CN105476601B - Portable mechanism pain sensitive detection device - Google Patents
Portable mechanism pain sensitive detection device Download PDFInfo
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- CN105476601B CN105476601B CN201510656872.8A CN201510656872A CN105476601B CN 105476601 B CN105476601 B CN 105476601B CN 201510656872 A CN201510656872 A CN 201510656872A CN 105476601 B CN105476601 B CN 105476601B
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- cylinder
- axostylus axostyle
- pipe
- probe
- cambered surface
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Abstract
The present invention relates to a kind of portable mechanism pain sensitive detection device.Structure of the present invention is probe connection axostylus axostyle, and axostylus axostyle is connected through cylinder with recording-member, recording-member connection pen core, and cambered surface graduated scale is provided with by pen core；It is provided with spring in cylinder, pipe is connected on bottom in cylinder；The probe includes needle body, basal part, and the core includes axostylus axostyle, disk, tightens up a screw, and the recording-member includes wire, metal tube, lower screw, and the cylinder part includes cylinder, cambered surface graduated scale, pipe.The present invention overcomes price is high, probe rapid wear, rely on power supply, it is more heavy the defects of.Measurement device of the present invention is prepared simply, and probe, axostylus axostyle, wire, cylinder, pipe, spring etc. are regular supplies, measures the Hyperalgesia degree of rat four limbs, sensitivity is good, easy to operate, without special equipment, without power supply and other specific conditions, compared with conventional method more energy-saving and environmental protection.
Description
Technical field
The present invention relates to medical instruments field, and in particular to a kind of portable mechanism pain sensitive detection device.
Background technology
Pain is divided into Acute Pain and chronic ache, and Acute Pain belongs to one of guarding reflex of body, but chronic
Pain is often a kind of morbid state performance.Chronic ache often shows as the hyperalgia of damage location and adjacent tissue and feels different
Often, have the characteristics that pathogenic factor and mechanism are complicated, be not easy to alleviate, the basic research for its mechanism and therapeutic strategy is always
Research hotspot.
The research of experimental chronic ache be unable to do without the measure to pain behavior, since pain is a kind of subjective sense
By animal cannot express feeling of pain by so often referring to mechanical hyperalgesia and thermal hyperalgesia measure, wherein machinery
Hyperalgesic measure is the most commonly used.
Before making the present invention, the quick monitoring of mechanical pain is all carried out using Von Frey at present, its principle is that rat is placed in
In iron net, the probe tip of machine is directed at rat sole, probe slowly jacks up vertically upward, until rat sole reflectivity is lifted
Rise, machine shows dynamics during paw withdrawal, is mechanical paw withdrawal threshold value, and the smaller explanation of the value gets over pain.Although its measurement sensitivity is high,
But its maximum shortcoming is：1. price is high, ready availability difference；2. probe rapid wear, probe belong to fine features, machine is determined
The sensitivity of device, once damage, maintenance cost are high；3. measurement relies on power supply；4. traditional instrument is more heavy.
The content of the invention
The purpose of the present invention, which is that, overcomes drawbacks described above, develops a kind of portable mechanism pain sensitive detection device.
The technical scheme is that：
Portable mechanism pain sensitive detection device, it is mainly characterized by probe connection axostylus axostyle, and axostylus axostyle is through cylinder with remembering
Component connection is recorded, recording-member connects pen core, cambered surface graduated scale is provided with by pen core；It is provided with spring in cylinder, bottom in cylinder
Pipe is connected in portion；The probe includes needle body, basal part, and the core includes axostylus axostyle, disk, tightens up a screw, the recording-member
Including wire, metal tube, lower screw, the cylinder part includes cylinder, cambered surface graduated scale, pipe.
There are recessed interface, the basal part of the recessed interface linking probe in upper end, the recessed interface in lower end in upper end, the lower end of the axostylus axostyle
By means of connection wire of tightening up a screw.
The axostylus axostyle is in the centre of disk, and Verticle disk, the axostylus axostyle sequentially pass through pipe and cylinder in cylinder interior
Bottom, borrows the connection wire of tightening up a screw immediately below bottom of cylinder after being pierced by.
Opening of the disk embedded in the upper end of cylinder.
Bottom of cylinder closure, a upward pipe is vertically fixedly connected with bottom centre, the lower part of core have one section
In the pipe.
The wire has elasticity, arc-shaped, and the concave surface of cambered surface graduated scale is directed toward in lower end, and lower end is connected with metal tube
It is structure as a whole.
The metal tube is magnetic material.
The cambered surface graduated scale is magnetic conductive metal material.
The cambered surface graduated scale in bottom of cylinder, by part barrel continues one downwards and continues to be formed.
For the spring in cylinder, outside pipe, upper end is connected to the disk lower part of core, and lower end is connected to the circle of cylinder part
Bottom in cylinder.
It is simple that the advantages of the present invention are prepared by measurement device, and material requested is ready availability good, spy used
Pin, axostylus axostyle, wire, cylinder, pipe, spring etc. are regular supplies；It can be used for measuring the Hyperalgesia degree of rat four limbs, its
Measurement result is represented with track maximum length x of the pen core on cambered surface graduated scale；It is good to measure sensitivity, passes through real-time recording compressed
Track, sensitive can catch slight dynamics change turning point；Easy to operate, without special equipment, without power supply and other are special
Condition, compared with conventional method more energy-saving and environmental protection；Applied to the measure of the mechanical pain thresholds suitable for large and small animal, it is worth
Promote and apply.
Brief description of the drawings：
Fig. 1 --- sectional elevation structure principle chart of the present invention.
Each label represents that corresponding component names are as follows in figure：
Probe 1, core 2, recording-member 3, cylinder part 4, spring 5, pen core 6.
Wherein, probe 1 includes needle body 1-1, basal part 1-2, and core 2 includes axostylus axostyle 2-1, disk 2-2, tighten up a screw 2-3, record
Component 3 includes wire 3-1, metal tube 3-2, lower screw 3-3, and cylinder part 4 includes cylinder 4-1, cambered surface graduated scale 4-2, circle
Pipe 4-3.
Embodiment：
As shown in Figure 1：
The present invention is made of probe 1, core 2, recording-member 3, cylinder part 4, spring 5 and pen core 6；Needle body 1-1 linkers
The axostylus axostyle 2-1 upper ends of bottom 1-2, basal part 1-2 connection core 2, axostylus axostyle 2-1 among the disk 2-2 of core 2, and on disk 2-2,
Under all vertical connection cores 2 axostylus axostyle 2-1, under off working state, the disk 2-2 of core 2 is embedded in the cylinder 4-1 upper ends of cylinder part 4
Opening, the axostylus axostyle 2-1 of core 2 is put into the cylinder 4-1 of cylinder part 4 and sequentially passes through the bottom of pipe 4-3 and cylinder 4-1,
Cylinder 4-1 bottom closures but circular hole is left at center, are fixedly connected with pipe 4-3 vertically upward herein, and axostylus axostyle 2-1 is from cylinder 4-
After 1 bottom or end come out, the 2-3 that tightens up a screw connects wire 3-1, in cylinder 4-1 bottoms, portion immediately below cylinder 4-1 bottoms
Divide barrel to continue to continue downwards, form cambered surface graduated scale 4-2 thereon；Tighten up a screw the wire 3-1 of 2-3 linkage records component 3, gold
Belong to silk 3-1 connection metal tube 3-2, metal tube 3-2 lower ends pass through lower screw 3-3 connections pen core 6；In the cylinder 4-1 of cylinder part 4
Outside interior and pipe 4-3, spring 5 is used as compression spring, and upper end is connected to disk 2-2 lower parts, and lower end is connected to cylinder 4-1 bottoms.
The upper end of the basal part 1-2 and axostylus axostyle 2-1 is detachably connected with, and can be used for the probe 1 for replacing different size；Institute
There are recessed interface, the basal part 1-2 of the recessed interface linking probe 1 in upper end, the recessed interface warp in lower end in upper end, the lower end of the axostylus axostyle 2-1 stated
Tighten up a screw 2-3 connection wires 3-1.
The 2-3 that tightens up a screw adjusts the distance of wire 3-1 lower ends and cambered surface graduated scale 4-2 concave surfaces, for school zero；Institute
Stating wire 3-1 has elasticity, arc-shaped, and the concave surface of cambered surface graduated scale 4-2 is directed toward in lower end, and is integrated knot with metal tube 3-2
Structure；The direction of the metal tube 3-2 can be by carrying out moulding adjustment, for aiding in returning to zero to wire 3-1；The metal tube 3-
2 be magnetic material, and the cambered surface graduated scale 4-2 is magnetic conductive metal material, both can be attracting, when plugging pen core 6, pen core 6
Nib position can pressure be used to record on cambered surface graduated scale 4-2 automatically.
The cylinder 4-1 bottoms are structure as a whole with pipe 4-3；Axostylus axostyle 2-1 and pipe 4-3 inner faces contacts position phase
Cut, ensure that axostylus axostyle 2-1 is moved all the time in cylinder 4-1 perpendicular to bottom；The cambered surface graduated scale 4-2 and cylinder 4-1 is integrated
Structure；The cambered surface graduated scale 4-2 concave surfaces indicate scale, for marking the track left on cambered surface graduated scale the length of pen core 6
Degree；There is a groove in the cambered surface graduated scale 4-2 vertical center lines, pen core 6 slides wherein, ensures pen core 6 all the time in vertical side
To slip, easy to the length of curved scale ruler 4-2 measurement straight line person's handwritings.
Application process explanation of the present invention：
Embodiment 1：
Direct Model (by taking rat as an example)
(1) zero graduation that pen core 6 can be directed to cambered surface graduated scale 4-2 by debugging lower screw 3-3 carries out school zero；
(2) cylinder 4-1 is held, probe 1 is directed at In The Rat Sole straight up, slowly jacks up vola, if rat at this time
Do not feel that foot-up would not occur for pain, the spring 5 in cylinder 4-1 will compress always as compression spring at this time, because disk
2-2 is fixed on 5 upper end of spring, and accordingly relative displacement occurs with cylinder 4-1 for integrated component such as recording-member downstream, such as schemes,
Due to having magnetic force attraction between metal tube 3-2 and cambered surface graduated scale 4-2, so the pen core 6 being fixed in metal tube 3-2 is in cambered surface
Track will be left on graduated scale 4-2 during slide downward, and because of pen core all the time in cambered surface graduated scale 4-2 concave surfaces center line upper groove
In slide, so the track left is straight line；
(3) when rat feels pain, vola is lifted, and the pressure of 1 upper end of probe disappears immediately at this time, and spring 5 recovers shape
Become, corresponding pen core 6 is (upward) round about to be slided, this track place of turning back have recorded at 5 largest deformation of spring, reflect
The threshold value of pain, by compare turn back position can qualitatively more different rats the threshold of pain；
Embodiment 2：
Indirect pattern (by taking rat as an example)
(1) debug after lower screw 3-3 completes school zero and the weight of set weight (such as 30g) is inserted on probe 1, recording track
Length s, the coefficient of elasticity k=mg/s of spring 5 is obtained by calculating；
By rat weight to be measured, quality m before measure；
(2) debug lower screw 3-3 and complete school zero again；
(3) cylinder 4-1 is held, probe 1 is directed at In The Rat Sole straight up, slowly jacks up vola, if rat at this time
Do not feel that foot-up would not occur for pain, the spring 5 in cylinder 4-1 will compress always as compression spring at this time, because disk
2-2 is fixed on 5 upper end of spring, and accordingly relative displacement occurs with cylinder 4-1 for integrated component such as recording-member downstream, such as schemes,
Due to having magnetic force attraction between metal tube 3-2 and cambered surface graduated scale 4-2, so the pen core 6 being fixed in metal tube 3-2 is in cambered surface
Track will be left on graduated scale 4-2 during slide downward, and because of pen core all the time in cambered surface graduated scale 4-2 concave surfaces center line upper groove
In slide, so the track left is straight line；
(4) when rat feels pain, vola is lifted, and the pressure of 1 upper end of probe disappears immediately at this time, and spring 5 recovers shape
Become, corresponding pen core 6 is (upward) round about to be slided, this track place of turning back is recorded as x1；
(5) can be according to x1Calculate quick threshold value (stimulation dynamics) F of pain1=kx1, quantitative comparison is carried out to all tested rats.
To sum up, the method for the present invention is simple, advantageously reduces the cost of pain mechanical hyperalgesia threshold value determination, can not only save section
Grind the expenditure of funds, moreover it is possible to save the energy and environmentally protective, promote the further development of pain research in the long term, meet
Innovate the needs of drive-type basic and clinic studies development.
Claims (2)
1. portable mechanism pain sensitive detection device, it is characterised in that probe connects axostylus axostyle, and axostylus axostyle is connected through cylinder with recording-member,
Recording-member connects pen core, and cambered surface graduated scale is provided with by pen core；It is provided with spring in cylinder, circle is connected on bottom in cylinder
Pipe；The probe includes needle body, basal part, and core includes axostylus axostyle, disk, tightens up a screw, and the recording-member includes wire, metal
Pipe, lower screw, cylinder part include cylinder, cambered surface graduated scale, pipe；There are recessed interface in upper end, the lower end of the axostylus axostyle, on
The basal part of recessed interface linking probe is held, the recessed interface in lower end borrows connection wire of tightening up a screw；The axostylus axostyle in the centre of disk, and
Verticle disk, the axostylus axostyle sequentially pass through pipe and bottom of cylinder in cylinder interior, are borrowed after being pierced by upper immediately below bottom of cylinder
Screw connection wire；Opening of the disk embedded in the upper end of cylinder；The spring is in cylinder, outside pipe, upper end connection
In the disk lower part of core, lower end is connected to bottom in the cylinder of cylinder part.
2. portable mechanism pain sensitive detection device according to claim 1, it is characterised in that the bottom of cylinder closure, the bottom of at
Portion center is vertically fixedly connected with a upward pipe, and the lower part of core has one section in the pipe；The metal tube is magnetic material,
The wire has elasticity, arc-shaped, and the concave surface of cambered surface graduated scale is directed toward in lower end, and lower end is connected as one knot with metal tube
Cambered surface graduated scale described in structure in bottom of cylinder, by part barrel continues one downwards and continues to be formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510656872.8A CN105476601B (en) | 2015-10-12 | 2015-10-12 | Portable mechanism pain sensitive detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510656872.8A CN105476601B (en) | 2015-10-12 | 2015-10-12 | Portable mechanism pain sensitive detection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105476601A CN105476601A (en) | 2016-04-13 |
| CN105476601B true CN105476601B (en) | 2018-04-17 |
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ID=55664137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510656872.8A Expired - Fee Related CN105476601B (en) | 2015-10-12 | 2015-10-12 | Portable mechanism pain sensitive detection device |
Country Status (1)
| Country | Link |
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| CN (1) | CN105476601B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107049236A (en) * | 2016-12-16 | 2017-08-18 | 北京大学 | A kind of In The Rat Sole threshold of pain measuring system |
| CN106821326B (en) * | 2017-03-13 | 2023-08-04 | 复旦大学附属中山医院 | Pain nerve detector and detection method |
| CN111419693A (en) * | 2020-02-21 | 2020-07-17 | 通化海恩达高科技股份有限公司 | Shank and foot acupuncture point treatment device |
| CN111419180B (en) * | 2020-03-25 | 2023-05-23 | 牡丹江医学院 | Mechanical pain measuring instrument |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2458985Y (en) * | 2001-01-18 | 2001-11-14 | 康孝理 | Algesimeter |
| JP2005052598A (en) * | 2003-08-01 | 2005-03-03 | Fijio Japan:Kk | Composite cutaneous sensitivity measuring instrument |
| CN2917550Y (en) * | 2006-06-06 | 2007-07-04 | 马巧玲 | Pen type analgesia diagnostic instrument |
| CN201200398Y (en) * | 2008-06-08 | 2009-03-04 | 李建华 | Device for inspecting pain sense |
| KR20100113747A (en) * | 2009-04-14 | 2010-10-22 | 김창범 | Ballpen type needle for acupucture |
| CN204520626U (en) * | 2014-12-29 | 2015-08-05 | 首都医科大学宣武医院 | A kind of mark device measuring length, angle and pain scores |
| CN205306955U (en) * | 2015-10-12 | 2016-06-15 | 南京大学医学院附属鼓楼医院 | Quick analyzer of portable machinery grief |
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2015
- 2015-10-12 CN CN201510656872.8A patent/CN105476601B/en not_active Expired - Fee Related
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| CN105476601A (en) | 2016-04-13 |
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