CN105411627B - A kind of device and method measuring blood flow lateral velocity - Google Patents
A kind of device and method measuring blood flow lateral velocity Download PDFInfo
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- CN105411627B CN105411627B CN201511002768.3A CN201511002768A CN105411627B CN 105411627 B CN105411627 B CN 105411627B CN 201511002768 A CN201511002768 A CN 201511002768A CN 105411627 B CN105411627 B CN 105411627B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4411—Device being modular
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5207—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image
Abstract
The invention discloses a kind of device and methods measuring blood flow lateral velocity, including control unit, described control unit to be connected with ultrasonic transmitting element and signal processing unit, and ultrasonic wave receiving unit is sequentially connected with the signal processing unit, speed display unit.The present invention places ultrasonic probe in human skin surface, launch ultrasonic signal using the ultrasound emission unit of measuring device, it is reflected after signal to blood, form reflection signal, two receiving circuits in ultrasonic reception unit receive reflection signal respectively, it obtains two-way and receives signal, two-way receives signal and obtains base band interference signal after signal processing unit processes, and signal processing unit extracts the lateral velocity of moving object according to the frequency characteristic of base band interference signal；By the measurement of lateral velocity, the measurement of traditional Doppler's radial velocity is compared, measurement accuracy is substantially increased, realizes the disease detection of finer human bloodstream tissue.
Description
Technical field
The invention belongs to ultrasonic technology fields, and in particular to a kind of device and method measuring blood flow lateral velocity.
Background technology
The existing method for measuring velocity of blood flow mainly has ultrasonic Doppler imaging philosophy and technique.Ultrasonic Doppler effect is
In continuous media, when wave source is opposite to be moved with receiving body (such as receiving instrument), the vibration frequency that receiving body is received occurs
Variation, different from the frequency that wave source is sent out, the frequency difference value of the two, i.e., so-called frequency displacement size is opposite with receiving body with wave source
The speed of movement is related.Ultrasonic Doppler technique is by studying between the ultrasonic wave received and the ultrasonic wave of certain angle transmitting
The frequency displacement of generation obtains velocity of blood flow according to the relationship of frequency displacement and speed.But existing ultrasonic Doppler technique has lower Lieque
It falls into：Human body major part blood vessel is parallel with body surface, and in order to realize conventional radial tachometric survey, ultrasonic probe must tilt, due to not
Same angle (ultrasonic beam has one fixed width) has very different radial component (projection), causes doppler spectral to broaden, shadow
Ring measurement accuracy.The pulsation of blood vessel also contributes Doppler spectrum, interferes radial velocity measurement, as shown in Figure 1.
Invention content
Present invention aim to address conventional radial blood flow velocity measurement ultrasonic probes to tilt, and it is accurate to influence to measure
Property, the problem of pulsation of blood vessel contributes Doppler spectrum, interferes radial velocity measurement.
To achieve the above object, it proposes, using the device and method of principle of interference measurement blood flow velocity, blood flow can be measured
Lateral velocity, and the diametral interference that do not pulse, measurement accuracy are also more increased.
The technical solution adopted by the present invention is：A kind of device measuring blood flow lateral velocity, including control unit, the control
Unit processed is connected with ultrasonic transmitting element and signal processing unit, ultrasonic wave receiving unit and the signal processing unit, speed
Degree display unit is sequentially connected.
Preferably, the ultrasonic transmitting element includes that high-frequency oscillating circuits, power amplification circuit and ultrasonic wave transmitting are visited
Head；Described control unit controls the high-frequency oscillating circuits output cosine impulse wave by switching；The high-frequency oscillating circuits
Output end is connected with the input terminal of the power amplification circuit, and the output end of the power amplification circuit emits with the ultrasonic wave
The input terminal of probe is connected.
Preferably, the ultrasonic wave receiving unit includes two receiving circuits, and the receiving circuit includes sequentially connected
Ultrasonic wave receiving transducer and low-noise amplifier circuit；Two low-noise amplifier circuits are connect with the signal processing unit respectively；
There is distance D between two ultrasonic wave receiving transducers.
Preferably, the signal processing unit includes interference and velocity information extraction unit and the two-way that is attached thereto
Sampling and range information extraction unit；The interference and velocity information extraction unit are connect with the speed display unit；It is described
Two-way samples and range information extraction unit is connect with two ultrasonic wave receiving transducers in the ultrasonic wave receiving unit respectively；
Described control unit is connect with two-way sampling and range information extraction unit respectively.
It is further preferred that it is described interference and velocity information extraction unit realize two-way baseband signal addition or subtract each other with
Obtain base band interference signal.
A kind of measurement method using the device for measuring blood flow lateral velocity includes the following steps：
The first step：Launch ultrasonic signal using ultrasonic transmitting element in the device for measuring blood flow lateral velocity, believes
Number reach blood of human body in encounter movement substance after reflected, formed reflection signal；
Second step：Two receiving circuits in the device of blood flow lateral velocity in ultrasonic wave receiving unit are measured to receive respectively
Signal is reflected, two-way is obtained and receives signal；
Third walks：Two-way obtained by second step is received into signal and obtains base band interference letter after signal processing unit processes
Number；
4th step：Extract the cross of blood of human body according to the phase change rate of base band interference signal by signal processing unit again
To speed.
Operation principle of the present invention：Ultrasonic probe is placed in human skin surface, utilizes the device for measuring blood flow lateral velocity
Ultrasonic transmitting element launches ultrasonic signal, is reflected after signal to blood, and reflection signal, ultrasonic wave receiving unit are formed
In two receiving circuits receive respectively reflection signal, obtain two-way receive signal, two-way receive signal pass through signal processing list
Base band interference signal is obtained after member processing, signal processing unit extracts moving object according to the phase change rate of base band interference signal
The lateral velocity of body obtains blood flow lateral velocity.
Beneficial effects of the present invention：By the measurement of blood flow lateral velocity, compared to traditional Doppler's radial velocity ultrasound
It measures, substantially increases measurement accuracy, realize the disease detection of finer human bloodstream tissue；In terms of precision and real-time
The detectability to blood flow velocity is improved, to improve the instruction performance of angiocardiopathy；Due to present system constitute and
Data processing is simple more many than conventional method measurement blood flow velocity, therefore cost can be greatly reduced.
Description of the drawings
Fig. 1 is that conventional ultrasound measures blood radial velocity schematic diagram；
Fig. 2 is ultrasonic measurement blood lateral velocity schematic diagram of the present invention；
Fig. 3 is the schematic diagram that the present embodiment measures blood lateral velocity；
Fig. 4 is the hyperbola cluster and ellipse cluster that two antenna position of the present embodiment is focus；
Fig. 5 is the present embodiment functional block diagram；
Wherein, 1- ultrasonic transmitting elements, 2- ultrasonic wave receiving units, 3- signal processing units, 4- speed display units,
5- control units；
Fig. 6 is the schematic diagram of the cosine impulse wave transmitter unit in the present embodiment；
Fig. 7 is the schematic diagram of the cosine impulse wave receiving unit in the present embodiment；
Fig. 8 is the functional block diagram of signal processing unit in the present embodiment；
Fig. 9 is the use state diagram of the present embodiment.
Specific implementation mode
By following detailed description combination attached drawing it will be further appreciated that the features and advantages of the invention.The implementation provided
Example is only the explanation to the method for the present invention, remaining content without limiting the invention in any way announcement.
Embodiment 1
As shown in figure 5, the technical solution of the present embodiment is as follows：A kind of device measuring blood flow lateral velocity, including control
Unit 5, described control unit 5 are connected with ultrasonic transmitting element 1 and signal processing unit 3, ultrasonic wave receiving unit 2 with it is described
Signal processing unit 3, speed display unit 4 are sequentially connected.
The ultrasonic transmitting element 1 includes high-frequency oscillating circuits, power amplification circuit and ultrasonic wave transmitting probe；It is described
Control unit 5 controls the high-frequency oscillating circuits output cosine impulse wave by switching；The output end of the high-frequency oscillating circuits
It is connected with the input terminal of the power amplification circuit, the output end of the power amplification circuit and the ultrasonic wave transmitting probe
Input terminal is connected.
The ultrasonic wave receiving unit 2 includes two receiving circuits, and the receiving circuit includes sequentially connected ultrasonic wave
Receiving transducer and low-noise amplifier circuit；Two low-noise amplifier circuits are connect with the signal processing unit 3 respectively；Two super
There is distance D between acoustic receiver probe.
The signal processing unit 3 include interference and velocity information extraction unit and be attached thereto two-way sampling and
Range information extraction unit；The interference and velocity information extraction unit are connect with the speed display unit；The two-way is adopted
Sample and range information extraction unit are connect with two ultrasonic wave receiving transducers in the ultrasonic wave receiving unit respectively；The control
Unit 5 processed is connect with two-way sampling and range information extraction unit respectively.
The interference and velocity information extraction unit are realized the addition of two-way baseband signal or are subtracted each other to obtain base band interference
Signal.
As shown in Fig. 2, being ultrasonic measurement lateral velocity schematic diagram.
Ultrasonic probe is placed in human skin surface with the present embodiment device, utilizes the ultrasonic wave of the present embodiment measuring device
Transmitter unit 1 launches ultrasonic signal, is reflected after signal to blood, is formed and reflects signal, in ultrasonic wave receiving unit 2
Two receiving circuits receive reflection signal respectively, obtain two-way and receive signal, two-way receives signal by signal processing unit
Base band interference signal is obtained after reason, signal processing unit 3 extracts moving object according to the phase change rate of base band interference signal
Lateral velocity.
As shown in figure 4, from popping one's head in one section of close region, equiphase surface is uniform, and the envelope of interference signal is
The slow changing unit phase change rate of one frequency-fixed signal, i.e. interference signal is constant, this is exactly that device is close to human body superficial blood
The situation of pipe, at this point, blood transverse flow speed can be obtained by the relationship of phase change rate and speed.
As shown in fig. 6, ultrasonic transmitting element 1 includes cosine impulse generation circuit, power amplification circuit and transmitting probe；
The switch control terminal of cosine impulse wave generation circuit is connect with control unit, cosine impulse generation circuit output end and power amplification
The input terminal of circuit is connected, and the output end of power amplification circuit is connected with the input terminal of ultrasonic wave transmitting probe, in control unit
Control under, cosine impulse generation circuit generates the cosine impulse signal of certain pulse width, is sent after power amplifier amplifies
Ultrasonic probe emits.
As shown in Fig. 3, Fig. 7, ultrasonic wave receiving unit 2 includes two receiving circuits, and each receiving circuit includes successively
Ultrasonic probe, the low noise amplifier of connection, the output end of two low noise amplifiers are connect with signal processing unit respectively；Two
There are certain distance D, this distance can ensure tachometric survey precision between ultrasonic wave receiving transducer；Moving object target is reflected back
The cosine impulse signal come amplifies after being received by ultrasonic probe, is sent into signal processing unit 3.
As shown in figure 8, signal processing unit 3 includes interference and velocity information extraction circuit and two samplings and range information
Extract circuit；Interference and velocity information extraction circuit are connect with speed display unit 4；Interference and velocity information extraction circuit difference
It is connect with two samplings and range information extraction circuit；Two samplings and range information extraction circuit receive with ultrasonic wave single respectively
Two low noise amplifiers connection in member 2；Control unit 5 is connect with two samplings and range information extraction circuit respectively.It is controlling
Under the control of unit 5 processed, signal processing unit 3 first carries out the two paths of signals from ultrasonic wave receiving unit sampling and apart from letter
Breath extraction, then the interference signal of this two paths of signals is obtained, by obtaining the lateral velocity of moving object to the processing of interference signal
Information, and shown by speed display unit 4.
As shown in figure 9, be the use state diagram of the present embodiment, transmitting probe emits cosine impulse wave signal, two
Ultrasonic probe reception is sent into circuit below and is carried out speed processing and shown by the reflected cosine impulse wave signal of moving object
Show.
Included the following steps using the method that the present embodiment device measures blood of human body lateral velocity：
The first step：Launch ultrasonic signal using ultrasonic transmitting element 1 in the present embodiment device, signal reaches human body
It is reflected after encountering movement substance in blood, forms reflection signal；
Second step：Two receiving circuits in the present embodiment device in ultrasonic wave receiving unit 2 receive reflection signal respectively,
It obtains two-way and receives signal；
Third walks：Two-way obtained by second step is received into signal and obtains base band interference letter after the processing of signal processing unit 3
Number；
4th step：Extract the cross of blood of human body according to the frequency characteristic of base band interference signal by signal processing unit 3 again
To speed.
It is illustrated in figure 3 the schematic diagram that the present embodiment measures blood lateral velocity, two secondary reception days of two-way receiving channel
Line spacing is D, and the position of their coordinate systems shown in Fig. 3 is (- D/2,0) and (- D/2,0) respectively, reception antenna 1 and reception
Antenna 2 is respectively r1 and r2 at a distance from moving object.Moving object is at a time r0, side at a distance from coordinate origin
Parallactic angle isIts speed is v.The expression formula for the reflection signal from moving object that two secondary reception antennas are received is respectively：
S1=cos [ω t- (2 π/λ) r1] (1)
S2=cos [ω t- (2 π/λ) r2] (2)
(1), the ω in (2) two formulas and λ is respectively the angular frequency and wavelength of electromagnetic wave, the sum after this two paths of signals interference
Signal s Σ and the expression formula of difference signal s Δs are respectively：
S Σ=2cos [ω t- (π/λ) (r1+r2)] cos [(π/λ) (r1-r2)] (3)
S Δs=- 2sin [ω t- (π/λ) (r1+r2)] sin [(π/λ) (r1-r2)] (4)
From formula (3) and formula (4) it can be seen that the slow changing unit of interference signal, i.e. base band interference signal, having the same
Phase factor (π/λ) (r1-r2).If moving object, should along being moved using two antenna positions as the hyperbolic locus of focus
Phase will not change；If projection components of the movement of moving object on the ellipse using two antenna positions as focus
It is not zero, which will produce variation, is projected in so can be finally inversed by moving object from the variation of the phase factor of envelope signal
Movement velocity component on above-mentioned ellipse.Hyperbola and ellipse are as shown in Figure 4.
If object is defined as radial motion along the movement of hyperbola cluster shown in Fig. 4, size is v ζ, along ellipse cluster
Movement be defined as transverse movement, relationship of the size between v η, phase factor change rate kp and lateral movement velocity v η is：
Wherein,
Blood flow velocity can be calculated it is found that extracting its frequency characteristic from base band interference signal by formula (5).It will be fast
Degree information send speed display unit to show blood flow velocity.
Such as：The rectified signal frequencies omega of signal of the ultrasonic wave actually received after interference changes with time can
With by being exported with the slow changing unit of difference signal：
If it is assumed that target moves on the line of two antennas, this is exactly that the transmitting-receiving probe of measuring device is close to human body superficial
Blood vessel situation, above formula can be reduced to：
The π v/ of ω=4 λ
From above formula it is found that as long as the frequency of interference signal, that is, Kp detected, so that it may to obtain blood vessel speed
Degree.
By the measurement of lateral velocity, traditional Doppler's radial velocity ultrasonic measurement is compared, substantially increases measurement essence
Degree, realizes the disease detection of finer human bloodstream tissue.
Claims (4)
1. a kind of device measuring blood flow lateral velocity, it is characterised in that：Including control unit, described control unit is connected with super
Acoustic wave emission unit and signal processing unit, ultrasonic wave receiving unit and the signal processing unit, speed display unit are successively
Connection；The ultrasonic transmitting element includes high-frequency oscillating circuits, power amplification circuit and ultrasonic wave transmitting probe；The control
Unit controls the high-frequency oscillating circuits output cosine impulse wave by switching；The output end of the high-frequency oscillating circuits with it is described
The input terminal of power amplification circuit is connected, the input terminal of the output end of the power amplification circuit and the ultrasonic wave transmitting probe
It is connected；The ultrasonic wave receiving unit includes two receiving circuits, and the receiving circuit includes that sequentially connected ultrasonic wave receives
Probe and low-noise amplifier circuit；Two low-noise amplifier circuits are connect with the signal processing unit respectively；Two ultrasonic waves
There is distance D between receiving transducer.
2. measuring the device of blood flow lateral velocity as described in claim 1, it is characterised in that：The signal processing unit packet
Include interference and velocity information extraction unit and the two-way being attached thereto sampling and range information extraction unit；The interference and speed
Degree information extraction unit is connect with the speed display unit；Two-way sampling and range information extraction unit respectively with it is described
Two ultrasonic wave receiving transducers connection in ultrasonic wave receiving unit；Described control unit is sampled respectively with the two-way and distance
Information extraction unit connects.
3. measuring the device of blood flow lateral velocity as claimed in claim 2, it is characterised in that：The interference and velocity information carry
Unit is taken to realize the addition of two-way baseband signal or subtract each other to obtain base band interference signal.
4. a kind of measurement side of device using the measurement blood flow lateral velocity described in any one of claims 1 to 33 claim
Method, it is characterised in that：Include the following steps：
The first step：Launch ultrasonic signal using ultrasonic transmitting element in the device for measuring blood flow lateral velocity, signal arrives
It is reflected after encountering movement substance in up to blood of human body, forms reflection signal；
Second step：It measures two receiving circuits in the device of blood flow lateral velocity in ultrasonic wave receiving unit and receives reflection respectively
Signal obtains two-way and receives signal；
Third walks：Two-way obtained by second step is received into signal and obtains base band interference signal after signal processing unit processes；
4th step：Extract the laterally speed of blood of human body according to the frequency characteristic of base band interference signal by signal processing unit again
Degree.
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| CN201511002768.3A CN105411627B (en) | 2015-12-28 | 2015-12-28 | A kind of device and method measuring blood flow lateral velocity |
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| CN201511002768.3A CN105411627B (en) | 2015-12-28 | 2015-12-28 | A kind of device and method measuring blood flow lateral velocity |
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| CN105411627B true CN105411627B (en) | 2018-10-09 |
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| CN106618496A (en) * | 2016-12-09 | 2017-05-10 | 华南师范大学 | All-optical photoacoustic Doppler transverse flow speed measuring method and device |
| CN110037741B (en) * | 2019-04-08 | 2024-02-20 | 深圳市贝斯曼精密仪器有限公司 | Blood flow velocity detection system |
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| CN103901425A (en) * | 2014-04-23 | 2014-07-02 | 武汉大学 | Radar and method for measuring transverse velocity of moving object |
| CN103932737A (en) * | 2014-04-28 | 2014-07-23 | 刘树英 | Cardiovascular blood flow velocity sensor |
| CN104146731A (en) * | 2014-07-21 | 2014-11-19 | 深圳先进技术研究院 | Estimating system and method for fluid velocity |
| CN104677437A (en) * | 2015-02-12 | 2015-06-03 | 延安大学 | Ultrasonic liquid phase flow rate precision measuring method |
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- 2015-12-28 CN CN201511002768.3A patent/CN105411627B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1298688A (en) * | 1999-11-05 | 2001-06-13 | Ge医疗系统环球技术有限公司 | Method and apparatus for pulsation repetive regulation, and ultrasonic imaging device |
| CN103479396A (en) * | 2013-10-11 | 2014-01-01 | 王卫东 | Detecting device for velocity of blood flow |
| CN103845080A (en) * | 2014-02-25 | 2014-06-11 | 深圳京柏医疗设备有限公司 | Ultrasonic umbilical cord blood measuring system and method based on linear frequency modulation coding |
| CN103901425A (en) * | 2014-04-23 | 2014-07-02 | 武汉大学 | Radar and method for measuring transverse velocity of moving object |
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| CN104677437A (en) * | 2015-02-12 | 2015-06-03 | 延安大学 | Ultrasonic liquid phase flow rate precision measuring method |
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