CN105434751A - 治疗青春痘药膏的制备方法 - Google Patents
治疗青春痘药膏的制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗青春痘药膏的制备方法,主要由以下重量份的原料制备而成:苦菜30-80、琉璃苣30-80、椰肉30-50、川连2-5、黄柏2-5、黄芩7-10、金银花10-15、蛇含草8-12、连翘8-12、马齿笕8-10、蒲公英10-15、生地5-8、丹皮5-8、绿豆8-15、水牛角8-12、红花4-6、桃仁4-6、灯心草8-12、冬瓜皮8-12、萹蓄8-12、橘皮6-8、玫瑰花5-8以及薄荷8-12。将原料干燥、粉碎,得到原料粉末;原料粉末与乙醇混合萃取,得到萃取液;萃取液浓缩,得到稠膏;将所得稠膏加稀释液稀释得到提取液,将提取液与软膏基质混合,调入适量牡丹籽油,即得所述药膏。
Description
技术领域
本发明涉及医药领域,尤其涉及一种治疗青春痘药膏的制备方法。
背景技术
青春痘学名痤疮,又称为粉刺、壮疙瘩,是毛囊皮脂腺单位的一种慢性炎症性皮肤病,主要好发于青少年,临床表现以好发于面部的粉刺、丘疹、脓疱、结节等多形性皮损为特点。
青春痘的发生主要与皮脂分泌过多、毛囊皮脂腺导管堵塞、细菌感染和炎症反应等因素密切相关。进入青春期后人体内雄激素特别是睾酮的水平迅速升高,促进皮脂腺发育并产生大量皮脂。同时毛囊皮脂腺导管的角化异常造成导管堵塞,皮脂排出障碍,形成角质栓即微粉刺。毛囊中多种微生物尤其是痤疮丙酸杆菌大量繁殖,痤疮丙酸杆菌产生的脂酶分解皮脂生成游离脂肪酸,同时趋化炎症细胞和介质,最终诱导并加重炎症反应。
目前,治疗青春痘一般使用外用抗生素或激素类药物,如维A酸乳膏、、过氧化苯甲酰、红霉素、氯霉素等,副作用较大。
另一方面,苦菜中含有的植物蛋白有良好的抗氧化性、消炎杀菌作用、消炎解毒作用;琉璃苣具有解毒、镇痛、消炎等多种功效;荔枝具有加速毒素排除、促进细胞生成、使皮肤细嫩等作用;胡萝卜富含有丰富的胡萝卜素、果胶糖类、挥发油、花青素及多种维生素,具有排毒养颜的功效。椰汁富含蛋白质及多种维生素、矿物质,能够起到很好的补水、养颜、嫩肤作用,而且能够促进细胞新陈代谢。
但是,目前还没有综合利用苦菜、琉璃苣、荔枝等,并将这些天然物质与中药组合物结合,制备用于治疗青春痘的纯草本药膏的报道。
发明内容
本发明的目的是提供一种治疗青春痘药膏的制备方法,能够高效治疗青春痘,无副作用。
为实现上述目的和一些其他的目的,本发明采用如下技术方案:
一种治疗青春痘药膏的制备方法,其特征在于,包括以下步骤:
步骤一、原料干燥、粉碎,得到原料粉末;其中,所述原料主要包含以下重量份的组分:苦菜30-80、琉璃苣30-80、椰肉30-50、川连2-5、黄柏2-5、黄芩7-10、金银花10-15、蛇含草8-12、连翘8-12、马齿笕8-10、蒲公英10-15、生地5-8、丹皮5-8、绿豆8-15、水牛角8-12、红花4-6、桃仁4-6、灯心草8-12、冬瓜皮8-12、萹蓄8-12、橘皮6-8、玫瑰花5-8以及薄荷8-12;
步骤二、将原料粉末与10-15倍体积的60-80%乙醇混合萃取,具体的萃取方法为:将原料粉末与乙醇溶液的混合物加热至30-45℃,然后保持该温度进行超声震荡10-18分钟,使细胞破碎,细胞内容物溶出,继续静置30-40分钟后,离心分离得到上清液,即得萃取液;
步骤三、萃取液浓缩,得到稠膏;
步骤四、将所得稠膏与1-2倍体积的稀释液混合,得到提取液;其中,所述稀释液由琉璃苣汁液、荔枝汁、胡萝卜汁、椰汁以及蒸馏水按照2∶5∶5∶10∶50的体积比混合而成;
步骤五、将所得提取液与等体积软膏基质混合,并加入1-2%牡丹籽油混合均匀,即得所述药膏;所述软膏基质包含以下重量份的组分:白凡士林5-7、十八醇3-5、单硬脂酸甘油酯0.5-1.5、十二烷基硫酸钠0.2-0.8、甘油2-5以及对羟基苯甲酸乙酯0.05-0.2。
优选的是,所述的治疗青春痘药膏的制备方法中,步骤二中,将原料粉末与12倍体积的75%乙醇混合萃取。
优选的是,所述的治疗青春痘药膏的制备方法中,步骤三中浓缩方法为:将萃取液进行40-45℃旋蒸至乙醇完全蒸发,得到稠膏。
优选的是,所述的治疗青春痘药膏的制备方法中,将所得稠膏与稀释液混合后,在冰水中超声震荡5-10分钟使稠膏分散,得到提取液。
优选的是,所述的治疗青春痘药膏的制备方法中,步骤五中,提取液与软膏基质的混合物中还添加珍珠粉2-4重量份并研磨。
优选的是,所述的治疗青春痘药膏的制备方法中,步骤四中所述琉璃苣汁液由新鲜琉璃苣叶片榨汁得到;所述荔枝汁由新鲜荔枝鲜榨得到;所述胡萝卜汁由新鲜胡萝卜鲜榨得到。
优选的是,所述的治疗青春痘药膏的制备方法中,所述原料主要包含以下重量份的组分:苦菜50、琉璃苣50、椰肉40、川连3、黄柏3、黄芩8、金银花12、蛇含草10、连翘10、马齿笕9、蒲公英12、生地6、丹皮6、绿豆12、水牛角10、红花5、桃仁5、灯心草10、冬瓜皮10、萹蓄10、橘皮7、玫瑰花7以及薄荷10。
本发明至少包括以下有益效果:本发明通过采用苦菜、琉璃苣、椰肉、琉璃苣汁液、荔枝汁、胡萝卜汁、椰汁与治疗青春痘的中药组合物相结合,利用苦菜、苦瓜消炎杀菌、清凉解毒,以及具备较强抗氧化性等功效的优点;琉璃苣具有解毒、镇痛、消炎等多种功效;荔枝加速毒素排除、促进细胞生成;胡萝卜排毒养颜;椰汁补水、养颜、嫩肤,加快细胞新陈代谢,结合中医理论,认为青春痘的病理为肺经血热而成,病因位于中上二焦,治疗以清肺凉血、活血化淤、利湿解毒为主,进而将苦菜、琉璃苣、椰肉、荔枝汁等与其他多种中药合理配伍,组成能够有效治疗青春痘的组合物,且通过优化制备工艺,能够最大限度地保留各种材料的有效成分,从而高效治疗青春痘,无副作用,并具有美白、养颜的功效。
本发明的其它优点、目标和特征将部分通过下面的说明体现,部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。
具体实施方式
下面对本发明做详细说明,以令本领域普通技术人员参阅本说明书后能够据以实施。
一种治疗青春痘药膏的制备方法,包括以下步骤:
步骤一、原料干燥、粉碎,得到原料粉末;其中,所述原料主要包含以下重量份的组分:苦菜30-80、琉璃苣30-80、椰肉30-50、川连2-5、黄柏2-5、黄芩7-10、金银花10-15、蛇含草8-12、连翘8-12、马齿笕8-10、蒲公英10-15、生地5-8、丹皮5-8、绿豆8-15、水牛角8-12、红花4-6、桃仁4-6、灯心草8-12、冬瓜皮8-12、萹蓄8-12、橘皮6-8、玫瑰花5-8以及薄荷8-12;
步骤二、将原料粉末与10-15倍体积的60-80%乙醇混合萃取,具体的萃取方法为:将原料粉末与乙醇溶液的混合物加热至30-45℃,然后保持该温度进行超声震荡10-18分钟,使细胞破碎,细胞内容物溶出,继续静置30-40分钟后,离心分离得到上清液,即得萃取液;
步骤三、萃取液浓缩,得到稠膏;
步骤四、将所得稠膏与1-2倍体积的稀释液混合,得到提取液;其中,所述稀释液由琉璃苣汁液、荔枝汁、胡萝卜汁、椰汁以及蒸馏水按照2:5:5:10:50的体积比混合而成;
步骤五、将所得提取液与等体积软膏基质混合,并加入1-2%牡丹籽油混合均匀,即得所述药膏;所述软膏基质包含以下重量份的组分:白凡士林5-7、十八醇3-5、单硬脂酸甘油酯0.5-1.5、十二烷基硫酸钠0.2-0.8、甘油2-5以及对羟基苯甲酸乙酯0.05-0.2。
本发明通过采用苦菜、琉璃苣、椰肉、琉璃苣汁液、荔枝汁、胡萝卜汁、椰汁与治疗青春痘的中药组合物相结合,利用苦菜、苦瓜消炎杀菌、清凉解毒,以及具备较强抗氧化性等功效的优点;琉璃苣具有解毒、镇痛、消炎等多种功效;荔枝加速毒素排除、促进细胞生成;胡萝卜排毒养颜;椰汁补水、养颜、嫩肤,加快细胞新陈代谢,结合中医理论,认为青春痘的病理为肺经血热而成,病因位于中上二焦,治疗以清肺凉血、活血化淤、利湿解毒为主,进而将苦菜、琉璃苣、椰肉、荔枝汁等与其他多种中药合理配伍,组成能够有效治疗青春痘的组合物,且通过优化制备工艺,能够最大限度地保留各种材料的有效成分,从而高效治疗青春痘,无副作用,并具有美白、养颜的功效。
所述中药组合物的具体药理为:川连用于痈肿疮毒,泻心脏之火,祛中焦湿热,诸疮必用;黄柏与川连同用能增强泻火解毒、去湿热的功效;黄芩苦寒、燥湿、泄热,并能解毒,尤其是肺经之热毒;金银花清热解毒,与丹皮、生地同用可清营护阴、凉血解毒;连翘用于热毒蕴结所致的各种疮毒痈肿,能消痈散结;马齿笕又叫五行草,能降低炎症,增加皮肤细胞的抗氧化力,并清热解毒、凉血止血、散瘀消肿;蒲公英清热解毒、消痈散结、利湿;生地清热凉血、养阴生津;绿豆清热解毒,利水消肿;水牛角凉血解毒;红花活血化淤,美容养颜,凉血解毒,能调节色素在肌肤表面沉淀;桃仁,味苦,能泻血热、滋肠燥;萹蓄味苦而寒,清热泻火;橘皮燥湿、化痰理气;玫瑰花降火气,调理血气,促进血液循环,养颜美容,有助于新陈代谢;薄荷疏风散热,解郁,清热解毒,止痒消炎。牡丹籽油有利于皮肤血液循环,并具有美白养颜的特效。
所述的治疗青春痘药膏的制备方法中,步骤二中,将原料粉末与12倍体积的75%乙醇混合萃取。
所述的治疗青春痘药膏的制备方法中,步骤三中浓缩方法为:将萃取液进行40-45℃旋蒸至乙醇完全蒸发,得到稠膏。选择低温旋蒸,并适当延长旋蒸的时间,也是为了能够最大地保留萃取液中有效物质的生物活性,避免其高温受到破坏。
所述的治疗青春痘药膏的制备方法中,将所得稠膏与稀释液混合后,在冰水中超声震荡5-10分钟使稠膏分散,得到提取液。在冰水中进行超声震荡能够保持低温状态,避免有效成分受到破坏。
所述的治疗青春痘药膏的制备方法中,步骤五中,提取液与软膏基质的混合物中还添加珍珠粉2-4重量份并研磨。珍珠粉不仅能够清心火,有助于青春痘的治愈,而且具有美白养颜的功效。
所述的治疗青春痘药膏的制备方法中,步骤四中所述琉璃苣汁液由新鲜琉璃苣叶片榨汁得到;所述荔枝汁由新鲜荔枝鲜榨得到;所述胡萝卜汁由新鲜胡萝卜鲜榨得到。采用鲜榨汁液直接添加到稠膏中,能够更加充分地保留有效物质成分,提高所述药膏的功效。
所述的治疗青春痘药膏的制备方法中,所述原料主要包含以下重量份的组分:苦菜50、琉璃苣50、椰肉40、川连3、黄柏3、黄芩8、金银花12、蛇含草10、连翘10、马齿笕9、蒲公英12、生地6、丹皮6、绿豆12、水牛角10、红花5、桃仁5、灯心草10、冬瓜皮10、萹蓄10、橘皮7、玫瑰花7以及薄荷10。
实施例1
1、称取苦菜80克、琉璃苣30克、椰肉40克、川连2克、黄柏2克、黄芩7克、金银花10克、连翘8克、马齿笕8克、蒲公英10克、生地5克、绿豆8克、水牛角8克、红花4克、桃仁4克、冬瓜皮8克、萹蓄8克、橘皮6克、玫瑰花5克以及薄荷8克,
2、干燥粉碎后得到原料粉末,将原料粉末与10倍体积的70%乙醇溶液混合,加热至45℃,然后保持该温度进行超声震荡12分钟,使细胞破碎,细胞内容物溶出,继续静置30分钟后,3000r/min离心分离得到上清液,即得萃取液。
3、离心分离出上清液,45℃旋蒸至乙醇完全蒸发,得到稠膏;
4、将稠膏与等体积稀释液混合,超声震荡8分钟,调匀,即得提取液;
5、将提取液与等体积软膏基质混合均匀,加入1%的牡丹籽油,调匀,即得所述药膏。
实施例2
1、称取苦菜100克、琉璃苣40克、椰肉35克、川连3克、黄柏3克、黄芩8克、金银花12克、连翘10克、蒲公英12克、生地6克、水牛角10克、红花5克、桃仁5克、冬瓜皮10克、萹蓄10克、橘皮8克、玫瑰花6克以及薄荷10克,干燥粉碎后得到原料粉末;
2、将原料粉末与10倍体积的70%乙醇溶液混合,加热至42℃,然后保持该温度进行超声震荡15分钟,使细胞破碎,细胞内容物溶出,继续静置40分钟后,4000r/min离心分离得到上清液,即得萃取液。
3、离心分离出上清液,42℃旋蒸至乙醇完全蒸发,得到稠膏;
4、将稠膏与等体积稀释液混合,超声震荡5分钟,调匀,即得提取液;
5、将提取液与等体积软膏基质混合均匀,加入1.5%的牡丹籽油,调匀,即得所述药膏。
以上所述仅为本发明的实施方案,并非因此限制本发明的专利范围,凡是利用本发明说明书内容所作的等效结构或等效流程变换,或间接或直接运用在其他相关技术领域,均包括在本发明的专利保护范围内。
Claims (7)
1.一种治疗青春痘药膏的制备方法,其特征在于,包括以下步骤:
步骤一、原料干燥、粉碎,得到原料粉末;其中,所述原料主要包含以下重量份的组分:苦菜30-80、琉璃苣30-80、椰肉30-50、川连2-5、黄柏2-5、黄芩7-10、金银花10-15、蛇含草8-12、连翘8-12、马齿笕8-10、蒲公英10-15、生地5-8、丹皮5-8、绿豆8-15、水牛角8-12、红花4-6、桃仁4-6、灯心草8-12、冬瓜皮8-12、萹蓄8-12、橘皮6-8、玫瑰花5-8以及薄荷8-12;
步骤二、将原料粉末与10-15倍体积的60-80%乙醇混合萃取,具体的萃取方法为:将原料粉末与乙醇溶液的混合物加热至30-45℃,然后保持该温度进行超声震荡10-18分钟,使细胞破碎,细胞内容物溶出,继续静置30-40分钟后,离心分离得到上清液,即得萃取液;
步骤三、萃取液浓缩,得到稠膏;
步骤四、将所得稠膏与1-2倍体积的稀释液混合,得到提取液;其中,所述稀释液由琉璃苣汁液、荔枝汁、胡萝卜汁、椰汁以及蒸馏水按照2∶5∶5∶10∶50的体积比混合而成;
步骤五、将所得提取液与等体积软膏基质混合,并加入1-2%牡丹籽油混合均匀,即得所述药膏;所述软膏基质包含以下重量份的组分:白凡士林5-7、十八醇3-5、单硬脂酸甘油酯0.5-1.5、十二烷基硫酸钠0.2-0.8、甘油2-5以及对羟基苯甲酸乙酯0.05-0.2。
2.如权利要求1所述的治疗青春痘药膏的制备方法,其特征在于,步骤二中,将原料粉末与12倍体积的75%乙醇混合萃取。
3.如权利要求1所述的治疗青春痘药膏的制备方法,其特征在于,步骤三中浓缩方法为:将萃取液进行40-45℃旋蒸至乙醇完全蒸发,得到稠膏。
4.如权利要求3所述的治疗青春痘药膏的制备方法,其特征在于,将所得稠膏与稀释液混合后,在冰水中超声震荡5-10分钟使稠膏分散,得到提取液。
5.如权利要求1所述的治疗青春痘药膏的制备方法,其特征在于,步骤五中,提取液与软膏基质的混合物中还添加珍珠粉2-4重量份并研磨。
6.如权利要求1所述的治疗青春痘药膏的制备方法,其特征在于,步骤四中所述琉璃苣汁液由新鲜琉璃苣叶片榨汁得到;所述荔枝汁由新鲜荔枝鲜榨得到;所述胡萝卜汁由新鲜胡萝卜鲜榨得到。
7.如权利要求1所述的治疗青春痘药膏的制备方法,其特征在于,所述原料主要包含以下重量份的组分:苦菜50、琉璃苣50、椰肉40、川连3、黄柏3、黄芩8、金银花12、蛇含草10、连翘10、马齿笕9、蒲公英12、生地6、丹皮6、绿豆12、水牛角10、红花5、桃仁5、灯心草10、冬瓜皮10、萹蓄10、橘皮7、玫瑰花7以及薄荷10。
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