CN105476601A - Portable mechanical hyperalgesia measuring apparatus - Google Patents
Portable mechanical hyperalgesia measuring apparatus Download PDFInfo
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- CN105476601A CN105476601A CN201510656872.8A CN201510656872A CN105476601A CN 105476601 A CN105476601 A CN 105476601A CN 201510656872 A CN201510656872 A CN 201510656872A CN 105476601 A CN105476601 A CN 105476601A
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Abstract
The invention relates to a portable mechanical hyperalgesia measuring apparatus. The portable mechanical hyperalgesia measuring apparatus is structurally characterized in that a probe is connected with a shaft lever, the shaft lever penetrates a barrel to be connected with a recording component, the recording component is connected with a pen refill, and a cambered-surface graduated scale is arranged beside the pen refill; a spring is arranged in the barrel, and a circular tube is connected onto the inner bottom of the barrel; the probe comprises a probe body and a base, a core comprises the shaft lever, a disc and an upper screw, the recording component comprises a metal wire, a metal tube and a lower screw, and a barrel component comprises the barrel, the cambered-surface graduated scale and the circular tube. The portable mechanical hyperalgesia measuring apparatus has the advantages that shortcomings of high prices, vulnerable probes, dependence on power sources, bulkiness and the like can be overcome by the aid of the portable mechanical hyperalgesia measuring apparatus; the portable mechanical hyperalgesia measuring apparatus is easy to manufacture, the probe, the shaft lever, the metal wire, the barrel, the circular tube, the spring and the like are frequently used articles, hyperalgesia degrees of four limbs of a rat can be measured by the portable mechanical hyperalgesia measuring apparatus, the portable mechanical hyperalgesia measuring apparatus is good in sensitivity and easy to operate and is energy-saving and environmental friendly as compared with the traditional method, and special devices, power sources and other special conditions can be omitted.
Description
Technical field
The present invention relates to medical instruments field, be specifically related to a kind of portable mechanism pain sensitive detection device.
Background technology
Pain is divided into acute pain and chronic pain, one of acute pain guarding reflex belonging to body, but chronic pain a kind of morbid state performance often.Chronic pain often shows as hyperpathia and the paraesthesia of damage location and adjacent tissue, and have the feature such as pathogenic factor and mechanism complexity, not easily alleviation, the basic research for its mechanism and therapeutic strategy is study hotspot always.
The research of experimental chronic pain be unable to do without the mensuration to Pain behaviour, because pain is a kind of subjective feeling, animal can not be expressed pain and is subject to, and measure so usually relate to mechanical hyperalgesia and thermal hyperalgesia, wherein the mensuration of mechanical hyperalgesia is the most conventional.
Before making the present invention, all use VonFrey to carry out the monitoring that machinery pain is quick at present, it is online that its principle is that rat is placed in ferrum, the probe tip of machine is aimed at rat sole, probe is slow jack-up vertically upward, until rat sole reflexive is lifted, and dynamics during machine display contracting foot, be the sufficient threshold value of machinery contracting, the less explanation of this value more bitterly.Although its mensuration is highly sensitive, its maximum weak point is: 1. price is high, ready availability difference; 2. probe rapid wear, probe belongs to fine features, determines the sensitivity of machine, once damage, maintenance cost is high; 3. measure and rely on power supply; 4. traditional instrument is comparatively heavy.
Summary of the invention
Object of the present invention is just to overcome above-mentioned defect, develops a kind of portable mechanism pain sensitive detection device.
Technical scheme of the present invention is:
Portable mechanism pain sensitive detection device, its technical characteristics is that probe connects axostylus axostyle, and axostylus axostyle is connected with recording-member through cylinder, and recording-member connects pen core, and pen core is other is provided with cambered surface rule; Be provided with spring in cylinder, cylinder inner bottom part is connected to pipe; Described probe comprises needle body, basilar part, and described core comprises axostylus axostyle, disk, tightens up a screw, and described recording-member comprises tinsel, metal tube, lower screw, and described cylinder part comprises cylinder, cambered surface rule, pipe.
All there is recessed interface upper end, the lower end of described axostylus axostyle, and the basilar part of the recessed interface linking probe in upper end, the recessed interface in lower end is by means of connection metal silk of tightening up a screw.
Described axostylus axostyle is in the centre of disk, and Verticle disk, described axostylus axostyle successively through pipe and bottom of cylinder, borrows the connection metal silk of tightening up a screw immediately below bottom of cylinder in cylinder interior after passing.
Described disk is embedded in the opening of the upper end of cylinder.
Described bottom of cylinder closes, and be vertically fixedly connected with a pipe upwards in bottom centre, the bottom of core has one section in this pipe.
Described tinsel has elasticity, curved, and the concave surface of cambered surface rule is pointed in lower end, and lower end and metal tube connect as one structure.
Described metal tube is magnetic material.
Described cambered surface rule is magnetic conductive metal material.
Described cambered surface rule, at bottom of cylinder, is continued integrally to continue downwards to be formed by part barrel.
Described spring is in cylinder, outside pipe, and upper end is connected to the disk bottom of core, and lower end is connected to the cylinder inner bottom part of cylinder part.
Advantage of the present invention and beneficial effect are that determinator preparation is simple, and material requested is ready availability good, and probe used, axostylus axostyle, tinsel, cylinder, pipe, spring etc. are staple; Can be used for measuring the Hyperalgesia degree of rat extremity, its measurement result represents with the track greatest length x of pen core on cambered surface rule; Mensuration susceptiveness is good, compresses track by real time record, the slight dynamics of sensitive seizure can change turning point; Simple to operate, without the need to special equipment, without the need to power supply and other specific conditions, comparatively traditional method more energy-saving and environmental protection; Be applied to the mensuration of the mechanical pain thresholds being applicable to large and small animal, be worthy of popularization.
Accompanying drawing illustrates:
Fig. 1---sectional elevation structure principle chart of the present invention.
In figure, each label represents that corresponding component names is as follows:
Probe 1, core 2, recording-member 3, cylinder part 4, spring 5, pen core 6.
Wherein, probe 1 comprises needle body 1-1, basilar part 1-2, and core 2 comprises axostylus axostyle 2-1, disk 2-2, tighten up a screw 2-3, and recording-member 3 comprises tinsel 3-1, metal tube 3-2, lower screw 3-3, and cylinder part 4 comprises cylinder 4-1, cambered surface rule 4-2, pipe 4-3.
Detailed description of the invention:
As shown in Figure 1:
The present invention is made up of probe 1, core 2, recording-member 3, cylinder part 4, spring 5 and pen core 6, needle body 1-1 connects basilar part 1-2, basilar part 1-2 connects the axostylus axostyle 2-1 upper end of core 2, axostylus axostyle 2-1 is in the middle of the disk 2-2 of core 2, and on disk 2-2, under all vertically connect the axostylus axostyle 2-1 of core 2, under off working state, the disk 2-2 of core 2 is embedded in the opening of the cylinder 4-1 upper end of cylinder part 4, the axostylus axostyle 2-1 of core 2 puts into the cylinder 4-1 of cylinder part 4 also successively through the bottom of pipe 4-3 and cylinder 4-1, described cylinder 4-1 bottom closure but circular hole is left at center, be fixedly connected with pipe 4-3 vertically upward herein, axostylus axostyle 2-1 bottom cylinder 4-1 or end out after, tighten up a screw 2-3 bottom cylinder 4-1 immediately below connection metal silk 3-1, bottom cylinder 4-1, part barrel continues continuity downwards, it forms cambered surface rule 4-2, tighten up a screw the tinsel 3-1 of 2-3 linkage record parts 3, tinsel 3-1 connection metal pipe 3-2, and metal tube 3-2 lower end connects pen core 6 by lower screw 3-3, in the cylinder 4-1 of cylinder part 4 and outside pipe 4-3, spring 5 is as stage clip, and upper end is connected to disk 2-2 bottom, and lower end is connected to bottom cylinder 4-1.
Described basilar part 1-2 is connected with the upper end dismountable of axostylus axostyle 2-1, may be used for the probe 1 changing different size; All there is recessed interface upper end, the lower end of described axostylus axostyle 2-1, the basilar part 1-2 of the recessed interface linking probe 1 in upper end, and the recessed interface in lower end is through the 2-3 connection metal silk 3-1 that tightens up a screw.
The distance of described tighten up a screw 2-3 scalable tinsel 3-1 lower end and cambered surface rule 4-2 concave surface, for school zero; Described tinsel 3-1 has elasticity, curved, and the concave surface of cambered surface rule 4-2 is pointed in lower end, and is structure as a whole with metal tube 3-2; The sensing of described metal tube 3-2 by carrying out moulding adjustment to tinsel 3-1, for auxiliary zeroing; Described metal tube 3-2 is magnetic material, and described cambered surface rule 4-2 is magnetic conductive metal material, and both can be attracting, and when plugging pen core 6, can exert pressure for record automatically in the nib position of pen core 6 on cambered surface rule 4-2.
Be structure as a whole with pipe 4-3 bottom described cylinder 4-1; Described axostylus axostyle 2-1 and pipe 4-3 inner faces contact position tangent, ensure that axostylus axostyle 2-1 moves all the time perpendicular to bottom in cylinder 4-1; Described cambered surface rule 4-2 and cylinder 4-1 is structure as a whole; Described cambered surface rule 4-2 concave surface indicates scale, for the path length stayed on cambered surface rule of labelling pen core 6; The vertical center line of described cambered surface rule 4-2 has a groove, and pen core 6 slides wherein, ensures that pen core 6 slides at vertical direction all the time, is convenient to the length that curved scale chi 4-2 measures straight line person's handwriting.
Application process of the present invention illustrates:
Embodiment 1:
Direct Model (for rat)
(1) zero graduation pen core 6 can being aimed at cambered surface rule 4-2 by debugging lower screw 3-3 carries out school zero;
(2) hand-held cylinder 4-1, probe 1 is aimed at In The Rat Sole straight up, slow jack-up vola, if now rat does not feel that pain would not lift foot, spring 5 now in cylinder 4-1 will compress as stage clip always, because disk 2-2 is fixed on spring 5 upper end, all there is relative displacement with cylinder 4-1 in its downstream integrated component corresponding such as recording-member, as figure, owing to having magnetic force to attract between metal tube 3-2 and cambered surface rule 4-2, so the pen core 6 be fixed in metal tube 3-2 will leave track during slide downward on cambered surface rule 4-2, again because pen core slides all the time in cambered surface rule 4-2 concave surface center line upper groove, so the track stayed is straight line,
(3) when rat feels pain, vola is lifted, now the pressure of probe 1 upper end disappears immediately, spring 5 recovers deformation, corresponding pen core 6 is (upwards) slip round about, namely this track place of turning back have recorded spring 5 largest deformation place, reflects the threshold value of pain, can the threshold of pain of more different rat qualitatively by comparing position of turning back;
Embodiment 2:
Indirect pattern (for rat)
(1) be inserted on probe 1 by the weight of set weight (as 30g) after the lower screw 3-3 of debugging completes school zero, recording track length s, by calculating the coefficient of elasticity k=mg/s obtaining spring 5;
By rat weight to be measured before measuring, quality is m;
(2) the lower screw 3-3 of debugging completes school zero again;
(3) hand-held cylinder 4-1, probe 1 is aimed at In The Rat Sole straight up, slow jack-up vola, if now rat does not feel that pain would not lift foot, spring 5 now in cylinder 4-1 will compress as stage clip always, because disk 2-2 is fixed on spring 5 upper end, all there is relative displacement with cylinder 4-1 in its downstream integrated component corresponding such as recording-member, as figure, owing to having magnetic force to attract between metal tube 3-2 and cambered surface rule 4-2, so the pen core 6 be fixed in metal tube 3-2 will leave track during slide downward on cambered surface rule 4-2, again because pen core slides all the time in cambered surface rule 4-2 concave surface center line upper groove, so the track stayed is straight line,
(4) when rat feels pain, vola is lifted, and now the pressure of probe 1 upper end disappears immediately, and spring 5 recovers deformation, and corresponding pen core 6 is (upwards) slip round about, and this track place of turning back is recorded as x
1;
(5) can according to x
1calculate pain quick threshold value (stimulation dynamics) F
1=kx
1, Quantitative Comparison is carried out to all tested rats.
To sum up, the inventive method is simple and easy, be conducive to the cost reducing pain mechanical hyperalgesia threshold value determination, the expenditure of research funding can not only be saved, can also energy savings and environmental protection, facilitate further developing of pain research in the long term, meet the needs of innovation drive-type basic and clinic studies development.
Claims (10)
1. portable mechanism pain sensitive detection device, it is characterized in that probe connects axostylus axostyle, axostylus axostyle is connected with recording-member through cylinder, and recording-member connects pen core, and pen core is other is provided with cambered surface rule; Be provided with spring in cylinder, cylinder inner bottom part is connected to pipe; Described probe comprises needle body, basilar part, and described core comprises axostylus axostyle, disk, tightens up a screw, and described recording-member comprises tinsel, metal tube, lower screw, and described cylinder part comprises cylinder, cambered surface rule, pipe.
2. portable mechanism pain sensitive detection device according to claim 1, it is characterized in that all there is recessed interface the upper end of described axostylus axostyle, lower end, the basilar part of the recessed interface linking probe in upper end, the recessed interface in lower end is by means of connection metal silk of tightening up a screw.
3. portable mechanism pain sensitive detection device according to claim 1, it is characterized in that the centre of described axostylus axostyle at disk, and Verticle disk, described axostylus axostyle successively through pipe and bottom of cylinder, borrows the connection metal silk of tightening up a screw immediately below bottom of cylinder in cylinder interior after passing.
4. portable mechanism pain sensitive detection device according to claim 3, is characterized in that described disk is embedded in the opening of the upper end of cylinder.
5. portable mechanism according to claim 1 pain sensitive detection device, is characterized in that described bottom of cylinder closes, and be vertically fixedly connected with a pipe upwards in bottom centre, the bottom of core has one section in this pipe.
6. portable mechanism pain sensitive detection device according to claim 1, it is characterized in that described tinsel has elasticity, curved, the concave surface of cambered surface rule is pointed in lower end, and lower end and metal tube connect as one structure.
7. portable mechanism pain sensitive detection device according to claim 5, is characterized in that described metal tube is magnetic material.
8. portable mechanism pain sensitive detection device according to claim 1, is characterized in that described cambered surface rule is magnetic conductive metal material.
9. portable mechanism pain sensitive detection device according to claim 7, is characterized in that described cambered surface rule is at bottom of cylinder, is continued integrally to continue downwards to be formed by part barrel.
10. portable mechanism pain sensitive detection device according to claim 1, it is characterized in that described spring is in cylinder, outside pipe, upper end is connected to the disk bottom of core, and lower end is connected to the cylinder inner bottom part of cylinder part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510656872.8A CN105476601B (en) | 2015-10-12 | 2015-10-12 | Portable mechanism pain sensitive detection device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510656872.8A CN105476601B (en) | 2015-10-12 | 2015-10-12 | Portable mechanism pain sensitive detection device |
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| CN105476601A true CN105476601A (en) | 2016-04-13 |
| CN105476601B CN105476601B (en) | 2018-04-17 |
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| CN201510656872.8A Expired - Fee Related CN105476601B (en) | 2015-10-12 | 2015-10-12 | Portable mechanism pain sensitive detection device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821326A (en) * | 2017-03-13 | 2017-06-13 | 复旦大学附属中山医院 | A kind of pain nerve detector and detection method |
| CN107049236A (en) * | 2016-12-16 | 2017-08-18 | 北京大学 | A kind of In The Rat Sole threshold of pain measuring system |
| CN111419180A (en) * | 2020-03-25 | 2020-07-17 | 牡丹江医学院 | Mechanical pain measuring instrument |
| CN111419693A (en) * | 2020-02-21 | 2020-07-17 | 通化海恩达高科技股份有限公司 | Shank and foot acupuncture point treatment device |
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| CN2458985Y (en) * | 2001-01-18 | 2001-11-14 | 康孝理 | Algesimeter |
| JP2005052598A (en) * | 2003-08-01 | 2005-03-03 | Fijio Japan:Kk | Composite cutaneous sensitivity measuring instrument |
| CN2917550Y (en) * | 2006-06-06 | 2007-07-04 | 马巧玲 | Pen type analgesia diagnostic instrument |
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| KR20100113747A (en) * | 2009-04-14 | 2010-10-22 | 김창범 | Ballpen type needle for acupucture |
| CN204520626U (en) * | 2014-12-29 | 2015-08-05 | 首都医科大学宣武医院 | A kind of mark device measuring length, angle and pain scores |
| CN205306955U (en) * | 2015-10-12 | 2016-06-15 | 南京大学医学院附属鼓楼医院 | Quick analyzer of portable machinery grief |
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2015
- 2015-10-12 CN CN201510656872.8A patent/CN105476601B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2458985Y (en) * | 2001-01-18 | 2001-11-14 | 康孝理 | Algesimeter |
| JP2005052598A (en) * | 2003-08-01 | 2005-03-03 | Fijio Japan:Kk | Composite cutaneous sensitivity measuring instrument |
| CN2917550Y (en) * | 2006-06-06 | 2007-07-04 | 马巧玲 | Pen type analgesia diagnostic instrument |
| CN201200398Y (en) * | 2008-06-08 | 2009-03-04 | 李建华 | Device for inspecting pain sense |
| KR20100113747A (en) * | 2009-04-14 | 2010-10-22 | 김창범 | Ballpen type needle for acupucture |
| CN204520626U (en) * | 2014-12-29 | 2015-08-05 | 首都医科大学宣武医院 | A kind of mark device measuring length, angle and pain scores |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107049236A (en) * | 2016-12-16 | 2017-08-18 | 北京大学 | A kind of In The Rat Sole threshold of pain measuring system |
| CN106821326A (en) * | 2017-03-13 | 2017-06-13 | 复旦大学附属中山医院 | A kind of pain nerve detector and detection method |
| CN106821326B (en) * | 2017-03-13 | 2023-08-04 | 复旦大学附属中山医院 | Pain nerve detector and detection method |
| CN111419693A (en) * | 2020-02-21 | 2020-07-17 | 通化海恩达高科技股份有限公司 | Shank and foot acupuncture point treatment device |
| CN111419180A (en) * | 2020-03-25 | 2020-07-17 | 牡丹江医学院 | Mechanical pain measuring instrument |
| CN111419180B (en) * | 2020-03-25 | 2023-05-23 | 牡丹江医学院 | Mechanical pain measuring instrument |
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| CN105476601B (en) | 2018-04-17 |
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