CN105412487A - Traditional Chinese medicine used for treating alcoholic liver diseases - Google Patents
Traditional Chinese medicine used for treating alcoholic liver diseases Download PDFInfo
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- CN105412487A CN105412487A CN201511012819.0A CN201511012819A CN105412487A CN 105412487 A CN105412487 A CN 105412487A CN 201511012819 A CN201511012819 A CN 201511012819A CN 105412487 A CN105412487 A CN 105412487A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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Abstract
The invention discloses a traditional Chinese medicine used for treating alcoholic liver diseases. The traditional Chinese medicine is prepared from the following traditional Chinese medicine raw materials, by weight, 33-40 parts of caulis polygoni multiflori, 21-29 parts of philippine flemingia root, 16-24 parts of lagotis gaertn, 11-18 parts of hindu datura flower, 9-16 parts of cudrania cochinchinensis, 5-11 parts of dioscorea nipponica makino, 3-8 parts of swertia pseudochinensis and 2-7 parts of oriental waterplantain rhizome. Compared with the prior art, the provided traditional Chinese medicine has good activity treating fatty liver. The provided traditional Chinese medicine is a pure traditional Chinese medicine preparation, and has no toxicity to human body especially to the liver. When the provided traditional Chinese medicine is employed as a medicine treating fatty liver, the medicine effects are comprehensive, the provided traditional Chinese medicine can relieve liver-qi stagnation, tonify spleen and help digestion and also has functions of activating blood circulation to dissipate stasis, dispelling phlegm and eliminating dampness, and the conditions of fatty liver patients can be improved rapidly. The provided traditional Chinese medicine composition is simple in preparation and is basically nontoxic, the raw materials are easily available, and the provided traditional Chinese medicine is suitable for popular usage and has good application prospects.
Description
Technical field
The present invention relates to a kind of Chinese medicine being used for the treatment of alcoholic liver disease.
Background technology
Alcoholic liver disease, is injured for basic acute and chronic liver number with liver metabolism confusion caused by hepatocellular breaking-up and poisonous effect by ethanol and metabolism product thereof.Alcoholic liver disease clinical point of 3 types: fatty liver, hepatitis, liver cirrhosis.This three often mixes existence.Alcoholic liver disease, except general liver cirrhosis, also has malnutrition, anemia, spider angioma, liver palm, neuritis, amyotrophy, parotid gland enlargement, gynecomasty, atrophy of testis etc.The pathogenesis of alcoholic liver disease develops complicated, clinical symptoms change multiterminal, and pattern of syndrome overlap is staggered, thus when dialectical, must in conjunction with the course of disease of patient and degree of being addicted to drink, cautiously grasping pathogenesis, sizes up the current situation, shrewd deficiency and excess, according to different phase and the syndrome characteristics of disease progression, formulates righting, eliminating evil method.The difference of the useful irritability of righting, nourishing liver-YIN, spleen reinforcing, kidney tonifying, eliminating evil have alcoholic intoxication, damp eliminating heat, reduce phlegm turbid, regulate the flow of vital energy, blood stasis dispelling different.In general, the disease initial stage should damp and hot, the promoting the function of the gallbladder to alleviate jaundice in Qinghua; Mid-term should promoting flow of QI and blood, the addiction that disappears reduce phlegm; Later stage suitable strengthening vital QI to eliminate pathogenic factors, reinforcement and elimination in combination, accomplishes that tonify deficiency does not forget reality, lets out and does not forget void in fact.Right primary disease is that accumulate long-pending removing toxic substances, thief kills caused by internal organs by damp and hot two property of wine, therefore its principle for the treatment of, when on the basis of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, coordinate alcoholic intoxication medicine, with a point clearing away damp-heat.Dissolve alcoholism when first heavy taste, make it thoroughly send out from flesh stock, or divide profit from urine, excrete.
Summary of the invention
Technical problem to be solved by this invention is: provide a kind of Chinese medicine being used for the treatment of alcoholic liver disease, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing alcoholic liver disease.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of Chinese medicine being used for the treatment of alcoholic liver disease provided by the invention, is made up of the raw material of Chinese medicine of following weight portion: Caulis Polygoni Multiflori 33-40 part, Radix Flemingiae Philippinensis 21-29 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 16-24 part, Flos Daturae 11-18 part, Radix Cudraniae 9-16 part, Rhizoma Dioscoreae Nipponicae 5-11 part, when medicine 3-8 part, Rhizoma Alismatis 2-7 part.
Preferably, Chinese medicine provided by the invention is made up of the raw material of Chinese medicine of following weight portion: Caulis Polygoni Multiflori 38 parts, Radix Flemingiae Philippinensis 26 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 20 parts, Flos Daturae 15 parts, Radix Cudraniae 14 parts, Rhizoma Dioscoreae Nipponicae 9 parts, when medicine 6 parts, and Rhizoma Alismatis 4 parts.
Usage and dosage: medicinal warm water soaking in above-mentioned, after 10 minutes, is simmered in water after boiling with high heat 30 minutes again, taking liquid 150 milliliters, then add water and two to decoct, filter after twice medicinal liquid mixing, take at twice.Twice daily, one after each meal.
The course for the treatment of: 15 days be a course for the treatment of, the 2-5 course for the treatment of need be taken.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Collect between in October, 2010 ~ 2015 year October and collect outpatient service and patients with alcoholic liver disease 200 example of being in hospital altogether, man 168 example, female 32 example, 32 ~ 65 years old age, 46 years old mean age, 5 ~ 22 years times of excessive drinking.Be divided into treatment group 100 example and matched group 100 example at random, 2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.
Diagnostic criteria:
Diagnostic criteria according to the meeting of national alcoholic liver disease clinical speciality: 1. sign: (1) alcoholic hepatitis: symptom of digestive tract is heavier to be had nauseating, and vomiting, loss of appetite, weak, become thin, hepatic region pain increases the weight of.Severe patient is acute severe hepatitis or hepatic failure; (2) alcoholic cirrhosis: outside general hepatocirrhosis symptoms, also have malnutrition, anemia, spider angioma, liver palm, neuritis, amyotrophy, parotid gland enlargement, gynecomasty, the symptoms such as atrophy of testis are common compared with posthepatitic cirrhosis, and visible Dupuytren slaps contracture, glossitis, can accompany pancreatitis during parotid gland enlargement.Early stage hepatomegaly, late period, liver reduced, and splenomegaly is common not as posthepatitic cirrhosis.Ascites occurs comparatively early, often merging Peptic Ulcers.
The ultrasonic examination of 2.B type:
1) fatty liver: display liver volume increases, and the tiny echo of uniformity appears in essence, and has tiny luminous point intensive, " bright liver " that acoustic beam decay strengthens;
2) spleen enlargement is seen in alcoholic cirrhosis.Liver parenchyma Echoenhance, caudal lobe increases relatively.The splenic vein and portal vein diameter are significantly more than normal (the former is normal 1.0cm, and the latter is 1.5cm).
2, test method
2.1 Therapeutic Method
The oral Chinese medicine of the present invention for the treatment of group, every day 2 times.15 days courses for the treatment of, 3 courses for the treatment of.
The each 0.2g of the happy sheet of the oral Thailand of matched group, each 0.2g of vitamin C, every day 3 times is oral, 15 days courses for the treatment of, 3 courses for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Clinical cure: clinical symptom disappearance.Liver function recovery is normal, and citrus orchards checks normal;
Effective: clinical symptoms disappears substantially, liver function is obviously recovered, citrus orchards alcoholic liver disease pathological changes alleviates (comprise fatty liver and transfer mild or moderate to by severe: or moderate recovers normal and liver cirrhosis lesion degree without increasing the weight of, ascites obviously alleviates or disappears);
Invalid: clinical symptoms is without alleviation, even liver function is not recovered to increase the weight of, citrus orchards pathological changes does not change or increases the weight of.
3.2 therapeutic outcomes are in table 1.
Two groups of comparitive study
| Group | Sample number | Cure | Effectively | Invalid | Total effective rate (%) | Serious adverse reaction example |
| Treatment group | 100 | 91 | 5 | 4 | 96 | 0 |
| Matched group | 100 | 45 | 15 | 40 | 60 | 0 |
Visible, the medicine that the present invention obtains can safe and effective treatment alcoholic liver disease, has promotional value.
Beneficial effect of the present invention:
The present invention compared with prior art, has the activity for the treatment of fatty liver very well, and can the present invention be pure Chinese medicinal preparation, to human body particularly to liver avirulence.When the present invention uses as fatty liver medicine, drug effect is comprehensive, and while dispersing the stagnated live-QI to relieve the stagnation of QI, spleen invigorating food stagnation removing, can also obtain effect of activating blood circulation to dissipate blood stasis, dispelling phlegm and eliminating dampness, sb.'s illness took a favorable turn can to make rapidly Patients with Fatty Liver; And Chinese medicine composition preparation of the present invention is simple, and substantially nontoxic, raw material is easy to get, and is suitable for popular use, has good application prospect.
Detailed description of the invention
Embodiment 1
A kind of Chinese medicine being used for the treatment of alcoholic liver disease that the present embodiment provides, is made up of the raw material of Chinese medicine of following weight portion: Caulis Polygoni Multiflori 38 parts, Radix Flemingiae Philippinensis 26 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 20 parts, Flos Daturae 15 parts, Radix Cudraniae 14 parts, Rhizoma Dioscoreae Nipponicae 9 parts, when medicine 6 parts, and Rhizoma Alismatis 4 parts.
Model case:
Case 1:
Wang, man, 32 years old, excessive drinking, suffered from alcoholic liver disease for many years, and take 2 courses for the treatment of of Chinese medicine of the present invention, symptom alleviates, and occasionally had stomachache; Continue to strengthen 2 courses for the treatment of, all symptoms all disappear, and cure.
Case 2:
Xu certain, man, 49 years old, suffers from alcoholic liver disease for many years, and take 3 courses for the treatment of of Chinese medicine of the present invention, symptom alleviates, and continue to strengthen 2 courses for the treatment of, all symptoms all disappear, and cures.
Case 3:
Yuan, female, 40 years old, suffers from alcoholic liver disease for many years.Take 1 course for the treatment of of Chinese medicine of the present invention, symptom alleviates, and continue to strengthen 2 courses for the treatment of, all symptoms all disappear, and cures.
Claims (2)
1. be used for the treatment of a Chinese medicine for alcoholic liver disease, it is characterized in that, be made up of the raw material of Chinese medicine of following weight portion: Caulis Polygoni Multiflori 33-40 part, Radix Flemingiae Philippinensis 21-29 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 16-24 part, Flos Daturae 11-18 part, Radix Cudraniae 9-16 part, Rhizoma Dioscoreae Nipponicae 5-11 part, when medicine 3-8 part, Rhizoma Alismatis 2-7 part.
2. Chinese medicine according to claim 1, is characterized in that, is made up of the raw material of Chinese medicine of following weight portion: Caulis Polygoni Multiflori 38 parts, Radix Flemingiae Philippinensis 26 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 20 parts, Flos Daturae 15 parts, Radix Cudraniae 14 parts, Rhizoma Dioscoreae Nipponicae 9 parts, when medicine 6 parts, and Rhizoma Alismatis 4 parts.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511012819.0A CN105412487A (en) | 2015-12-31 | 2015-12-31 | Traditional Chinese medicine used for treating alcoholic liver diseases |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201511012819.0A CN105412487A (en) | 2015-12-31 | 2015-12-31 | Traditional Chinese medicine used for treating alcoholic liver diseases |
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| CN105412487A true CN105412487A (en) | 2016-03-23 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104644915A (en) * | 2015-01-22 | 2015-05-27 | 泸州医学院附属中医医院 | Pharmaceutical composition for treating alcoholic liver diseases as well as preparation method and application of pharmaceutical composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104644915A (en) * | 2015-01-22 | 2015-05-27 | 泸州医学院附属中医医院 | Pharmaceutical composition for treating alcoholic liver diseases as well as preparation method and application of pharmaceutical composition |
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Application publication date: 20160323 |
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