CN105476731A - Aortic valve device conveyed by catheter - Google Patents

Aortic valve device conveyed by catheter Download PDF

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Publication number
CN105476731A
CN105476731A CN201610029060.5A CN201610029060A CN105476731A CN 105476731 A CN105476731 A CN 105476731A CN 201610029060 A CN201610029060 A CN 201610029060A CN 105476731 A CN105476731 A CN 105476731A
Authority
CN
China
Prior art keywords
support frame
valve device
described support
aortic valve
air
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610029060.5A
Other languages
Chinese (zh)
Inventor
代高旭
周庆亮
孟坚
可大年
史欢欢
李阳
黄韬
杨宇霆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BEIJING MAIDI DINGFENG MEDICAL TECHNOLOGY Co Ltd
Beijing Med Zenith Medical Scientific Co Ltd
Original Assignee
BEIJING MAIDI DINGFENG MEDICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BEIJING MAIDI DINGFENG MEDICAL TECHNOLOGY Co Ltd filed Critical BEIJING MAIDI DINGFENG MEDICAL TECHNOLOGY Co Ltd
Priority to CN201610029060.5A priority Critical patent/CN105476731A/en
Publication of CN105476731A publication Critical patent/CN105476731A/en
Priority to PCT/CN2016/107225 priority patent/WO2017121195A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466Delivery devices therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

The invention discloses an aortic valve device conveyed by a catheter. The aortic valve device comprises a supporting frame, valve leaflets fixed to the inner side of the middle part of the supporting frame, and skirt rims which are fixed along the periphery of the inner side of the supporting frame and fixed to the valve leaflets. An upper horn mouth structure in a three-valve form is formed at the upper end of the supporting frame. Three round connecting claws used for loading the supporting frame are arranged at the tail end of the upper horn mouth structure. A tentacle structure expanding outwards and assisting location by clamping a valve ring is arranged at the outer side of the middle part of the supporting frame. A lower horn mouth structure used for reducing pervalvular leakage and expanding outwards is arranged at the bottom end of the supporting frame.

Description

A kind of through conduit conveying aortic valve valve device
Technical field
The present invention relates to medical instruments field, particularly relate to a kind of aortic valve valve device through conduit conveying.
Background technology
Along with increasing the weight of of aged tendency of population, the valve pathological changes caused after senile valvular heart disease and coronary heart disease, myocardial infarction is also more and more common.Surgical operation and the operative treatment such as Prosthetic valve replacement or valve forming are the radical cure methods of valvular heart disease, but for some advanced ages, multiple complication or the patient having surgery open chest surgery history, the mortality rate of surgery open chest surgery is very high.In recent years, along with the progress of interventional therapeutic technique, through this epoch-making technology of conduit artificial valve, push intervene operation to technology summit, and attempt all deficiencies solving surgery valve replacement.2002, the success that first case is performed the operation through conduit artificial valve replacement, indicated that this revolutionary interventional medicine technology has really entered into feasibility stage, through the development of 10 years, has had more than 10 ten thousand people by this reconstruction cardiac function, has obtained new life.
But existing aortic valve valve device or can recovery be discharged, but locate inaccurate; Or accurate positioning but can not reclaim; Or recovery can be discharged and accurate positioning, but indication is limited.
Summary of the invention
The object of the present invention is to provide a kind of aortic valve valve device through conduit conveying, for implantation into causing because of aortic stenosis in the original position aortic valve of pathological changes, to solve the problem of aortic valve valve device accurate positioning; Further, the problem adapting to various disease conditions is solved, as diseases such as independent aortic stenosis or incompetences.
The invention provides a kind of aortic valve valve device through conduit conveying, described aortic valve valve device comprises: support frame; Be fixed on the lobe leaf inside described support frame mid portion; And fix and the shirt rim fixing with described lobe leaf along described support frame inner peripheral; Wherein, the upper end of described support frame forms the upper bell-mouth structure of air in three lobe forms; Bell-mouth structure of air end has that three of loading for described support frame are circular connects pawls on described; The feeler structure by blocking lobe ring auxiliary positioning expanded outwardly is had outside the described mid portion of described support frame; There is the lower bell-mouth structure of air expanded outwardly for reducing perivalvular leakage the bottom of described support frame.
Selectively, described support frame is nickel-titanium alloy material; Described mid portion is vertical section, and the extent of opening of described lower bell-mouth structure of air is less than the extent of opening of described upper bell-mouth structure of air.
Selectively, described support frame is the network that the grid cell assumed diamond in shape is formed; And the inclination angle that the end of described upper bell-mouth structure of air and lower bell-mouth structure of air departs from the central axis of described support frame is respectively 1 ° to 15 °.
Selectively, described circle connects the center of pawl be circular or square through hole or without hole shape, described circular connection pawl is connected by short connecting rod with upper bell-mouth structure of air.
Selectively, described feeler structure is upwards expanded, and described feeler structure is uniformly distributed in described support frame circumferencial direction.Preferably, the feeler number of structures of described support frame is 3 to 9.
Preferably, the external diameter of a circle of the feeler structure of described support frame is greater than mid portion diameter 3mm to the 9mm of described support frame.
The lower bell-mouth structure of air of described support frame can for the straight bell-mouth structure of air in outside micro-expansion.
Selectively, the mid portion of described support frame and the upper bell-mouth structure of air of described support frame are connected to each other by short connecting rod.Selectively, described short connecting rod length is 1.5mm to 4mm, and width is 0.25mm to 1mm.
Selectively, the short connecting rod of left and right indent is adopted to connect between the adjacent described grid cell of described support frame.Selectively, the minimum widith of the short connecting rod of described left and right indent is 0.25mm to 0.5mm.
Selectively, the short connecting rod of described left and right indent is the concave inward structure that the concave inward structure that formed of two circular arcs in left and right or a bit of straightway add left and right circular arc and formed.
Selectively, the material of described lobe leaf is Cor Sus domestica bag, bovine pericardium, Cor Equi bag or macromolecular material politef; The material of described shirt rim is Cor Sus domestica bag, bovine pericardium, Cor Equi bag, macromolecular material politef or woven dacron.
Selectively, the feeler structure of described support frame and the bottom of described support frame are concave inward structure.
Selectively, described concave inward structure length is 1mm to 8mm.
Selectively, the diameter of described concave inward structure is consistent with the diameter of described support frame mid portion.
Selectively, described lower bell-mouth structure of air height is 3mm to 8mm, and its maximum gauge is greater than described concave inward structure 3mm to 6mm.
Advantage of the present invention is, by three the circular connection pawls being arranged to bell-mouth structure of air end in the support frame upper end of aortic valve valve, achieves loading and the release of aortic valve valve device; There is the feeler structure of outside micro-expansion state by the mid portion of support frame, achieve the accurate location of aortic valve valve device; By the straight bell-mouth structure of air of support frame bottom, decrease perivalvular leakage; Thus make operation process more safe and reliable.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of a kind of aortic valve valve device of the present invention;
Fig. 2 is the expansion schematic diagram of a kind of aortic valve valve device of the present invention;
Fig. 3 is the schematic diagram that aortic valve valve device of the present invention is loaded into induction system;
Fig. 4 is the schematic diagram of aortic valve valve device feeler structure release of the present invention;
Fig. 5 is the schematic diagram of aortic valve valve device feeler structure of the present invention and the release of support frame bottom;
Fig. 6 is that aortic valve valve device of the present invention discharges schematic diagram completely;
Fig. 7 is that aortic valve valve device of the present invention is at cardiac position feeler structure location schematic diagram;
Fig. 8 is that aortic valve valve device of the present invention is at cardiac position feeler structure and location, support frame bottom schematic diagram;
Fig. 9 is that aortic valve valve device of the present invention discharges schematic diagram completely at cardiac position;
Detailed description of the invention
Of the present invention a kind of through conduit conveying aortic valve valve device for implantation into causing because of aortic stenosis in the original position aortic valve of pathological changes, to solve the problem of aortic valve valve device accurate positioning; Further, the problem adapting to various disease conditions is solved, as diseases such as independent aortic stenosis or incompetences.
Below in conjunction with accompanying drawing, the embodiment of the present invention is described in further detail.
A kind of aortic valve valve device 100 as shown in Fig. 1 to Fig. 2, for implantation into causing in the original position aortic valve of pathological changes because of aortic stenosis, comprise: support frame, be fixed on the lobe leaf 104 inside described support frame mid portion, and fix and the shirt rim 102 fixing with described lobe leaf along described support frame inner peripheral.Furtherly, shirt rim 102 forms a circle along support frame surrounding, and fixes by suture; Lobe leaf 104 is three, is sewn in support frame mid portion, and sews up with shirt rim 102 is fixing.
Described support frame comprises: the upper bell-mouth structure of air 105 in three lobe forms of the upper end formation of described support frame; Bell-mouth structure of air end has that three of loading for described support frame are circular connects pawls 106 on described; The feeler structure 103 by blocking lobe ring auxiliary positioning expanded outwardly is had outside the described mid portion of described support frame; There is the lower bell-mouth structure of air 101 expanded outwardly for reducing perivalvular leakage the bottom of described support frame.(see Fig. 1)
The material of described support frame can be memorial alloy, such as, be nickel-titanium alloy material.
Described mid portion is vertical section, and the extent of opening of described lower bell-mouth structure of air 101 is less than the extent of opening of described upper bell-mouth structure of air 105.
Described support frame is the network that the grid cell assumed diamond in shape is formed; The short connecting rod of left and right indent is adopted to connect between the adjacent described grid cell of described support frame.Selectively, the minimum widith of the short connecting rod of described left and right indent is 0.25mm to 0.5mm.Selectively, the short connecting rod of described left and right indent is the concave inward structure that the concave inward structure that formed of two semicircles in left and right or a bit of straightway add left and right circular arc and formed.
The inclination angle that the end of described upper bell-mouth structure of air and lower bell-mouth structure of air departs from the central axis of described support frame is respectively 1 ° to 15 °.Lower bell-mouth structure of air 101 seamlessly transits with the mid portion of support frame; Mid portion and the upper bell-mouth structure of air 105 of support frame seamlessly transit; The mid portion of support frame is connected (please refer to Fig. 2) by short connecting rod 107 with upper bell-mouth structure of air 105, and described short connecting rod length is 1.5mm to 4mm, and width is 0.25mm to 1mm.Short connecting rod 108 is adopted to connect (please refer to Fig. 2) between the grid cell assumed diamond in shape of support frame; Upper bell-mouth structure of air 105 mid portion assumes diamond in shape expansion, and upper bell-mouth structure of air 105 is uniformly distributed in support frame surrounding; The circular pawl 106 that connects is connected by short connecting rod with upper bell-mouth structure of air 105, and circular to connect pawl 106 be hollow or solid construction, and furtherly, the center of described circular connection pawl 106 is circle or square through hole or without hole shape.
Lower bell-mouth structure of air 101 is connected by short connecting rod 108 with between feeler structure 103 and is concave inward structure (please refer to Fig. 1 and Fig. 2); Lower bell-mouth structure of air 101 is micro-bell-mouth structure of air expanded outwardly, for reducing perivalvular leakage; Feeler structure 103 is the horn mouth shape of upwards micro-expansion, for location (please refer to Fig. 1).
The material of described lobe leaf and the material of described shirt rim can be respectively Cor Sus domestica bag, bovine pericardium, Cor Equi bag or macromolecular material politef etc.
One described in the embodiment of the present invention is as follows through conduit conveying aortic valve valve device work process:
First described aortic valve valve device 100 is shunk by special device in the head end 201 and loading sheath 202 being loaded into induction system 200 (please refer to Fig. 3), moved backward by the loading sheath 202 of handle 203 by induction system 200, the feeler structure 103 of described aortic valve valve device 100 is discharged (please refer to Fig. 4 and Fig. 7), now due to described aortic valve valve device 100 material shape memory characteristic, feeler structure 103 automatic expansion, slowly push induction system 200 downwards, feeler structure 103 is made to touch human body natural's lobe leaf texture 300, stop pushing induction system 200.Moved forward by the head end 201 of handle 203 by induction system 200 again, the lower bell-mouth structure of air 101 of described aortic valve valve device 100 is discharged from the head end 201 of induction system 200, due to described aortic valve valve device 100 material shape memory characteristic, lower bell-mouth structure of air 101 automatic expansion (please refer to Fig. 5), human body natural's lobe leaf texture 300 is strutted, now human body natural's lobe leaf texture 300 is between the lower bell-mouth structure of air 101 of described aortic valve valve device 100 and feeler structure 103 (please refer to Fig. 8), described aortic valve valve device 100 completes accurate location.Again by the handle 203 of induction system 200, loading sheath 202 is continued to move backward, the upper bell-mouth structure of air 105 of described aortic valve valve device 100 is connected pawl 106 to discharge (please refer to Fig. 6) from loading sheath 202 with circle, due to the shape memory characteristic of described aortic valve valve device 100 material, upper bell-mouth structure of air 105 automatic expansion is to maximum, fixing (please refer to Fig. 9) is fitted with blood vessel wall, induction system 200 is connected pawl 106 with circle and departs from, finally withdraw from induction system 200, described aortic valve valve device 100 has been implanted.
Above embodiment is only for illustration of the present invention; and be not limitation of the present invention; the those of ordinary skill of relevant technical field; without departing from the spirit and scope of the present invention; can also make a variety of changes and modification; therefore all equivalent technical schemes also belong to category of the present invention, and scope of patent protection of the present invention should be defined by the claims.

Claims (10)

1., through an aortic valve valve device for conduit conveying, described aortic valve valve device comprises: support frame; Be fixed on the lobe leaf inside described support frame mid portion; And fix and the shirt rim fixing with described lobe leaf along described support frame inner peripheral; It is characterized in that: the upper end of described support frame forms the upper bell-mouth structure of air in three lobe forms; Bell-mouth structure of air end has that three of loading for described support frame are circular connects pawls on described; The feeler structure by blocking lobe ring auxiliary positioning expanded outwardly is had outside the described mid portion of described support frame; There is the lower bell-mouth structure of air expanded outwardly for reducing perivalvular leakage the bottom of described support frame.
2. aortic valve valve device according to claim 1, is characterized in that: described support frame is nickel-titanium alloy material; Described mid portion is vertical section, and the extent of opening of described lower bell-mouth structure of air is less than the extent of opening of described upper bell-mouth structure of air.
3. aortic valve valve device according to claim 1, is characterized in that: described support frame is the network that the grid cell assumed diamond in shape is formed; And the inclination angle that the end of described upper bell-mouth structure of air and lower bell-mouth structure of air departs from the central axis of described support frame is respectively 1 ° to 15 °.
4. aortic valve valve device according to claim 1, is characterized in that: the center of described circle connection pawl is for circle or square through hole or without hole shape, described circle is connected pawl and is connected by short connecting rod with upper bell-mouth structure of air.
5. aortic valve valve device according to claim 1, is characterized in that: described feeler structure is upwards expanded, and described feeler structure is uniformly distributed in described support frame circumferencial direction.
6. aortic valve valve device according to claim 1, is characterized in that: the mid portion of described support frame and the upper bell-mouth structure of air of described support frame are connected to each other by short connecting rod.
7. aortic valve valve device according to claim 3, is characterized in that: adopt the short connecting rod of left and right indent to connect between the adjacent described grid cell of described support frame.
8. aortic valve valve device according to claim 7, is characterized in that: the short connecting rod of described left and right indent is the concave inward structure that the concave inward structure that formed of two, left and right circular arc or a bit of straightway add left and right circular arc and formed.
9. aortic valve valve device according to claim 1, is characterized in that: the material of described lobe leaf is Cor Sus domestica bag, bovine pericardium, Cor Equi bag or macromolecular material politef; The material of described shirt rim is Cor Sus domestica bag, bovine pericardium, Cor Equi bag, macromolecular material politef or woven dacron.
10. aortic valve valve device according to claim 1, is characterized in that: the feeler structure of described support frame and the bottom of described support frame are concave inward structure.
CN201610029060.5A 2016-01-11 2016-01-11 Aortic valve device conveyed by catheter Pending CN105476731A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610029060.5A CN105476731A (en) 2016-01-11 2016-01-11 Aortic valve device conveyed by catheter
PCT/CN2016/107225 WO2017121195A1 (en) 2016-01-11 2016-11-25 Transcatheter aortic valve device having tentacle structures

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610029060.5A CN105476731A (en) 2016-01-11 2016-01-11 Aortic valve device conveyed by catheter

Publications (1)

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CN105476731A true CN105476731A (en) 2016-04-13

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WO (1) WO2017121195A1 (en)

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CN106510902A (en) * 2016-06-16 2017-03-22 马建录 Method and design used for mitral regurgitation treatment device
CN106890035A (en) * 2017-04-17 2017-06-27 乐普(北京)医疗器械股份有限公司 One kind is through conduit implanted aorta petal film device
WO2017121195A1 (en) * 2016-01-11 2017-07-20 北京迈迪顶峰医疗科技有限公司 Transcatheter aortic valve device having tentacle structures
WO2017121192A1 (en) * 2016-01-11 2017-07-20 北京迈迪顶峰医疗科技有限公司 Apparatus, having spinous positioning rods, for transcatheter delivery of aortic valve
WO2018077146A1 (en) * 2016-10-24 2018-05-03 宁波健世生物科技有限公司 Asymmetrical heart valve prosthesis
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CN108904101A (en) * 2018-06-29 2018-11-30 金仕生物科技(常熟)有限公司 Intervene valve component, the fixed device of intervention valve and its application
CN109124829A (en) * 2018-06-29 2019-01-04 金仕生物科技(常熟)有限公司 It is a kind of through conduit aortic valve and preparation method thereof
CN109567985A (en) * 2017-09-29 2019-04-05 上海微创心通医疗科技有限公司 Heart valve prosthesis
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US10321995B1 (en) 2018-09-20 2019-06-18 Vdyne, Llc Orthogonally delivered transcatheter heart valve replacement
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US11273032B2 (en) 2019-01-26 2022-03-15 Vdyne, Inc. Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis
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US11076956B2 (en) 2019-03-14 2021-08-03 Vdyne, Inc. Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis
US11173027B2 (en) 2019-03-14 2021-11-16 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
EP3965701A4 (en) 2019-05-04 2023-02-15 Vdyne, Inc. Cinch device and method for deployment of a side-delivered prosthetic heart valve in a native annulus
AU2020334080A1 (en) 2019-08-20 2022-03-24 Vdyne, Inc. Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves
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CN204121202U (en) * 2014-09-25 2015-01-28 北京迈迪顶峰医疗科技有限公司 A kind of intervention replacement valve and controlled delivery device thereof
CN205322548U (en) * 2016-01-11 2016-06-22 北京迈迪顶峰医疗科技有限公司 Carry aortic valve valve device through pipe

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WO2017121192A1 (en) * 2016-01-11 2017-07-20 北京迈迪顶峰医疗科技有限公司 Apparatus, having spinous positioning rods, for transcatheter delivery of aortic valve
CN106510902A (en) * 2016-06-16 2017-03-22 马建录 Method and design used for mitral regurgitation treatment device
WO2018077146A1 (en) * 2016-10-24 2018-05-03 宁波健世生物科技有限公司 Asymmetrical heart valve prosthesis
WO2018077143A1 (en) * 2016-10-24 2018-05-03 宁波健世生物科技有限公司 Heart valve prosthesis
WO2018077145A1 (en) * 2016-10-24 2018-05-03 宁波健世生物科技有限公司 Adaptive heart valve prosthesis
WO2018099484A1 (en) * 2016-12-02 2018-06-07 Sino Medical Sciences Technology Inc. Low profile heart valve and delivery system
CN106890035A (en) * 2017-04-17 2017-06-27 乐普(北京)医疗器械股份有限公司 One kind is through conduit implanted aorta petal film device
CN109567985A (en) * 2017-09-29 2019-04-05 上海微创心通医疗科技有限公司 Heart valve prosthesis
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CN112089507A (en) * 2020-08-28 2020-12-18 江苏大学 Balloon expansion type aortic valve stent

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