CN105411505B - A kind of device and method that control capsule endoscope is moved in human body alimentary canal - Google Patents
A kind of device and method that control capsule endoscope is moved in human body alimentary canal Download PDFInfo
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- CN105411505B CN105411505B CN201510567611.9A CN201510567611A CN105411505B CN 105411505 B CN105411505 B CN 105411505B CN 201510567611 A CN201510567611 A CN 201510567611A CN 105411505 B CN105411505 B CN 105411505B
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Abstract
The present invention describes a kind of device and method that capsule endoscope can be made to suspend in human body alimentary canal liquid/gas interface.Capsule endoscope includes permanent magnetic dipoles, and its density is greater than the density of liquid in human body alimentary canal.One bulbous exterior portion magnet for realizing capsule endoscope human body alimentary canal liquid/gas interface suspension and positioning.Capsule endoscope can move along each axis according to the movement of external magnets, rotate and tilt.External magnets occur mobile simultaneously and rotate to keep capsule endoscope static and be fixed on liquid/gas interface same position.External magnets adjust its distance for arriving liquid/gas interface during turning, provide a constant magnetic field force to capsule endoscope.
Description
Related application
Present patent application is the continuation application of on May 23rd, the 2013 PCT application PCT/CN2013/076162 submitted.It is special
The full content of PCT application is incorporated into herein as reference by this.
Technical field
The present invention relates to medical instrument, a kind of move in particular to control capsule endoscope in human body alimentary canal device and
Method.
Background technique
With large scale integrated circuit technology, the development of MEMS, wireless communication, optical technology, capsule endoscope is as one
The method of the effective diagnosis intestines problem of kind, is widely studied and is rapidly developed at present.The domestic and international first generation
The research of capsule endoscope has mature product and deep Research foundation.The production of Given Imaging company, Israel
The production that M2A, the Japanese Endo Capsule of Olympus company exploitation and Chongqing Kingsoft scientific & technical corporation of China put goods on the market
Product all occupy very big share in capsule endoscope field.Since movement of the first generation capsule in enteron aisle relies solely on human body
Intestines peristalsis system, its own athletic posture, speed, direction, location status at any time all will be it is random, this will
It is unfavorable for acquisition and diagnosis of the doctor to enteron aisle inner disease foci location information.
If cannot capsule endoscope be positioned and be controlled in vivo, it will cause capsule endoscope in traversal enteron aisle
It is led to the problem of during detection very much.Existing all kinds of capsule endoscopes rely primarily on the wriggling of organ in human body and shrink
It completes along gastrointestinal motor, movement velocity is slow, and detection efficiency is very low, while checking that there is also blind areas.It cannot front and back driving
Capsule rests on some position and is further checked or certain operation, at the same be difficult to realize athletic posture control and movement it is fast
Slow and direction control, and then be unable to complete and implement diagnosis or operation for some specific diseased region.
Domestic Chongqing Kingsoft group once controlled capsule endoscope in gastral positioning with manually magnet out of the human body
And control, this mode is although cheap, but manual control controls precisely without mechanical equipment after all, can not achieve intelligence
Change.The also external magnet of some scientific research institutions elongate in shape is positioned and is controlled to magnetic capsule endoscope, this side
Although method speed in direct route positions standard fastly, our alimentary canal is not straight line, and especially our enteron aisle is curved
Bending is bent, so with the magnet of strip being positioned and being controlled to capsule endoscope in such a case or highly difficult.
About with magnetic field capsule be suspended in United States Patent (USP) US20070221233, US20100268026,
US20110054255, US20110184235 are it has been mentioned that mistake.In the application of these patents, magnetic capsule is by the liquid institute of surrounding
It suspends, this requires the density of capsule to be less than fluid density.Most common liquid is water in clinical practice, this suspension capsule
Weight will be limited in 3g or less.If capsule configures permanent magnetic dipoles to realize better positioning, the weight of capsule will
It can easily exceed 3g.How stable suspension is realized greater than the capsule endoscope that water and weight are more than 3g for specific gravity, not yet
It was disclosed.
Summary of the invention
The present invention captures the technical problem of the prior art, provides a kind of control capsule endoscope and moves in human body alimentary canal
Device and method.Device and method disclosed herein can accurately generate 5 maintenance and operations and move rotating excitation field and to peeping in magnetic capsule
Mirror generates remote action power, it is made to be suspended in gas-liquid interface.
One aspect of the present invention, capsule endoscope is comprising a capsule shape shell and is placed on capsule shape in a position-stable manner
The intracorporal imaging unit of shell, when capsule endoscope is suspended in liquid/gas interface, inside imaging unit shooting organ
Image.Liquids and gases are introduced into the organ of patient.One embodiment of the present of invention, capsule endoscope are suspended in gas-liquid interface packet
Containing permanent magnetic dipoles, wherein capsule endoscope has a mass center, and permanent magnetic dipoles in capsule endoscope has a magnetic
The heart.Capsule endoscope changes its position or orientation by interacting with external magnets.
In one embodiment of the invention, the density of capsule endoscope is greater than fluid density.Another implementation of the invention
The quality of example, capsule endoscope is greater than 3g.
In another embodiment of the invention, the distance between the mass center of capsule endoscope and magnetic core are less than 2mm.
The second aspect of the invention discloses a kind of using the method with the sub- capsule endoscope of permanent magnetic dipoles.This
Kind of method include capsule endoscope liquid/gas interface shape at a tilt angle when, partial rotational capsule endoscope is seen
Examine internal.This method includes:
One capsule endoscope comprising permanent magnetic dipoles and camera is provided；
Capsule endoscope is set to be suspended in liquid/gas interface；
Magnetic field, which is provided, by external magnets gives permanent magnetic dipoles；
When capsule endoscope is suspended in liquid/gas interface same position, by along one or more axial rotations
Change the tilt angle of capsule endoscope with mobile external magnets；
Constant magnetic field force is received by permanent magnetic dipoles.
By reading following present invention detailed description of preferred embodiment, and in combination with attached drawing, will be better understood
Above and other feature, advantage and technology and industrial significance of the present invention.
Detailed description of the invention
Fig. 1 is according to one aspect of the present invention, an example principles figure of capsule endoscope；
Fig. 2 is to illustrate glue according to one aspect of the present invention, the gravity of capsule endoscope and the change curve of magnetic moment
Intracapsular sight glass reaches the Maximum Permissible Weight of stable suspersion；
Fig. 3 is the schematic diagram of device viewgraph of cross-section disclosed by the invention, and wherein capsule endoscope sensation level moves
External magnets move in the horizontal direction；
Fig. 4 is the schematic diagram of device viewgraph of cross-section disclosed by the invention, and wherein capsule endoscope induction moves vertically
External magnets, in movement in vertical direction；
Fig. 5 is the schematic diagram of device viewgraph of cross-section disclosed by the invention, illustrates and is suspended in gas/liquid interface
When, how capsule endoscope is rotated in organ, and wherein the aggregate motion of external magnets only changes the tilt angle of capsule,
It almost has not been changed in the position of liquid/gas interface；
Fig. 6 is the schematic diagram of device viewgraph of cross-section disclosed by the invention, illustrates capsule suspension in gas/liquid
When interface, under external magnets rotary action, capsule endoscope leaves original position, this is more than turns in the simple of original position
It is dynamic；
Fig. 7 is the relation schematic diagram (use of the vertical rotation angle of external magnets magnetic moment and the from deviating from the position of capsule endoscope
Normalizing numerical value indicates)；
Fig. 8 is the vertical rotation angle of external magnets magnetic moment and vertically adjusts apart from (being indicated with normalization numerical value)
Relation schematic diagram, distance adjustment be in order to which stationary magnetic field power is acted on capsule endoscope；
Fig. 9 is the relation curve of the rotational angle rotational angle vertical with the external magnetic moment of spherical magnet of capsule endoscope
Figure；
Figure 10 is the schematic diagram of capsule endoscope levitation gas/liquid surface according to the present invention, according to of the invention one
A aspect illustrates the various power for having an inclination angle when capsule endoscope suspends and being subject to；
Figure 11 is one embodiment according to the automatic magnet in outside of one aspect of the present invention.
Specific embodiment
The following further describes the present invention in detail with reference to the accompanying drawings and specific embodiments, and following embodiment is to this hair
Bright explanation and the invention is not limited to following embodiments.
The wireless medicine capsule that can be taken is known in medical domain.After swallowing this wireless capsule, capsule traverses people
Body alimentary canal acquires in the process and transmits data, if configuration camera can also acquire image.When capsule endoscope is matched
Permanent magnetic dipoles is set, capsule endoscope can be stopped in target position during checking.
It is an object of the invention to be accurately positioned capsule endoscope target area (may be focal area), and acquire
Real-time medicine relevant information is so that doctor can make diagnosis to accurate target position or perform the operation.
Further when capsule endoscope is placed on target position, in order to acquire accurate information or unambiguous image,
Capsule endoscope need to be fixed on target position, and remain broadly stable within one section of specific period.Stablize, refers to capsule at this
State, i.e. the position and direction of holding capsule do not change, or detectable variation does not occur, or do not occur significantly to become
Change, so that this variation can be ignored in the applicable experiment of ideal or clinical setting.According to the present invention, capsule endoscope packet
Containing permanent magnetic dipoles.Magnetic dipole is a vector.The positioning of capsule endoscope of the present invention, comprising it relative to ginseng
Examine the positioning of position, and the angle relative to reference position.The direction of capsule endoscope includes the direction relative to reference position.
Here, target position includes liquids and gases, and there is specific liquid/gas interface.
In one embodiment, capsule endoscope at least needs taking adequate resolution image or carrying out one simply
The duration of test or process keeps stablizing.
The various prior arts provide a variety of methods that capsule endoscope is accurately positioned, dress disclosed by the invention so far
It sets and how method is changed under being in stable suspersion state in predetermined position mainly for capsule endoscope using external magnets
Its direction.
Device disclosed herein includes capsule endoscope, is placed on the target area that essence is made of liquids and gases
Domain.Capsule endoscope includes a capsule shape shell and is placed in the intracorporal imaging unit of capsule shape shell in a position-stable manner, works as glue
When intracapsular sight glass is suspended in liquid/gas interface, the image inside imaging unit photographic subjects region is used.Of the invention one
Embodiment includes permanent magnetic dipoles in the capsule endoscope that liquid/gas interface suspends, and wherein capsule endoscope has a matter
The heart, permanent magnetic dipoles have a magnetic core.Capsule endoscope changes its position and direction by interacting with external magnets.
In an example, target area is internal organs.In an example, target area is stomach.In another reality
In example, stomach part is filled with liquid.
In an example, liquids and gases are introduced into target area after target area is emptied.In an example, liquid
Body is water.In another example, gas is air.In another example, gas is the air of additional carbon dioxide, is produced by oral
Gas agent generates.
The present invention is suspended in liquid/gas interface for capsule endoscope." being suspended in liquid/gas interface " is not limited to
Situation of the capsule a part in liquid or gas.Within the scope of the present invention, as long as buoyancy of the capsule by liquid, capsule by
Think to be left floating, immerses situation about be largely exposed in air with capsule completely comprising capsule, but these examples are simultaneously
It is not using best mode of the invention.
Capsule endoscope has a shell in the present invention.In field of general technology, capsule endoscope can be any shape
The pill of shape or any size.In one example, it is hemisphere planar, capsule shape but one end that capsule, which is cylindrical, both ends,
Size is greater than the other end or American football shape.Capsule endoscope of the invention is symmetrical along its long axis direction.Capsule endoscope
Have a mass center, i.e., the center of gravity measured in air, this is because the structure of capsule endoscope it is intrinsic, will not be because of putting
The environment set and change.Capsule endoscope includes permanent magnetic dipoles, there is a magnetic moment center, i.e. referred to as magnetic dipole
Center.
The density of capsule endoscope disclosed herein is the inherent characteristic determined by the material and construction package of capsule, no
It can change because of the environment of placement.Different from most of suspensions capsule endoscope disclosed in the prior art, usually require that
Capsule density is less than fluid density.In order to successfully and accurately be suspended in target position, capsule endoscope density requirements of the present invention
Greater than fluid density.
Device disclosed herein includes an external magnets, and generation external magnetic field, 5 maintenance and operations are moved and rotating excitation field, Lai Yuancheng
Control magnetic capsule endoscope.
It is the schematic diagram of capsule endoscope stable suspersion with reference to Fig. 1.In this example, as shown, being peeped in capsule
Mirror is a basic three-dimensional geometry form, is hemispherical cylindrical body comprising a both ends.The length of the capsule is L,
The radius at hemisphere face end is R.Capsule endoscope has permanent magnetic dipoles, is placed in the column part of capsule endoscope.Institute
The magnetic moment for the capsule endoscope magnetic dipole stated is m.Capsule endoscope further includes one or more image devices.At one
In example, image device is camera.Camera is placed on one end of capsule endoscope.When there is 2 cameras to be placed on
Capsule endoscope, it is preferable that 2 cameras are individually positioned in the both ends of capsule.The present apparatus further includes an external magnetic
Body, to be spherical, and magnetic moment is M.
Such a capsule endoscope, is suspended in liquid/gas interface, will receive 3 power, the gravity W of capsule, outside
The magnetic field force F in magnetic fieldmAnd the buoyancy F of liquidfloat.In stable suspersion state, capsule is by buoyancy FfloatAnd external magnetic field power Fm
Support.The gravity W of capsule, buoyancy FfloatWith magnetic force FmWith following relationship (formula 1).
Fm+Ffloat=W ... ... formula 1
... ... formula 2
Ffloat=ρliquid(L/2+z)πR2... ... formula 3
Further, in the same circumstances, buoyancy FfloatWith external magnetic field power FmIt is established by formula 2 and formula 3.Wherein M
It is the magnetic moment of present apparatus external magnets, m is the magnetic moment of magnetic dipole in magnetic capsule.D is the magnetic core of external magnets to Magnetic adhesive
The vertical range of capsule magnetic core；Z is vertical range of the liquid gas interface to capsule magnetic core, as shown in Figure 1.
The stable suspersion of magnetic capsule must meet the following conditions (formula 4 and formula 5):
... formula 4
4 ρ of D/L >capsule/ρliquid+ 1/2 ... ... formula 5
Therefore, it can show that capsule reaches the maximum weight W of stable suspersion permission according to formula 1-5.Fig. 2 is according to the present invention
The key configuration that various aspects are provided with capsule endoscope limits.Effective and useful capsule endoscope suspension system in order to obtain,
The magnetic moment m of capsule endoscope magnetic dipole and the weight of capsule endoscope must meet the concerns mandate of Fig. 2.In Fig. 2, under the curve
The region in face is allowed band, is forbidden range in curve area above.Fig. 2 shows the magnetic moment of whole device external magnets
For 2000Am2, then the magnetic moment range of magnetic dipole is 0.01-0.6Am inside capsule endoscope2, in order to enable capsule to suspend,
The weight range of capsule must be 3-8g.From the point of view of an angle, known to design capsule endoscope will have one and fixed magnetic
Square, Fig. 2 describe the weight limitation of capsule.In other words, in an example, when the magnetic moment of capsule is 0.1Am2, capsule
Weight is less than 6g；Otherwise capsule will be too heavy and cannot suspend.In another example, when the magnetic moment of capsule is 0.2Am2,
The weight of capsule is less than 6.2g；Otherwise capsule will be too heavy and cannot suspend.In another example, when the magnetic moment of capsule is
0.3Am2, the weight of capsule is less than 7g；Otherwise capsule will be too heavy and cannot suspend.In another example, when capsule
Magnetic moment is 0.4Am2, the weight of capsule is less than 7.5g；Otherwise capsule will be too heavy and cannot suspend.In another example,
When the magnetic moment of capsule is 0.5Am2, the weight of capsule is less than 7.8g；Otherwise capsule will be too heavy and cannot suspend.At another
In example, when the magnetic moment of capsule is 0.6Am2, the weight of capsule is less than 8g；Otherwise capsule will be too heavy and cannot suspend.
On the other hand, in some special examples, when configuration capsule endoscope makes it have a desired wt or weight
Range, Fig. 2 propose the limitation that capsule endoscope magnetic dipole corresponds to magnetic moment.In an example, when the target weight of capsule
When for 5g, the magnetic moment of capsule endoscope is greater than 0.05Am2.In another example, when the target weight of capsule is 6g, glue
The magnetic moment of intracapsular sight glass is greater than 0.15Am2.In another example, when the target weight of capsule is 7g, capsule endoscope
Magnetic moment be greater than 0.3Am2.In another example, when the target weight of capsule is 8g, the magnetic moment of capsule endoscope is big
In 0.55Am2。
In the above-described example, a fixed system is disclosed, wherein external magnets configuration has the mechanical arm of magnetic moment.Formula
1-5 and Fig. 1 and Fig. 2 the weight or magnetic moment for how changing capsule in varied situations is shown, to obtain systems stabilisation.On but
Stating example should be understood that a limitation.On the contrary, formula 1-5 can also be used to design such a system, capsule endoscope
There are fixed weight and magnetic moment, external magnets can change in varied situations.For example, in a portable system,
External magnets are a hand-held devices, are preferably applied although it is not one of the invention.
Refering to Fig. 3 and Fig. 4, the present invention relates to a kind of magnetic endoscopic system with external automatic magnet, wherein capsule
Endoscope liquid suspension, the density of capsule endoscope can be greater than fluid density in human body in human body.Without external automatic magnet
Directed force Fm, capsule cannot suspend or float in a liquid.That is, capsule endoscope motion can only lean on response external magnetic
The movement of body.As shown in Figure 1, magnetic capsule endoscope follows external magnets to move in X/Y plane.When external magnets carry out it is flat
It moves, capsule endoscope response magnetic field power does same movement.In X/Y plane, magnetic capsule endoscope is transported in the same direction with external magnets
It is dynamic.When external magnets move right, capsule endoscope also moves right.When external magnets move forward, capsule endoscope also to
Preceding movement, and shown in X-direction.When external magnets are translated, the magnetic field force induced work of magnetic capsule is used as same movement.
Magnetic capsule endoscope can also move vertically, as shown in Figure 4 along Z-direction.An example of the present invention, disease
People lies low in one plane, parallel with X/Y plane, stomach of the capsule endoscope in patient.Capsule endoscope is suspended in human body
Liquid or liquid/gas interface.When external magnets move vertically up and down, capsule endoscope response external magnet change location
In movement in vertical direction.Opposite movement routine as shown in Figure 3, wherein capsule endoscope moves in the same direction with external magnets.Fig. 4 institute
It is shown as magnetic capsule endoscope and external magnets counter motion.When external magnets move downward, the magnetic field of generation is closer to glue
The magnetic dipole of intracapsular sight glass, capsule endoscope, which is attracted, to be moved upwards.When external magnets move upwards, i.e., far from magnetic capsule
Endoscope movement, as external magnets move upwards field weakening, capsule endoscope is then moved downward.By controlling external magnets
Vertically or Z-direction moves, and can accurately control position of the capsule along Z-direction.When checking stomach, capsule endoscope can
To facilitate positioning, a remote view is first obtained, the top or bottom of stomach wall are then observed by the close-up view of gastric mucosa.
It is moved as shown in Figure 3-4 along three axis directions, magnetic capsule endoscope can also rotate, and be included in external magnets
The inclination and rotation occurred under the influence of the magnetic field of generation.In clinic, inclination and rotation are very important, and work as capsule endoscope
Stable suspersion can make doctor have the broader visual field when checking stomach in fixed position.Fig. 5 show the area of inclination and rotary motion
Not.
Capsule endoscope of the invention is suspended in liquid/gas interface, and capsule and liquid/gas interface form an angle
Degree.The angle is defined as inclination angle.The range at inclination angle is 0-360 ° according to the present invention.In an example, in order to more
It easily and accurately positions, the tilt angle ranges are 45-135 °.
Various aspects according to the present invention, rotation or rotary motion mean magnetic capsule endoscope in two-dimensional surface or three-dimensional
Space changes its direction.Rotation or rotary motion had both included inclination, changed capsule and gas/liquid surface angle in two-dimensional surface
Degree, and include rotation, change capsule and gas/liquid surface angle in three-dimensional space, wherein capsule endoscope is in liquid/gas
The position of body interface does not change during the motion, but inclination angle or the inclination angle of the two-dimensional cross sectional view in rotation exist
It changes before and after rotation.In one embodiment, rotary motion is banking motion.Inclination occurs in Z axis plane, by ball
The vertical rotary magnetic moment of shape magnet causes, as shown in figure 5, wherein capsule changes its inclination angle as pendulum is mobile.In another reality
It applies in example, rotary motion is rotation.Rotation occurs to peep in liquid/gas interface capsule as shown in Figure 5 in XYZ three-dimensional space
Mirror is fixed position around it and is rotated.Capsule endoscope is rotated according to the magnetic moment of external spherical magnet in the floor projection of X/Y plane.Fig. 5
In, the angle between the long axis of capsule endoscope and the surface of liquid/gas interface is to maintain consistent during rotation.?
In the viewgraph of cross-section of rotation, movement of the Angles Projections that the long axis and liquid/gas interface of capsule are formed according to external magnets
And change.
To illustrate purpose, inclination refers to that capsule endoscope does not change its position in XYZ coordinate system, only changes the length of capsule
Angle between axis and gravity direction, preferably gas/liquid interface.Various aspects according to the present invention, rotation refer to capsule endoscope
Do not change its position in XYZ coordinate system, only changes capsule long axis along the direction of liquid/gas interface, cause corresponding two
Tie up the variation at inclination angle in viewgraph of cross-section.
Different from rotary motion, capsule endoscope can be inducted into target position by external automatic magnet single stepping；Turn
Dynamic is a more complicated process.When external automatic magnet rotates, establishing stable suspension system will be by various interference.
In liquid/gas interface most high-intensity magnetic field position, at liquid/gas interface external magnetic field strength and external magnetic-field direction (or angle
Degree) can all it change.It is mobile to keep capsule endoscope static (such as Fig. 6 and Fig. 7) while external magnets need 1) to rotate；2) more
Close to liquid/gas interface, to make up the magnetic field weakened by rotation, in order to which constant magnetic field is provided to capsule during turning
Power (such as Fig. 8)；3) when the direction of external magnetic field is still relatively small, rotated within the scope of 45-135 °, so as to capsule endoscope with
Change its inclination angle (such as Fig. 9) with the rotation of external magnets；Alternatively, 4) when the mass center of capsule and magnetic core distance are less than 2mm,
Change the inclination angle (such as Figure 10) of capsule endoscope by changing magnetic direction.
Only change its inclination angle to rotate capsule endoscope, while remaining at original position, external spherical magnet must be same
When rotate and mobile.If external magnets only rotate, capsule endoscope is not only rotated by the rotating excitation field that external magnets generate,
Capsule endoscope can be made mobile in XY coordinate system unintentionally, for example, change the position of capsule endoscope in liquid/gas interface,
Because the most high-intensity magnetic field of liquid/gas interface has changed when responding with rotating excitation field from a position to another position,
Capsule endoscope with permanent magnetic dipoles is attracted by the second high-intensity magnetic field of liquid/gas interface.For example, as shown in fig. 6, working as
External automatic magnet rotation, capsule, which also rotates, changes it at the inclination angle of liquid/gas interface.Simultaneously when rotating generation, glue
Intracapsular sight glass is from X0It is moved horizontally to X1.In Fig. 6, the ellipse that dotted line is drawn is to wait magnetic field lines, and the point of contact on gas/liquid interface is
Most high-intensity magnetic field point Bm, from X in Fig. 70To X1Distance be known as offset distance t.Fig. 7 depict external magnets angle of rotation (degree) and
Relationship between the undesirable movement of capsule, by x/d it is worth go out, wherein d is the center of external magnets to liquid/gas interface
Distance, x is distance of the magnetic core of capsule endoscope to external magnets center between the subpoint of liquid/gas interface, with
The distance of X0 to X1 is identical.According to Fig. 7, when external spherical magnet rotates about 10 °, capsule endoscope will be moved horizontally, at this time
The value of x/d is 0.25, that is, is shown when distance d is 30cm, capsule can unintentionally move 7.5cm.
Anyway, no matter this unintentionally move all is undesirable in X or Y-coordinate system, therefore is disclosed most at this
Smallization method.Fig. 3 show capsule endoscope and external magnets is followed to move in an x or y direction.In order to avoid due to external magnets
The undesirable movement of capsule endoscope caused by rotating, external magnets of the invention will also move in an x or y direction to offset.Outside
The direction of motion of portion's magnet will not expect the direction of motion with capsule on the contrary, the moving distance of external magnets will be according to capsule endoscope
The distance of movement is not expected to calculate.The example of identical selection in Fig. 7, when distance d be 30cm, and external magnets rotate 10 °, lead to
It crosses and external magnets is moved right to 7.5cm again to correct the 7.5cm that capsule is moved to the left, this moves right 7.5cm with by capsule
It is of equal value.Under the control of suspension capsule, when the magnetic moments parallel of magnet is in the earth, it is under external spherical magnet
Side, thus it is vertical with liquid/gas interface.When external spherical magnet is along horizontal overturning angle, capsule will fully comply with horizontal angle.Such as
Fig. 5 show the axis of capsule and the line of magnetization plan view of external spherical magnet.The Plane Rotation is symmetrical.So if we
X/Y plane corrects translational motion, then
X=X0+tsinα
Y=Y0+tcosα
Wherein X0、Y0For the home position of external spherical magnet；X, Y is the final position of external spherical magnet.α is horizontal
Angle of rotation, t are offset distances shown in fig. 5.
During translation is likely to occur in rotation or before/after rotation.Preferably external magnets rotate while into
Row translation.
One embodiment of the present of invention discloses a kind of method that capsule endoscope is maintained at same position in rotation,
Wherein capsule endoscope, which is suspended in liquid/gas interface, an initial inclination angle.This method includes to provide one to contain
The capsule endoscope of permanent magnetic dipoles and camera；So that capsule endoscope is suspended in liquid/gas interface, is wherein peeped in capsule
Mirror forms an inclination angle in liquid/gas interface to observe inside organ；Magnetic field force is provided to forever by an external magnets
Long magnetic dipole；When capsule is when liquid/gas interface same position suspends, by rotation and along one or more axial movement
The angle at external magnets change inclination angle.
Further, in addition to keeping capsule endoscope in same position during translation, it is also desirable to make during rotation
Capsule endoscope is realized smooth rotation by identical magnetic field force.When external magnets rotate, magnetic field force experienced in capsule and peep
Mirror variation.In order to provide constant magnetic field force to capsule endoscope, need to change the distance between external magnets and magnetic capsule.Its
Calculated result is as shown in Figure 8.Fig. 8 depicts calculated result of the external magnetic ball according to moving distance required for its rotational angle.Example
Such as, in a system, the distance d at external spherical shape magnet center to gas/liquid interface is 30cm before rotation, when external magnetic
Body intends 90 ° of rotation, then external magnets need to be adjusted along its upright position, so that the value of d/z is reached 1.18, also meaned that and rotating
Afterwards, external magnets are a position, wherein z=d/1.18=30/1.18=25.4cm.This calculated result further demonstrates that outer
Portion's magnet need to be closer to liquid/gas interface 30-25.4=4.6cm.
Another embodiment of the present invention discloses one kind and provides the method for stationary magnetic field to capsule endoscope when rotated,
Wherein capsule endoscope, which is suspended in liquid/gas interface, an initial inclination angle.This method includes to provide one to contain
The capsule endoscope of permanent magnetic dipoles and camera；So that capsule endoscope is suspended in liquid/gas interface, is wherein peeped in capsule
Mirror forms an inclination angle in liquid/gas interface to observe inside organ；Magnetic field force is provided to forever by an external magnets
Long magnetic dipole；When capsule liquid/gas interface same position suspend when, pass through rotation external magnets change capsule endoscope
Inclination angle；During turning, the distance adjusted between external magnets and liquid/gas interface is constant to be supplied to capsule endoscope
Magnetic field force.
Refering to Fig. 9, during external magnets rotation, according to angle of rotation, its magnetic direction can also change.In Fig. 9, y-axis
It is field angle (direction) of the external magnetic field in gas/liquid interface most high-intensity magnetic field position.When magnetic field is very strong or capsule center of gravity and magnetic
Dipole subcenter is very close to capsule will follow external magnetic-field direction.By rotating external spherical magnet, the inclination of capsule endoscope
Corresponding change will occur for angle.If Fig. 9 shows the rotational angle of capsule at 45-135 °, angle control is relatively easy.
However sometimes in clinic setting, manipulation capsule endoscope completes bigger water by a wider range
Flat dip eliminates the needs that capsule endoscope relocates, and allows a quickly and effectively process.
Alternative embodiment of the invention, if the magnetic outside very little, change between the magnetic core of capsule and the mass center of capsule
The direction of field can change the inclination angle of capsule endoscope.In one example, the distance between the magnetic core of capsule and the mass center of capsule is small
In 2mm.The magnetic core of the capsule is the center of magnetic dipole inside capsule endoscope.
Refering to fig. 10, capsule suspension is by 3 power, FfloatIt is buoyancy, W is the gravity of capsule, and W ' is that capsule is outstanding in liquid
Floating effective weight, liquid is water in this example.D1It is the center of gravity (mass center) for the liquid for being occupied or being replaced by partial capsules
To the horizontal distance of the effective center of gravity of capsule；D2It is that the center of gravity (mass center) of the liquid occupied by partial capsules arrives the level of capsule mass center
Distance.Further, FmIt is the magnetic field force for acting on capsule magnetic dipole；B is magnetic field, and the angle with horizontal plane is β,
M is the magnetic moment of capsule magnetic dipole.DdmIt is between the center of capsule magnetic dipole and effective center of gravity (mass center) of capsule
Distance.θ is the additional inclination angle for connecting magnetic dipole center and the effective center of gravity line of capsule.In stable state, establish with
Lower formula:
W '=W-Ffloat... ... formula 6
D1=D2W '/W ... ... formula 7
Fm=W ' ... ... formula 8
Bm sin θ=W ' Dd-mSin (β-θ) ... formula 9
It can be obtained by above-mentioned formula, change the direction of external magnetic field B, can control the inclination angle of suspension capsule.To the greatest extent
It manages effective center of gravity to change with the variation of capsule submergence volume, it still surrounds mass center.For inclination angle easier to control, DdmIt should
Sufficiently small, it is therefore preferred to make the magnetic dipole of capsule close to the mass center of capsule, such as < 2mm.In a preferred embodiment, when
Capsule endoscope has a camera, and the distance between magnetic dipole and mass center is less than 2mm.In an alternative example, peeped in capsule
The length of mirror is L, and when capsule has 2 cameras, and respectively in one end of capsule, length is greater than 12mm.
As Figure 11 show one embodiment of external automatic magnet, provide a spherical shape according to each aspect of the present invention
External magnets allow to translate, vertical movement, horizontal and vertical rotation.
Those skilled in the art is readily conceivable that other embodiments and its modification.Therefore, the present invention is wider at it
Aspect is not limited to detail and representative embodiment here it is shown that with description.Therefore, it does not depart from by accessory claim
And its spirit and scope of the content of present invention as defined in equivalent, various modifications can be done.
Claims (9)
1. a kind of capsule endoscopic device, comprising:
Capsule endoscope is suspended in the liquid environment with liquid/gas interface, and the density of the capsule endoscope is greater than
The density of liquid, capsule endoscope and liquid/gas interface form an inclination angle, and the capsule endoscope includes:
Permanent magnetic dipoles, wherein capsule endoscope has a mass center and permanent magnetic dipoles has a magnetic core；And in capsule
Sight glass has an effective center of gravity when suspending in liquid environment；
It is characterized in that,
The capsule endoscopic device includes the bulbous exterior portion magnet for applying external magnetic field, by turning between 45-135 degree
It moves the bulbous exterior portion magnet and interacts with permanent magnetic dipole inside the capsule endoscope, it is described to change
The inclination angle of capsule endoscope, to control the capsule endoscope in the position and direction at gas/liquid interface, to connect institute
The line for stating magnetic core and mass center is not orthogonal to the gas/liquid interface；
Wherein, pass through rotation spherical external magnets and change the distance between bulbous exterior portion magnet and capsule endoscope, thus real
The smooth rotation of existing capsule endoscope；
Wherein, bulbous exterior portion magnet and capsule endoscope meet following relationship: before rotation spherical external magnets center to gas/
The distance of liquid surface is 30cm, and when external magnets intend 90 ° of rotation, then external magnets need to be adjusted along its upright position, be made
The value of d/z reaches 1.18, and wherein d is distance of the bulbous exterior portion magnet center to gas/liquid interface, and z is liquid gas interface and glue
The vertical range of intracapsular sight glass magnetic core.
2. the quality of capsule endoscopic device according to claim 1, capsule endoscope is greater than 3g.
3. capsule endoscopic device according to claim 1, the magnetic moment range of capsule endoscope inside permanent magnetic dipoles
For 0.001-0.6Am2。
4. capsule endoscopic device according to claim 1, the mass range of capsule endoscope is 3-8g.
5. capsule endoscopic device according to claim 1, the magnetic moment of external magnetic field is 2000Am2。
6. capsule endoscopic device according to claim 1, the magnetic core and glue of capsule endoscope inside permanent magnetic dipoles
Distance between intracapsular sight glass mass center is less than 2mm.
7. the length L of capsule endoscopic device according to claim 1, capsule is less than 12mm.
8. capsule endoscopic device according to claim 6, capsule endoscope only has 1 camera.
9. capsule endoscopic device according to claim 7, capsule endoscope has 2 cameras.
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910439941.8A CN110192838A (en) | 2014-09-15 | 2015-09-09 | A kind of device and method that control capsule endoscope is moved in human body alimentary canal |
| ES15185178T ES2738551T3 (en) | 2013-04-18 | 2015-09-15 | Apparatus for controlling the movement of a capsule endoscope in the digestive tract of a human body |
| EP15185178.9A EP2995240B1 (en) | 2014-09-15 | 2015-09-15 | Apparatus for controlling the movement of a capsule endoscope in the digestive tract of a human body |
| ES19170669T ES2887301T3 (en) | 2013-04-18 | 2015-09-15 | Apparatus and method for controlling the movement of a capsule endoscope in the digestive tract of a human body |
| HUE15185178A HUE044961T2 (en) | 2014-09-15 | 2015-09-15 | Apparatus for controlling the movement of a capsule endoscope in the digestive tract of a human body |
| DK15185178.9T DK2995240T3 (en) | 2013-04-18 | 2015-09-15 | Apparatus for controlling the movement of a capsule endoscope in the digestive tract of a human body |
| SI201530838T SI2995240T1 (en) | 2014-09-15 | 2015-09-15 | Apparatus for controlling the movement of a capsule endoscope in the digestive tract of a human body |
| EP19170669.6A EP3539456B1 (en) | 2014-09-15 | 2015-09-15 | Apparatus for controlling the movement of a capsule endoscope in the digestive tract of a human body |
| HRP20191287TT HRP20191287T1 (en) | 2014-09-15 | 2019-07-17 | Apparatus for controlling the movement of a capsule endoscope in the digestive tract of a human body |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/486,131 US10076234B2 (en) | 2013-04-18 | 2014-09-15 | Apparatus and method for controlling movement of a capsule endoscope in digestive tract of a human body |
| US14/486,131 | 2014-09-15 |
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| CN201910439941.8A Division CN110192838A (en) | 2014-09-15 | 2015-09-09 | A kind of device and method that control capsule endoscope is moved in human body alimentary canal |
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| CN201510567611.9A Active CN105411505B (en) | 2013-04-18 | 2015-09-09 | A kind of device and method that control capsule endoscope is moved in human body alimentary canal |
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| US11504024B2 (en) | 2018-03-30 | 2022-11-22 | Vibrant Ltd. | Gastrointestinal treatment system including a vibrating capsule, and method of use thereof |
| GB2554354B (en) | 2016-09-21 | 2021-06-02 | Vibrant Ltd | Systems for adaptive treatment of disorders in the gastrointestinal tract |
| US10478048B2 (en) * | 2016-09-23 | 2019-11-19 | Ankon Medical Technologies (Shanghai) Co., Ltd. | System and method for using a capsule device |
| US10905378B1 (en) | 2017-01-30 | 2021-02-02 | Vibrant Ltd | Method for treating gastroparesis using a vibrating ingestible capsule |
| US10888277B1 (en) | 2017-01-30 | 2021-01-12 | Vibrant Ltd | Method for treating diarrhea and reducing Bristol stool scores using a vibrating ingestible capsule |
| CN107997734A (en) * | 2017-11-29 | 2018-05-08 | 重庆金山医疗器械有限公司 | A kind of control method of capsule endoscope, apparatus and system |
| US11638678B1 (en) | 2018-04-09 | 2023-05-02 | Vibrant Ltd. | Vibrating capsule system and treatment method |
| US10537720B2 (en) | 2018-04-09 | 2020-01-21 | Vibrant Ltd. | Method of enhancing absorption of ingested medicaments for treatment of parkinsonism |
| US11510590B1 (en) | 2018-05-07 | 2022-11-29 | Vibrant Ltd. | Methods and systems for treating gastrointestinal disorders |
| EP3906086A4 (en) | 2019-01-03 | 2022-10-19 | Vibrant Ltd. | Device and method for delivering an ingestible medicament into the gastrointestinal tract of a user |
| GB201900780D0 (en) | 2019-01-21 | 2019-03-06 | Vibrant Ltd | Device and method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user |
| GB201901470D0 (en) | 2019-02-04 | 2019-03-27 | Vibrant Ltd | Vibrating capsule for gastrointestinal treatment, and method of use thereof |
| US20220248943A1 (en) * | 2019-06-17 | 2022-08-11 | Shenzhen Sibernetics Co., Ltd. | Magnetic control device of capsule endoscope and method for controlling movement of capsule endoscope in tissue cavity |
| CN117982086A (en) * | 2020-04-23 | 2024-05-07 | 深圳硅基智控科技有限公司 | Capsule endoscope system |
| CN113647893B (en) * | 2021-08-13 | 2022-06-10 | 元化智能科技(深圳)有限公司 | Autonomous navigation system, device and medium for wireless capsule endoscope |
| CN115067863B (en) * | 2022-05-31 | 2023-03-14 | 元化智能科技(深圳)有限公司 | Wireless capsule endoscope driving system based on spherical driver |
| CN117562486A (en) * | 2022-08-08 | 2024-02-20 | 安翰科技(武汉)股份有限公司 | Control method and device of magnetic control capsule system |
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