CN105396176A - Compound tissue repair patch and production method thereof - Google Patents
Compound tissue repair patch and production method thereof Download PDFInfo
- Publication number
- CN105396176A CN105396176A CN201510840715.2A CN201510840715A CN105396176A CN 105396176 A CN105396176 A CN 105396176A CN 201510840715 A CN201510840715 A CN 201510840715A CN 105396176 A CN105396176 A CN 105396176A
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- China
- Prior art keywords
- mesh sheet
- tissue repair
- soft tissue
- container cavity
- diaphragm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Abstract
The invention discloses a compound tissue repair patch and a production method thereof. The production method comprises the steps of firstly, preparing/selecting a woven mesh; secondly, preparing a non-woven mesh soft tissue repair diaphragm with an accommodation cavity; thirdly, placing the woven mesh into the accommodation cavity of the soft tissue repair diaphragm; fourthly, shrinking the soft tissue repair diaphragm. By the aid of the method, the firmness of the integration between the woven mesh and the non-woven mesh soft tissue repair diaphragm is greatly improved. Operation is convenient, and material selection is less constrained. The compound tissue repair patch has beneficial mechanical performances of the woven mesh, and particularly the produced compound tissue repair patch formed by an electrostatic spinning membrane and the woven mesh has the advantages of being high in porosity, good in breathability/water resistance, good for diffusion and delivery of nutriment and metabolic substances and is more beneficial to tissue growth; besides, after the compound tissue repair patch is implanted into a human body, surrounding tissue is combined more tightly.
Description
Technical field
The present invention relates to biomedical sector, more particularly relate to a kind of compound tissue repairing patch and preparation method thereof.
Background technology
Polypropylene line braiding mesh sheet (hereinafter referred to as mesh sheet) is widely used in organ prolapse, urinary incontinence etc. at the bottom for the treatment of hernia, fistula, basin.But because the material of polypropylene own is hard, after implanting easily and surrounding tissue or wound generation sliding friction, add the inflammatory reaction that foreign body reaction causes, wound healing even causes damaging adjacent healthy tissue very slowly.Meanwhile, because braiding mesh sheet itself is formed by the overlap joint of macromolecular material line one by one, overall structure is more open, and pullling and shrinking due to newborn scar tissue after implantation, often causes mesh sheet craping deform.This can cause the generation of some complication, as overallly in shrinkage mesh sheet hardeningly causes very strong foreign body sensation, or size of netting reduce after pull the tissue of attachment, patient feels pain.
In order to overcome the above-mentioned defect of polypropylene line braiding mesh sheet, usually made improvements by coating or the tape casting in prior art.Coating refers to such as, weaving the surface-coated of mesh sheet or adhering to layer of material, collagen, plays the effect of isolation mesh sheet and surrounding tissue.But there are the following problems for this method: 1) material is combined loosely with braiding mesh sheet, easy layering, rupture, come off; 2) coating surface is difficult to smooth; 3) coating material is difficult to enter hole equably; 4) processing difficulties, selection is limited, and (need composite to have certain mobility due to during coating, (as material needs to dissolve, and solvent can not affect mesh sheet to need to add solvent or high-temperature fusion; Or high temperature can not melt mesh sheet)).The tape casting refers to and immerses in liquid by mesh sheet, obtains compound mesh sheet after solidified liquid.Also there is material and be combined loosely with braiding mesh sheet in the tape casting, easy layering, processing and selection restricted, and the front and back of mesh sheet process after the larger problem of varying topography.
In addition, in existing method, no matter the coating that to be coating formed on mesh sheet surface or the cast layer that the tape casting is formed on mesh sheet surface, usually all finer and close, porosity is low, and tissue is grown into slow, cause compound mesh sheet and surrounding tissue associativity poor.
Summary of the invention
The present invention is intended to the defect overcoming above-mentioned prior art, provides a kind of preparation of compound tissue repairing patch
Method.The method can make to combine closely between non-woven mesh sheet class soft tissue repair diaphragm and braiding mesh sheet.
Another object of the present invention is to the compound tissue repairing patch providing a kind of described method to prepare.Described compound tissue repairing patch has the useful mechanical property of braiding mesh sheet, can be combined closely after described compound tissue repairing patch implant into body with surrounding tissue simultaneously.
Goal of the invention of the present invention is achieved by following technical solution.
A preparation method for compound tissue repairing patch, comprises the steps:
S1. prepare/choose braiding mesh sheet;
S2. the non-woven mesh sheet class soft tissue repair diaphragm with container cavity is prepared; Described container cavity is semi-enclosed container cavity, and described container cavity comprises passage and cavity volume, and described passage capable of being passes through for weaving mesh sheet described in S1, and the size of described cavity volume is enough to weave mesh sheet described in accommodation S1;
S3. the braiding mesh sheet of S1 is put into the container cavity of soft tissue repair diaphragm described in S2, insert jointing material, solidification, makes container cavity be complete closed;
S4. shrink process is carried out to soft tissue repair diaphragm.
Braiding mesh sheet is placed in the container cavity of non-woven mesh sheet class soft tissue repair diaphragm, then makes the two combine closely by shrink process, greatly can increase the fastness of braiding mesh sheet and non-woven mesh sheet class soft tissue repair diaphragm.Non-woven mesh sheet class soft tissue repair diaphragm with container cavity can be prepared by existing multiple method, and it can not be subject to the restriction of mesh grid sheet material kind.By selecting different non-woven mesh sheet class soft tissue repair diaphragms, the soft tissue repair sticking patch several functions of composite construction can be given.Because shrink process can be carried out under better simply condition, therefore easy to operate, and selection is not easy to be restricted.
Preferably, the described non-woven mesh sheet class soft tissue repair diaphragm with container cavity is nonwoven film, static spinning membrane or foam films.
Preferably, the described non-woven mesh sheet class soft tissue repair diaphragm with container cavity is static spinning membrane.It is high that static spinning membrane has porosity, ventilative/and aqueous is good, and be beneficial to the advantages such as the diffusion of nutrient substance and metabolite and transmission, the soft tissue repair sticking patch prepared with it is more conducive to tissue growth, is combined tightr after implant into body with surrounding tissue.
Alternatively, the described non-woven mesh sheet class soft tissue repair diaphragm with container cavity is prepared by the following method:
S21. non-woven mesh sheet class soft tissue repair diaphragm is conventionally prepared;
S22. according to the appearance structure of braiding mesh sheet, non-woven mesh sheet class soft tissue repair diaphragm prepared by processing S21, makes it have described container cavity;
Described processing method is hot pressing, cutting or etching.
Alternatively, the described non-woven mesh sheet class soft tissue repair diaphragm with container cavity is prepared by the following method:
S23. scanning braiding mesh sheet pattern;
S24. according to S23. scanning obtain information incrementally manufacture method directly prepare the non-woven mesh sheet class soft tissue repair diaphragm with container cavity.
Preferably, jointing material described in S3. is collagen, polysaccharide or hydrogel.
Preferably, the material preparing non-woven mesh sheet class soft tissue repair diaphragm described in S2 is medical high polymer material.
Preferably, described medical high polymer material is PLA, PLGA, PVDF, PTFE, PU, PCL or PGA.
Preferably, shrink process described in S4 is to soak soft tissue repair diaphragm with the ethanol of volumetric concentration more than 50% or carry out non-contact thermal.
Preferably, the time of described immersion is 30 minutes ~ 12 hours, and the temperature of described non-contact thermal is 40 ~ 80 DEG C, and heat time heating time is 30 minutes ~ 12 hours.
A kind of compound tissue repairing patch prepared by described preparation method.
Preferably, the thickness of described braiding mesh sheet is 2mm-8mm, and the aperture of braiding mesh sheet is 1mm-2mm.The thickness of described non-woven mesh sheet class soft tissue repair diaphragm is about 4mm-10mm.
Compared with prior art, the present invention has following beneficial effect:
Braiding mesh sheet is placed in the container cavity of non-woven mesh sheet class soft tissue repair diaphragm by method of the present invention, then makes the two combine closely by shrink process, greatly can increase the fastness of braiding mesh sheet and non-woven mesh sheet class soft tissue repair diaphragm.Non-woven mesh sheet class soft tissue repair diaphragm with container cavity can be prepared by existing multiple method, and it can not be subject to the restriction of mesh grid sheet material kind.By selecting different non-woven mesh sheet class soft tissue repair diaphragms, the soft tissue repair sticking patch several functions of composite construction can be given.Because shrink process can be carried out under better simply condition, therefore easy to operate, and selection is not easy to be restricted.Compound tissue repairing patch prepared by the present invention has the useful mechanical property of braiding mesh sheet; simultaneously; braiding mesh sheet is positioned at the inside of non-woven mesh sheet class soft tissue repair diaphragm, thus makes complex repairation sticking patch have soft surface, protects the tissue contacted better.Especially, with static spinning membrane and the compound tissue repairing patch that formed of braiding mesh sheet, there is porosity high, to breathe freely/aqueous is good, be beneficial to the advantages such as the diffusion of nutrient substance and metabolite and transmission, it is more conducive to tissue growth, combines tightr after implant into body in surrounding tissue.
Detailed description of the invention
Embodiment 1
A preparation method for the soft tissue repair sticking patch of tool composite construction, comprises the following steps:
S1. prepare/choose PP and weave mesh sheet; The thickness of described mesh sheet is 5mm, and hole is 1mm, and filament diameter is 100um;
S2. the non-woven mesh sheet class soft tissue repair diaphragm with container cavity is prepared; Described container cavity is semi-enclosed container cavity, and described container cavity comprises passage and cavity volume, and described passage capable of being passes through for weaving mesh sheet described in S1, and the size of described cavity volume is enough to hold PP described in S1 and weaves mesh sheet.
The described concrete grammar with the non-woven mesh sheet class soft tissue repair diaphragm of container cavity of preparation is:
Select PVDF, obtain electrostatic spinning diaphragm by electrostatic spinning technique, it has three-dimensional porous structure, and its aperture is 1um to 100um, and thickness is 8mm.
Preparation weaves the identical copper mesh sheet of mesh sheet appearance and size with the PP of S1, places it in membrane surface, then makes it generate heat to the energising of copper mesh sheet and reaches 80 degrees Celsius, copper mesh sheet gradually coining is inner to diaphragm, after about 1 minute, remove copper mesh sheet, the container cavity of Formation Depth 6mm on described diaphragm.
S3. the PP of S1 is woven the container cavity that mesh sheet puts into static spinning membrane described in S2, insert jointing material, solidification, makes container cavity be complete closed; Described jointing material to be PVA mass content be 20% aqueous solution.Describedly be cured as employing Freeze Drying Technique.
S4. shrink process is carried out to soft tissue repair diaphragm: adopted by the soft tissue repair diaphragm after S3 process 95 volume % alcoholic solutions to soak 4 hours, soft tissue repair diaphragm is shunk, make electrostatic spinning diaphragm be combined tightr with braiding mesh sheet.
embodiment 2
A preparation method for the soft tissue repair sticking patch of tool composite construction, comprises the following steps:
S1. prepare/choose PVDF and weave mesh sheet; The thickness of described mesh sheet is 4mm, and hole is 1mm, and filament diameter is 100um;
S2. the non-woven mesh sheet class soft tissue repair diaphragm with container cavity is prepared; Described container cavity is semi-enclosed container cavity, and described container cavity comprises passage and cavity volume, and described passage capable of being passes through for weaving mesh sheet described in S1, and the size of described cavity volume is enough to hold PVDF described in S1 and weaves mesh sheet.
The described concrete grammar with the non-woven mesh sheet class soft tissue repair diaphragm of container cavity of preparation is:
Select PLA, obtain electrostatic spinning diaphragm by electrostatic spinning technique, it has three-dimensional porous structure, and its aperture is 10um to 100um, and thickness is 6mm.
Weave the pattern of mesh sheet according to S1.PVDF, cut by laser cutting machine on electrostatic spinning diaphragm surface, it is consistent that formation size and S1.PVDF weave mesh sheet, the container cavity of dark 5mm.
S3. the PVDF of S1 is woven the container cavity that mesh sheet puts into static spinning membrane described in S2, insert jointing material, dry solidification, make container cavity be complete closed; Described jointing material is collagen solution.
S4. shrink process is carried out to soft tissue repair diaphragm: adopted by the soft tissue repair diaphragm after S3 process 60 volume % alcoholic solutions to soak 12 hours, soft tissue repair diaphragm is shunk, make electrostatic spinning diaphragm be combined tightr with braiding mesh sheet.
embodiment 3
A preparation method for the soft tissue repair sticking patch of tool composite construction, comprises the following steps:
S1. prepare/choose PVDF and weave mesh sheet; The thickness of described mesh sheet is 4mm, and hole is 1mm, and filament diameter is 100um;
S2. the non-woven mesh sheet class soft tissue repair diaphragm with container cavity is prepared; Described container cavity is semi-enclosed container cavity, and described container cavity comprises passage and cavity volume, and described passage capable of being passes through for weaving mesh sheet described in S1, and the size of described cavity volume is enough to hold PVDF described in S1 and weaves mesh sheet.
The described concrete grammar with the non-woven mesh sheet class soft tissue repair diaphragm of container cavity of preparation is:
Scanning S1.PVDF weaves the pattern of mesh sheet, selects PLA, and prepare the static spinning membrane with container cavity by 3D printing technique or near field electrostatic spinning technology, it has three-dimensional porous structure, and its aperture is 10um to 100um, and thickness is 6mm, and the container cavity degree of depth is 5mm.
S3. the braiding mesh sheet of S1 is put into the container cavity of static spinning membrane described in S2, insert jointing material, solidification, makes container cavity be complete closed; Described jointing material is the collagenic aqueous solution of 10 volume %.Describedly be cured as employing Freeze Drying Technique.
S4. shrink process is carried out to soft tissue repair diaphragm: the soft tissue repair diaphragm after S3 process is adopted soaked in absolute ethyl alcohol 4 hours, soft tissue repair diaphragm is shunk, make electrostatic spinning diaphragm be combined tightr with braiding mesh sheet.
The above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.All any amendments done within the spirit and principles in the present invention, equivalent to replace and improvement etc., within the protection domain that all should be included in the claims in the present invention.
Claims (10)
1. a preparation method for compound tissue repairing patch, is characterized in that, comprises the steps:
S1. prepare/choose braiding mesh sheet;
S2. the non-woven mesh sheet class soft tissue repair diaphragm with container cavity is prepared; Described container cavity is semi-enclosed container cavity, and described container cavity comprises passage and cavity volume, and described passage capable of being passes through for weaving mesh sheet described in S1, and the size of described cavity volume is enough to weave mesh sheet described in accommodation S1;
S3. the braiding mesh sheet of S1 is put into the container cavity of soft tissue repair diaphragm described in S2, insert jointing material, solidification, makes container cavity be complete closed;
S4. shrink process is carried out to soft tissue repair diaphragm.
2. the preparation method of compound tissue repairing patch according to claim 1, it is characterized in that, the described non-woven mesh sheet class soft tissue repair diaphragm with container cavity is nonwoven film, static spinning membrane or foam films.
3. the preparation method of compound tissue repairing patch according to claim 1, it is characterized in that, the described non-woven mesh sheet class soft tissue repair diaphragm with container cavity is prepared by the following method:
S21. non-woven mesh sheet class soft tissue repair diaphragm is conventionally prepared;
S22. according to the appearance structure of braiding mesh sheet, non-woven mesh sheet class soft tissue repair diaphragm prepared by processing S21, makes it have described container cavity;
Described processing method is hot pressing, cutting or etching.
4. the preparation method of compound tissue repairing patch according to claim 1, it is characterized in that, the described non-woven mesh sheet class soft tissue repair diaphragm with container cavity is prepared by the following method:
S23. scanning braiding mesh sheet pattern;
S24. according to S23. scanning obtain information incrementally manufacture method directly prepare the non-woven mesh sheet class soft tissue repair diaphragm with container cavity.
5. the preparation method of compound tissue repairing patch according to claim 1, it is characterized in that, jointing material described in S3. is collagen, polysaccharide or hydrogel.
6. the preparation method of compound tissue repairing patch according to claim 1, is characterized in that, described in preparation S2, the material of non-woven mesh sheet class soft tissue repair diaphragm is medical high polymer material.
7. the preparation method of compound tissue repairing patch according to claim 6, it is characterized in that, described medical high polymer material is PLA, PLGA, PVDF, PTFE, PU, PCL or PGA.
8. the preparation method of compound tissue repairing patch according to claim 1, is characterized in that, shrink process described in S4 is to soak soft tissue repair diaphragm with the ethanol of volumetric concentration more than 50% or carry out non-contact thermal.
9. the preparation method of compound tissue repairing patch according to claim 8, it is characterized in that, the time of described immersion is 30 minutes ~ 12 hours, and the temperature of described non-contact thermal is 40 ~ 80 DEG C, and heat time heating time is 30 minutes ~ 12 hours.
10. the compound tissue repairing patch prepared by preparation method described in claim 1 ~ 9 any one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510840715.2A CN105396176B (en) | 2015-11-27 | 2015-11-27 | A kind of compound tissue repairing patch and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510840715.2A CN105396176B (en) | 2015-11-27 | 2015-11-27 | A kind of compound tissue repairing patch and preparation method thereof |
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| Publication Number | Publication Date |
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| CN105396176A true CN105396176A (en) | 2016-03-16 |
| CN105396176B CN105396176B (en) | 2019-09-20 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106693059A (en) * | 2016-12-28 | 2017-05-24 | 广州迈普再生医学科技有限公司 | Composite tissue repair patch and preparation method and application thereof |
| CN107756781A (en) * | 2016-08-22 | 2018-03-06 | 香港纺织及成衣研发中心有限公司 | A kind of hernia sticking patch and preparation method thereof |
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| CN101066474A (en) * | 2007-04-28 | 2007-11-07 | 徐志飞 | Degradable soft tissue patch |
| CN101530353A (en) * | 2008-04-11 | 2009-09-16 | 北京天助畅运医疗技术有限公司 | Anti-adhesion hernia repair patch |
| WO2010093333A1 (en) * | 2009-02-11 | 2010-08-19 | Nanyang Technological University | Multi-layered surgical prosthesis |
| CN203122677U (en) * | 2012-12-29 | 2013-08-14 | 上海索康医用材料有限公司 | Hernia repair piece |
| CN103741312A (en) * | 2013-12-31 | 2014-04-23 | 深圳迈普再生医学科技有限公司 | Medical braided wire and preparation method as well as product thereof |
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2015
- 2015-11-27 CN CN201510840715.2A patent/CN105396176B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101066474A (en) * | 2007-04-28 | 2007-11-07 | 徐志飞 | Degradable soft tissue patch |
| CN101530353A (en) * | 2008-04-11 | 2009-09-16 | 北京天助畅运医疗技术有限公司 | Anti-adhesion hernia repair patch |
| WO2010093333A1 (en) * | 2009-02-11 | 2010-08-19 | Nanyang Technological University | Multi-layered surgical prosthesis |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107756781A (en) * | 2016-08-22 | 2018-03-06 | 香港纺织及成衣研发中心有限公司 | A kind of hernia sticking patch and preparation method thereof |
| CN107756781B (en) * | 2016-08-22 | 2020-03-10 | 香港纺织及成衣研发中心有限公司 | Hernia patch and preparation method thereof |
| CN106693059A (en) * | 2016-12-28 | 2017-05-24 | 广州迈普再生医学科技有限公司 | Composite tissue repair patch and preparation method and application thereof |
| CN106693059B (en) * | 2016-12-28 | 2020-07-14 | 广州迈普再生医学科技股份有限公司 | Composite tissue repair patch and preparation method and application thereof |
| CN111803711A (en) * | 2016-12-28 | 2020-10-23 | 广州迈普再生医学科技股份有限公司 | Composite tissue repair patch prepared by freeze drying process and preparation method thereof |
| CN111840648A (en) * | 2016-12-28 | 2020-10-30 | 广州迈普再生医学科技股份有限公司 | Multilayer composite tissue repair patch and preparation method thereof |
| CN111840649A (en) * | 2016-12-28 | 2020-10-30 | 广州迈普再生医学科技股份有限公司 | Composite tissue repair patch prepared by coating process and preparation method thereof |
| CN111840648B (en) * | 2016-12-28 | 2022-03-25 | 广州迈普再生医学科技股份有限公司 | Multilayer composite tissue repair patch and preparation method thereof |
| CN111840649B (en) * | 2016-12-28 | 2022-03-29 | 广州迈普再生医学科技股份有限公司 | Composite tissue repair patch prepared by coating process and preparation method thereof |
| CN111803711B (en) * | 2016-12-28 | 2022-03-29 | 广州迈普再生医学科技股份有限公司 | Composite tissue repair patch prepared by freeze drying process and preparation method thereof |
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