CN105477168A - Traditional Chinese medicine preparation for treating anaphylactoid purpura - Google Patents

Traditional Chinese medicine preparation for treating anaphylactoid purpura Download PDF

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CN105477168A
CN105477168A CN201610005101.7A CN201610005101A CN105477168A CN 105477168 A CN105477168 A CN 105477168A CN 201610005101 A CN201610005101 A CN 201610005101A CN 105477168 A CN105477168 A CN 105477168A
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radix
chinese medicine
blood
medicine preparation
traditional chinese
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张加营
李梅
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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine preparation for treating anaphylactoid purpura. The traditional Chinese medicine preparation is prepared from, by weight, 3 parts of folium isatidis, 1 part of lithospermum, 1 part of cortex dictamni, 1 part of radix scrophulariae, 1 part of scutellaria baicalensis, 1 part of fructus forsythiae, 1 part of cornu bubali, 1 part of caltrop, 1 part of horsetail, 1 part of periostracum cicada, 1 part of rheum officinale, 1 part of moutan bark, 1 part of fructus kochiae and 1 part of roots of common peony. The traditional Chinese medicine preparation has the advantages of being exact in curative effect, quick in effect, free of relapse after the anaphylactoid purpura is cured and small in toxic and side effect.

Description

The Chinese medicine preparation for the treatment of anaphylactoid purpura
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of anaphylactoid purpura.
Background technology
Anaphylactoid purpura is that some antigen and antibodies form immune complex deposit and cause peripheral circulation disorders in blood vessel wall, a kind of pathological state that vascular permeability increases.Primary disease is apt to occur in child and teenager, very easily damages kidney, and sensitinogen is various and be difficult to find, and the many recurrent exerbation of disease are difficult to recovery from illness, belongs to the categories such as the blood disorder of Chinese medicine.
The pathogenic factor of anaphylactoid purpura be due to virus and streptococcus thereof or some sensitizer such as medicine or food and antibodies formed blood capillary that immune complex deposit causes in blood vessel wall and around the inflammation of thin vessels.Because the multiformity of primary disease paathogenic factor, and not easily quick and precisely find, so be just difficult to try to achieve its basic cause of disease, thus do not accomplish the object of " treatment must aim at the pathogenesis of disease ".But be which kind of paathogenic factor infringement human body all can cause struggle between vital QI and pathogen, bring out the immunologic rejection reaction of human body and occur in pyretic toxicity raw, damage blood vessels, network removing blood stasis overflows, and the stasis of blood is in subcutaneous and pathogenic.Clinically by dialectical, adopt the principle for the treatment of of heat-clearing and toxic substances removing, cooling blood, expelling wind, blood circulation promoting and blood stasis dispelling, vital energy benefiting and the kidney invigorating.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of anaphylactoid purpura, have the advantages that after determined curative effect, instant effect, healing, nothing recurs, toxic and side effects is little.
The Chinese medicine preparation for the treatment of anaphylactoid purpura of the present invention is made up of the raw material of Chinese medicine of following parts by weight: Folium Isatidis 3 parts, Radix Arnebiae (Radix Lithospermi) 1 part, Cortex Dictamni 1 part, Radix Scrophulariae 1 part, Radix Scutellariae 1 part, Fructus Forsythiae 1 part, Cornu Bubali 1 part, Fructus Tribuli 1 part, Herba Equiseti Hiemalis 1 part, Periostracum Cicadae 1 part, Radix et Rhizoma Rhei (processed) 1 part, Cortex Moutan 1 part, the Fructus Kochiae 1 part, Radix Paeoniae Rubra 1 part.
The preparation method of the Chinese medicine preparation of described treatment anaphylactoid purpura be get above-mentioned raw materials clean, roguing, first Cornu Bubali is filed broken put in multi-function extractor to add water be decocted first 15 minutes; Then put into Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni, Radix Scrophulariae, Radix Scutellariae, Fructus Forsythiae, Fructus Tribuli, Herba Equiseti Hiemalis, Periostracum Cicadae, Cortex Moutan, the Fructus Kochiae, Radix Paeoniae Rubra decocts with water 2 times.First time adds up the water of medical material 12 times of weight, decocts 30 minutes, and elder generation decocts with high heat and within 15 minutes, puts into Radix et Rhizoma Rhei (processed) again and make slow fire boiling into, leaches decocting liquid after decocting; The soak by water of second time totalling medical material 5 times of weight 15 minutes, leaches decocting liquid after decocting; Get twice decocting liquid and filter mixing, in heat-sealing bag, 100 DEG C of high temperature sterilizes, every packed 200ml is for subsequent use.
Usage and consumption: oral, adult and more than 30kg child 200ml, a twice-daily; 30kg and following child are by per kilogram of body weight 10ml every day.Two weeks is a course for the treatment of.
Points for attention and taboo:
Points for attention: avoid being affected by the cold, diet should be light, fasting fish Trionyx sinensis Wiegmann shrimp Eriocheir sinensis and maror; The food of not edible band additive and milk product.Not easily abuse medicine; Use no or little glucocorticoid as far as possible.Take medicine and will detect Liver and kidney function and routine urinalysis urine sediment analysis a course for the treatment of.
Taboo: Deficiency and coldness of spleen and stomach person is forbidden; Lupus erythematosus, dermatomyositis, dry syndrome, hepatorenal disease patient forbidding.
Drug action mechanism in the present invention is as follows:
Folium Isatidis: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.This product can be killed virus and can sterilizing, has the merit of hemostasis among blood cooling and ecchymoses removing concurrently, is the key medicine for the treatment of anaphylactoid purpura in fact.
Radix Arnebiae (Radix Lithospermi): promoting blood circulation and cooling blood, removing toxic substances rash.Be good at and control epidemic febrile disease and send out speckle to separate noxious heat in the blood system.
Cortex Dictamni: heat-clearing and toxic substances removing, removing damp to relieve itching.Have while removing toxic substances and alleviate human body to the effect of outside virulence factor sensitivity.
Radix Scrophulariae: eliminating fire and detoxication, removing heat from blood yin nourishing.Its dissipating rashes prevent kidney yin impaired of detoxifying when nourishing YIN to lower pathogenic fire.
Radix Scutellariae: eliminating fire and detoxication, heat clearing and damp drying, hemostasis, antiabortive.For bleeding due to blood-heat, digestive tract hemorrhage can be prevented.
Fructus Forsythiae: bitter, be slightly cold.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.With the effect of removing toxic substances expelling pathogenic factors from the exterior strengthen.
Cornu Bubali: heat-clearing and toxic substances removing, removing heat from blood.Be longer than and control intenseness of heat macule, hemorrhage.
Fructus Tribuli: suppressing the hyperactive liver liver heat removing, dispelling pathogenic wind for improving eyesight.With can eliminate some irritated hidden danger.
Herba Equiseti Hiemalis: dispelling wind and heat pathogens, improving eyesight, hemostasis.
Periostracum Cicadae: dispelling wind and heat pathogens, removing nebula to improve visual acuity, rash is antipruritic, relieving spasm by subduing liver-wind.
Radix et Rhizoma Rhei (processed): clearing away heat-fire, catharsis detoxifies, blood circulation promoting and blood stasis dispelling.This product tool is invigorated blood circulation, removing heat from blood, hemostasis, removing toxic substances merit, adjust six internal organs gas and except blood stasis in body.
Cortex Moutan: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.Macule is sent out for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases.
The Fructus Kochiae: antipyretic and itching-stopping.Some bacterial growth can be suppressed.
Radix Paeoniae Rubra: clearing away heat and cooling blood, stasis-dispelling and pain-killing.Be longer than into blood system, drive hot and suffocating, dissipating rashes rash.
The Chinese medicine preparation of the treatment anaphylactoid purpura that the present invention utilizes Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni, Radix Scrophulariae, Radix Scutellariae, Fructus Forsythiae, Cornu Bubali, Fructus Tribuli, Herba Equiseti Hiemalis, Periostracum Cicadae, Radix et Rhizoma Rhei (processed), Cortex Moutan, the Fructus Kochiae, Radix Paeoniae Rubra to be made into, be a kind of have heat-clearing and toxic substances removing, cooling blood for hemostasis, the speckle removing effect that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. one newly create prescription, clinical efficacy is remarkable.Why be new wound, be because it changes prescription theory in the past, use the viewpoint formula of the combination of Chinese and Western medicine.Folium Isatidis is reused as monarch drug, can either heat-clearing and toxic substances removing to remove the bacterium of invading in body, again can cooling blood for hemostasis speckle removing to dissolve the stasis of blood in subcutaneous purpura, and gastrointestinal can be prevented hemorrhage.Radix Arnebiae (Radix Lithospermi) promoting blood circulation and cooling blood, removing toxic substances speckle removing; Coordinate blood cooling and ecchymoses removing multiplying action to be ministerial drug with Folium Isatidis.Radix Scrophulariae, Radix Scutellariae, Fructus Forsythiae, Cornu Bubali, Radix et Rhizoma Rhei (processed), Cortex Moutan, Radix Paeoniae Rubra help Folium Isatidis removing toxic substances pathogenic fire purging jointly, and cooling blood for hemostasis is adjuvant drug.Fructus Tribuli, Herba Equiseti Hiemalis, Periostracum Cicadae, the Fructus Kochiae search the wind in blood, and anti-harmful wind invasion is for making medicine.Full side's compatibility is dispelled bacterium in blood, only body internal hemorrhage, and resistant to blood is excessive, and disappear ecchymosis.Sterilization of gathering altogether is also antitoxin, invigorating blood circulation hemostasis of holding concurrently, removing heat from blood the effect of speckle removing.
The present invention compared with prior art, has following beneficial effect:
(1) the present invention combines clinical practice experience for many years to develop on the basis of Traditional Chinese Medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and all medicines are harmonious and have that heat-clearing and toxic substances removing eliminates cause of disease, cooling blood, expelling wind is driven away anaphylactogen, nourishing the liver and kidney and prevented the change of disease former.Treatment anaphylactoid purpura has determined curative effect, instant effect, feature that toxic and side effects is little.
(2) medicine selected by the present invention all meets the regulation of the Pharmacopoeia of the People's Republic of China, and safety of medicine is reliable.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1
Raw material of Chinese medicine forms: Folium Isatidis 3 parts, Radix Arnebiae (Radix Lithospermi) 1 part, Cortex Dictamni 1 part, Radix Scrophulariae 1 part, Radix Scutellariae 1 part, Fructus Forsythiae 1 part, Cornu Bubali 1 part, Fructus Tribuli 1 part, Herba Equiseti Hiemalis 1 part, Periostracum Cicadae 1 part, Radix et Rhizoma Rhei (processed) 1 part, Cortex Moutan 1 part, the Fructus Kochiae 1 part, Radix Paeoniae Rubra 1 part.
Preparation method be get above-mentioned raw materials clean, roguing, first Cornu Bubali is filed broken put in multi-function extractor to add water be decocted first 15 minutes; Then put into Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni, Radix Scrophulariae, Radix Scutellariae, Fructus Forsythiae, Fructus Tribuli, Herba Equiseti Hiemalis, Periostracum Cicadae, Cortex Moutan, the Fructus Kochiae, Radix Paeoniae Rubra decocts with water 2 times.First time adds up the water of medical material 12 times of weight, decocts 30 minutes, and elder generation decocts with high heat and within 15 minutes, puts into Radix et Rhizoma Rhei (processed) again and make slow fire boiling into, leaches decocting liquid after decocting; The soak by water of second time totalling medical material 5 times of weight 15 minutes, leaches decocting liquid after decocting; Get twice decocting liquid and filter mixing, in heat-sealing bag, 100 DEG C of high temperature sterilizes, every packed 200ml is for subsequent use.
Outcome measure:
Recovery from illness: skin purpura is disappeared, without suffering from abdominal pain, suffer from diarrhoea, have blood in stool, arthralgia symptom; Detect blood, urinalysis is all normal; Without recurrence within 2 years.
Take a turn for the better: skin purpura is disappeared, without suffering from abdominal pain, suffer from diarrhoea, have blood in stool, arthralgia symptom; Detect urinalysis have albumen and occult blood; Recur within 2 years.
Invalid: skin purpura is not disappeared, or with suffering from abdominal pain, suffering from diarrhoea, have blood in stool, or with arthralgia symptom; Or detection urinalysis has albumen and occults blood.
Therapeutic outcome:
Treatment group: from year January in January, 2010 to 2012 treat patients with anaphylactoid purpura 36 example, the age 4-16 year, wherein: man 17 example, female 19 example.Taking the present invention 15 days is a course for the treatment of.Through four course of therapy, recovery from illness 28 example, accounts for 77.8%, and take a turn for the better 5 examples, accounts for 13.9%, and invalid 3 examples, account for 8.3%, total cure rate 77.8%, total effective rate 91.7%.Shown in treating: this product is to patient's non-evident effect, and detecting urinalysis and chemically examining hepatic and renal function detection has a routine glutamate pyruvate transaminase slightly to raise.
Matched group: from year January in January, 2010 to 2012 treat patients with anaphylactoid purpura 35 example, the age 4-17 year, wherein: man 17 example, female 18 example.Taking the treatments such as prednisone, vitamin c, intravenous drip FUFANG DANSHEN ZHUSHEYE and antibiotic, 15 days is a course for the treatment of.Through four course of therapy, recovery from illness 10 example, accounts for 28.6%, and take a turn for the better 7 examples, accounts for 20.0%, and invalid 18 examples, account for 51.4%, total cure rate 28.6%, total effective rate 48.6%.Shown in treating: occur uncomfortable in chest, palpitation and short breath, fatigue and weakness 19 example; Stomachache, diarrhoea 6 example; Central obesity 7 example; Glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, glutaminase transpeptidase raise 5 examples.
Model case:
Case 1
Fan, man, 16 years old.Occur having a headache, having sore throat on May 13rd, 2011.There is punctation in bilateral skin of lower extremity immediately, bright-colored, with gargalesthesia, is symmetrically distributed, and do not move back by hands pressing redness.Remarkable with two lower limb internal malleolus position.Without symptoms such as stomachache, diarrhoea.The urine sediment analysis that has a routine urine test shows: urine protein+2, occults blood+2; All the other results of laboratory test and platelets analysis are all normal.
Diagnosis: anaphylactoid purpura
Treatment: oral Chinese medicine preparation of the present invention, a 200ml, one day twice, takes for 30 minutes after meal.
Result: take medicine one week, skin purpura is disappeared, chemical examination urine sediment analysis shows: urine protein disappears, and occults blood+1; Following the service is fully recovered after two months, does not recur so far again.
Case 2
Wei, female, 7 years old.Consultation time: on November 23rd, 2010.There is red macule, needle point size without the unexpected bilateral lower limb of obvious inducement in infant, symmetrical, by do not fade, without gargalesthesia, with stomachache.All the other are without exception.
Diagnosis: anaphylactoid purpura
Treatment: oral Chinese medicine preparation of the present invention, a 100ml, three times on the one.
Result: take medicine three days purpuras of infant disappear; Namely medication heals for ten days.
Case 3
Ma, man, 11 years old.Consultation time: on February 2nd, 2011.This child suffered from respiratory tract infection before one week, occurred heating, cough, nasal obstruction watery nasal discharge, had sore throat.Take a turn for the better after intravenous drip cefotaxime sodium injection and ribavirin injection immediately.In last night find the maculopapule that differing in size appears in bilateral buttocks and preaxial and come institute go to a doctor, color is scarlet, is symmetrically distributed, by redness do not move back.Chemical examination hemanalysis shows that platelet is normal; Routine urinalysis urine sediment analysis shows urine protein+2, and urine occults blood+3.
Diagnosis: anaphylactoid purpura
Treatment: oral Chinese medicine preparation of the present invention, a 200ml, one day twice, takes for 30 minutes after meal.
Result: take medicine one week, skin purpura reduces, and the urine sediment analysis that has a routine urine test shows: urine protein+1, occults blood+3; After continuing to take one month, skin purpura disappears, and urine protein+1, occults blood+1; Skin discovery without exception after continuing to take two months, routine urinalysis urine sediment analysis is without exception; So far do not recur again.

Claims (1)

1. treat a Chinese medicine preparation for anaphylactoid purpura, it is characterized in that being made up of the raw material of Chinese medicine of following parts by weight: Folium Isatidis 3 parts, Radix Arnebiae (Radix Lithospermi) 1 part, Cortex Dictamni 1 part, Radix Scrophulariae 1 part, Radix Scutellariae 1 part, Fructus Forsythiae 1 part, Cornu Bubali 1 part, Fructus Tribuli 1 part, Herba Equiseti Hiemalis 1 part, Periostracum Cicadae 1 part, Radix et Rhizoma Rhei (processed) 1 part, Cortex Moutan 1 part, the Fructus Kochiae 1 part, Radix Paeoniae Rubra 1 part.
CN201610005101.7A 2016-01-05 2016-01-05 Traditional Chinese medicine preparation for treating anaphylactoid purpura Pending CN105477168A (en)

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CN111228367A (en) * 2019-08-06 2020-06-05 湖北省中医院(湖北中医药大学附属医院、湖北省中医药研究院) Traditional Chinese medicine external lotion for treating infantile anaphylactoid purpura and preparation method thereof

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CN102283951A (en) * 2011-07-28 2011-12-21 北京中科血康血液病医学研究院 Chinese medicinal composition for treating anaphylactoid purpura and thrombocytopenic purpura
CN102716266A (en) * 2012-06-01 2012-10-10 于忠东 Buffalo horn-unprocessed rehmannia-lithospermum-cortex dictamni medicinal decoction for treating anaphylactoid purpura
CN102772684A (en) * 2012-07-16 2012-11-14 梁艳龙 Traditional Chinese medicinal preparation for treating allergic purpura
CN103690803A (en) * 2013-11-27 2014-04-02 刘闯 Traditional Chinese medicine preparation for treating anaphylactoid purpura
CN104587071A (en) * 2015-02-27 2015-05-06 韩建东 Traditional Chinese medicament for treating infantile blood-heat allergic purpura

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CN102283951A (en) * 2011-07-28 2011-12-21 北京中科血康血液病医学研究院 Chinese medicinal composition for treating anaphylactoid purpura and thrombocytopenic purpura
CN102716266A (en) * 2012-06-01 2012-10-10 于忠东 Buffalo horn-unprocessed rehmannia-lithospermum-cortex dictamni medicinal decoction for treating anaphylactoid purpura
CN102772684A (en) * 2012-07-16 2012-11-14 梁艳龙 Traditional Chinese medicinal preparation for treating allergic purpura
CN103690803A (en) * 2013-11-27 2014-04-02 刘闯 Traditional Chinese medicine preparation for treating anaphylactoid purpura
CN104587071A (en) * 2015-02-27 2015-05-06 韩建东 Traditional Chinese medicament for treating infantile blood-heat allergic purpura

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111228367A (en) * 2019-08-06 2020-06-05 湖北省中医院(湖北中医药大学附属医院、湖北省中医药研究院) Traditional Chinese medicine external lotion for treating infantile anaphylactoid purpura and preparation method thereof
CN111228367B (en) * 2019-08-06 2021-09-21 湖北省中医院(湖北中医药大学附属医院、湖北省中医药研究院) Traditional Chinese medicine external lotion for treating infantile anaphylactoid purpura and preparation method thereof

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Application publication date: 20160413