CN105434462A - Iodine-supported skin bactericide and iodine supporting method - Google Patents
Iodine-supported skin bactericide and iodine supporting method Download PDFInfo
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- CN105434462A CN105434462A CN201510980846.0A CN201510980846A CN105434462A CN 105434462 A CN105434462 A CN 105434462A CN 201510980846 A CN201510980846 A CN 201510980846A CN 105434462 A CN105434462 A CN 105434462A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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Abstract
The invention belongs to the technical field of medicine, and particularly relates to an iodine-supported skin bactericide and an iodine supporting method. The iodine-supported skin bactericide is formed by supporting iodine on a modified natural mineral zeolite molecular sieve which is used as a supporter. The iodine accounts for 1-15 wt% of the supporter. The supporter comprises STI stilbite, MOR mordenite and HEU clinoptilolite. The iodine supporting method is implemented by supporting the simple substance iodine in a vapor phase or supporting the iodine from an iodine-containing KI water solution. The iodine-supported skin bactericide can take effect quickly and can not burn the skin to cause pains when in use. The iodine-supported skin bactericide can be prepared into powder or granules. The iodine-supported skin bactericide is safe, reliable, green and environment-friendly, and is convenient for abundant storage, carrying and transportation. The production technique of the bactericide is simple, and the process is green and environment-friendly.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of iodine load skin sterilization agent and load iodine method.
Background technology
Iodine tincture and iodine tincture are conventional liquid skin disinfection sanitizers.The former is dissolved in alcoholic solution by with iodine, potassium iodide and makes, and the iodine concentration of commercially available iodine tincture is 2%.The latter is the indefinite form conjugate of iodine and polyvinylpyrrolidone (Povidone), and medical povidone iodine is containing iodine 1% or following.The two all has certain stimulation to skin, should not be used for the sterilization of damaged skin, eye and oral mucosa.Taking ethanol as the iodine tincture of solvent, is combustibles, and a large amount of storage and transport have certain danger.The solvent polyvinylpyrrolidone of povidone iodine is nitrogenous organic micromolecule compound, and after a large amount of use, abandoned can produce certain pollution to environment.
For this reason, people are always at the immobilized iodine disinfection sanitizer of Seeking Development Through.Solid material used for this purpose has chitosan porous microsphere (CN102407162A), polystyrene (CN101773146A) and anion exchange resin (CN100411626C, CN1911241A) etc.US Patent No. 2006078628A1 proposition for carrier, prepares zeolite iodine clathrate (zeolite-iodineinclusion) as wound disinfection agent with 5A zeolite.Its content of iodine 1-10%.The dominant cation of 5A zeolite is Ca
+ 2 ,the framework silicon-aluminum atomic ratio of this zeolite is 1.0.With framework aluminum with the commutative Ca that balances each other of negative charge
+ 2the quantity of ion is 1/2nd, Ca of framework aluminum
+ 2ionic radius is little, electrically strong, and strongly, iodine molecule is at the Ca of the strong polarization force of One's name is legion in its polarization force effect
+ 2under encirclement, from the duct and cage of A zeolite, discharge quite difficulty, with slow, cause its sterilization onset slower.Moreover 5A molecular sieve is strong water absorbent, it is industrial conventional deep dehydration desiccant.It is once flow out contacting blood with wound, and meeting sharply heat release because of the moisture content in absorption blood, gives pain, may skin ambustion time serious.
Summary of the invention
The iodine load skin sterilization agent that the object of the present invention is to provide a kind of bactericidal effect good, easy to use and the method for load iodine.
The iodine load skin sterilization agent that the present invention proposes, using modified natural mineral zeolite molecular sieve as carrier, load iodine and forming; Wherein, the load capacity of iodine is the 1-15% of carrier quality.
In the present invention, described carrier comprises: the clinoptilolite of the foresite of STI type, the modenite of MOR type and HEU type.
In the present invention, the modenite of the foresite of described STI type, the clinoptilolite of HEU type and MOR type, its cation can be Hydrogen, calcium type, sodium form, potassium type, magnesium types, also can mixed-cation type.
In the present invention, described iodine load skin sterilization agent, can be powdery also can be granular.
The preparation method of above-mentioned iodine load skin sterilization agent that the present invention proposes and the method for load iodine, can have 2 kinds, one is vapor phase load iodine, and another kind is from load iodine the KI aqueous solution containing iodine; The load capacity of iodine is the 1-15% of carrier quality.
Described vapor phase load iodine method, be carrier by realizing load to the absorption of vapor phase iodine, the iodine of vapor phase can in atmosphere by load, also can in a vacuum by load; The temperature range of load is 25-50 DEG C, and the time is 1-12h.
Described from containing the method for load iodine the KI aqueous solution of iodine, be by carrier from KI concentration be 0.2-2 mole, the content of iodine is load iodine the solution of 1-5%; The temperature of load is 25-50 DEG C, and the time is 5-10h; Carrier is 5 to 15 with the liquid/solid weight ratio of solution.
In the present invention, the described modified natural mineral zeolite molecular sieve as carrier, the method for its modification mainly contains: natural minerals zeolite molecular sieve powder is heated 2-8 hour at 250-500 DEG C, sloughs adsorbed water; Or at room temperature exchange tradable Ca, Na, K, Mg plasma of removing with diluted mineral acid example hydrochloric acid, sulphuric acid, nitric acid or acetic acid and make H type zeolite; Or with aluminium oxide or Kaolin as binding agent, make granule (as bead) shape by natural minerals zeolite molecular sieve original ore powder or through acid-treated h-type zeolite powder molding bonded, binder content is generally carrier quality at 15-25%.
The natural minerals zeolite that carrier Dou Shi China used in the present invention richness is produced, to human body and environment nontoxic; Their framework silicon-aluminum mol ratio belongs to silica-rich zeolite between 5-12, and structure aperture is greater than 0.5 nanometer.Exchangeable cations number in its duct is only about 1/5th of type A zeolite.Cation is the strong electrostatic center of adsorbed water in zeolite structured.Therefore, water adsorption amount and the water adsorption rate of above-mentioned natural zeolite are more much lower than A zeolite, and the iodine of institute's load is also than being easy to release from A zeolite.Therefore, instant effect when novel iodine load skin sterilization agent of the present invention uses, can not cause pain by skin ambustion.Can powdery be made, also can make graininess, safe and reliable, environmental protection, be convenient to mass storage, carry and transport.
The production technology of antibacterial of the present invention is simple, process environmental protection.Should particularly point out, the natural STI mineral zeolite molecular sieve that China's richness is produced, high-grade, high-purity, the whole world only one, makes medical preparation with it, has Special Significance.
The domestic natural minerals zeolite molecular sieve chemical composition of used carrier of the present invention and percentage composition thereof are as following table:
Above-mentioned data show, the present invention's carrier S TI zeolite used is the natural foresite that purity is very high, belongs to calcium type.MOR purity is lower, belongs to sodium calcium type, and because of containing more quartzy stray crystal, silicone content is higher, and the content of ferrum is also considerable.HEU zeolite belongs to potassium calcium type, and because of K-feldspar stray crystal, potassium content is higher, and containing a small amount of magnesium and ferrum.
Accompanying drawing explanation
Fig. 1 is the antibacterial effect figure of the staphylococcus aureus that the STI zeolite sterilization powder of iodine load capacity 2.5% prepared by the embodiment of the present invention 1 obtains.
Detailed description of the invention
The invention is further illustrated by the following examples.
Embodiment 1, from iodine steam phase absorption carriage iodine
At one
place the pure iodine crystal of solid in the arm of side, the below bottom lock of shape trident glass tubing, put into powdery or graininess (spherical) carrier in the arm of opposite side bottom lock, the arm of upward opening is used for UNICOM and controls air pipe.This trident pipe is placed in water bath with thermostatic control, keeps certain load temperature.The iodine steam that iodine crystal distillation produces diffuses in the opposite side arm be connected, loaded body adsorbed.Adsorb the sample of iodine of the load after certain hour at a certain temperature, measure its iodine load capacity by X-ray fluorescence spectrophotometer (XRF).
Absorption control climate: air-normal pressure; Vacuum-pressure 0.1 holds in the palm.Load test the results are shown in following table 1.
Table 1
。
Embodiment 2, absorption carriage iodine from the KI aqueous solution being dissolved with iodine
In glass container, pour the KI solution containing a certain amount of iodine into, take a certain amount of carrier subsequently and put this container into.Container be placed in can heated for controlling temperature magnetic stirrer hot plate on.Under stirring condition consumingly, be suspended in the iodine that nanometer micropore support materials in solution can be dissolved in rapid adsorption solution.After load test terminates, after filtration, dry 1 hour by acetone rinsing, air at room temperature after deionized water wash after to measure the load capacity of its iodine by XRF method.Result of the test sees the following form 2.
Table 2
。
Embodiment 3, antibacterial effect detect
Picking staphylococcus aureus in 1mlTSB culture medium 37 DEG C, 200rpm hatches 18h.Bacterium liquid is diluted to 3-7 × 10
5cFU/ml, pours in culture dish, every ware 5ml, places 30min, pours out bacterium liquid, dry.By the sterilization powder containing iodine 2.5 zeolite-loaded for the present invention STI, mix with TSB culture medium, doubling dilution, concentration is respectively 500mg/ml, 250mg/ml, 125mg/ml, 62.5mg/ml, 31.75mg/ml, 15.88mg/ml, 7.94mg/ml, 3.96mg/ml.In culture dish, put into the scraps of paper, 6, every ware, drip containing iodine microbicide powder, ANER DIAN, TSB culture medium respectively to the scraps of paper in independent culture dish and do not contain each 6 μ l of iodine STI breeze, the concentration containing iodine sterilization powder in each culture dish is unique.Hatch 18h for 37 DEG C, observe the size of bacterial restrain.Result shows that the sterilization powder of three kinds of different amount of iodine all has bacteriostasis to staphylococcus aureus, and the fungistatic effect of M3 is more obvious, still has fungistatic effect when low concentration.
Fig. 1 photo is staphylococcus aureus bacteriostatic test, in photo, the leftmost side one is classified as ANER DIAN contrast, the rightmost side is respectively be classified as containing iodine styptic powder concentration from height to low in the middle of blank, laterally three row M1, M2, M3 are that different ratio contains iodine sterilization powder, the middle white scraps of paper contain medicine, and the bacterial restrain ring wider display of dark-shaded display around bacteriostasis is stronger.Show M3 in figure and still have bacteriostasis at the least concentration of test, fungistatic effect is the most obvious.
Claims (8)
1. an iodine load skin sterilization agent, is characterized in that, using the natural minerals zeolite molecular sieve of modification as carrier, and load iodine and obtaining; Wherein, the load capacity of iodine is the 1-15% of carrier quality.
2. iodine load skin sterilization according to claim 1 agent, it is characterized in that, described carrier comprises: the clinoptilolite of the foresite of STI type, the modenite of MOR type and HEU type.
3. iodine load skin sterilization according to claim 1 agent, it is characterized in that, the modenite of the foresite of described STI type, the clinoptilolite of HEU type and MOR type, its cation be Hydrogen, calcium type, sodium form, potassium type or magnesium types, or wherein several mixed type.
4. iodine load skin sterilization according to claim 1 agent, it is characterized in that, dosage form is powder, or granule.
5. the preparation method of iodine load skin sterilization agent as claimed in claim 1, is characterized in that, be divided into 2 kinds: one be carrier by vapor phase load iodine, another kind is carrier from containing load iodine the KI aqueous solution of iodine; The load capacity of iodine is the 1-15% of carrier quality.
6. the preparation method of iodine load skin sterilization according to claim 5 agent, it is characterized in that, described vapor phase load iodine, is that carrier is by realizing load to the absorption of vapor phase iodine, the iodine of vapor phase can in atmosphere by load, also can in a vacuum by load; The temperature range of load is 25-50 DEG C, and the time is 1-12h.
7. the preparation method of iodine load skin sterilization according to claim 5 agent, is characterized in that, described from containing load iodine the KI aqueous solution of iodine, be by carrier from KI concentration be 0.2-2 mole, the content of iodine is load iodine the solution of 1-5%; The temperature of load is 25-50 DEG C, and the time is 5-10h; The liquid/solid weight ratio of carrier and solution is 5 to 15.
8. according to the preparation method of the iodine load skin sterilization agent one of claim 5-7 Suo Shu, it is characterized in that, the described modified natural mineral zeolite molecular sieve as carrier, the method for its modification has: natural minerals zeolite molecular sieve powder is heated 2-8 hour at 250-500 DEG C, sloughs adsorbed water; Or at room temperature exchange tradable Ca, Na, K, Mg plasma of removing with diluted mineral acid example hydrochloric acid, sulphuric acid, nitric acid or acetic acid and make H type zeolite; Or with aluminium oxide or Kaolin as binding agent, make graininess by natural minerals zeolite molecular sieve original ore powder or through acid-treated h-type zeolite powder molding bonded, binder content is generally carrier quality at 15-25%.
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| CN201510980846.0A CN105434462A (en) | 2015-12-24 | 2015-12-24 | Iodine-supported skin bactericide and iodine supporting method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581051A (en) * | 2016-11-08 | 2017-04-26 | 太原市诚诚科技有限公司 | Nano microemulsion iodine and preparation method thereof |
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| CN1743065A (en) * | 2005-07-27 | 2006-03-08 | 复旦大学 | Method for preparing in-situ silver-carried natural zeolite deiodinating adsorbent |
| US20060078628A1 (en) * | 2004-10-09 | 2006-04-13 | Karl Koman | Wound treating agent |
| WO2006098680A1 (en) * | 2005-03-14 | 2006-09-21 | Benjaminson Haakan | The use of a hydrophobic zeolite, that contains and gives a slow release of an active element, for treatment of skin |
| CN102210665A (en) * | 2011-03-24 | 2011-10-12 | 桂林理工大学 | Method for preparing feed antibacterial agent by absorbing and grafting potassium diformate on epidesmine molecular screen |
| CN103826739A (en) * | 2012-04-02 | 2014-05-28 | 科莱恩产品(德国)股份有限公司 | Methyl iodide adsorber, use of the same, and method for adsorption of methyl iodide |
| CN104936691A (en) * | 2012-11-23 | 2015-09-23 | 西江大学校产学协力团 | Zeolite composite containing iodine or bromine confined pores, and use thereof |
-
2015
- 2015-12-24 CN CN201510980846.0A patent/CN105434462A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060078628A1 (en) * | 2004-10-09 | 2006-04-13 | Karl Koman | Wound treating agent |
| WO2006098680A1 (en) * | 2005-03-14 | 2006-09-21 | Benjaminson Haakan | The use of a hydrophobic zeolite, that contains and gives a slow release of an active element, for treatment of skin |
| CN1743065A (en) * | 2005-07-27 | 2006-03-08 | 复旦大学 | Method for preparing in-situ silver-carried natural zeolite deiodinating adsorbent |
| CN102210665A (en) * | 2011-03-24 | 2011-10-12 | 桂林理工大学 | Method for preparing feed antibacterial agent by absorbing and grafting potassium diformate on epidesmine molecular screen |
| CN103826739A (en) * | 2012-04-02 | 2014-05-28 | 科莱恩产品(德国)股份有限公司 | Methyl iodide adsorber, use of the same, and method for adsorption of methyl iodide |
| CN104936691A (en) * | 2012-11-23 | 2015-09-23 | 西江大学校产学协力团 | Zeolite composite containing iodine or bromine confined pores, and use thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581051A (en) * | 2016-11-08 | 2017-04-26 | 太原市诚诚科技有限公司 | Nano microemulsion iodine and preparation method thereof |
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Application publication date: 20160330 |