CN105481759A - Synthesis method of light stabilizer N,N-bis-(2,2,6,6-tetramethyl-4-piperidyl) isophthalamide - Google Patents
Synthesis method of light stabilizer N,N-bis-(2,2,6,6-tetramethyl-4-piperidyl) isophthalamide Download PDFInfo
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- CN105481759A CN105481759A CN201610033043.9A CN201610033043A CN105481759A CN 105481759 A CN105481759 A CN 105481759A CN 201610033043 A CN201610033043 A CN 201610033043A CN 105481759 A CN105481759 A CN 105481759A
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- tetramethyl
- piperidyl
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- isophtalamide
- photostabilizer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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Abstract
The invention discloses a synthesis method of light stabilizer N,N-bis-(2,2,6,6-tetramethyl-4-piperidyl) isophthalamide. Isophthaloyl dichloride and 2,2,6,6-tetramethyl-4-piperidyl are taken as raw materials and react in the presence of a catalyst and a solvent, and N,N-bis-(2,2,6,6-tetramethyl-4-piperidyl) isophthalamide is prepared. According to the synthesis method of the N,N-bis-(2,2,6,6-tetramethyl-4-piperidyl) isophthalamide, the separation and purification process is simple, the reaction time is short, the product yield can be higher than 96%, the product purity is higher, the energy consumption is low, the environmental pollution is small, the cost is low, and the method is a more ideal process for industrial production.
Description
Technical field
The present invention relates to a kind of photostabilizer N, N, the synthetic method of-bis--(2,2,6,6-tetramethyl--4-piperidyl) isophtalamide.
Background technology
N, N ,-bis--(2,2,6,6-tetramethyl--4-piperidyl) isophtalamide, white crystalline solid, be excellent photostabilizer, tint permanence is little, and volatility is low, acid and alkali-resistance.Be applicable to the photostabilizer of polypropylene, polyethylene, igelite, can be used alone, also can with benzophenone ultraviolet absorption agent or phosphite ester kind antioxidant and use, have good synergistic effect, its molecular formula is C
26h
42o
2n
4, molecular weight is 442.56, molecular structural formula:
Its outward appearance is white crystalline solid, fusing point is 270-275 DEG C, N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) synthetic method of isophtalamide mainly contains direct esterification, Williamson (A.W.Williamson) method and phase transfer catalysis process, aforesaid method can generate N in theory, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide, usually can by m-phthalic acid, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine and sulfur oxychloride are that raw material carries out contracting and reacting obtaining, but the chloride ability of sulfur oxychloride is more weak, need to use excessive sulfur oxychloride, even so, the yield of product is also very low, therefore select m-phthaloyl chloride comparatively reasonable.This research is that raw material directly carries out contracting and reacting with m-phthaloyl chloride, 2,2,6,6-tetramethyl--4-piperylhydrazines, generates N, N ,-bis--(2,2,6,6-tetramethyl--4-piperidyl) isophtalamide.Experimental result shows, experiment condition is gentle, and the reaction times is short, easy and simple to handle, good product quality.
Summary of the invention
The object of the invention is, in order to overcome above deficiency, to provide the N that a kind of product yield is high, N, the synthetic method of-bis--(2,2,6,6-tetramethyl--4-piperidyl) isophtalamide.
The present invention is achieved through the following technical solutions: a kind of photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) synthetic method of isophtalamide, it is characterized in that: be with m-phthaloyl chloride, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine is main raw material, condensation reaction is carried out under catalysts and solvents existent condition, described m-phthaloyl chloride, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine, catalyzer, the usage ratio of solvent is 1:1.57 ~ 1.85:0.025 ~ 0.075:1.5 ~ 3.0 by mass, the temperature of condensation reaction is 110 ~ 120 DEG C, reaction times is 4.5-10h, after reaction terminates, under violent stirring, by in the aqueous solution of slow for reactant impouring alkali, remove excessive unreacted m-phthaloyl chloride, and then reflux water-dividing, be cooled to 15-20 DEG C and carry out crystallization, filtration can obtain photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide.
Further improvement of the present invention is: described catalyzer is aluminum chloride or iron trichloride or zinc dichloride.
Further improvement of the present invention is: described solvent is benzene or toluene or dimethylbenzene.
Further improvement of the present invention is: described alkali is sodium hydroxide or potassium hydroxide or sodium carbonate or salt of wormwood.
The present invention compared with prior art has the following advantages: the present invention synthesizes N, N ,-bis--(2,2,6,6-tetramethyl--4-piperidyl) isophtalamide, separating-purifying process is simple, reaction times is moderate, and product yield can reach more than 96%, and product purity is higher, less energy consumption, environmental pollution is little, and cost is low, is the comparatively ideal technique realizing suitability for industrialized production.
embodiment:
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, and following examples only for explaining the present invention, do not form limiting the scope of the present invention.
Invention shows a kind of photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) embodiment of synthetic method of isophtalamide, with m-phthaloyl chloride, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine is main raw material, condensation reaction is carried out under catalysts and solvents existent condition, described m-phthaloyl chloride, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine, catalyzer, the usage ratio of solvent is 1:1.57 ~ 1.85:0.025 ~ 0.075:1.5 ~ 3.0 by mass, the temperature of condensation reaction is 110 ~ 120 DEG C, reaction times is 4.5-10h, after reaction terminates, under violent stirring, by in the aqueous solution of slow for reactant impouring alkali, remove excessive unreacted m-phthaloyl chloride, and then reflux water-dividing, be cooled to 15-20 DEG C and carry out crystallization, filtration can obtain photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide.Catalyzer is aluminum chloride or iron trichloride or zinc dichloride, the preferred aluminum chloride of catalyzer of the present invention, solvent is benzene or toluene or dimethylbenzene, the preferred toluene of solvent of the present invention, alkali is sodium hydroxide or potassium hydroxide or sodium carbonate or salt of wormwood, the preferred sodium hydroxide of alkali of the present invention.
Embodiment one: electric mixer is being housed, in four mouthfuls of reaction flasks of reflux exchanger and thermometer, add m-phthaloyl chloride 20.3g successively, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine 32g, solvent 35g, catalyzer 0.55g, load onto reflux condensing tube, thermometer, start agitator, when being warming up to 110 DEG C, start timing, reaction times 4.5-10h, after reaction terminates, under violent stirring, by in the aqueous solution of slow for reactant impouring alkali, remove unreacted m-phthaloyl chloride, and then reflux water-dividing, be cooled to 15-20 DEG C and carry out crystallization, filtration can obtain photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide, photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide yield reaches 96.12%, fusing point is 270-275 DEG C.
Embodiment two: electric mixer is being housed, in four mouthfuls of reaction flasks of reflux exchanger and thermometer, add m-phthaloyl chloride 20.3g successively, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine 33.6g, solvent 35g, catalyzer 0.55g, load onto reflux condensing tube, thermometer, start agitator, when being warming up to 110 DEG C, start timing, reaction times 4.5-10h, after reaction terminates, under violent stirring, by in the aqueous solution of slow for reactant impouring alkali, remove unreacted m-phthaloyl chloride, and then reflux water-dividing, be cooled to 15-20 DEG C and carry out crystallization, filtration can obtain photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide, photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide yield reaches 96.78%, fusing point is 270-275 DEG C.
Embodiment three: electric mixer is being housed, in four mouthfuls of reaction flasks of reflux exchanger and thermometer, add m-phthaloyl chloride 20.3g successively, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine 33.6g, solvent 45g, catalyzer 0.55g, load onto reflux condensing tube, thermometer, start agitator, when being warming up to 110 DEG C, start timing, reaction times 4.5-10h, after reaction terminates, under violent stirring, by in the aqueous solution of slow for reactant impouring alkali, remove unreacted m-phthaloyl chloride, and then reflux water-dividing, be cooled to 15-20 DEG C and carry out crystallization, filtration can obtain photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide, photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide yield reaches 96.35%, fusing point is 270-275 DEG C.
Embodiment four: electric mixer is being housed, in four mouthfuls of reaction flasks of reflux exchanger and thermometer, add m-phthaloyl chloride 20.3g successively, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine 37.5g, solvent 45g, catalyzer 0.95g, load onto reflux condensing tube, thermometer, start agitator, when being warming up to 110 DEG C, start timing, reaction times 4.5-10h, after reaction terminates, under violent stirring, by in the aqueous solution of slow for reactant impouring alkali, remove unreacted m-phthaloyl chloride, and then reflux water-dividing, be cooled to 15-20 DEG C and carry out crystallization, filtration can obtain photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide, photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide yield reaches 97.09%, fusing point is 270-275 DEG C.
Embodiment five: electric mixer is being housed, in four mouthfuls of reaction flasks of reflux exchanger and thermometer, add m-phthaloyl chloride 20.3g successively, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine 36g, solvent 60g, catalyzer 1.5g, load onto reflux condensing tube, thermometer, start agitator, when being warming up to 110 DEG C, start timing, reaction times 4.5-10h, after reaction terminates, under violent stirring, by in the aqueous solution of slow for reactant impouring alkali, remove unreacted m-phthaloyl chloride, and then reflux water-dividing, be cooled to 15-20 DEG C and carry out crystallization, filtration can obtain photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide, photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide yield reaches 97.38%, fusing point is 270-275 DEG C.
Claims (4)
1. a photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) synthetic method of isophtalamide, it is characterized in that: be with m-phthaloyl chloride, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine is main raw material, condensation reaction is carried out under catalysts and solvents existent condition, described m-phthaloyl chloride, 2, 2, 6, 6-tetramethyl--4-piperylhydrazine, catalyzer, the usage ratio of solvent is 1:1.57 ~ 1.85:0.025 ~ 0.075:1.5 ~ 3.0 by mass, the temperature of condensation reaction is 110 ~ 120 DEG C, reaction times is 4.5-10h, after reaction terminates, under violent stirring, by in the aqueous solution of slow for reactant impouring alkali, remove excessive unreacted m-phthaloyl chloride, and then reflux water-dividing, be cooled to 15-20 DEG C and carry out crystallization, filtration can obtain photostabilizer N, N,-bis--(2, 2, 6, 6-tetramethyl--4-piperidyl) isophtalamide.
2. photostabilizer N, N according to claim 1, the synthetic method of-bis--(2,2,6,6-tetramethyl--4-piperidyl) isophtalamide, is characterized in that: described catalyzer is aluminum chloride or iron trichloride or zinc dichloride.
3. photostabilizer N, N according to claim 1, the synthetic method of-bis--(2,2,6,6-tetramethyl--4-piperidyl) isophtalamide, is characterized in that: described solvent is benzene or toluene or dimethylbenzene.
4. photostabilizer N, N according to claim 1, the synthetic method of-bis--(2,2,6,6-tetramethyl--4-piperidyl) isophtalamide, is characterized in that: described alkali is sodium hydroxide or potassium hydroxide or sodium carbonate or salt of wormwood.
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Cited By (5)
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| CN107382828A (en) * | 2017-08-02 | 2017-11-24 | 新秀化学（烟台）有限公司 | A kind of synthetic method of N, N ' two (piperidyl of 2,2,6,6 tetramethyl 4) 1,3 benzenedicarboxamides |
| CN111013493A (en) * | 2019-12-28 | 2020-04-17 | 萧县新秀新材料有限公司 | Pipeline reaction system and method for preparing light stabilizer |
| CN114015114A (en) * | 2021-11-10 | 2022-02-08 | 湖南岳化化工股份有限公司 | Hindered amine light stabilizer and preparation method and application thereof |
| CN115557935A (en) * | 2022-10-17 | 2023-01-03 | 南通大学 | Preparation method of hindered amine light stabilizer |
| CN117903040A (en) * | 2023-12-12 | 2024-04-19 | 江苏富比亚化学品有限公司 | Preparation method of nylon auxiliary N, N' -bis (2, 6-tetramethyl-4-piperidinyl) -1, 3-phthalamide |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107382828A (en) * | 2017-08-02 | 2017-11-24 | 新秀化学（烟台）有限公司 | A kind of synthetic method of N, N ' two (piperidyl of 2,2,6,6 tetramethyl 4) 1,3 benzenedicarboxamides |
| CN107382828B (en) * | 2017-08-02 | 2020-05-12 | 烟台新秀化学科技股份有限公司 | Synthesis method of N, N' -bis (2,2,6, 6-tetramethyl-4-piperidyl) -1, 3-benzenedicarboxamide |
| CN111013493A (en) * | 2019-12-28 | 2020-04-17 | 萧县新秀新材料有限公司 | Pipeline reaction system and method for preparing light stabilizer |
| CN114015114A (en) * | 2021-11-10 | 2022-02-08 | 湖南岳化化工股份有限公司 | Hindered amine light stabilizer and preparation method and application thereof |
| CN115557935A (en) * | 2022-10-17 | 2023-01-03 | 南通大学 | Preparation method of hindered amine light stabilizer |
| CN117903040A (en) * | 2023-12-12 | 2024-04-19 | 江苏富比亚化学品有限公司 | Preparation method of nylon auxiliary N, N' -bis (2, 6-tetramethyl-4-piperidinyl) -1, 3-phthalamide |
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