CN105466891B - Double modulation mode is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor - Google Patents
Double modulation mode is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor Download PDFInfo
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- CN105466891B CN105466891B CN201510818101.4A CN201510818101A CN105466891B CN 105466891 B CN105466891 B CN 105466891B CN 201510818101 A CN201510818101 A CN 201510818101A CN 105466891 B CN105466891 B CN 105466891B
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- 239000013307 optical fiber Substances 0.000 title claims abstract description 21
- 238000001514 detection method Methods 0.000 title claims abstract description 18
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 title claims abstract description 10
- 239000000835 fiber Substances 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000010931 gold Substances 0.000 claims abstract description 8
- 229910052737 gold Inorganic materials 0.000 claims abstract description 8
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000004033 plastic Substances 0.000 claims abstract description 7
- 238000004544 sputter deposition Methods 0.000 claims abstract description 7
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229910052709 silver Inorganic materials 0.000 claims abstract description 5
- 239000004332 silver Substances 0.000 claims abstract description 5
- 238000005498 polishing Methods 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 5
- 238000001338 self-assembly Methods 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- GRCJTSHIYCFXFK-UHFFFAOYSA-N [O--].[O--].[O--].[O--].[Ag+].[In+3].[Sn+4] Chemical compound [O--].[O--].[O--].[O--].[Ag+].[In+3].[Sn+4] GRCJTSHIYCFXFK-UHFFFAOYSA-N 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 4
- 108091006146 Channels Proteins 0.000 description 11
- 238000000576 coating method Methods 0.000 description 11
- 239000011248 coating agent Substances 0.000 description 10
- 239000000523 sample Substances 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 4
- 108090000862 Ion Channels Proteins 0.000 description 3
- 102000004310 Ion Channels Human genes 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- MRNHPUHPBOKKQT-UHFFFAOYSA-N indium;tin;hydrate Chemical compound O.[In].[Sn] MRNHPUHPBOKKQT-UHFFFAOYSA-N 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000007747 plating Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- GFLJTEHFZZNCTR-UHFFFAOYSA-N 3-prop-2-enoyloxypropyl prop-2-enoate Chemical compound C=CC(=O)OCCCOC(=O)C=C GFLJTEHFZZNCTR-UHFFFAOYSA-N 0.000 description 1
- 241000252506 Characiformes Species 0.000 description 1
- 244000137852 Petrea volubilis Species 0.000 description 1
- 239000003012 bilayer membrane Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000000080 chela (arthropods) Anatomy 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000001755 magnetron sputter deposition Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004444 near reflex Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920000371 poly(diallyldimethylammonium chloride) polymer Polymers 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
- G01N2021/5903—Transmissivity using surface plasmon resonance [SPR], e.g. extraordinary optical transmission [EOT]
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The present invention provides a kind of double modulation modes from accurate optical fiber surface plasmon resonance body biochemistry detection sensor, belongs to technical field of optical fiber sensing.The sensor uses end reflection formula sensing arrangement, is 400-600m by core diameter, and the core end surface of plastic envelope multimode fibre of the numerical aperture not less than 0.24 polishes, and the fiber core end face of polishing is sputtered 200nm or more silverskin, forms mirror surface；By on multimode fibre two sections of coats and covering peel off to be formed two length be 5mm-10mm sensing passage；The fixed nano gold spherical in one sensing passage surface, another sensing passage surface is according to the sequential sputtering silver-ITO duplicature of silver-ITO, and wherein silver thickness is 35-45nm, ITO layer 5-15nm.Using relatively simple sputter coating process and the independently demodulation of dress method realization double modulated signal layer by layer, avoid influencing using the accuracy that single modulating mode generates.
Description
Technical field
The invention belongs to technical field of optical fiber sensing, be related to a kind of double modulation optical fiber surface with from precise function etc. from
Daughter resonance biochemical detection sensor.
Background technique
Prism coupling structure is mostly used using the binary channels biochemical sensor of Surface Plasmon Resonance Technology at present, such
Sensor structure is complicated, volume is larger, cost of manufacture is expensive, it is difficult to be formed be widely applied in the industrial production；Though having at present more
The surface plasma resonance sensor of layer metal alternating membrane system occurs, but mostly single-pass configuration, to biological sample
It is easy to be influenced by temperature or the factors such as the variation of sample solution bulk refractive index and sample volatilization in sensing detection, sensor is not
Has compensation ability, the accuracy of detection is poor.And the binary channels based on Surface Plasmon Resonance Technology occurred at present
Fibre optical sensor mostly uses the mode of plated film modulation wavelength, and modulation system is single, and detection accuracy is poor.
Summary of the invention
The object of the present invention is to provide a kind of double modulation mode optical fiber surface plasma body resonant vibrations with from precise function
Biochemistry detection sensor replaces the signal demodulation in two channels without the target to sensing surface progress complexity and repeats friendship
For plated film mode, can be realized using simple coating process and autonomous dress mode；Signal is transmitted using optical patchcord, avoids rib
The labyrinth of mirror manifold type surface plasma resonance sensor；Independently the fixed nano gold spherical of dress method is sensed at one layer by layer
Channel realizes two channels to sample refractive index by the Coating Materials on regulation plated film sensing passage fibre core surface, coating film thickness
With the sensitivity of temperature change response, wavelength occurs simultaneously with intensity debud mode, to can avoid the temperature in biochemistry detection
Or sample ontology variations in refractive index is interfered caused by detection, realize sensor from precise function, improve the accuracy of detection.
Technical solution of the present invention:
From accurate optical fiber surface plasmon resonance body biochemical sensor, the sensor is anti-using terminal for a kind of double modulation mode
Formula sensing arrangement is penetrated, using plastic envelope multimode fibre, core diameter is 400-600 μm, numerical aperture is not less than 0.24；End
The core end surface sputtering of the plastic envelope multimode fibre of face polishing forms mirror surface with a thickness of the silverskin of 200nm or more；It is leaning on
Two sections of coats and covering on plastic envelope multimode fibre are peelled off near reflex mirror surface end, form two sensing passages, two biographies
The length for feeling channel is 5mm-10mm, and two interchannels have appropriate intervals；One sensing passage surface passes through LBL self-assembly side
Method fixes nano gold spherical, and the diameter of nano gold spherical is 15-30nm；Another sensing passage surface uniform sputter plated film, according to silver-
The sequential sputtering overall thickness of tin indium oxide (ITO) is the silver-ITO duplicature of 50nm, and wherein silver thickness is 35-45nm, ITO layer
For 5-15nm；Coating Materials, coating film thickness by regulating and controlling plated film channel surface separate the spectrum in two channels, two channels
Response sensitivity is all had to temperature and sample solution refractive index, plating membrane channels have wavelength modulation effect to different refractivity solution
It answers, nano gold spherical sensing passage then has intensity modulated effect, has the double modulation sensor to oneself of temperature and refractive index
Precise function realizes more accurate sensing detection.
The coupled transfer of signal is carried out using the multimode fibre wire jumper of Y type.The wide spectrum optical of optical fiber source transmitting is through y-type optical fiber
One of wire jumper enters double modulation self compensation optical fiber surface plasmon resonance body biochemical sensor, in sensing passage fibre core and metal
Film interface excitating surface plasma resonance, transducing signal occur mirror-reflection in reflection end face, are coupled to through wire jumper one
It is detected on spectrometer CCD.
The invention has the advantages that: it is real using relatively simple magnetron sputtering membrane process and Chemical self-assembly method
The demodulation for having showed double modulated signal makes two channels by Coating Materials, the coating film thickness on regulation plating membrane channels fibre core surface
Spectrum separates and all has higher response sensitivity to temperature and sample refractive index, realizes two for temperature and sample refractive index
Kind mode is modulated, so that sensor be made to have from precise function.Sensor performance stabilization, simple process, cost is relatively low and right
Sensing detection accuracy with higher.
Detailed description of the invention
Attached drawing is double modulation from accurate optical fiber surface plasmon resonance body biochemistry detection sensor structure schematic diagram.
In figure: 1 nano-gold film；2 silver medal-ITO duplicatures；3 mirror surfaces.
Specific embodiment
A specific embodiment of the invention is described in detail below in conjunction with technical solution and attached drawing.
For the present invention using surface plasma body resonant vibration as sensing principle, the generation of the effect depends on wide spectrum light source, purpose
It is the sensing detection for realizing wavelength modulation and intensity modulated mode in a fiber.In order to enhance signal strength, optimization sensing capabilities,
The optical fiber for making sensor selects large aperture multimode fibre.The optical fiber that the present invention uses is fibre core, covering, coat diameter difference
For 400 μm, 430 μm, 730 μm, the large aperture plastic-clad optical fiber of numerical aperture 0.37.
Preparation process of the invention is as follows:
(1) one section of 60mm long plastic envelope multimode fibre is taken to make at the position away from fiber end face 10mm and 20mm first
Peel off the optical fiber coating of 5mm respectively with optical fiber pincers.
(2) fiber core end face is polished with sand paper, and is coated with the silverskin of 300nm thickness with coating machine, form reflection
Mirror surface.
(3) epoxy resin A, B glue 1:1 ratio is mixed into post package mirror surface, prevented in use process to mirror surface
It damages.
(4) the fibre cladding removal of the sensing passage of coat will be peelled off.Sensing passage is impregnated using acetone soln, makes light
Fine plastic envelope is completely fallen off.
(5) one of channel surface is by LBL self-assembly method, after being handled with Piranha washing lotion, in polymer
Alternate immersion in PDDA, PSS and PAH polymer solution, every kind of polymer solution impregnate 10 minutes, and being immersed in diameter later is
1 hour in the nano gold spherical solution of 15-30nm, the preparation of intensity modulated sensing passage is completed.
(6) the plating membrane channels of sensor plated film by the way of 360 ° of rotations in coating machine, splashes Coating Materials uniformly
It is mapped to sensing passage all surfaces；Plated film sensing passage surface is according to the alternate sequential sputtering overall thickness of silver-ITO (tin indium oxide)
For the silver-ITO bilayer membrane system of 50nm, wherein silver thickness is 40nm, ITO layer 10nm, completes wavelength modulation sensing passage
Preparation.
Claims (2)
1. a kind of double modulation mode is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor, which is characterized in that use
End reflection formula sensing arrangement uses core diameter to be not less than 0.24 optical fiber for 300-600 μm, numerical aperture；End face polishing
Optical fiber core end surface sputtering with a thickness of 200nm or more silverskin, formed mirror surface；Close to mirror surface end, peel off
Two sections of coats and covering on plastic envelope multimode fibre, form two sensing passages, the length of two sensing passages is
5mm-10mm, two interchannels have appropriate intervals；One sensing passage surface is 15- by LBL self-assembly method fixed diameter
The nano gold spherical of 30nm；Another sensing passage surface uniform sputter plated film, according to silver-tin indium oxide sequential sputtering overall thickness
For the silver-ITO duplicature of 50nm, wherein silver thickness is 35-45nm, ITO layer 5-15nm.
2. double modulation mode according to claim 1 is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor,
It is characterized in that, the sensor uses assemble nanometer material and the two different surface plasma generation mechanisms of metal-coated membrane,
Intensity modulated and wavelength modulate two kinds of modulating modes and are used for biochemistry detection simultaneously.
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| CN201510818101.4A CN105466891B (en) | 2015-11-23 | 2015-11-23 | Double modulation mode is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor |
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| CN201510818101.4A CN105466891B (en) | 2015-11-23 | 2015-11-23 | Double modulation mode is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor |
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| CN105466891A CN105466891A (en) | 2016-04-06 |
| CN105466891B true CN105466891B (en) | 2019-04-05 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108535220B (en) * | 2018-07-17 | 2024-02-27 | 河南师范大学 | Wedge-shaped tip nanostructure integrated optical fiber surface plasma resonance biochemical sensor |
| CN109652752B (en) * | 2018-12-28 | 2021-02-19 | 北京信息科技大学 | Method for preparing optical fiber reflector by using ultrasonic fusion coating optical fiber end face |
| CN110044463B (en) * | 2019-04-28 | 2021-05-07 | 陕西师范大学 | Sensing structure based on optical fiber sensing |
| CN110672564A (en) * | 2019-10-22 | 2020-01-10 | 重庆理工大学 | Nano-gold shell LSPR (localized surface plasmon resonance) optode biosensor of graphene oxide fiber bragg grating |
| CN112033932B (en) * | 2020-09-07 | 2021-09-07 | 科竟达生物科技有限公司 | Local surface plasmon resonance biochip, manufacturing method thereof, biosensing system comprising local surface plasmon resonance biochip and application of biosensing system |
| CN118518641A (en) * | 2024-07-22 | 2024-08-20 | 中国计量大学 | Pt-WO3 thin film hydrogen sensor based on surface plasma resonance |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104020140A (en) * | 2014-06-05 | 2014-09-03 | 大连理工大学 | Dual-channel self-compensation optical fiber surface plasma resonance biochemical sensor |
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| TWI404982B (en) * | 2009-09-22 | 2013-08-11 | Nat Univ Chung Cheng | Localized plasma resonance sensing device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104020140A (en) * | 2014-06-05 | 2014-09-03 | 大连理工大学 | Dual-channel self-compensation optical fiber surface plasma resonance biochemical sensor |
Non-Patent Citations (3)
| Title |
|---|
| Microstructure and optical properties of nano Ag-ITO films;XIAO Lei, et al.;《Sci China Tech Sci》;20100415;第53卷(第5期);1266–1270 |
| SPR based fiber opticsensorforrefractiveindexsensingwithenhanced detectionaccuracyand figureofmeritinvisibleregion;A.K.Mishraetal.;《Optics Communications》;20150115;第344卷;86-91 |
| Surface Plasmon Resonance Investigation of Silver and Gold Films Coated with Thin Indium Tin Oxide Layers: Influence on Stability and Sensitivity;Szunerits et al.;《J. Phys. Chem. C》;20081231;第112卷(第40期);摘要、第15813页右栏最后一段，第15814页左栏和2.4节，第15815页第3.1节至15817页第4节 |
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