CN105477268A - Traditional Chinese medicine patch for treating osseous rheumatism and preparation method thereof - Google Patents

Traditional Chinese medicine patch for treating osseous rheumatism and preparation method thereof Download PDF

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CN105477268A
CN105477268A CN201511031696.5A CN201511031696A CN105477268A CN 105477268 A CN105477268 A CN 105477268A CN 201511031696 A CN201511031696 A CN 201511031696A CN 105477268 A CN105477268 A CN 105477268A
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chinese medicine
herba
medicine patch
radix
traditional chinese
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张茂全
刘宝龙
宋彩霞
张婷婷
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88Liliopsida (monocotyledons)
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    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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    • A61K2236/30Extraction of the material
    • A61K2236/35Extraction with lipophilic solvents, e.g. Hexane or petrol ether

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Abstract

The invention discloses a traditional Chinese medicine patch for treating osseous rheumatism and a preparation method thereof. The traditional Chinese medicine patch is prepared from Chinese herbal medicine and auxiliary materials, wherein the Chinese herbal medicine comprises, by weight, 8 g of rhizoma dioscoreae nipponicae, 8 g of caesalpinia cucullata, 8 g of clematis argentilucida, 6 g of scorpions, 6 g of buddleja asiatica, 10 g of stellaria saxatilis buch.-ham.[s. vestita kurz], 8 g of prepared kusnezoff monkshood roots, 10 g of hemsley monkshood roots, 8 g of neocinnamomum poilanei h. liou, 8 g of whitewood, 5 g of Chinese silkvine root-bark, 8 g of common bluebeard herbs, 6 g of parish's ironweed, 6 g of tarenna attenuata (voigt) hutch and 6 g of radix angelicae; the auxiliary materials comprise, by weight, 200 g of sesame oil and 200 g of yellow lead. The traditional Chinese medicine patch can achieve the effects of dispelling wind, eliminating dampness, relaxing muscles and tendons, promoting blood circulation and relieving pain, when the traditional Chinese medicine patch is used for treating osseous rheumatism, no side effect is caused, the recurrence rate is low, and the pharmacological effect is remarkable.

Description

A kind ofly treat wet Chinese medicine patch of GUFENG and preparation method thereof
Technical field
The present invention relates to and a kind ofly treat wet Chinese medicine patch of GUFENG and preparation method thereof.
Background technology
Rheumatism is one group, and to invade joint, skeleton, muscle, blood vessel and relevant soft tissue or connective tissue be the disease led, and wherein majority is autoimmune disease.Morbidity is much more hidden and slow, and the course of disease is longer, and mostly has genetic predisposition.Treatment and diagnosis all acquires a certain degree of difficulty; How different autoantibodys can be checked out in blood, may be relevant from different HLA hypotype; To nonsteroidal anti-inflammatory agent (NSAID), glucocorticoid and immunosuppressant have good short-term or the reaction of long-term palliative.And the medicine for the treatment of rheumatism can be divided into following a few class: 1. nonsteroidal anti-inflammatory agent (NSAIDs), the effect of this type of medicine, is mainly antipyretic, antiinflammatory and analgesia; Conventional has ibuprofen, diclofenac, indomethacin, piroxicam, naproxen etc., but the pharmacokinetics of various medicine and untoward reaction different, mainly to gastrointestinal, kidney, liver and blood system, must note dosage during use, usage, side effect etc.; 2. adrenocortical hormone, mainly refer to glucocorticoid, because this kind of medicine has antiinflammatory and immunosuppressive action, have more by force and diminish inflammation fast and various symptoms that inflammatory reaction brings, but because it not effects a radical cure medicine, long-term a large amount of use can bring out infection, osteoporosis, femur head necrosis, diabetes, peptic ulcer, hypertension, psychological problem etc.; And easy generation state of an illness rebound phenomenon as too fast in drug withdrawal; 3. the antirheumatic (DMARDs) improving the state of an illness is also called and acts on antirheumatic slowly, and it is different that this type of medicine comprises numerous species structure, acts on different medicine.Their general character is that onset is slow, has certain cumulative action, therefore after drug withdrawal, event resolves is also comparatively slow, still can maintain a period of time.Internal organs (the liver that above, various medicine is wanted body weight for humans, kidney, bladder, lung, gastrointestinal, gonad) and tissue (bone marrow) toxic action of having nothing in common with each other, so use time comparatively careful, also have some other treatments comprise Tripterygium glycosides, Pa Fulin, Yun Ke etc., although this type for the treatment of mostly be direct injection treat effect pretty good, taboo scope is comparatively large, and part special population can not use.
Summary of the invention
The object of the present invention is to provide one to have no side effect, relapse rate is low, and drug effect is remarkable, easy to use, and the Chinese medicine patch that the wide treatment GUFENG of the scope of application is wet.
For solving the problems of the technologies described above, the present invention adopts following technical scheme: a kind of Chinese medicine patch for the treatment of GUFENG and wetting, and described Chinese medicine patch includes Chinese herbal medicine and adjuvant;
Described herbal component and parts by weight proportioning are: Rhizoma Dioscoreae Nipponicae 6-8g, Radix Zanthoxyli Spinifolii 8-10g, clematis biondiana Pavolini 8-10g, Scorpio 5-8g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 6-8g, Herba Cucubali 8-10g, Radix Aconiti Kusnezoffii Preparata 6-8g, Radix aconiti hemsleyani 8-10g, hundred taste leaf 6-8g, Rhizoma Atractylodis macrocephalae 6-8g, Cortex Periplocae 5-8g, Herba Caryopteridis Incanae 6-9g, Vernonia parishii Hook. F. 6-8g, reach logical sequence wood 6-8g, Radix Angelicae Dahuricae 6-8g;
Adjuvant component and parts by weight proportioning are: Oleum sesami 200-220g, Plumbum preparatium 200-220g.
Rhizoma Dioscoreae Nipponicae 8g, Radix Zanthoxyli Spinifolii 8g, clematis biondiana Pavolini 8g, Scorpio 6g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 6g, Herba Cucubali 10g, Radix Aconiti Kusnezoffii Preparata 8g, Radix aconiti hemsleyani 10g, hundred taste leaf 8g, Rhizoma Atractylodis macrocephalae 8g, Cortex Periplocae 5g, Herba Caryopteridis Incanae 8g, Vernonia parishii Hook. F. 6g, reach logical sequence wood 6g, Radix Angelicae Dahuricae 6g; Oleum sesami 200g, Plumbum preparatium 200g.
Present invention also offers the preparation method of the Chinese medicine patch that above-mentioned treatment GUFENG wets, comprise the following steps:
1) get the raw materials ready: proportioning is extracted Rhizoma Dioscoreae Nipponicae 6-8g, Radix Zanthoxyli Spinifolii 8-10g, clematis biondiana Pavolini 8-10g, Scorpio 5-8g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 6-8g, Herba Cucubali 8-10g, Radix Aconiti Kusnezoffii Preparata 6-8g, Radix aconiti hemsleyani 8-10g, hundred taste leaf 6-8g, Rhizoma Atractylodis macrocephalae 6-8g, Cortex Periplocae 5-8g, Herba Caryopteridis Incanae 6-9g, Vernonia parishii Hook. F. 6-8g, reached logical sequence wood 6-8g, Radix Angelicae Dahuricae 6-8g and grind to form medicamental pulverata after cleaning up by weight; Get Oleum sesami, Plumbum preparatium is for subsequent use;
2) soak: get step 1) in the medicamental pulverata of grinding be immersed in Oleum sesami, soaks after 7 days, fry and decoct into brownish black, elimination medicinal residues to spice in importing pot, medicine oil is stand-by;
3) refine oil: step 2) in medicine oil, use big fire heating oil refining, stir simultaneously, be heated to pasta has smog to stop heating, add Plumbum preparatium and be stirred to Plumbum preparatium and all melt;
4) releasing fire-toxin: step 3) plaster pour in cold water and soak more than 24 hours, take out after plaster and be applied on hospital gauze, namely packaging seal obtains described Chinese medicine patch.
The using method of above-mentioned Chinese medicine patch is: apply at sufferer place, within every 12 hours, changes once, two courses for the treatment of Monday.
The Chinese medicine patch that treatment GUFENG of the present invention is wet, effect of its medical material is as follows:
Rhizoma Dioscoreae Nipponicae: property is put down, bitter in the mouth; Return liver, lung meridian; Expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral.Before main air arthralgia chiefly caused by damp pathogen; Numb limbs and tense tendons; Traumatic injury.
Radix Zanthoxyli Spinifolii: pungent, temperature.Expelling wind and cold, relaxing muscles and tendons to promote blood circulation, analgesia.Dispelling the wind and dampness pathogens is numb, traumatic injury.
Clematis biondiana Pavolini: diuresis, removing toxic substances, rheumatism;
Scorpio: primary medicinal component is charybdotoxin, carries according to Compendium of Material Medica and " Chinese Pharmacopoeia ", function that Scorpio has " spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain ".
Herba Gendarussae (Caulis et Folium Gendarussae vulgaris): promoting tissue regeneration by removing blood stasis, reducing swelling and alleviating pain, controls traumatic injury, fracture, rheumatic ostalgia;
Herba Cucubali: dampness removing, promoting blood circulation and stopping pain;
Radix Aconiti Kusnezoffii Preparata: pungent, heat, very toxic.Enter liver, spleen channel, wind-damp dispelling, dispersing cold for relieving pain, detumescence.Control anemofrigid-damp arthralgia; Arthralgia; Wind syndrome of head is had a headache; Traumatic injury; Swelling and pain due to blood stasis; Carbuncle of yin nature toxic swelling; Narcotic analgesic.
Radix aconiti hemsleyani: spasmolytic, blood pressure lowering, diaphoresis, diuresis;
Hundred taste leaves: promoting blood circulation by removing blood stasis, dispersing cold for relieving pain;
Rhizoma Atractylodis macrocephalae: control treating swelling and pain by traumatic injury, fracture, sprains, rheumatalgia, laryngalgia;
Cortex Periplocae: nature and flavor are warm in nature, acrid in the mouth, hardship; Function cures mainly wind-damp dispelling, bone and muscle strengthening.For anemofrigid-damp arthralgia, soreness of the waist and knees, edema of lower limbs.
Herba Caryopteridis Incanae: expelling wind and removing dampness, cough-relieving dissipating blood stasis;
Vernonia parishii Hook. F.: expelling wind and clearing away heat, nourish heart tonify deficiency;
Reach logical sequence wood: detumescence of dispeling the wind, eliminating stasis to stop pain;
The Radix Angelicae Dahuricae: be used as medicine with root, the functions such as the dehumidifying that gets rid of illness, evacuation of pus granulation promoting, promoting blood circulation and stopping pain.Cure mainly pain furuncle and phyma poison and wait disease, also can make spice.
The beneficial effect that the present invention treats the Chinese medicine patch that GUFENG wets is: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, and promoting blood circulation and stopping pain has no side effect, and relapse rate is low, and drug effect is remarkable, easy to use.
Detailed description of the invention
For the concrete function that can understand feature of the present invention, technological means further and reach, with detailed description of the invention, the present invention is described in further detail below.
Embodiment:
Treat the Chinese medicine patch that GUFENG is wet, described Chinese medicine patch includes Chinese herbal medicine and adjuvant;
Described herbal component and parts by weight proportioning are: Rhizoma Dioscoreae Nipponicae 8g, Radix Zanthoxyli Spinifolii 8g, clematis biondiana Pavolini 8g, Scorpio 6g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 6g, Herba Cucubali 10g, Radix Aconiti Kusnezoffii Preparata 8g, Radix aconiti hemsleyani 10g, hundred taste leaf 8g, Rhizoma Atractylodis macrocephalae 8g, Cortex Periplocae 5g, Herba Caryopteridis Incanae 8g, Vernonia parishii Hook. F. 6g, reach logical sequence wood 6g, Radix Angelicae Dahuricae 6g;
Adjuvant component and parts by weight proportioning are: Oleum sesami 200g, Plumbum preparatium 200g.
The preparation method process of the Chinese medicine patch that described treatment GUFENG wets is as follows:
1) get the raw materials ready: proportioning is extracted Rhizoma Dioscoreae Nipponicae 8g, Radix Zanthoxyli Spinifolii 8g, clematis biondiana Pavolini 8g, Scorpio 6g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 6g, Herba Cucubali 10g, Radix Aconiti Kusnezoffii Preparata 8g, Radix aconiti hemsleyani 10g, hundred taste leaf 8g, Rhizoma Atractylodis macrocephalae 8g, Cortex Periplocae 5g, Herba Caryopteridis Incanae 8g, Vernonia parishii Hook. F. 6g, reached logical sequence wood 6g, Radix Angelicae Dahuricae 6g by weight; Medicamental pulverata is ground to form after cleaning up; Get Oleum sesami 200g, Plumbum preparatium 200g is for subsequent use;
2) soak: get step 1) in the medicamental pulverata of grinding be immersed in Oleum sesami, soaks after 7 days, fry and decoct into brownish black, elimination medicinal residues to spice in importing pot, medicine oil is stand-by;
3) refine oil: step 2) in medicine oil, use big fire heating oil refining, stir simultaneously, be heated to pasta has smog to stop heating, add Plumbum preparatium and be stirred to Plumbum preparatium and all melt;
4) releasing fire-toxin: step 3) plaster pour in cold water and soak more than 24 hours, take out after plaster and be applied on hospital gauze, namely packaging seal obtains described Chinese medicine patch.
Experimental example:
Experimental subject: suffer from the wet patient of GUFENG, be divided into 2 groups, often organize 10 people for 20.
Experimental technique and time: matched group uses usual manner to treat, experimental group uses the present invention to treat the wet Chinese medicine patch of GUFENG, contrast the rheumatoid factor (RF) that two groups of patients use front and back, writing time is two months, record number of times is once, after experiment terminates, two groups of patients that fully recovered are carried out to the check of half a year by a definite date.
Experimental result:
Sum up from experimental data, experimental group is better compared with the therapeutic effect of matched group, and experimental group is all fully recovered, and in check after half a year, recurrence does not appear in experimental group.
As can be seen here, the Chinese medicine patch that treatment GUFENG of the present invention wets compares existing medicine, good effect, and relapse rate is low.
Typical case:
Case 1: Zhao, man, 36 years old, company clerk, computer is bowed race, suffers from scapulohumeral periarthritis 2 years hurt like hells, can not raise one's arm, goes for a stroll during summer attack, once used the method treatments such as hot compress, massage, acupuncture, and had alleviation, do not recur in the future, use the Chinese medicine patch of this law, every day two pastes, and within 12 hours, changes once, use 7 days, symptom obviously alleviates, slightly sour swollen sense of discomfort, continue use after 7 days, pain disappears, can be freely movable.
Case 2: Yin, female 45 years old, gonarthromeningitis hydrops, knee joint has an intense pain, difficulty in walking, use Chinese medicine patch of the present invention, every day two pastes, and within 12 hours, change once, use 7 days, symptom obviously alleviates, walking pain alleviates, and continue use after 7 days, pain disappears, can be freely movable.

Claims (3)

1. treat the Chinese medicine patch that GUFENG is wet, it is characterized in that: described Chinese medicine patch includes Chinese herbal medicine and adjuvant;
Described herbal component and parts by weight proportioning are: Rhizoma Dioscoreae Nipponicae 6-8g, Radix Zanthoxyli Spinifolii 8-10g, clematis biondiana Pavolini 8-10g, Scorpio 5-8g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 6-8g, Herba Cucubali 8-10g, Radix Aconiti Kusnezoffii Preparata 6-8g, Radix aconiti hemsleyani 8-10g, hundred taste leaf 6-8g, Rhizoma Atractylodis macrocephalae 6-8g, Cortex Periplocae 5-8g, Herba Caryopteridis Incanae 6-9g, Vernonia parishii Hook. F. 6-8g, reach logical sequence wood 6-8g, Radix Angelicae Dahuricae 6-8g;
Adjuvant component and parts by weight proportioning are: Oleum sesami 200-220g, Plumbum preparatium 200-220g.
2. the Chinese medicine patch that treatment GUFENG according to claim 1 is wet, is characterized in that:
Described herbal component and parts by weight proportioning are: Rhizoma Dioscoreae Nipponicae 8g, Radix Zanthoxyli Spinifolii 8g, clematis biondiana Pavolini 8g, Scorpio 6g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 6g, Herba Cucubali 10g, Radix Aconiti Kusnezoffii Preparata 8g, Radix aconiti hemsleyani 10g, hundred taste leaf 8g, Rhizoma Atractylodis macrocephalae 8g, Cortex Periplocae 5g, Herba Caryopteridis Incanae 8g, Vernonia parishii Hook. F. 6g, reach logical sequence wood 6g, Radix Angelicae Dahuricae 6g;
Adjuvant component and parts by weight proportioning are: Oleum sesami 200g, Plumbum preparatium 200g.
3. prepare the method for the Chinese medicine patch that treatment GUFENG according to claim 1 wets, it is characterized in that: comprise the following steps:
1) get the raw materials ready: proportioning is extracted Rhizoma Dioscoreae Nipponicae 6-8g, Radix Zanthoxyli Spinifolii 8-10g, clematis biondiana Pavolini 8-10g, Scorpio 5-8g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 6-8g, Herba Cucubali 8-10g, Radix Aconiti Kusnezoffii Preparata 6-8g, Radix aconiti hemsleyani 8-10g, hundred taste leaf 6-8g, Rhizoma Atractylodis macrocephalae 6-8g, Cortex Periplocae 5-8g, Herba Caryopteridis Incanae 6-9g, Vernonia parishii Hook. F. 6-8g, reached logical sequence wood 6-8g, Radix Angelicae Dahuricae 6-8g and grind to form medicamental pulverata after cleaning up by weight; Get Oleum sesami, Plumbum preparatium is for subsequent use;
2) soak: get step 1) in the medicamental pulverata of grinding be immersed in Oleum sesami, soaks after 7 days, fry and decoct into brownish black, elimination medicinal residues to spice in importing pot, medicine oil is stand-by;
3) refine oil: step 2) in medicine oil, use big fire heating oil refining, stir simultaneously, be heated to pasta has smog to stop heating, add Plumbum preparatium and be stirred to Plumbum preparatium and all melt;
4) releasing fire-toxin: step 3) plaster pour in cold water and soak more than 24 hours, take out after plaster and be applied on hospital gauze, namely packaging seal obtains described Chinese medicine patch.
CN201511031696.5A 2015-12-31 2015-12-31 Traditional Chinese medicine patch for treating osseous rheumatism and preparation method thereof Pending CN105477268A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105582174A (en) * 2015-12-31 2016-05-18 张茂全 Traditional Chinese medicine plaster for treating bone rheumatism

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105582174A (en) * 2015-12-31 2016-05-18 张茂全 Traditional Chinese medicine plaster for treating bone rheumatism

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Application publication date: 20160413