CN105412234A - Composition for treating inflammatory bowel disease - Google Patents
Composition for treating inflammatory bowel disease Download PDFInfo
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- CN105412234A CN105412234A CN201510937077.6A CN201510937077A CN105412234A CN 105412234 A CN105412234 A CN 105412234A CN 201510937077 A CN201510937077 A CN 201510937077A CN 105412234 A CN105412234 A CN 105412234A
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- inflammatory bowel
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- ganoderma
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- 208000022559 Inflammatory bowel disease Diseases 0.000 title abstract description 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 241000222336 Ganoderma Species 0.000 claims abstract description 19
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 12
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims abstract description 12
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- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000018417 cysteine Nutrition 0.000 claims abstract description 12
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims abstract description 11
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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Abstract
The invention discloses a composition for treating inflammatory bowel disease, and belongs to the field of drugs. The composition comprises ganoderma, radix salviae miltiorrhizae, threonine, serine, cysteine, vitamin C, vitamin E, vitamin A and beta-carotene, wherein ganoderma and radix salviae miltiorrhizae have efficacies of strengthening blood supply and oxygen supply to the human body; threonine, serine and cysteine are components of mucoprotein; vitamin C, vitamin E, vitamin A and beta-carotene have functions of inhibiting the activity of oxygen free radicals, scavenging the oxygen free radicals, and protecting human cells. The composition provides nutrition, oxygen and raw materials for generation, renewal and repairing of goblet cells as well as forming of an intestinal surface mucous layer barrier by utilizing mucoprotein secreted by the goblet cells, has obvious effects of eliminating inflammation, repairing intestinal tissues and building the normal intestinal surface mucous layer barrier for the human body, and is used for effectively treating the inflammatory bowel disease.
Description
Technical field
The present invention relates to the combination formula of the treatment Chinese crude drug of inflammatory bowel and aminoacid, vitamin, belong to medicine field.
Background technology
Inflammatory bowel (inflammatoryboweldisease, IBD) is the disease that a kind of pathogenic factor and pathogenesis are not yet completely clear and definite.Because pathogenic factor and pathogenesis are illustrated not yet completely, old friends can not fundamentally stop or delay the progress of this disease course.
Medical Immunology is thought, immune system occurs abnormal to antigen recognition and tolerance, namely normally perches the improper identification of microorganism to intestinal and produces immunne response, cause this disease.Histology and Embryology is then thought, intestinal permeability is too high, causes a large amount of Intestinal Antigens to enter intestinal tissue, has caused the permanent responsing reaction of immune system and has caused this disease.
At present the treatment of inflammatory bowel is taken as the leading factor with Medical Immunology, primary treatment measure be intervene, Immunosuppression response and inflammation to the damage of intestinal, as used glucocorticoid, aminosalicyclic acid supplement, monoclonal antibody, immunosuppressant etc.Above-mentioned remedy measures effect is undesirable and side effect large, so, to the research of the inflammatory bowel cause of disease, find pathogenic factor, take corresponding remedy measures to be the instant task of medical circle.
Summary of the invention
The present invention is based on modern medicine, the basis probing into inflammatory bowel pathogenic factor proposes the remedy measures of oneself, namely intestinal tissue and epithelial goblet cell is reinforced, build normal intestinal tract surface slime layer barrier, stop Intestinal Antigens close, contact, adhere to and enter intestinal tissue, thus block the generation of abnormal immune response, stop the intestinal tissue of inflammation, repairing damage simultaneously.
If carrying out intervention to the immunne response occurred and inflammation is try to stop water from boiling by skimming it off and pouring it back, and prescription therapeutic measure so of the present invention is removing burning wood away under the boiler.
First the gut muco-membranous barrier of human body is intestinal tract surface slime layer barrier, and intestinal tract surface slime layer barrier is the first line of defence of gut muco-membranous barrier.What intestinal tract surface slime layer was secreted by gut epithelium goblet cell mucoproteinly forms.The function of normal intestinal tract surface slime layer be stop the microorganism in intestinal comprise pathogenic microorganism, normally perch microorganism close with food source property antigen, contact, adhere to and enter gut epithelium and intestinal walls, and " attempt " is passed through to microorganism particularly pathogenic microorganism performance adhesion and the effect of parcel of surperficial slime layer, avoid the generation of abnormal immune response and inflammation.
Intestinal slime layer barrier has certain fluctuation, causes a small amount of microbes antigen or food source property antigen to pass through intestinal tract surface slime layer, close, contact, adheres to and adheres to, enters gut epithelium.These antigens passing through intestinal tract surface slime layer first identify by the pattern recognition receptors of inherent immunity system (PRRs) and cause innate immune response to remove antigen.
When innate immune response can not remove antigen, antigen can by antigen presenting cell (APC) as macrophage (Μ φ), dendritic cell (DC) etc. be absorbed, are offered and cause adaptive immune response.Adaptive immune response enters immune system in the Process of Antigen of intestinal tissue in removing can discharge a large amount of secretory immunoglobulin As (secretorylffA, slgA) to enteric cavity.Can be combined with antigen specifically after slgA releases people's enteric cavity, suppress or kill bacteria, neutralization virus, prevent antigen close, contact, adhere to and enter enteric epithelium, thus reach immunologic balance.
The imbalance of intestinal tract surface slime layer barrier cause Intestinal Antigens in a large number close, contact, adhere to and enter intestinal wall, immune system cannot remove antigen in time, thus immunologic balance is broken, exception throw immunne response and inflammation, damage intestinal tissue, this is the pathogenic factor of inflammatory bowel.
The reason of intestinal tract surface slime layer barrier imbalance may be the performance of goblet cell abnormal condition, comprises the defect of goblet cell, deficiency and renewal, dysfunction; Also may be that goblet cell secretes mucoprotein obstacle.The main cause that goblet cell abnormal condition and goblet cell secrete mucoprotein obstacle is that intestinal blood supply supplies hypoxgia or and has proteinacious malnutrition to cause intestinal cell metabolism substrate deficiency, synthesize mucoprotein insufficient raw material etc.
Content of the present invention is the combination formula of Chinese crude drug Ganoderma, Radix Salviae Miltiorrhizae and threonine, serine, cysteine, injection Vitamin B_6, A and beta-carotene.
Ganoderma, Radix Salviae Miltiorrhizae have the effect strengthening blood of human body supply and oxygen supply.
The oxygen reserves of human body is relative to very pettiness nutrient deposit, and may cause damage because oxygen supply is not enough to human body when human body has excess oxygen consumption demand, old friend's body increases oxygen supply when morbid state particularly important.
Ganoderma is rapid-action but acting duration is short; Radix Salviae Miltiorrhizae onset is slow but acting duration is long, and the two cooperation can obtain better effect.
Threonine, serine, cysteine are that goblet cell secretes mucoprotein primary raw material.
Apply Ganoderma of the present invention, Radix Salviae Miltiorrhizae and threonine, serine, the prescription of cysteine, intestinal tissue blood supply and oxygen supply can be strengthened, for the generation of goblet cell, repair, upgrade and normal work nutrition and oxygen that abundance is provided, furnish ample material and oxygen for goblet cell secretion is mucoprotein, thus build normal intestinal tract surface slime layer barrier, stop Intestinal Antigens close, contact, adhere to and enter into intestinal tissue, stop the generation of abnormal immune response, and then reach the termination of inflammation and the reparation of intestinal tissue, the mechanism of action of Here it is prescription therapeutic inflammatory bowel of the present invention.
Pathologic data shows, Leukocyte Killing, degraded pathogen, antigen, fragment of tissue need to consume than the oxygen of many 2 ~ 20 times time normal, so the oxygen supply that inflammatory bowel patient strengthens inflammation part is extremely important to the efficiency of inflammation and the termination of inflammation.
Human body can produce a large amount of oxygen-derived free radicals under inflammatory conditions, and oxygen-derived free radicals can cause damage to body, affects the termination of inflammation and the reparation of tissue.
The oxygen supply that the present invention applies Ganoderma, Radix Salviae Miltiorrhizae can strengthen intestinal tissue, thus the removing accelerating antigen in intestinal tissue, accelerate the generation of intestinal tissue cell, reparation, renewal process, also can produce more oxygen-derived free radicals simultaneously.Injection Vitamin B_6, A and beta-carotene have the effect preventing oxygen-derived free radicals activity, scavenging activated oxygen, protection human body cell, thus inflammatory bowel patient while taking Ganoderma, Radix Salviae Miltiorrhizae, supplement the reparation of these vitamin to the termination of enteritis and tissue especially necessary.
Ganoderma of the present invention, Radix Salviae Miltiorrhizae be the Pharmacopoeia of the People's Republic of China specify Ganoderma, Radix Salviae Miltiorrhizae.Ganoderma does not especially still discharge the ganoderma lucidum sporocarp of spore as well to be about to maturation.Consumption in detailed description of the invention measures with the Ganoderma sporophore of drying.The consumption of Radix Salviae Miltiorrhizae is with the former medicine metering of the root and rhizome of drying.
Formula of the present invention can be made into masticatory, containing agent and oral agents, with masticatory, best containing agent effect.
According to mucosal immune system (mucosalimmunesystem), the mucosa traversal system (mucosalmigrationsystem of Medical Immunology, MMS) and " immunity is patrolled and examined " theoretical, the imbalance of intestinal tract surface slime layer barrier can also cause the diseases such as such as periphery arthritis, erythema nodosum, Pyoderma gangrenosum, episcleritis, recurrent oral ulceration; The imbalance of intestinal tract surface slime layer barrier also may cause autoimmune disease, rheumatism and anaphylactic disease.The important research field that the relation of probing into intestinal tract surface slime layer barrier and disease will be 21 century preclinical medicine.Build normal intestinal tract surface slime layer barrier, the intestinal tissue of repairing damage is important content of the present invention, is the primary efficacy of formula of the present invention.
A large amount of facts have proved, applies prescription therapeutic irritable bowel syndrome of the present invention, infectious diarrhea, the long-term diarrhea of unknown cause, asthma, allergic rhinitis have reliable effect.
According to the theory of the combination of Chinese and Western medicine, the disease of human body comes from deficiency of vital energy blood deficiency mostly, and formula of the present invention can strengthen blood supply and the oxygen supply of human body integral, so have good therapeutical effect to the people of deficiency of vital energy blood deficiency.
Reinforce according to healthy and beautiful longevity and says, disease, the aging of human body are mostly relevant with body hypoxic-ischemic, solution body hypoxic-ischemic problem, and most of disease can prevention and therapy, and human longevity can significantly extend.
Detailed description of the invention
One, Ganoderma 0.5 gram, Radix Salviae Miltiorrhizae 0.6 gram, threonine 0.5 gram, serine 0.6 gram, cysteine 0.06 gram, vitamin C 50 milligrams, vitamin E 4 milligrams, vitamin A 0.1 milligram, beta-carotene 0.6 milligram are made into masticatory, every day 2 to 4 times.
Two, Ganoderma 0.25 gram, Radix Salviae Miltiorrhizae 0.3 gram, threonine 0.25 gram, serine 0.3 gram, cysteine 0.03 gram, Catergen 5 milligrams, vitamin E2 milligram, vitamin A 0.05 milligram, beta-carotene 0.3 milligram are made into masticatory, every day 2 to 4 times.
Three, Ganoderma 0.5 gram, Radix Salviae Miltiorrhizae 0.6 gram, threonine 0.5 gram, serine 0.6 gram, cysteine 0.06 gram, vitamin C 50 milligrams, vitamin E 4 milligrams, vitamin A 0.1 milligram, beta-carotene 0.6 milligram are made into containing agent, every day 2 to 4 times.
Four, Ganoderma 0.25 gram, Radix Salviae Miltiorrhizae 0.3 gram, threonine 0.25 gram, serine 0.3 gram, cysteine 0.03 gram, Catergen 5 milligrams, vitamin E2 milligram, vitamin A 0.05 milligram, beta-carotene 0.3 milligram are made into containing agent, every day 2 to 4 times.
Five, Ganoderma 5 grams, Radix Salviae Miltiorrhizae 0.6 gram, threonine 0.5 gram, serine 0.6 gram, cysteine 0.06 gram, vitamin C 50 milligrams, vitamin E 4 milligrams, vitamin A 0.1 milligram, beta-carotene 0.6 milligram are made into oral agents, every day 2 to 4 times.
Six, Ganoderma 2.5 grams, Radix Salviae Miltiorrhizae 3 grams, threonine 0.25 gram, serine 0.3 gram, cysteine 0.03 gram, Catergen 5 milligrams, vitamin E2 milligram, vitamin A 0.05 milligram, beta-carotene 0.3 milligram are made into oral agents, every day 2 to 4 times.
Claims (1)
1. treat a combination formula for inflammatory bowel, its prescription is characterized as: Ganoderma 5 ~ 50 parts, Radix Salviae Miltiorrhizae 6 ~ 60 parts, threonine 5 parts, serine 6 parts, cysteine 0.6 part, vitamin C 0.5 part, vitamin E 0.04 part, vitamin A 0.001 part, beta-carotene 0.006 part.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080011921A (en) * | 2006-08-01 | 2008-02-11 | 퓨리메드 주식회사 | Compositions for treating autoimmune disease containing extracts of salviae miltiorrhizae radix |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080011921A (en) * | 2006-08-01 | 2008-02-11 | 퓨리메드 주식회사 | Compositions for treating autoimmune disease containing extracts of salviae miltiorrhizae radix |
Non-Patent Citations (4)
| Title |
|---|
| ANNAÏG LAN ET AL: "Mucosal Healing in Inflammatory Bowel Diseases: Is There a Place for Nutritional Supplementation?", 《INFLAMM BOWEL DIS》 * |
| 中华医学会: "维生素矿物质补充剂在炎症性肠病防治中的临床应用：专家共识", 《中华临床营养杂志》 * |
| 何松庆: "咀嚼灵芝与肠道黏膜屏障--食物过敏、过敏性哮喘、口腔溃疡与炎症性肠病", 《医药卫生》 * |
| 陈培丰 等: "《中西医结合临床内科学》", 31 August 2006, 浙江科学技术出版社 * |
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