CN105434525A - Combination formula for treating inflammatory bowel disease - Google Patents
Combination formula for treating inflammatory bowel disease Download PDFInfo
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- CN105434525A CN105434525A CN201510937038.6A CN201510937038A CN105434525A CN 105434525 A CN105434525 A CN 105434525A CN 201510937038 A CN201510937038 A CN 201510937038A CN 105434525 A CN105434525 A CN 105434525A
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- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract description 5
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- Natural Medicines & Medicinal Plants (AREA)
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- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
The invention discloses a combination formula for treating the inflammatory bowel disease, and belongs to the field of medicines. The formula comprises Mythic Fungus, Salvia miltiorrhiza, ginseng, Poria cocos, glutamine, threonine, serine and cysteine. Mythic Fungus, Salvia miltiorrhiza, ginseng and Poria cocos have the efficacy of enhancing human body blood supply and oxygen supply; glutamine is the main energy source of intestinal mucosa; and threonine, serine and cysteine are composition parts of mucoproteins. The combination formula provides nutrition, oxygen and raw materials for generation, updating and restoration of goblet cells and an intestinal tract surface mucus layer barrier composed of mucoproteins secreted by the goblet cells. The combination formula has obvious inflammation termination, intestinal tract tissue restoration and human body normal intestinal tract surface mucus layer barrier construction effects, and is an effective composition for treating the inflammatory bowel disease.
Description
Technical field
The present invention relates to the Chinese crude drug for the treatment of inflammatory bowel and amino acid whose combination formula, belong to medicine field.
Background technology
Inflammatory bowel (inflammatoryboweldisease, IBD) is the disease that a kind of pathogenic factor and pathogenesis are not yet completely clear and definite.Because pathogenic factor and pathogenesis are illustrated not yet completely, old friends can not fundamentally stop or delay the progress of this disease course.
Medical Immunology is thought, immune system occurs abnormal to antigen recognition and tolerance, namely normally perches the improper identification of microorganism to intestinal and produces immunne response, cause this disease.Histology and Embryology is then thought, intestinal permeability is too high, causes a large amount of Intestinal Antigens to enter intestinal tissue, has caused the permanent responsing reaction of immune system and has caused this disease.
At present the treatment of inflammatory bowel is taken as the leading factor with Medical Immunology, primary treatment measure be intervene, Immunosuppression response and inflammation to the damage of intestinal, as used glucocorticoid, aminosalicyclic acid supplement, monoclonal antibody, immunosuppressant etc.Above-mentioned remedy measures effect is undesirable and side effect large, so, to the research of the inflammatory bowel cause of disease, find pathogenic factor, take corresponding remedy measures to be the instant task of medical circle.
Summary of the invention
The present invention is based on modern medicine, the basis probing into inflammatory bowel pathogenic factor proposes the remedy measures of oneself, namely intestinal tissue and epithelial goblet cell is reinforced, build normal intestinal tract surface slime layer barrier, stop Intestinal Antigens close, contact, adhere to and enter intestinal tissue, thus block the generation of abnormal immune response, stop the intestinal tissue of inflammation, repairing damage simultaneously.
If carrying out intervention to the immunne response occurred and inflammation is try to stop water from boiling by skimming it off and pouring it back, and prescription therapeutic measure so of the present invention is removing burning wood away under the boiler.
First the gut muco-membranous barrier of human body is intestinal tract surface slime layer barrier, and intestinal tract surface slime layer barrier is the first line of defence of gut muco-membranous barrier.What intestinal tract surface slime layer was secreted by gut epithelium goblet cell mucoproteinly forms.The function of normal intestinal tract surface slime layer be stop the microorganism in intestinal comprise pathogenic microorganism, normally perch microorganism close with food source property antigen, contact, adhere to and enter gut epithelium and intestinal walls, and " attempt " is passed through to microorganism particularly pathogenic microorganism performance adhesion and the effect of parcel of surperficial slime layer, avoid the generation of abnormal immune response and inflammation.
Intestinal slime layer barrier has certain fluctuation, causes a small amount of microbes antigen or food source property antigen to pass through intestinal tract surface slime layer, close, contact, adhere to and enter gut epithelium.These antigens passing through intestinal tract surface slime layer first identify by the pattern recognition receptors of inherent immunity system (PRRs) and cause innate immune response to remove antigen.
When innate immune response can not remove antigen, antigen can by antigen presenting cell (APC) as macrophage (Μ φ), dendritic cell (DC) etc. be absorbed, are offered and cause adaptive immune response.Adaptive immune response enters immune system in the Process of Antigen of intestinal tissue in removing can discharge a large amount of secretory immunoglobulin As (secretorylffA, slgA) to enteric cavity.Can be combined with antigen specifically after slgA releases people's enteric cavity, suppress or kill bacteria, neutralization virus, prevent antigen close, contact, adhere to and enter enteric epithelium, thus reach immunologic balance.
The imbalance of intestinal tract surface slime layer barrier cause Intestinal Antigens in a large number close, contact, adhere to and enter intestinal wall, immune system cannot remove antigen in time, thus immunologic balance is broken, exception throw immunne response and inflammation, damage intestinal tissue, this is the pathogenic factor of inflammatory bowel.
The reason of intestinal tract surface slime layer barrier imbalance may be the performance of goblet cell abnormal condition, comprises the defect of goblet cell, deficiency and renewal, dysfunction; Also may be that goblet cell secretes mucoprotein obstacle.The main cause that goblet cell abnormal condition and goblet cell secrete mucoprotein obstacle is that intestinal blood supply supplies hypoxgia or and has proteinacious malnutrition to cause intestinal cell metabolism substrate deficiency, synthesize mucoprotein insufficient raw material etc.
Content of the present invention is the combination formula of Chinese crude drug Ganoderma, Radix Salviae Miltiorrhizae, Radix Ginseng, Poria and glutamine, threonine, serine, cysteine.
Ganoderma, Radix Salviae Miltiorrhizae, Radix Ginseng, Poria have the effect strengthening blood of human body supply and oxygen supply.
Ganoderma is rapid-action but acting duration is short; Radix Salviae Miltiorrhizae, Radix Ginseng, Poria onset is slow but acting duration is long, and many persons coordinate can obtain better effect.
The oxygen reserves of human body is relative to very pettiness nutrient deposit, and may cause damage because oxygen supply is not enough to human body when human body has excess oxygen consumption demand, old friend's body increases oxygen supply when morbid state particularly important.
Glutamine is intestinal mucosa main energy sources.Glutamine can promote nitrogen balance, keeps intestinal mucosa complete, prevents bacterial translocation and enterotoxin from entering blood.Threonine, serine, cysteine are that goblet cell secretes mucoprotein primary raw material.
Apply Ganoderma of the present invention, Radix Salviae Miltiorrhizae, Radix Ginseng, Poria and glutamine, threonine, serine, the prescription of cysteine, intestinal tissue blood supply and oxygen supply can be strengthened, for the generation of goblet cell, repair, upgrade and normal work nutrition and oxygen that abundance is provided, furnish ample material and oxygen for goblet cell secretion is mucoprotein, thus build normal intestinal tract surface slime layer barrier, stop Intestinal Antigens close, contact, adhere to and enter into intestinal tissue, stop the generation of abnormal immune response, and then reach the termination of inflammation and the reparation of intestinal tissue, the mechanism of action of Here it is prescription therapeutic inflammatory bowel of the present invention.
Pathologic data shows, Leukocyte Killing, degraded pathogen, antigen, fragment of tissue need to consume than the oxygen of many 2 ~ 20 times time normal, so the oxygen supply that inflammatory bowel patient strengthens inflammation part is extremely important to the efficiency of inflammation and the termination of inflammation.
Ganoderma of the present invention, Radix Salviae Miltiorrhizae, Radix Ginseng, Poria be the Pharmacopoeia of the People's Republic of China specify Ganoderma, Radix Salviae Miltiorrhizae, Radix Ginseng, Poria.Ganoderma does not especially still discharge the ganoderma lucidum sporocarp of spore as well to be about to maturation, and in detailed description of the invention, the consumption of Ganoderma measures with the sporophore of drying; In detailed description of the invention, the consumption of Radix Salviae Miltiorrhizae is with the former medicine metering of the root and rhizome of drying; In detailed description of the invention, the consumption of Radix Ginseng measures with dry root and rhizome; In detailed description of the invention, the consumption of Poria measures with the sclerotium of drying.
Formula of the present invention can be made into masticatory, containing agent and oral agents, with masticatory, best containing agent effect.
According to mucosal immune system (mucosalimmunesystem), the mucosa traversal system (mucosalmigrationsystem of Medical Immunology, MMS) and " immunity is patrolled and examined " theoretical, the imbalance of intestinal tract surface slime layer barrier can also cause the diseases such as such as periphery arthritis, erythema nodosum, Pyoderma gangrenosum, episcleritis, recurrent oral ulceration; The imbalance of intestinal tract surface slime layer barrier also may cause autoimmune disease, rheumatism and anaphylactic disease.The important research field that the relation of probing into intestinal tract surface slime layer barrier and disease will be 21 century preclinical medicine.Build normal intestinal tract surface slime layer barrier, the intestinal tissue of repairing damage is important content of the present invention, is the primary efficacy of formula of the present invention.
A large amount of facts have proved, applies prescription therapeutic irritable bowel syndrome of the present invention, infectious diarrhea, the long-term diarrhea of unknown cause, asthma, allergic rhinitis have reliable effect.
According to the theory of the combination of Chinese and Western medicine, the disease of human body comes from deficiency of vital energy blood deficiency mostly, and formula of the present invention can strengthen blood supply and the oxygen supply of human body integral, so have good therapeutical effect to the people of deficiency of vital energy blood deficiency.
Reinforce according to healthy and beautiful longevity and says, disease, the aging of human body are mostly relevant with body hypoxic-ischemic, solution body hypoxic-ischemic problem, and most of disease can prevention and therapy, and human longevity can significantly extend.
Detailed description of the invention
One, Ganoderma 0.5 gram, Radix Salviae Miltiorrhizae 0.6 gram, Radix Ginseng 0.3 gram, 0.8 gram, Poria, glutamine 1.2 grams, threonine 0.5 gram, serine 0.6 gram, cysteine 0.06 restraint are made masticatory, every day 2 to 4 times.
Two, Ganoderma 0.25 gram, Radix Salviae Miltiorrhizae 0.3 gram, Radix Ginseng 1.5 grams, 0.4 gram, Poria, glutamine 0.6 gram, threonine 0.25 gram, serine 0.3 gram, cysteine 0.03 restraint are made masticatory, every day 2 to 4 times.
Three, Ganoderma 0.5 gram, Radix Salviae Miltiorrhizae 0.6 gram, Radix Ginseng 0.3 gram, 0.8 gram, Poria, glutamine 1.2 grams, threonine 0.5 gram, serine 0.6 gram, cysteine 0.06 restraint are made containing agent, every day 2 to 4 times.
Four, Ganoderma 0.25 gram, Radix Salviae Miltiorrhizae 0.3 gram, Radix Ginseng 1.5 grams, 0.4 gram, Poria, glutamine 0.6 gram, threonine 0.25 gram, serine 0.3 gram, cysteine 0.03 restraint are made containing agent, every day 2 to 4 times.
Five, Ganoderma 5 grams, Radix Salviae Miltiorrhizae 6 grams, Radix Ginseng 1 gram, 5 grams, Poria, glutamine 1.2 grams, threonine 0.5 gram, serine 0.6 gram, cysteine 0.06 restraint are made oral agents, every day 2 to 4 times.
Six, Ganoderma 2.5 grams, Radix Salviae Miltiorrhizae 3 grams, Radix Ginseng 0.5 gram, 2.5 grams, Poria, glutamine 0.6 gram, threonine 0.25 gram, serine 0.3 gram, cysteine 0.03 restraint are made oral agents, every day 2 to 4 times.
Claims (1)
1. treat a combination formula for inflammatory bowel, its prescription is characterized as: Ganoderma 5 ~ 50 parts, Radix Salviae Miltiorrhizae 6 ~ 60 parts, Radix Ginseng 3 ~ 10 parts, 8 ~ 50 parts, Poria, glutamine 12 parts, threonine 5 parts, serine 6 parts, cysteine 0.6 part.
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Citations (1)
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KR20080011921A (en) * | 2006-08-01 | 2008-02-11 | 퓨리메드 주식회사 | Compositions for treating autoimmune disease containing extracts of salviae miltiorrhizae radix |
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Publication number | Priority date | Publication date | Assignee | Title |
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KR20080011921A (en) * | 2006-08-01 | 2008-02-11 | 퓨리메드 주식회사 | Compositions for treating autoimmune disease containing extracts of salviae miltiorrhizae radix |
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