CN105111185A - Pharmaceutical composition for treating vaginitis of elder people - Google Patents
Pharmaceutical composition for treating vaginitis of elder people Download PDFInfo
- Publication number
- CN105111185A CN105111185A CN201510629715.8A CN201510629715A CN105111185A CN 105111185 A CN105111185 A CN 105111185A CN 201510629715 A CN201510629715 A CN 201510629715A CN 105111185 A CN105111185 A CN 105111185A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- compound
- senile vaginitis
- treatment
- vaginitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WNDXRJBYZOSNQO-UHFFFAOYSA-N CCCC(C)CN Chemical compound CCCC(C)CN WNDXRJBYZOSNQO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a pharmaceutical composition for treating vaginitis of elder people. The pharmaceutical composition comprises effective quantity of compound and a medicinally acceptable carrier, wherein the formula of the compound is as shown in the specification. The pharmaceutical composition has evident effect on pathogenic bacteria causing the vaginitis of elder people and can be developed into a new clinically effective pharmaceutical composition.
Description
Technical field
The present invention relates to field of medicaments, specifically, the present invention relates to a kind of pharmaceutical composition for the treatment of senile vaginitis.
Background technology
Senile vaginitis is common clinical frequently-occurring disease, and the cause of disease is many caused by cause pathogeny imcrobe infection, causes the pathogenic micro-organism of infection to mainly contain bacterium, virus and mycoplasma, chlamydozoan.Find after deliberation, in the secretory product at patient infection position, various pathogens detected, find that in the recent period pseudomonas putida ATCC17485 is also one of pathogenic bacterium wherein.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of senile vaginitis.
In order to realize object of the present invention, the invention provides a kind of compound for the treatment of senile vaginitis, this compound has having structure:
The present invention also provides a kind of pharmaceutical composition for the treatment of senile vaginitis, and described pharmaceutical composition includes the compound of effective amount and pharmaceutically acceptable carrier, and described compound has having structure:
Preferably, described pharmaceutically acceptable carrier is thinner, disintegrating agent, tackiness agent, lubricant, stablizer or corrigent.
Preferably, described thinner is sugar derivatives, starch derivative or derivatived cellulose.
Preferably, described thinner is lactose.
Preferably, described pharmaceutical composition is powder, microgranules, granule, capsule or tablet.
The present invention also provides the purposes of compound in the medicine of preparation treatment senile vaginitis, and this compound has having structure:
Preferably, described senile vaginitis is caused by pseudomonas putida ATCC17485.
The present invention also provides the purposes of compound in the medicine of preparation vitro inhibition pseudomonas putida ATCC17485, and this compound has having structure:
Term used herein " pharmaceutically acceptable " refers to not eliminate the biologic activity of compound as herein described or the material of character, as carrier or thinner.This kind of material is applied to and individual does not cause undesirable biological action or not with harmful way and any component interaction comprised in its composition.
" pharmaceutically acceptable carrier " comprises any and all solvents as the term is employed herein, dispersion medium, coating material, tensio-active agent, antioxidant, sanitas (such as antiseptic-germicide, anti-mycotic agent), isotonic agent, absorption delay agent, salt, sanitas, drug stabilizing agent, tackiness agent, vehicle, disintegrating agent, lubricant, sweeting agent, correctives, dyestuff etc. and its combination, this is well-known to those skilled in the art (for example, see Remington'sPharmaceuticalSciences, 18thEd.MackPrintingCompany, 1990, pp.1289-1329).Except with except the inconsistent carrier of activeconstituents, consider to use any conventional carrier in treatment or pharmaceutical composition.
Compound of the present invention, for the pathogenic bacteria Be very effective causing senile vaginitis, can be developed to pharmaceutical composition effectively new clinically.
Embodiment
Below by way of the description of embodiment, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
The research of the purposes of experimental example the compounds of this invention in the medicine of preparation vitro inhibition pseudomonas putida ATCC17485
Bacteriostatic test
Use following compounds, adopt filter paper enzyme classical in this area to carry out bacteriostatic test, wherein:
The structural formula of compound is:
For examination bacterial classification pseudomonas putida ATCC17485 purchased from Bei Nuo bio tech ltd, Shanghai.
Nutrient solution
Nutrient agar medium and nutrient broth, purchased from Chen Yu experimental installation company limited of BeiJing ZhongKe.
Test method
Pseudomonas putida ATCC17485 is inoculated in agar plate nutritive medium plane, evenly gathers during inoculation.
Take target compound 0.06 gram, add 5000 ml sterile waters, ultrasonic 30 minutes, then the filtering with microporous membrane of 0.22 μm, obtained solution.The aseptic circular filter paper sheet of tweezer, sprays above-mentioned solution to complete wetting, is attached in the agar plate nutritive medium plane of inoculated bacteria.Agar plate is placed in the incubator of 37 DEG C, incubation 4 hours.Measure the diameter of bacterial restrain.Measure and average for 3 times.
1.4 result
The mean diameter of the bacterial restrain of pseudomonas putida ATCC17485 is 14.16mm, and this shows that target compound has the effect of extremely strong suppression pseudomonas putida ATCC17485.
Claims (9)
1. treat a compound for senile vaginitis, it is characterized in that, this compound has having structure:
2. treat a pharmaceutical composition for senile vaginitis, it is characterized in that, described pharmaceutical composition includes the compound of effective amount and pharmaceutically acceptable carrier, and described compound has having structure:
3. the pharmaceutical composition for the treatment of senile vaginitis according to claim 2, is characterized in that, described pharmaceutically acceptable carrier is thinner, disintegrating agent, tackiness agent, lubricant, stablizer or corrigent.
4. the pharmaceutical composition for the treatment of senile vaginitis according to claim 3, is characterized in that, described thinner is sugar derivatives, starch derivative or derivatived cellulose.
5. the pharmaceutical composition for the treatment of senile vaginitis according to claim 4, is characterized in that, described thinner is lactose.
6. the pharmaceutical composition for the treatment of senile vaginitis according to claim 3, is characterized in that, described pharmaceutical composition is powder, microgranules, granule, capsule or tablet.
7. the purposes of compound in the medicine of preparation treatment senile vaginitis, it is characterized in that, this compound has having structure:
8. purposes according to claim 7, is characterized in that, described senile vaginitis is caused by pseudomonas putida ATCC17485.
9. the purposes of compound in the medicine of preparation vitro inhibition pseudomonas putida ATCC17485, it is characterized in that, this compound has having structure:
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510629715.8A CN105111185A (en) | 2015-09-29 | 2015-09-29 | Pharmaceutical composition for treating vaginitis of elder people |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510629715.8A CN105111185A (en) | 2015-09-29 | 2015-09-29 | Pharmaceutical composition for treating vaginitis of elder people |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105111185A true CN105111185A (en) | 2015-12-02 |
Family
ID=54659339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510629715.8A Pending CN105111185A (en) | 2015-09-29 | 2015-09-29 | Pharmaceutical composition for treating vaginitis of elder people |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105111185A (en) |
-
2015
- 2015-09-29 CN CN201510629715.8A patent/CN105111185A/en active Pending
Non-Patent Citations (2)
Title |
---|
STN REGISTRY: "RN936703-55-9", 《STN REGISTRY》 * |
张涛等: "新型苯并咪唑衍生物的合成及生物活性研究", 《化学研究与应用》 * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151202 |
|
WD01 | Invention patent application deemed withdrawn after publication |