without new throw out with the speed of 3ml/min while stirring, continuing to stir 2h, obtaining mixture slurry;
(4) by obtain in step (2) slurry suction filtration, washing, drying, obtain described antacid nano calcium hydroxide.
The nano calcium hydroxide that aforesaid method obtains, uniform particle sizes, specific surface area is 83 ~ 86m
2/ g, specific surface area is large, active high, has low consumption, the advantage of senior middle school and performance, is suitable for the use of antacid.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (6)
1. a preparation method for antacid nano calcium hydroxide, is characterized in that, comprises the steps:
(1) calcium chloride, organic solvent and deionized water are mixed with mixing solutions by certain mass ratio, and ultrasonic disperse is even;
(2) a certain amount of dispersion agent is added, stirring and dissolving in the mixing solutions obtained in step (1);
(3) mixture obtained in step (2) is placed in water-bath, and mixed solution is maintained at a constant temperature, then dripping sodium hydroxide solution wherein to producing without new throw out with given pace while stirring, continuing stirring 1 ~ 2h, obtaining mixture slurry;
(4) by obtain in step (2) slurry suction filtration, washing, drying, obtain described antacid nano calcium hydroxide.
2. the preparation method of antacid nano calcium hydroxide according to claim 1, is characterized in that, in described step (1), the mass ratio of described calcium chloride, organic solvent and deionized water is 1:3 ~ 5:5 ~ 15.
3. the preparation method of antacid nano calcium hydroxide according to claim 1, is characterized in that, in described step (2), described dispersion agent is polyvinyl alcohol, and its mass ratio adding calcium chloride in quality and step (1) is 1 ~ 1.5:10.
4. the preparation method of antacid nano calcium hydroxide according to claim 1, is characterized in that, in described step (3), the temperature of described mixed solution is 15 ~ 20 DEG C.
5. the preparation method of antacid nano calcium hydroxide according to claim 1, is characterized in that, in described step (3), the concentration of described sodium hydroxide solution is 0.25 ~ 0.4mol/L, and its drop rate is 1 ~ 3ml/min.
6. the preparation method of antacid nano calcium hydroxide according to claim 1, is characterized in that, described organic solvent is ethanol, propyl alcohol or butanols.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510994823.5A CN105502459A (en) | 2015-12-28 | 2015-12-28 | Preparing method of nanometer calcium hydroxide for antacid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510994823.5A CN105502459A (en) | 2015-12-28 | 2015-12-28 | Preparing method of nanometer calcium hydroxide for antacid |
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| Publication Number | Publication Date |
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| CN105502459A true CN105502459A (en) | 2016-04-20 |
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| CN201510994823.5A Pending CN105502459A (en) | 2015-12-28 | 2015-12-28 | Preparing method of nanometer calcium hydroxide for antacid |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854322A (en) * | 2017-10-24 | 2018-03-30 | 武汉大学 | A kind of preparation method of nano calcium hydroxide for root canal filling material |
| CN111484059A (en) * | 2020-04-30 | 2020-08-04 | 广西夏阳环保科技有限公司 | Preparation method of high-purity calcium hydroxide |
| CN114853046A (en) * | 2022-05-26 | 2022-08-05 | 镇江华茂新材料科技有限公司 | Method for preparing nano calcium hydroxide by adopting micro-channel reactor |
| CN114917863A (en) * | 2022-04-24 | 2022-08-19 | 西安工业大学 | Dopamine-coated nano calcium hydroxide and preparation method thereof |
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| CN1800025A (en) * | 2005-11-03 | 2006-07-12 | 福建师范大学 | Process for preparing nano calcium hydroxide |
| CN101168446A (en) * | 2007-10-22 | 2008-04-30 | 福建师范大学 | Method for preparing dendritic calcium hydroxide |
| CN102390854A (en) * | 2011-08-08 | 2012-03-28 | 天津市化学试剂研究所 | Preparation method of pH reference reagent calcium hydroxide |
| CN104291371A (en) * | 2014-10-30 | 2015-01-21 | 杨富巍 | Preparation method for nanometer calcium hydroxide |
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2015
- 2015-12-28 CN CN201510994823.5A patent/CN105502459A/en active Pending
Patent Citations (4)
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| CN1800025A (en) * | 2005-11-03 | 2006-07-12 | 福建师范大学 | Process for preparing nano calcium hydroxide |
| CN101168446A (en) * | 2007-10-22 | 2008-04-30 | 福建师范大学 | Method for preparing dendritic calcium hydroxide |
| CN102390854A (en) * | 2011-08-08 | 2012-03-28 | 天津市化学试剂研究所 | Preparation method of pH reference reagent calcium hydroxide |
| CN104291371A (en) * | 2014-10-30 | 2015-01-21 | 杨富巍 | Preparation method for nanometer calcium hydroxide |
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| A. ROY ET AL.: ""Synthesis of Ca(OH)2 nanoparticles by wet chemical method"", 《MICRO & NANO LETTERS》 * |
| XU JING ET AL.: ""Application of Hydrosoluble Polymers to Preparation of Nanoscale Calcium Hydroxide"", 《CHEM. RES. CHINESE U.》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854322A (en) * | 2017-10-24 | 2018-03-30 | 武汉大学 | A kind of preparation method of nano calcium hydroxide for root canal filling material |
| CN111484059A (en) * | 2020-04-30 | 2020-08-04 | 广西夏阳环保科技有限公司 | Preparation method of high-purity calcium hydroxide |
| CN114917863A (en) * | 2022-04-24 | 2022-08-19 | 西安工业大学 | Dopamine-coated nano calcium hydroxide and preparation method thereof |
| CN114853046A (en) * | 2022-05-26 | 2022-08-05 | 镇江华茂新材料科技有限公司 | Method for preparing nano calcium hydroxide by adopting micro-channel reactor |
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Application publication date: 20160420 |