CN105497634A - Zhuang medicine composition for treating rheumatoid arthritis - Google Patents
Zhuang medicine composition for treating rheumatoid arthritis Download PDFInfo
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Abstract
The invention belongs to the field of Zhuang medicines, and discloses a Zhuang medicine composition for treating rheumatoid arthritis. The Zhuang medicine composition is prepared from the following raw materials in parts by weight: 20-50 parts of homalocladium platycladum, 20-50 parts of paederia scandens, 20-40 parts of tinospora sinensis merr, 20-40 parts of tetrastigma planicaule, 10-40 parts of pinkflower ecdysanthera roots and leaves, 10-50 parts of indian epimeredi herb, 10-40 parts of hedyotis hedyotidea, 10-30 parts of drynaria total flavonoids, 10-30 parts of remote lemongrass herb and 10-30 parts of whiteflower leadword roots. The dosage form of the Zhuang medicine composition is a decoction. The preparation method comprises the following steps: cleaning and selecting medicinal materials for raw material composition decoction pieces respectively according to parts by weight; adding water, and decocting with a slow fire to 200ml; decocting the dregs again; and mixing the decoction solutions of twice to form the decoction. A clinical experiment shows that the Zhuang medicine composition has the efficacies of dispelling wind, dredging collaterals, dispelling cold and removing dampness, is obvious in collateral-dredging and pain-relieving effects, and is a good medicine for treating the rheumatoid arthritis; and the clinical symptoms of painful swelling of joints or even deformation and the like can be obviously improved.
Description
Technical field
The invention belongs to national medicine and strengthen medicine field, be specifically related to a kind of strong drug composition for the treatment of rheumatoid arthritis.
Background technology
Rheumatoid arthritis with chronic, many synovial jointss of symmetry outside scorching and joint pathological changes be main clinical manifestation, the cause of disease not bright, the autoimmune inflammatory disease that there is no particular diagnostic index at present.Clinical manifestation comprises arthralgia, swelling, moving obstacle, has stiff phenomenon in morning, for a long time then joint deformity, and anemia, lab testing RF increases, and ESR speeds more, and initial stage x-ray only shows soft tissue swelling and osteoporosis, middle and advanced stage visible joint gap turn narrow or difference.
The therapeutic purposes of rheumatoid arthritis are that symptom management develops, and ease the pain, and stop irreversible osteoclasia, and the function of Saving cortilage and muscle improves the quality of life of patient.Western medicine achieves obvious progress in rheumatoid arthritis pathogenesis and pathological change research in recent years, but in treatment and medicine, still do not have a kind of medicine can slow down or stop rheumatoid arthritis sclerotin to attack and destruction of joint.Lack the medicine of effectively real symptom management development.
Doctor it is generally acknowledged that rheumatoid arthritis is when the category belonging to Chinese medical ' arthralgia syndrome ' now.According to its clinical manifestation, it is extremely similar to " the bone addiction " in " arthromyodynia ", " severe and migratory arthralgia ", " severe and migratory arthralgia ", " arthroncus of knee ", " stupid addiction ", " rising sun is fought " etc.Ancient Chinese medicine doctor has discussion to its pathogeny more.To the etiological study of arthromyodynia, "Nei Jing" is recognized " wet three gas of wind and cold mix to combined into fighting ", " Plain Questions pyretography " is pointed out " wind and rain cold and heat; must not be empty; can not solely hurt sb.'s feelings ", point out again " do not close with wind and cold dampness; therefore be not numbness ", thus illustrate that " heresy is invaded " is the pathogenetic external condition of disease, and " weakened body resistance " is the basic factor that evolution occurs disease, around " weakened body resistance ", " heresy is invaded ", " the tired blood of phlegm retention " three aspects, cause the direct or indirect reason of three, the reason of namely arthromyodynia generation.Strong doctor claims arthromyodynia to be " sending out prosperous ", and what think arthromyodynia is due to invasions such as pathogenic wind toxic, noxious dampness, acute diseases such as cholera and sunstroke poison, pyretic toxicity, severe pathogenic cold, and poison is strong just weak, vital QI cannot conquer pathogen, evil poison retardance three road two-way, people from world three gas can not synchronously cause a disease, and is even deformed into main manifestations with arthralgia.Strong treatment rheumatoid arthritis of curing has been carried out for many years, and have dispelling wind and removing obstruction in the collateral, the merit of dispelling cold and removing dampness, clinical efficacy is reliable.
Summary of the invention
The invention provides a kind of strong drug composition for the treatment of rheumatoid arthritis.This pharmaceutical composition adopts dispelling wind and removing obstruction in the collateral, the strong medicine composition of the effects such as dispelling cold and removing dampness, removing obstruction in the collateral to relieve pain successful, and can obviously improve the clinical symptoms such as arthralgia is even out of shape, and is a kind of good medicine for the treatment of rheumatoid arthritis.
The present invention is achieved through the following technical solutions:
A kind of strong drug composition for the treatment of rheumatoid arthritis, its raw material, with parts by weight, comprises few 20 ~ 50 parts of ring, Herba Paederiae 20 ~ 50 parts, Herba Lycopodii 20 ~ 40 parts, Tetrastigma planicaule 20 ~ 40 parts, boon wind 10 ~ 40 parts, Herba Epimeredis Indicae 10 ~ 50 parts, Caulis et Folium hedyotis hedyotideae 10 ~ 40 parts, Rhizoma Drynariae 10 ~ 30 parts, Herba Cymbopogonis 10 ~ 30 parts, Radix Plumbaginis Zeylanicae 10 ~ 30 parts.
Dosage form is decoction.
The present invention strengthens the characteristic of raw material included by drug composition:
Herba Homalocladii Platycladii: strong by name: Nyacijrip.Medicinal: to be the herb of polygonaceae plant Herba Homalocladii Platycladii Homalocladiumplatycladum (F.Muell.exHook.) L.H.Bailey.Nature and flavor: sweet are light, flat.Effect: heat clearing away poison, Tong Longlu.Cure mainly: carbuncle skin ulcer, rheumatic arthralgia, traumatic injury, snake bite and insect sting, centipete bite.
Herba Paederiae: strong by name: Gaeuroetma.Medicinal: to be the stem and leaf of Maguireothamnus speciosus Herba Paederiae Paederiascandens (Lour.) Merr..Nature and flavor: sweet, acid, flat.Effect: expelling wind and removing dampness, promoting digestion and removing stagnation, removing toxic substances and promoting subsidence of swelling, promoting blood circulation and stopping pain.Cure mainly: rheumatic arthralgia, dyspeptic abdominal distention, infantile malnutrition, diarrhoea, dysentery, heatstroke, jaundice, hepatitis, hepatosplenomegaly, cough, scrofula, acute appendicitis, innominate toxic swelling, foot damp-edema are rotten, burn and scald, eczema, dermatitis, traumatic injury, Serpentis flood dragon scorpion sting.
Herba Lycopodii: medicinal: be the stem of menispermaceae plant Tinospora sinensis Tinosporasinensis (Lour.) Merr..Nature and flavor: mildly bitter flavor, cool in nature.Effect: wind-expelling pain-stopping; Relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly: rheumatic arthralgia; Lumbar muscle strain; Traumatic injury.
Tetrastigma planicaule: medicinal: be root or the rattan of vitaceae Tetrastigma planicaule Tetrastigmaplanicaule (Hook.f.) Gagnep..Nature and flavor: pungent, acid, flat.Effect: removing dampness of dispeling the wind; Relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly: rheumatic arthralgia; Lumbar muscle strain; Apoplectic hemiplegia; Traumatic injury.
Boon wind: strong by name: Gaeugoq.Medicinal: to be the stem and leaf of Gnetaceae plant Caulis Gneti Parvifolii Gnetumparvifolium (Warb.) C.Y.ChengexChum.Nature and flavor: bitter, temperature.Effect: expelling wind and removing dampness, dissipating blood stasis blood, preventing phlegm from forming and stopping coughing.Cure mainly: rheumatic arthralgia, lumbago, arthromyodynia, apoplectic hemiplegia, the arthroncus of knee, traumatic injury, ulcer haemorrhage, chronic tracheitis.
Caulis et Folium hedyotis hedyotideae: strong by name: Gaeumoxgauj.Medicinal: to be the stem and leaf of Maguireothamnus speciosus Caulis et Folium hedyotis hedyotideae HedyotishedyotideaDC..Nature and flavor: sweet are light, cool.Effect: dispelling, collateral-activating, detumescence hemostasis.Cure mainly: rheumatic arthritis, bleeding hemorrhoids, furuncle carbuncle, traumatic injury.
Rhizoma Drynariae: strong by name: Hingbwn.Medicinal: to be the rhizome of Drynariaceae plant Mongolian oak Herba pteridii latiusculi Drynariafortune (Kunze) J.Smith.Nature and flavor: sweet are bitter, warm in nature.Effect: the kidney invigorating bone strengthening; Promoting blood circulation and stopping pain.Cure mainly: lumbago due to renal deficiency, foot and knee flaccidity, deafness, toothache, rheumatic arthralgia, chronic diarrhea, the enuresis, injury and bone fracture and alopecia areata.
Herba Epimeredis Indicae: strong by name: Gofangzfungh.Medicinal: to be the herb of labiate wide Radix Saposhnikoviae Epimerediindica (L.) Rothm.Nature and flavor: pungent are bitter, flat.Effect: dispel the wind, dehumidifying, removing toxic substances, eliminating carbuncle poison.Cure mainly: rheumatic arthralgia, hypertension, exanthema subitum, flu fever of the body, vomiting, stomachache, bones and muscles pain, skin infection, eczema, haemorrhoids.
Herba Cymbopogonis: medicinal: be the herb of grass Herba Cymbopogonis Cymbopogondistans (NeesexSteud.) W.Wats.Nature and flavor: pungent are bitter, warm in nature.Effect: induce sweat, dampness removing, relieving cough and asthma.Cure mainly: anemofrigid cold, Sunstroke, vomiting and diarrhoea stomachache, urine leaching pain, rheumatic arthralgia, cough and asthma.
Radix Plumbaginis Zeylanicae: strong by name: Godanhhau.Medicinal: to be the herb of Plumbaginaceae plant Radix Plumbaginis Zeylanicae PlumbagozeylanicaL..Nature and flavor: pungent, bitter, puckery, temperature, poisonous.Effect: dispel the wind, dissipating blood stasis, removing toxic substances, parasite killing.Cure mainly: Fengshi Guanjie pain, stomachache, diseases due to noxious agents produced by various parasites, hepatosplenomegaly, liver cirrhosis, acute catarrhal conjunctivitis, skin pruritus, blood stasis amenorrhea, traumatic injury, toxic swelling malignant boil, scabies.
Beneficial effect of the present invention:
Reuse Herba Homalocladii Platycladii heat clearing away poison, Tong Longlu in side, Herba Paederiae, Herba Lycopodii, boon wind, Caulis et Folium hedyotis hedyotideae expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral are monarch drug altogether; Rhizoma Drynariae the kidney invigorating bone strengthening, Herba Epimeredis Indicae, Herba Cymbopogonis regulating QI to relieve pain, dispels the wind as ministerial drug; Radix Plumbaginis Zeylanicae dissipating blood stasis for subsidence of swelling is adjuvant drug.Full side plays the merit of dispelling wind and removing obstruction in the collateral, dispelling cold and removing dampness altogether, removing obstruction in the collateral to relieve pain successful, obviously can improve the clinical symptoms that arthralgia is even out of shape, and is the active drug for the treatment of rheumatoid arthritis.
Detailed description of the invention
Below by embodiment, the invention will be further described, but not as any restriction to scope.
Embodiment 1:
Treat a strong drug composition for rheumatoid arthritis, raw material components is: the few 45g of ring, Herba Paederiae 45g, Herba Lycopodii 40g, Tetrastigma planicaule 40g, boon wind 40g, Herba Epimeredis Indicae 45g, Caulis et Folium hedyotis hedyotideae 35g, Rhizoma Drynariae 30g, Herba Cymbopogonis 30g, Radix Plumbaginis Zeylanicae 30g.Parts by weights another name gets above-mentioned raw materials, is cleaned by raw material, pours medicine pot into, soak 1 hour; Head is decocted: intense fire decocts to medicinal liquid boiling, uses slow fire instead and decocts 25 minutes again, leached by medicine juice; Two decoct: rejoin in medicine pot normal-temperature water paramount go out 0.5 centimetre, medical material plane, intense fire decoct to boiling after change slow fire boiling into 20 minutes, medicine juice is leached; Head is decocted and decocts gained medicine juice with two and merge.
Application method: oral, every day 1 dose, by twice fried liquid mixing, point morning and evening 2 times, each 200ml decoction being taken warmly 15 days is a course for the treatment of.
Clinic Case:
Wei so-and-so, man, 41 years old, Fangchenggang City people, rheumatoid arthritis 5 years, take continuously 3 the course for the treatment of posterior joint swell and ache symptom take a turn for the better.
Huang, female, 49 years old, people from Rongan County, rheumatoid arthritis 2 years, took symptom recovery from illness after 3 course for the treatment of arthralgia continuously.
Embodiment 2:
Treat a strong drug composition for rheumatoid arthritis, raw material components is: calculate the few 35g of ring, Herba Paederiae 35g, Herba Lycopodii 30g, Tetrastigma planicaule 20g, boon wind 25g, Herba Epimeredis Indicae 30g, Caulis et Folium hedyotis hedyotideae 25g, Rhizoma Drynariae 20g, Herba Cymbopogonis 20g, Radix Plumbaginis Zeylanicae 20g.Parts by weights another name gets above-mentioned raw materials, is cleaned by raw material, pours medicine pot into, soak 1 hour; Head is decocted: intense fire decocts to medicinal liquid boiling, uses slow fire instead and decocts 25 minutes again, leached by medicine juice; Two decoct: rejoin in medicine pot normal-temperature water paramount go out 0.5 centimetre, medical material plane, intense fire decoct to boiling after change slow fire boiling into 20 minutes, medicine juice is leached; Head is decocted and decocts gained medicine juice with two and merge.
Application method: with embodiment 1.
Clinic Case:
Remaining so-and-so, man, 46 years old, people from Pingnan County, rheumatoid arthritis 6 years, took 6 stiff symptoms of the posterior joint course for the treatment of continuously and takes a turn for the better.
Tooth so-and-so, female, 50 years old, people from Xingan County, rheumatoid arthritis 2 years, took 4 stiff transference cures of the posterior joint course for the treatment of continuously.
Embodiment 3:
Treat a strong drug composition for rheumatoid arthritis, raw material components is: the few 30g of ring, Herba Paederiae 30g, Herba Lycopodii 30g, Tetrastigma planicaule 40g, boon wind 30g, Herba Epimeredis Indicae 25g, Caulis et Folium hedyotis hedyotideae 15g, Rhizoma Drynariae 20g, Herba Cymbopogonis 15g, Radix Plumbaginis Zeylanicae 10g.Parts by weights another name gets above-mentioned raw materials, is cleaned by raw material, pours medicine pot into, soak 1 hour; Head is decocted: intense fire decocts to medicinal liquid boiling, uses slow fire instead and decocts 25 minutes again, leached by medicine juice; Two decoct: rejoin in medicine pot normal-temperature water paramount go out 0.5 centimetre, medical material plane, intense fire decoct to boiling after change slow fire boiling into 20 minutes, medicine juice is leached; Head is decocted and decocts gained medicine juice with two and merge.
Application method: with embodiment 1.
Clinic Case:
Cover so-and-so, man, 48 years old, people from Shanglin County, rheumatoid arthritis 4 years, take continuously 6 the course for the treatment of posterior joint swell and ache, the good symptom of stiff symptom obviously improves.
Xue so-and-so, female, 52 years old, Fructus Mali pumilae people from county, rheumatoid arthritis 4 years, take continuously 6 the course for the treatment of posterior joint swell and ache, stiff symptom alleviates substantially.
Below the clinical statistics data that patient uses medicine of the present invention:
1 basic document
Gather hospital admission patient, with reference to Americanism damp disease institute (ACR) the rheumatoid arthritis revised standard that proposes in 1987, rheumatoid arthritis is diagnosed.Show as with bed: 1, refuse to budge morning continuous at least 1 hour.2, the soft tissue swelling (arthritis) of the joint part of more than 3 or 3 is had.3, metacarpophalangeal joints, proximal interphalangeal joint or type joint swelling are more than 6 weeks or 12 weeks.4, symmetrical swelling (arthritis), namely identical joint, health both sides simultaneously or first sequela.5, X-ray film display hands and (or) carpal joint cartilage surface are that rotten to the corn sample and (or) periarticular osteoporosis change.6, rheumatoid factor positive person enters group, totally 240 examples, wherein man 125 example, female 111 example, 35 ~ 70 years old age, the state of an illness 3 ~ 10 years.
2 experiment groupings
Patient is divided into 3 groups at random, comprises treatment group 1, treatment group 2, matched group, often organize 80 examples.
3 therapeutic schemes
Treatment group 1 adopts medicine and the Therapeutic Method of embodiment 1, and every day, potion, point took for 2 times, and serveing on 15 days is 1 course for the treatment of; Treatment group 2 adopts medicine and the Therapeutic Method of embodiment 2, and every day, potion, point took for 2 times, and serveing on 15 days is 1 course for the treatment of; Matched group: with Chinese patent medicine XIAOHUOLUO WAN oral medication, each 1 ball, one day twice, warm water was taken.Taking continuously 15 days is a course for the treatment of.Treatment group and matched group all observe 4 courses for the treatment of.
4 efficacy determinations
The efficacy assessment standard of rheumatoid arthritis is drafted as curing: ankylosis, to swell and ache and clinical sign disappears, and does not show effect more than 2 years; Effective: ankylosis, swelling and ache alleviates; Do not heal: symptom is without obvious change.
5 statistical procedures
Adopt SPSS20.0 statistical software to analyze, enumeration data adopts X 2 test, and measurement data adopts t inspection.Be that difference has statistical significance with P<0.05.
6 experimental results
Treatment group 1 cures 63 examples, effective 10 examples, invalid 7 examples, total effective rate 91.25%; Treatment group 2 cures 53 examples, effective 21 examples, invalid 6 examples, total effective rate 92.5%; Matched group cures 50 examples, effective 14 examples, invalid 16 examples, total effective rate 80%.Treatment group compares with matched group, and difference has statistical significance.Treatment group clinical efficacy is better than matched group.
Table 1 matched group and treatment group Clinical efficacy comparison
Note: compare with matched group, P<0.05.
Claims (2)
1. treat the strong drug composition of rheumatoid arthritis for one kind, it is characterized in that: its raw material, with parts by weight, comprises few 20 ~ 50 parts of ring, Herba Paederiae 20 ~ 50 parts, Herba Lycopodii 20 ~ 40 parts, Tetrastigma planicaule 20 ~ 40 parts, boon wind 10 ~ 40 parts, Herba Epimeredis Indicae 10 ~ 50 parts, Caulis et Folium hedyotis hedyotideae 10 ~ 40 parts, Rhizoma Drynariae 10 ~ 30 parts, Herba Cymbopogonis 10 ~ 30 parts, Radix Plumbaginis Zeylanicae 10 ~ 30 parts.
2. a kind of strong drug composition for the treatment of rheumatoid arthritis as claimed in claim 1, is characterized in that: dosage form is decoction.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108568034A (en) * | 2018-03-14 | 2018-09-25 | 广西中医药大学 | A kind of graphene strengthens medicine infrared treatment head-shield and its preparation, purposes and application process |
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| CN103272064A (en) * | 2013-06-17 | 2013-09-04 | 贵州鸿德中药开发有限公司 | Traditional Chinese medicine for treating rheumatoid arthritis and preparation method of traditional Chinese medicine |
| CN104096142A (en) * | 2014-07-16 | 2014-10-15 | 刘斌 | Medicine for treating arthritis and arthralgia |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272064A (en) * | 2013-06-17 | 2013-09-04 | 贵州鸿德中药开发有限公司 | Traditional Chinese medicine for treating rheumatoid arthritis and preparation method of traditional Chinese medicine |
| CN104096142A (en) * | 2014-07-16 | 2014-10-15 | 刘斌 | Medicine for treating arthritis and arthralgia |
Non-Patent Citations (2)
| Title |
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| 何天有等: "《何氏药物铺灸疗法》", 30 June 2010, 中国中医药出版社 * |
| 钟鸣等: "《常用壮药临床手册》", 31 July 2010, 广西科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108568034A (en) * | 2018-03-14 | 2018-09-25 | 广西中医药大学 | A kind of graphene strengthens medicine infrared treatment head-shield and its preparation, purposes and application process |
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