CN105412601A - 用于抗化疗副反应的口服液 - Google Patents
用于抗化疗副反应的口服液 Download PDFInfo
- Publication number
- CN105412601A CN105412601A CN201510904489.XA CN201510904489A CN105412601A CN 105412601 A CN105412601 A CN 105412601A CN 201510904489 A CN201510904489 A CN 201510904489A CN 105412601 A CN105412601 A CN 105412601A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- hour
- rhizoma
- spleen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种用于抗化疗副反应的口服液,取下述重量配比的主要原料制备而成:白芍5-9份,丹参6-12份,白及3-9份,茯苓6-15份,佩兰8-15份,葛根20-35份,黄连4-12份,刘寄奴6-15份,白术4-9份,菟丝子3-9份,苍术3-7份,补骨脂(盐炙)2-8份,威灵仙2-6份,松花粉3-8份。本发明所选材料均为传统中药材,无任何毒副作用,对化疗引起的副反应具有很好的治疗效果,具有健脾和胃的功效。
Description
分案申请,原申请号2014101448674,申请日2014.04.12,名称抗化疗副反应的健脾和胃制剂及制法。
技术领域
本发明公开了一种健脾和胃制剂,尤其是抗化疗副反应的健脾和胃制剂及制法。本发明属中医中药领域。
背景技术
化疗,是用化学物质来治疗疾病,是目前治疗肿瘤及某些自身免疫性疾病的主要手段之一。它是利用化学药物杀死肿瘤细胞、抑制肿瘤细胞的生长繁殖和促进肿瘤细胞的分化的一种治疗方式,它是一种全身性治疗手段对原发灶、转移灶和亚临床转移灶均有治疗作用,但是化疗治疗肿瘤在杀伤肿瘤细胞的同时,也将正常的细胞和免疫(抵抗)细胞一同杀灭,所以是一种“玉石俱焚”的治疗方法。
肿瘤疾患,早期多以化疗治疗为主,且大多病程历时较长,久病易耗气伤阴,因此肿瘤患者多见气阴两虚之症,容易出现口干咽燥、身体乏力等症状;而化疗多为化学毒,每次放疗都直指脾胃,对脾胃会造成以下副作用:脾胃虚弱、升降失常而出现玩腹胀痛,恶心呕吐,身体疲乏,精神不振等症状,除此之外,还常伴有与化疗有关的全身反应、免疫功能下降等。脾胃虚弱后天之本受损,则气血不足,更加导致气阴亏虚。如此循环往复,病情更加不易好转。肿瘤化疗后引起的消化道反应属于中医“胃痞”、“呕吐”等范畴,其病位主要在五脏,与脾胃有很大关系:脾胃失和、脾胃虚弱、气阴两虚是主要的病理基础。
化疗对肿瘤有一定的治疗效果,能在一定程度上缓解患者的病痛,提高肿瘤的治愈效果,但是化疗的毒副作用对脾胃产生很大的抑制作用,所以研制抗化疗副反应的药物,使肿瘤患者能更好的的接受治疗具有十分重要的意义。中医药在改善这种反应方面,具有明显的优势,但是真正开发成新药的并不是很多,而且已开发的药物治疗效果亦不明显。本发明健脾和胃制剂是在查阅了大量的文献资料和临床试验的基础上,针对化疗所致的脾胃虚弱、脾胃失和以及气阴两虚的主要中医病机,在显著改善化疗对脾胃所造成的毒副反应的同时,还能提高病人的免疫功能、骨髓造血功能等,从而达到改善病人身体状况,增强患者身体素质的目的,使患者更好的接受治疗,以提高患者的治愈率。
申请公布号为CN102327390A(申请号201110314905.2)的中国专利文献公开了一种名为“一种防治化疗毒副反应的中药组方及其丸剂的制备方法”,该中药组方有阿胶、人参、肉桂、川芎、熟地黄、茯苓、白术、黄芪、当归、白芍、菟丝子、枸杞子、川牛膝、陈皮、灵芝、肉苁蓉、鹿茸、麝香、钟乳石、巴戟天、附子、海参、甘草、鹿角胶、黄酒按照一定的重量配比组成。其配方药材众多,且个别药材价格较高,增加了患者的经济负担。申请公布号为CN103623338A(申请号201310275217.9)的中国专利文献公开了一种名为“治疗癌症化疗后消化道副作用的中药颗粒剂及其制备方法”,该中药颗粒剂由黄芪600-800g、麦冬250-350g、红参150-250g、麸炒白术150-250g、茯苓150-250g、甘草200-300g、玄参200-300g、当归200-300g、乌梅250-350g、法半夏250-350g、广藿香200-300g、陈皮200-300g、莪术200-300g组成。该中药颗粒剂制备方法复杂,不适宜个人操作。
发明内容
针对现有抗化疗副反应的略有不足的现状,本发明的目的之一在于提供一种抗化疗副反应的健脾和胃制剂,具有易操作、疗效显著等特点,并且它采用地方上较为常见的中药材作为原料,成本低廉且无任何毒副作用。
本发明的另一目的就是提供上述健脾和胃制剂的制备方法。
本发明的技术方案是:
抗化疗副反应的健脾和胃制剂,取下述重量配比的主要原料制备而成:白芍5-9份,丹参6-12份,白及3-9份,茯苓6-15份,佩兰8-15份,葛根20-35份,黄连4-12份,刘寄奴6-15份,白术4-9份,菟丝子3-9份,苍术3-7份,补骨脂(盐炙)2-8份,威灵仙2-6份,松花粉3-8份。
抗化疗副反应的健脾和胃制剂,优选的方案为,取下述重量配比的主要原料制备而成:白芍6-8份,丹参8-10份,白及5-7份,茯苓8-11份,佩兰10-13份,葛根25-30份,黄连6-10份,刘寄奴9-12份,白术5-8份,菟丝子5-7份,苍术4-6份,补骨脂(盐炙)4-6份,威灵仙3-5份,松花粉5-7份。
抗化疗副反应的健脾和胃制剂,更加优选的方案为,取下述重量配比的主要原料制备而成:白芍7份,丹参9份,白及6份,茯苓10份,佩兰11份,葛根28份,黄连8份,刘寄奴10份,白术7份,菟丝子6份,苍术5份,补骨脂(盐炙)5份,威灵仙4份,松花粉6份。
本发明还提供了将上述健脾和胃制剂制成药学上可接受的粉剂、水剂、膏剂、颗粒剂、片剂或胶囊。
所述粉剂的制备方法是:
(1)将松花粉粉碎,过100-140目筛(优选的,过110-130目筛;更加优选的,过120目筛);
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙混合粉碎过65-125目筛(优选的,过80-110目筛;更加优选的,过95目筛);
(3)将步骤(1)和(2)所得混匀即可。
所述水剂的制备方法是:
(1)将松花粉粉碎,过100-140目筛(优选的,过110-130目筛;更加优选的,过120目筛);
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙置于砂锅内,加水(用水量为原料药总重的2-4倍(优选的,2.5-3.5倍;更加优选的,3倍))煎煮3次,第一次1.5-2.5小时(优选的1.8-2.2小时;更加优选的,2小时),第二次0.5-1.2小时(优选的,0.7-1.0小时;更加优选的,0.8小时),第三次0.5-1.2小时(优选的,0.7-1.0小时;更加优选的,0.8小时),将三次所得滤液合并,静置,滤过;
(3)将步骤(1)粉碎后的松花粉加入步骤(2)所得药液,无菌封装。
所述膏剂的制备方法是:
(1)将松花粉粉碎,过100-140目筛(优选的,过110-130目筛;更加优选的,过120目筛);
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙置于砂锅内,加水(用水量为原料药总重的2-4倍(优选的,2.5-3.5倍;更加优选的,3倍))煎煮3次,第一次1.5-2.5小时(优选的1.8-2.2小时;更加优选的,2小时),第二次0.5-1.2小时(优选的,0.7-1.0小时;更加优选的,0.8小时),第三次0.5-1.2小时(优选的,0.7-1.0小时;更加优选的,0.8小时),将三次所得滤液合并,静置,滤过;
(3)将步骤(2)所得滤液浓缩至相对密度为1.05-1.50(50℃)的清膏,冷却至室温;
(4)将步骤(1)粉碎后的松花粉加入步骤(3)所得清膏,无菌封装。
所述颗粒剂的制备方法是:
(1)将松花粉粉碎,过100-140目筛(优选的,过110-130目筛;更加优选的,过120目筛);
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙置于砂锅内,加水(用水量为原料药总重的2-4倍(优选的,2.5-3.5倍;更加优选的,3倍))煎煮3次,第一次1.5-2.5小时(优选的1.8-2.2小时;更加优选的,2小时),第二次0.5-1.2小时(优选的,0.7-1.0小时;更加优选的,0.8小时),第三次0.5-1.2小时(优选的,0.7-1.0小时;更加优选的,0.8小时),将三次所得滤液合并,静置,滤过;
(3)将步骤(2)所得滤液浓缩至相对密度为1.05-1.50(50℃)的清膏,冷却至室温;
(4)取清膏0.5-1.2份(优选的,0.7-1.0份;更加优选的,0.8份),加入步骤(1)粉碎后的松花粉,混匀,加蔗糖4-7份(优选的,5-7份;更加优选的,6份)及乙醇适量,制成颗粒,干燥,即可。
所述片剂的制备方法是:将权利要求5所得粉剂按照0.4-0.8g/片(优选的,0.5-0.7g/片;更加优选的,0.6g/片)计量,按照片剂的加工制备方法压制成圆形或其他形状的片状剂型。
所述胶囊的制备方法是:将权利要求5所得药剂粉剂按照0.6-1.0g/粒(优选的,0.7-0.9g/粒;更加优选的,0.8g/粒)计量,按照胶囊的加工制备方法加工成胶囊状剂型。
本发明所用主要中药原料的药理如下:
白芍:性味:味苦,酸,微寒。归经:归肝、脾经。功效:养血合营,缓急止痛,敛阴平肝。主治:血虚寒热,脘腹疼痛,胁痛,肢体痉挛疼痛,痛经,月经不调,崩漏,自汗,盗汗,下痢泄泻,头痛眩晕。
丹参:性味:味苦,微寒。归经:归心、心包、肝经。功效:活血祛瘀,调经止痛,除烦安神,凉血消痈。主治:妇女月经不调,痛经,经闭,产后淤滞腹痛,心腹疼痛,癥瘕积聚,热痹肿痛,跌打损伤,热入营血,烦躁不安,心烦失眠,痈疮肿毒。
白及:性味:味苦、甘、涩,微寒。归经:归肺、肾经。功效:收敛止血,消肿生肌。主治:咯血,吐血,衄血,便血,外伤出血,痈疮肿毒,烫灼伤,手足皲裂,肛裂。
茯苓:性味:味甘、淡,平。归经:归心、肺、脾、肾经。功效:利水渗湿,健脾宁心。主治:用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
佩兰:性味:味辛,平。归经:归脾、胃经。功效:解暑化湿,醒脾和中。主治:暑湿或湿温初起,发热头重,胸闷腹胀,脘痞不饥,恶心呕吐,口中甜腻,消渴。
葛根:性味:味甘、辛,平。归经:归脾、胃经。功效:升阳解肌,透疹止泻,除烦止温。主治:伤寒、温热头痛项强,烦热消渴,泄泻,痢疾,癍疹不透,高血压,心绞痛,耳聋。
黄连:性味:味苦,寒。归经:归心、肝、胃、大肠经。功效:清热泻火,燥湿,解毒。主治:热病邪入心经之高热,烦躁,谵妄或热盛迫血妄行之吐衄,湿热熊痞泄泻,痢疾,心火亢盛之心烦失眠,胃热呕吐,消谷善饥,肝火目赤肿痛,以及热毒疮疡,疔毒走黄,牙龈肿痛,口舌生疮,聤耳,痔血,湿疹,烫伤。
刘寄奴:性味:味苦,温。归经:归心、肺经。功效:破血通经,敛疮消肿。主治:经闭症瘕,胸腹胀痛,产后血瘀,跌打损伤,金疮出血,痈毒焮肿。
白术:性味:味苦、甘,温。归经:归脾、胃经。功效:健脾益气,燥湿利水,止汗,安胎。主治:脾气虚弱之乏力,食少腹胀,泄泻便秘,水饮内停之小便不利,水肿,痰饮眩晕,寒湿痹,身痛,气虚自汗,胎动不安。
菟丝子:性味:微辛,甘,平。归经:归肝、肾经。功效:补肾益精,养肝明目。主治:适用于肝肾不足的腰膝筋骨酸痛,腿脚软弱无力、阳痿遗精、呓语、小便频数、尿有余沥、头晕眼花、视物不清、耳鸣耳聋以及妇女带下、习惯性流产等症。
苍术:性味:味辛、苦,温。归经:归脾、胃、肝经。功效:燥湿健脾,祛风湿,明目。主治:湿困脾胃,倦怠嗜卧,胸痞腹胀,食欲不振,呕吐泄泻,痰饮,湿肿,表证夹湿,头身重痛,痹症湿胜,肢节酸痛重着,痿躄,夜盲。
补骨脂(盐炙):性味:味辛、苦,温。归经:归肾、脾经。功效:补肾助阳,纳气平喘,温脾止泻。主治:主肾阳不足,下元虚冷,腰膝冷痛,阳痿遗精,尿频,遗尿,肾不纳气,虚喘不止,脾肾两虚,大便久泻,外用于白癜风,斑秃,银屑病。
威灵仙:性味:辛,咸,温。归经:归膀胱经。功效:祛风除湿,通络止痛,消痰水,散癖积。主治:痛风顽痹、风湿痹痛,肢体麻木,腰膝冷痛,筋脉拘挛,屈伸不利,脚气,疟疾,症瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。
松花粉:性味:味甘,温。归经:归肝、脾经。功效:祛风益气,收湿,止血。主治:头旋眩晕,中虚胃疼,久痢,诸疮湿烂,创伤出血。
本发明健脾和胃制剂是在研究了大量文献资料和临床试验的基础上制成的,具有健脾和胃的功效,对于化疗引起的副反应有很好的治疗效果。而且选用的药材均为传统中药材,疗效确切且无任何毒副作用。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不限于此。
实施例1抗化疗副反应的健脾和胃制剂,取下述重量配比的主要原料制备而成(每份取10g):白芍7份,丹参9份,白及6份,茯苓10份,佩兰11份,葛根28份,黄连8份,刘寄奴10份,白术7份,菟丝子6份,苍术5份,补骨脂(盐炙)5份,威灵仙4份,松花粉6份。
上述健脾和胃制剂粉剂的制备方法为:
(1)将松花粉粉碎,过120目筛;
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙混合粉碎过95目筛;
(3)将步骤(1)和(2)所得混匀即可。
本发明粉剂服用方法:将粉剂分8g/袋,采用每天2-3次,每次一袋,用温开水冲服,7天一个疗程。
典型病例一黄XX,年龄:80岁,性别:女。患者2006年8月发现腹部肿物进行性增大,2007年5月双侧胸腔及腹腔积液,腹水找到腺癌细胞,原发灶不详,2007年6月因巨大腹腔肿物伴重度腹水,急诊住院要求立即放腹水,后通过化疗进行治疗。化疗引起脾胃虚弱、恶心呕吐、口干舌燥、身体疲乏等不适症状。服用本实施例所得健脾和胃制剂粉剂,采用每日3次,每次一袋,用温开水冲服,7天一个疗程。服用21天,患者口干舌燥症状减轻,不适症状有所缓解;服用2个月,患者不适症状逐渐消失,精神、体力增强;继续服用2个月,患者自感无不适症状。
实施例2抗化疗副反应的健脾和胃制剂,取下述重量配比的主要原料制备而成(每份取20g):白芍7份,丹参9份,白及6份,茯苓10份,佩兰11份,葛根28份,黄连8份,刘寄奴10份,白术7份,菟丝子6份,苍术5份,补骨脂(盐炙)5份,威灵仙4份,松花粉6份。
上述健脾和胃制剂膏剂的制备方法为:
(1)将松花粉粉碎,过120目筛;
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙置于砂锅内,加水(用水量为原料药总重的3倍)煎煮3次,第一次2小时,第二次0.8小时,第三次0.8小时,将三次所得滤液合并,静置,滤过;
(3)将步骤(2)所得滤液浓缩至相对密度为1.05-1.50(50℃)的清膏,冷却至室温;
(4)将步骤(1)粉碎后的松花粉加入步骤(3)所得清膏,无菌封装。
本发明膏剂服用方法:膏剂采用每天2次,每次6-10g,按照1:10的比例冲水服用,7天一个疗程。
典型病例二陈XX,年龄:48岁,性别:男。患者腹围103cm,腹部触及有多个如拳大肿物,直肠窝触及如鸡蛋大转移肿块。腹胀如鼓、消瘦、乏力、气促、身痛腹水找到腺癌细胞。定期接受化疗来治疗,但是化疗引起脾胃不适、身体乏力、食欲不振并伴有恶心呕吐等现象,服用抗化疗副反应的药物,无明显效果,现在患者异常消瘦。服用本实施例所得健脾和胃制剂膏剂,采用每日2次,每次10g,按照1:10的比例冲水服用,7天一个疗程。服用14天,患者不适症状减轻,纳食渐多;服用1个月,患者恶心呕吐减轻,体力增强,不适症状逐渐消失;继续服用2个月,患者自感痊愈。
实施例3抗化疗副反应的健脾和胃制剂,取下述重量配比的主要原料制备而成(每份30g):白芍7份,丹参9份,白及6份,茯苓10份,佩兰11份,葛根28份,黄连8份,刘寄奴10份,白术7份,菟丝子6份,苍术5份,补骨脂(盐炙)5份,威灵仙4份,松花粉6份。
上述健脾和胃制剂颗粒剂的制备方法为:
(1)将松花粉粉碎,过120目筛;
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙置于砂锅内,加水(用水量为原料药总重的3倍)煎煮3次,第一次2小时,第二次0.8小时,第三次0.8小时,将三次所得滤液合并,静置,滤过;
(3)将步骤(2)所得滤液浓缩至相对密度为1.05-1.50(50℃)的清膏,冷却至室温;
(4)取清膏0.8份,加入步骤(1)粉碎后的松花粉,混匀,加蔗糖6份及乙醇适量,制成颗粒,干燥,即可。
本发明颗粒剂服用方法:将颗粒剂分10g/袋,每天2-3次,每次一袋,用温开水冲服,7天一个疗程。
典型病例三吴XX,年龄:45岁,性别:女。患者2006年8月进行右侧输软管乳头状腺癌切除术,癌瘤侵犯子宫、直肠,进行一周期化疗产生了严重的副反应:脾胃虚弱、食欲低下、嗜睡、恶心呕吐、精神不振等。服用本实施例所得健脾和胃制剂颗粒剂,采用每日3次,每次1一袋,用温开水冲服,7天一个疗程。服用1个月,患者食欲增强,不适症状逐渐改善;服用2个月,患者体力增强,精神状态明显好转,不适症状逐渐消失;继续服用2个月,不适症状消失。
实施例4抗化疗副反应的健脾和胃制剂,取下述重量配比的主要原料制备而成(每份40g):白芍7份,丹参9份,白及6份,茯苓10份,佩兰11份,葛根28份,黄连8份,刘寄奴10份,白术7份,菟丝子6份,苍术5份,补骨脂(盐炙)5份,威灵仙4份,松花粉6份。
上述健脾和胃制剂片剂的制备方法为:
(1)将松花粉粉碎,过120目筛;
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙混合粉碎过95目筛;
(3)将步骤(1)和(2)所得混匀得粉剂;
(4)将步骤(3)所得粉剂按照0.6g/片计量,按照片剂的加工制备方法压制成圆形或其他形状的片状剂型。
本发明片剂服用方法:片剂采用每天3次,每次5-8片,用温开水冲服,7天一个疗程。
典型病例四李XX,年龄:68岁,性别:男。2008年2月胃部不适,自触及上腹部有鸡蛋大肿物,胃镜病理证实恶性淋巴瘤,定期化疗来接受治疗,化疗引起以下副反应:口干舌燥、脾胃不适、精神不振、身体疲乏等不适症状。服用本实施例所得健脾和胃制剂片剂,次用每日3次,每次6片,用温开水冲服,7天一个疗程。服用10天,口干舌燥减轻,不适症状缓解;服用1个月,患者食欲增强,精神状态改善,不适症状逐渐消失;继续服用2个月,患者不适症状完全消失。
实施例5抗化疗副反应的健脾和胃制剂,取下述重量配比的主要原料制备而成(每份50g):白芍7份,丹参9份,白及6份,茯苓10份,佩兰11份,葛根28份,黄连8份,刘寄奴10份,白术7份,菟丝子6份,苍术5份,补骨脂(盐炙)5份,威灵仙4份,松花粉6份。
上述健脾和胃制剂胶囊剂的制备方法为:
(1)将松花粉粉碎,过120目筛;
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙混合粉碎过95目筛;
(3)将步骤(1)和(2)所得混匀得粉剂;
(4)将步骤(3)所得粉剂按照0.8g/粒计量,按照胶囊的加工制备方法加工成胶囊状剂型。
本发明胶囊剂服用方法:胶囊剂采用每天3次,每次4-6粒,用温开水冲服,7天一个疗程。
典型病例五王XX,年龄:53岁,性别:男。2007年患食管中段恶性肿瘤,在医院接受化疗,化疗之后出现肢端麻木、恶心呕吐、食欲不振、身体疲乏等症状,吃过许多抗化疗副反应的药物,均无明显效果。服用本实施所得健脾和胃制剂胶囊剂,采用每日3次,每次6粒,用温开水冲服,7天一个疗程。服用15天,患者食欲有所增强,恶心呕吐减轻;服用1个月,不适症状明显好转,体力增强;继续服用2个月,患者自述不适症状消失。
实施例6抗化疗副反应的健脾和胃制剂,取下述重量配比的主要原料制备而成(每份60g):白芍7份,丹参9份,白及6份,茯苓10份,佩兰11份,葛根28份,黄连8份,刘寄奴10份,白术7份,菟丝子6份,苍术5份,补骨脂(盐炙)5份,威灵仙4份,松花粉6份。
上述健脾和胃制剂水剂的制备方法为:
(1)将松花粉粉碎,过120目筛;
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙置于砂锅内,加水(用水量为原料药总重的3倍)煎煮3次,第一次2小时,第二次0.8小时,第三次0.8小时,将三次所得滤液合并,静置,滤过;
(3)将步骤(1)粉碎后的松花粉加入步骤(2)所得药液,无菌封装。
本发明水剂服用方法:水剂采用每天2次(温热),每次300-500ml,7天一个疗程。
试验例1实施例6所得健脾和胃制剂水剂的临床应用:2008年10月-2012年3月,在8所医院筛选200例患者,其中女性106例,男性94例。试验之前3周,对该人群进行连续观察,记录症状及变化,随机分为两组,实验组及对照组,实验组服用实施例6所得产品,对照组服用其它药品(康泰安口服液、圣液口服液、硒维康等常规药品)。使用方法为:每日服用两次(温热),每次300m1-500m1(视具体情况有所调整),7天一个疗程。疗效情况判定标准:治愈:服用本品一个疗程,不适症状消失,精力及体力明显增强;有效:服用本品一个疗程,不适症状减轻或部分消失,精力及体力增强;无效:服用本品一个疗程,不适症状无变化。结果如表1所示。
表1:服用实施例6所得产品治疗效果验证
治疗效果:治愈71例(71%),有效28例(28%),无效1例(1%),总有效率99%。效果明显优于对照组。
服用期间自感症状及其体力精神变化如表2所示。
表2:
由表2可知:服用10天,54%以上的患者恶心呕吐减轻、不适症状有所好转;服用20天,73%以上的患者感到有所好转,脾胃虚弱症状改善,不适症状改善或消失,精神、体力增强;服用30天,95%以上的感到有所好转,不适症状改善或消失,精神、体力增强,部分患者自感痊愈。实验组中服用30天以上,有效率可达95%,而对照组仅为75%。
应当指出的是,具体实施方式只是本发明比较有代表性的例子,显然本发明的技术方案不限于上述实施例,还可以有很多变形。本领域的普通技术人员,以本发明所明确公开的或根据文件的书面描述毫无异议的得到的,均应认为是本专利所要保护的范围。
Claims (2)
1.抗化疗副反应的健脾和胃制剂,其特征在于,取下述重量配比的主要原料制备而成:白芍6份,丹参8份,白及5份,茯苓8份,佩兰10份,葛根25份,黄连6份,刘寄奴9份,白术5份,菟丝子5份,苍术4份,补骨脂(盐炙)4份,威灵仙3份,松花粉5份。
2.抗化疗副反应的健脾和胃制剂水剂的制备方法,其特征在于,
(1)将松花粉粉碎,过100-140目筛(优选的,过110-130目筛;更加优选的,过120目筛);
(2)将白芍、丹参、白及、茯苓、佩兰、葛根、黄连、刘寄奴、白术、菟丝子、苍术、补骨脂(盐炙)和威灵仙置于砂锅内,加水(用水量为原料药总重的2-4倍(优选的,2.5-3.5倍;更加优选的,3倍))煎煮3次,第一次1.5-2.5小时(优选的1.8-2.2小时;更加优选的,2小时),第二次0.5-1.2小时(优选的,0.7-1.0小时;更加优选的,0.8小时),第三次0.5-1.2小时(优选的,0.7-1.0小时;更加优选的,0.8小时),将三次所得滤液合并,静置,滤过;
(3)将步骤(1)粉碎后的松花粉加入步骤(2)所得药液,无菌封装。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410144867.4A CN103908579A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂及制法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410144867.4A Division CN103908579A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂及制法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105412601A true CN105412601A (zh) | 2016-03-23 |
Family
ID=51034783
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510904009.XA Withdrawn CN105434862A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃粉剂 |
CN201510904258.9A Withdrawn CN105395870A (zh) | 2014-04-12 | 2014-04-12 | 一种抗化疗副反应的健脾和胃药物 |
CN201510904489.XA Withdrawn CN105412601A (zh) | 2014-04-12 | 2014-04-12 | 用于抗化疗副反应的口服液 |
CN201410144867.4A Pending CN103908579A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂及制法 |
CN201510904383.XA Withdrawn CN105412600A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂胶囊剂 |
CN201510904259.3A Withdrawn CN105412599A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂片剂 |
CN201510904350.5A Withdrawn CN105395871A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的口服液 |
CN201510904490.2A Withdrawn CN105434863A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂颗粒剂 |
CN201510904239.6A Withdrawn CN105477336A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂膏剂 |
CN201510904486.6A Withdrawn CN105395872A (zh) | 2014-04-12 | 2014-04-12 | 一种用于抗化疗副反应的健脾和胃口服液 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510904009.XA Withdrawn CN105434862A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃粉剂 |
CN201510904258.9A Withdrawn CN105395870A (zh) | 2014-04-12 | 2014-04-12 | 一种抗化疗副反应的健脾和胃药物 |
Family Applications After (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410144867.4A Pending CN103908579A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂及制法 |
CN201510904383.XA Withdrawn CN105412600A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂胶囊剂 |
CN201510904259.3A Withdrawn CN105412599A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂片剂 |
CN201510904350.5A Withdrawn CN105395871A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的口服液 |
CN201510904490.2A Withdrawn CN105434863A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂颗粒剂 |
CN201510904239.6A Withdrawn CN105477336A (zh) | 2014-04-12 | 2014-04-12 | 抗化疗副反应的健脾和胃制剂膏剂 |
CN201510904486.6A Withdrawn CN105395872A (zh) | 2014-04-12 | 2014-04-12 | 一种用于抗化疗副反应的健脾和胃口服液 |
Country Status (1)
Country | Link |
---|---|
CN (10) | CN105434862A (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104491182A (zh) * | 2015-01-08 | 2015-04-08 | 李宏 | 减轻化疗副作用的中药药剂及制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101675989A (zh) * | 2008-09-18 | 2010-03-24 | 天津市中宝制药有限公司 | 益气健脾补肾生血的中药组合物 |
CN102302630A (zh) * | 2011-09-05 | 2012-01-04 | 黎淦森 | 一种增加白细胞和提高免疫力的中成药 |
CN102614442B (zh) * | 2012-01-01 | 2013-07-17 | 徐永波 | 增力、益血、止吐中药胶囊 |
CN103536638B (zh) * | 2013-10-22 | 2017-06-13 | 中国人民解放军第三军医大学第二附属医院 | 一种治疗胃肠功能紊乱的药物及其制备方法 |
-
2014
- 2014-04-12 CN CN201510904009.XA patent/CN105434862A/zh not_active Withdrawn
- 2014-04-12 CN CN201510904258.9A patent/CN105395870A/zh not_active Withdrawn
- 2014-04-12 CN CN201510904489.XA patent/CN105412601A/zh not_active Withdrawn
- 2014-04-12 CN CN201410144867.4A patent/CN103908579A/zh active Pending
- 2014-04-12 CN CN201510904383.XA patent/CN105412600A/zh not_active Withdrawn
- 2014-04-12 CN CN201510904259.3A patent/CN105412599A/zh not_active Withdrawn
- 2014-04-12 CN CN201510904350.5A patent/CN105395871A/zh not_active Withdrawn
- 2014-04-12 CN CN201510904490.2A patent/CN105434863A/zh not_active Withdrawn
- 2014-04-12 CN CN201510904239.6A patent/CN105477336A/zh not_active Withdrawn
- 2014-04-12 CN CN201510904486.6A patent/CN105395872A/zh not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN105412600A (zh) | 2016-03-23 |
CN105395870A (zh) | 2016-03-16 |
CN105477336A (zh) | 2016-04-13 |
CN105434863A (zh) | 2016-03-30 |
CN105434862A (zh) | 2016-03-30 |
CN105395871A (zh) | 2016-03-16 |
CN105412599A (zh) | 2016-03-23 |
CN105395872A (zh) | 2016-03-16 |
CN103908579A (zh) | 2014-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103920034A (zh) | 减轻肿瘤病人化疗副反应的中药组合物及制法 | |
CN103690889A (zh) | 一种治疗胃癌的中药汤剂 | |
CN104623600A (zh) | 一种治疗末梢神经炎的中药及其制备方法 | |
CN104042981A (zh) | 一种治疗产后便秘的药剂及制备方法 | |
CN103908616B (zh) | 缓解肿瘤病人放疗反应的药剂及制备方法 | |
CN103495103B (zh) | 消食健脾的药物 | |
CN105412601A (zh) | 用于抗化疗副反应的口服液 | |
CN103908495B (zh) | 提高肿瘤患者术后免疫功能的中药组合物及制法 | |
CN103919995A (zh) | 术后肿瘤患者抗副反应药剂及制备方法 | |
CN104042993A (zh) | 缓解产后便秘的中药膏剂及其制备方法 | |
CN105748911A (zh) | 术后肿瘤患者抗副反应胶囊剂的制备方法 | |
CN103479953A (zh) | 消食健脾药物的制备方法 | |
CN102058818A (zh) | 虫草壁虎抗癌粉 | |
CN103495104A (zh) | 一种消食健脾的药物 | |
CN103479954A (zh) | 一种消食健脾药物的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information |
Address after: Qujing City, Yunnan Province, 655000 West Road No. 6 Xiyuan District Feng kylin District 2-2-601 Applicant after: Chen Xin Address before: 250014 Shandong City, Ji'nan province area of the liberation of East Road, No. 34, No. 5 modern Yi Building, unit 1001, 2 Applicant before: Chen Xin |
|
CB02 | Change of applicant information | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160323 |
|
WW01 | Invention patent application withdrawn after publication |