CN105412076A - Medicine composition treating children diarrhea - Google Patents
Medicine composition treating children diarrhea Download PDFInfo
- Publication number
- CN105412076A CN105412076A CN201510760561.6A CN201510760561A CN105412076A CN 105412076 A CN105412076 A CN 105412076A CN 201510760561 A CN201510760561 A CN 201510760561A CN 105412076 A CN105412076 A CN 105412076A
- Authority
- CN
- China
- Prior art keywords
- compound
- pharmaceutical composition
- infantile diarrhea
- treatment
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
- A01N43/32—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Medicinal Chemistry (AREA)
- Dentistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a medicine composition treating children diarrhea. The medicine composition comprises an effective quantity of compounds and a carrier acceptable in pharmacy. The composition is of the structure (please see the structure in the specification). The composition has a remarkable effect on pathogenic bacteria causing children diarrhea and can be developed into new medicine compositions which are effective clinically.
Description
Technical field
The present invention relates to field of medicaments, specifically, the present invention relates to a kind of pharmaceutical composition for the treatment of infantile diarrhea.
Background technology
Infantile diarrhea is common disease in children, and they are many is caused by various pathogenic bacterium, finds that bacillus perfringens ATCC13124 is also one of pathogenic bacteria wherein in the recent period.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of infantile diarrhea.
In order to realize object of the present invention, the invention provides a kind of compound for the treatment of infantile diarrhea, this compound has having structure:
The present invention also provides a kind of pharmaceutical composition for the treatment of infantile diarrhea, and described pharmaceutical composition includes the compound of effective amount and pharmaceutically acceptable carrier, and described compound has having structure:
Preferably, described pharmaceutically acceptable carrier is diluent, disintegrating agent, binding agent, lubricant, stabilizing agent or corrigent.
Preferably, described diluent is sugar derivatives, starch derivatives or cellulose derivative.
Preferably, described diluent is lactose.
Preferably, described pharmaceutical composition is powder, microgranule, granule, capsule or tablet.
The present invention also provides the purposes of compound in the medicine of preparation treatment infantile diarrhea, and this compound has having structure:
Preferably, described diarrhoea is caused by bacillus perfringens ATCC13124.
The present invention also provides the purposes of compound in the medicine of preparation vitro inhibition bacillus perfringens ATCC13124, and this compound has having structure:
Term used herein " pharmaceutically acceptable " refers to not eliminate the biologic activity of compound as herein described or the material of character, as carrier or diluent.This kind of material is applied to and individual does not cause undesirable biological action or not with harmful way and any component interaction comprised in its compositions.
" pharmaceutically acceptable carrier " comprises any and all solvents as the term is employed herein, disperse medium, coating material, surfactant, antioxidant, antiseptic (such as antibacterial, antifungal), isotonic agent, absorption delay agent, salt, antiseptic, drug stabilizing agent, binding agent, excipient, disintegrating agent, lubricant, sweeting agent, correctives, dyestuff etc. and its combination, this is well-known to those skilled in the art (for example, see Remington'sPharmaceuticalSciences, 18thEd.MackPrintingCompany, 1990, pp.1289-1329).Except with except the inconsistent carrier of active component, consider to use any conventional carrier in treatment or pharmaceutical composition.
Compound of the present invention, for the pathogen Be very effective causing infantile diarrhea, can be developed to pharmaceutical composition effectively new clinically.
Detailed description of the invention
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
The research of the purposes of experimental example the compounds of this invention in the medicine of preparation vitro inhibition bacillus perfringens ATCC13124
Bacteriostatic test
Use following compounds, adopt filter paper enzyme classical in this area to carry out bacteriostatic test, wherein:
The structural formula of target compound is:
For examination strain bacillus perfringens ATCC13124 purchased from Bei Nuo bio tech ltd, Shanghai.
Culture fluid
Nutrient agar and nutrient broth, purchased from Chen Yu experimental facilities company limited of BeiJing ZhongKe.
Test method
Bacillus perfringens ATCC13124 is inoculated in agar plate nutritional solution plane, evenly gathers during inoculation.
Take target compound 0.01 gram, add 20000 ml sterile waters, ultrasonic 30 minutes, then the filtering with microporous membrane of 0.22 μm, obtained solution.The aseptic circular filter paper sheet of tweezer, sprays above-mentioned solution to complete wetting, is attached in the agar plate nutritional solution plane of inoculated bacteria.Agar plate is placed in the incubator of 37 DEG C, incubation 4 hours.Measure the diameter of bacterial restrain.Measure and average for 3 times.
1.4 result
The average diameter of the bacterial restrain of bacillus perfringens ATCC13124 is 14.22mm, and this shows that target compound has the effect of extremely strong vitro inhibition bacillus perfringens ATCC13124.
Claims (9)
1. treat a compound for infantile diarrhea, it is characterized in that, this compound has having structure:
2. treat a pharmaceutical composition for infantile diarrhea, it is characterized in that, described pharmaceutical composition includes the compound of effective amount and pharmaceutically acceptable carrier, and described compound has having structure:
3. the pharmaceutical composition for the treatment of infantile diarrhea according to claim 2, is characterized in that, described pharmaceutically acceptable carrier is diluent, disintegrating agent, binding agent, lubricant, stabilizing agent or corrigent.
4. the pharmaceutical composition for the treatment of infantile diarrhea according to claim 3, is characterized in that, described diluent is sugar derivatives, starch derivatives or cellulose derivative.
5. the pharmaceutical composition for the treatment of infantile diarrhea according to claim 4, is characterized in that, described diluent is lactose.
6. the pharmaceutical composition for the treatment of infantile diarrhea according to claim 3, is characterized in that, described pharmaceutical composition is powder, microgranule, granule, capsule or tablet.
7. the purposes of compound in the medicine of preparation treatment infantile diarrhea, it is characterized in that, this compound has having structure:
8. purposes according to claim 7, is characterized in that, described diarrhoea is caused by bacillus perfringens ATCC13124.
9. the purposes of compound in the medicine of preparation vitro inhibition bacillus perfringens ATCC13124, it is characterized in that, this compound has having structure:
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610344559.5A CN105997990B (en) | 2015-11-10 | 2015-11-10 | Purposes of the compound in the external medicine for suppressing C.perfringens ATCC 13124 is prepared |
| CN201510760561.6A CN105412076B (en) | 2015-11-10 | 2015-11-10 | Compound purposes in the medicine of preparation treatment infantile diarrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510760561.6A CN105412076B (en) | 2015-11-10 | 2015-11-10 | Compound purposes in the medicine of preparation treatment infantile diarrhea |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610344559.5A Division CN105997990B (en) | 2015-11-10 | 2015-11-10 | Purposes of the compound in the external medicine for suppressing C.perfringens ATCC 13124 is prepared |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105412076A true CN105412076A (en) | 2016-03-23 |
| CN105412076B CN105412076B (en) | 2016-08-31 |
Family
ID=55490933
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610344559.5A Active CN105997990B (en) | 2015-11-10 | 2015-11-10 | Purposes of the compound in the external medicine for suppressing C.perfringens ATCC 13124 is prepared |
| CN201510760561.6A Expired - Fee Related CN105412076B (en) | 2015-11-10 | 2015-11-10 | Compound purposes in the medicine of preparation treatment infantile diarrhea |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610344559.5A Active CN105997990B (en) | 2015-11-10 | 2015-11-10 | Purposes of the compound in the external medicine for suppressing C.perfringens ATCC 13124 is prepared |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN105997990B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748478A (en) * | 2016-04-08 | 2016-07-13 | 魏芳芳 | Medicine for treating infantile diarrhea |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791578A (en) * | 2003-05-16 | 2006-06-21 | 阿斯特拉泽尼卡公司 | Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070015738A1 (en) * | 2005-07-15 | 2007-01-18 | Walker Stephen G | Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores from becoming infectious vegetative cells |
| CN102552239B (en) * | 2011-12-31 | 2013-10-30 | 沈阳药科大学 | Method for preparing anti-inflammatory and anti-tumor active ingredient group from liquorice dregs and application thereof |
| CN104770405A (en) * | 2015-04-21 | 2015-07-15 | 王志效 | Spray for disinfecting used in blood stations |
-
2015
- 2015-11-10 CN CN201610344559.5A patent/CN105997990B/en active Active
- 2015-11-10 CN CN201510760561.6A patent/CN105412076B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791578A (en) * | 2003-05-16 | 2006-06-21 | 阿斯特拉泽尼卡公司 | Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748478A (en) * | 2016-04-08 | 2016-07-13 | 魏芳芳 | Medicine for treating infantile diarrhea |
| CN105748478B (en) * | 2016-04-08 | 2016-10-12 | 郭晓辉 | A kind of medicine treating infantile diarrhea |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105997990B (en) | 2017-08-29 |
| CN105997990A (en) | 2016-10-12 |
| CN105412076B (en) | 2016-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Chen Yan Inventor before: Xing Lili |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160804 Address after: 272100 Pediatrics, the first people's Hospital of Jining, 6 health Road, Taibai Lake New District, Shandong, Jining Applicant after: Chen Yan Address before: 071003 Hebei Province, Baoding City area Yonghua No. 9 North Street Applicant before: Xing Lili |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160831 Termination date: 20171110 |