CN105395315A - Special dressing used after burn wound mesh grafting - Google Patents
Special dressing used after burn wound mesh grafting Download PDFInfo
- Publication number
- CN105395315A CN105395315A CN201510744119.4A CN201510744119A CN105395315A CN 105395315 A CN105395315 A CN 105395315A CN 201510744119 A CN201510744119 A CN 201510744119A CN 105395315 A CN105395315 A CN 105395315A
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- CN
- China
- Prior art keywords
- dressing
- internal layer
- layer
- burn wound
- postoperative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 45
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920005830 Polyurethane Foam Polymers 0.000 claims abstract description 8
- 239000011496 polyurethane foam Substances 0.000 claims abstract description 8
- 239000000835 fiber Substances 0.000 claims abstract description 6
- 229920000742 Cotton Polymers 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 230000002980 postoperative effect Effects 0.000 claims description 18
- 206010048629 Wound secretion Diseases 0.000 claims description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 6
- 229920002101 Chitin Polymers 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 2
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 37
- 208000015181 infectious disease Diseases 0.000 abstract description 15
- 230000035876 healing Effects 0.000 abstract description 11
- 230000001737 promoting effect Effects 0.000 abstract description 9
- 229920001661 Chitosan Polymers 0.000 abstract description 3
- 230000029663 wound healing Effects 0.000 abstract description 3
- 229920000049 Carbon (fiber) Polymers 0.000 abstract description 2
- 239000004917 carbon fiber Substances 0.000 abstract description 2
- 230000000740 bleeding effect Effects 0.000 abstract 2
- 210000000416 exudates and transudate Anatomy 0.000 abstract 1
- 238000009941 weaving Methods 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 description 8
- 230000023597 hemostasis Effects 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- 210000000981 epithelium Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 206010018833 Haematocoele Diseases 0.000 description 1
- 208000005873 Hematocele Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 201000004920 hematocele of tunica vaginalis testis Diseases 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- A61F13/01029—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00157—Wound bandages for burns or skin transplants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00387—Plasters use skin protection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00463—Plasters use haemostatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00727—Plasters means for wound humidity control
- A61F2013/00731—Plasters means for wound humidity control with absorbing pads
Abstract
The invention discloses special dressing used after burn wound mesh grafting and belongs to the technical field of medical dressing. The side, making contact with a wound portion, of the dressing sequentially comprises an inner layer, a middle layer and an outer layer. The inner layer of the dressing is rich in zinc ions, and a plurality of through drainage holes are formed in the thickness direction of the inner layer of the dressing. The inner layer of the dressing is formed by blending chitosan fibers and active carbon fibers and used for resisting infection, stopping bleeding, promoting healing and absorbing a small amount of wound secreta. The middle layer of the dressing is made of a polyurethane foam sponge layer and used for absorbing exudates discharged form the drainage holes of the inner layer of the dressing. The outer layer of the dressing is a cotton weaving gauze layer and used for fixing and binding. According to the special dressing, the inner layer, the middle layer and the outer layer are matched, design is ingenious, and the dressing has the advantages of stopping bleeding, resisting infection, preserving moisture, promoting healing, being good in drainage performance and the like, and can effectively used for wound healing after burn wound mesh grafting.
Description
Technical field
The invention belongs to medical science dressing technical field, be specifically related to the postoperative specialized dressing of a kind of burn wound mesh graft.
Background technology
Mesh graft is the modal a kind of skin-grafting mode of Patients with Big Area Burn.After bark fetching terminates, institute's netted skin-making machine of bark fetching sheet is trimmed to netted, is implanted in burn wound.Treat that netted skin and wound capital construction are stood after blood transports, epithelium starts to creep, and mesh is closed gradually, and wound surface heals completely.The advantage of mesh graft subcutaneous hematocele is less likely to occur, and be easy to survival, the wound closure of vast scale, and postoperative function is good; Shortcoming is that anti-infection ability is poor, and the bacterial content of exposed wound surface is once exceed threshold limit value, and antibacterial will nibble newborn epithelium, even mesh skin graft.So the treatment key after burn wound's mesh graft is exactly prevent and treat infection, healing acceleration.
For above problem, traditional way is changed dressings in conjunction with various antibacterials with gauze, and as modal medical dressing, the advantage of gauze is protection wound surface, have absorbability, wide material sources, making are simple, low price.But shortcoming is outstanding equally: cannot keep wound surface moistening, hinder histiocyte epithelization, wound healing postpones; Dressing fiber easily comes off, and causes foreign body reaction, impact healing; Wound granulation is organized and is easily grown in the mesh of dressing, can cause pain when changing dressings; The epithelium of easy damaged new life when changing dressings; Workload of changing dressings is large.Based on above shortcoming, many new pattern compress are applied to the postoperative wound surface of mesh graft by Chinese scholars, attempt the deficiency solving traditional dressing.Chitosan dressing is clinical practice the most a kind of new bio dressing, the various biological effect such as have hemostasis, infection, moisturizing, promoting healing, ease the pain.But find through a large amount of clinical practices, the ability of this new pattern compress drain sepage is poor, if the wound surface sepage after skin-grafting is more; usually can accumulate between dressing and wound surface; make dressing to be close to wound surface, effective biological action can not be played, even increase the weight of local infection.The certain hemostasis of active carbon fiber dressing, infection, moisturizing, agglutinant effect, and there is good absorbability, but a small amount of sepage can only be adsorbed.Polyurethane foam sponge is a kind of novel synthetic dressing, has the ability of powerful absorption sepage, and active absorption, original position retain, but it does not have infection and agglutinant biological effect.In addition, no matter be chitosan dressing, activated carbon fiber or polyurethane foam sponge, the toughness of three and tensile strength are all inadequate, are unfavorable for pressure dressing.
Summary of the invention
In order to overcome the defect that above-mentioned prior art exists, the object of the present invention is to provide the postoperative specialized dressing of a kind of burn wound mesh graft, this dressing structure is reasonable in design, has the advantages such as hemostasis, infection, moisturizing, promoting healing, drain are good.
The present invention is achieved through the following technical solutions:
The postoperative specialized dressing of a kind of burn wound mesh graft disclosed by the invention, from skin-grafting location contacts side, comprise internal layer dressing, middle level dressing and outer dressing successively; The thickness direction of internal layer dressing is provided with some conduction holes run through, and is rich in zinc ion in internal layer dressing; Internal layer dressing is the composite layer of chitin fiber and activated carbon fiber blending, for a small amount of wound secretion of infection, hemostasis, promoting healing and absorption; Middle level dressing is polyurethane foam sponge layer, for absorbing the sepage that internal layer dressing conduction hole is discharged; Outer dressing is that cotton knits gauze layer, for fixing and wrapping; Be rich in zinc ion in described internal layer dressing, and on the thickness direction of internal layer dressing, be provided with some conduction holes run through.
The thickness of described internal layer dressing is 2 ~ 3mm.
The thickness of described middle level dressing is 2 ~ 3mm.
The thickness of described outer dressing is 4 ~ 6mm.
The aperture of described conduction hole is 3mm.
Described some conduction hole spaced sets.
Pitch of holes between some conduction holes is 7mm.
The area of internal layer dressing, middle level dressing and outer dressing is suitable.
Compared with prior art, the present invention has following useful technique effect:
The specialized dressing postoperative for burn wound's mesh graft disclosed by the invention, comprise interior, in, outer three layers, internal layer dressing is that chitin fiber and activated carbon fiber blending form, wherein be rich in zinc ion composition, because internal layer dressing is also provided with some conduction holes run through in a thickness direction, the secretions of burn wound can pass through the abundant drain of conduction hole, internal layer dressing and burn wound is well attached, better plays hemostasis, infection, moisturizing, promoting healing, analgesic biological effect.Because the burn wound below conduction hole does not directly contact with internal layer dressing, but the zinc ion be rich in internal layer dressing can drain into the wound surface under hole by this conduction hole slow release, plays infection, agglutinant dual function.Middle level dressing is polyurethane foam sponge foam layer, has the function of active absorption, original position reservation, fully can absorb the sepage of discharging from the conduction hole of internal layer dressing, make conduction hole place also not have sepage and gather.Outer dressing is that cotton knits gauze layer, has good toughness and intensity, can ensure the integrity of dressing, pressurizes when being also convenient to wrapping.Specialized dressing of the present invention, interior, in, outer three layers cooperatively interact, design ingenious, there is the advantages such as hemostasis, infection, moisturizing, promoting healing, drain be good, can effectively for the wound healing that burn wound's mesh graft is postoperative.
Further, the aperture of conduction hole is set to 3mm by the present invention, and the spacing between conduction hole is set to 7mm, and aperture is larger, and pitch of holes is less, and wound secretion drain is better, but wound surface under conduction hole is more, and the biological effect of internal layer dressing is just little.Through many experiments test performance repeatedly, aperture design of the present invention is 3mm, and pitch of holes is designed to 7mm, for optimal data, can ensure the abundant drain of secretions, also farthest can play the effect of internal layer dressing, the dressing aperture of 3mm is also in the release range of zinc ion simultaneously.
Accompanying drawing explanation
Fig. 1 is Special dressing structure side view of the present invention;
Fig. 2 is Special dressing structure top view of the present invention.
Wherein, 1 is internal layer dressing; 2 is middle level dressing; 3 is outer dressing; 4 is conduction hole.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, and the explanation of the invention is not limited.
See Fig. 1, the postoperative specialized dressing of burn wound of the present invention mesh graft, from skin-grafting location contacts side, comprise internal layer dressing 1, middle level dressing 2 and outer dressing 3 successively; The thickness direction of internal layer dressing 1 is provided with some conduction holes 4 run through, and is rich in zinc ion in internal layer dressing 1; Internal layer dressing 1 forms for chitin fiber and activated carbon fiber blending, for a small amount of wound secretion of infection, hemostasis, promoting healing and absorption; ; Middle level dressing 2 is polyurethane foam sponge layer, for absorbing the sepage that internal layer dressing conduction hole is discharged; Outer dressing 3 knits gauze layer for cotton, for fixing and wrap up.
The thickness of internal layer dressing 1 is 2 ~ 3mm, and the thickness of middle level dressing 2 is 2 ~ 3mm, and the thickness of outer dressing 3 is 4 ~ 6mm.The area of three layers of dressing is suitable.
See Fig. 2, preferably, the aperture of conduction hole 4 is 3mm, and the pitch of holes between some conduction holes 4 is 7mm.Aperture is larger, and pitch of holes is less, and wound secretion drain is better, but wound surface under conduction hole is more, and the biological effect of internal layer dressing is just little.Find through many experiments, aperture 3mm, pitch of holes 7mm are optimal data, can ensure the abundant drain of secretions, also farthest can play the effect of internal layer dressing, and the dressing aperture of 3mm is also in the release range of zinc ion simultaneously.
The postoperative specialized dressing of burn wound of the present invention mesh graft, in use:
After skin-grafting terminates, by complete for specialized dressing of the present invention flap coverage, make internal layer dressing 1 and the wound surface close contact of specialized dressing, and bandage firmly in outer dressing 3 outside.
The secretions of burn wound by the fully drain of the conduction hole 4 of internal layer dressing 1, can make internal layer dressing and wound surface well attach, better plays hemostasis, infection, moisturizing, promoting healing, analgesic biological effect.
Owing to being provided with multiple conduction hole 4 in internal layer dressing 1, the wound surface under conduction hole 4 does not directly contact with internal layer dressing, makes the various biological effect of internal layer dressing be difficult to play.Now, the zinc ion be rich in internal layer dressing then can slow release to the wound surface under conduction hole 4, play infection, agglutinant dual function.(aperture is larger, and pitch of holes is less, and wound secretion drain is better, but wound surface under conduction hole is more, and the biological effect of internal layer dressing is just little.Find through many experiments, aperture 3mm, pitch of holes 7mm are optimal data, can ensure the abundant drain of secretions, also farthest can play the effect of internal layer dressing, and the dressing aperture of 3mm is also in the release range of zinc ion simultaneously)
Middle level dressing 2 is polyurethane foam sponge layer, can fully absorb the sepage of discharging in mesh, and active absorption, original position retain, and make conduction hole 4 place also not have sepage and gather.
Outer dressing 3 be cottonly knit gauze and can have good toughness and intensity, can ensure the integrity of dressing, pressurize when being also convenient to wrapping.
Claims (8)
1. the postoperative specialized dressing of burn wound's mesh graft, is characterized in that, from skin-grafting location contacts side, comprise internal layer dressing (1), middle level dressing (2) and outer dressing (3) successively; The thickness direction of internal layer dressing (1) is provided with some conduction holes (4) run through, and is rich in zinc ion in internal layer dressing (1);
The composite layer that internal layer dressing (1) is chitin fiber and activated carbon fiber blending, absorbs wound secretion for anti-sense;
Middle level dressing (2) is polyurethane foam sponge layer, the sepage that the conduction hole (4) for absorbing internal layer dressing (1) is discharged;
Outer dressing (3) knits gauze layer, for fixing and wrapping for cotton.
2. the postoperative specialized dressing of burn wound according to claim 1 mesh graft, is characterized in that, the thickness of described internal layer dressing (1) is 2 ~ 3mm.
3. the postoperative specialized dressing of burn wound according to claim 1 mesh graft, is characterized in that, the thickness of described middle level dressing (2) is 2 ~ 3mm.
4. the postoperative specialized dressing of burn wound according to claim 1 mesh graft, is characterized in that, the thickness of described outer dressing (3) is 4 ~ 6mm.
5. the postoperative specialized dressing of burn wound according to claim 1 mesh graft, is characterized in that, the aperture of described conduction hole (4) is 3mm.
6. the postoperative specialized dressing of burn wound according to claim 1 mesh graft, is characterized in that, described some conduction holes (4) spaced set.
7. the postoperative specialized dressing of burn wound according to claim 6 mesh graft, is characterized in that, the pitch of holes between some conduction holes (4) is 7mm.
8. the postoperative specialized dressing of burn wound according to claim 1 mesh graft, is characterized in that, the area of internal layer dressing (1), middle level dressing (2) and outer dressing (3) is suitable.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510744119.4A CN105395315A (en) | 2015-11-03 | 2015-11-03 | Special dressing used after burn wound mesh grafting |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510744119.4A CN105395315A (en) | 2015-11-03 | 2015-11-03 | Special dressing used after burn wound mesh grafting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105395315A true CN105395315A (en) | 2016-03-16 |
Family
ID=55461319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510744119.4A Pending CN105395315A (en) | 2015-11-03 | 2015-11-03 | Special dressing used after burn wound mesh grafting |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105395315A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107397974A (en) * | 2017-09-11 | 2017-11-28 | 北京煜煌科技有限公司 | A kind of wound patch for treating chronic trauma |
| CN107898489A (en) * | 2017-12-04 | 2018-04-13 | 泰州市人民医院 | One kind skin-grafting packing fixed structure and fixing means |
| CN108309565A (en) * | 2018-02-07 | 2018-07-24 | 苏州元禾医疗器械有限公司 | A kind of adhesive dressing |
| CN110475531A (en) * | 2017-04-05 | 2019-11-19 | 墨尼克医疗用品有限公司 | Composite material for fluid flow pipe reason |
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| CN2897209Y (en) * | 2006-04-26 | 2007-05-09 | 冯君 | Medical bandage |
| CN201414876Y (en) * | 2009-05-14 | 2010-03-03 | 武汉华纳联合药业有限公司 | Compound chitosan dressing |
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| CN202699681U (en) * | 2012-04-26 | 2013-01-30 | 青岛明药堂医药科技开发有限公司 | Composite biological dressing of carboxymethyl chitosan and calcium alginate |
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| CN103394117A (en) * | 2013-08-28 | 2013-11-20 | 广东泰宝医疗科技股份有限公司 | Self-adhesive type composite active carbon fiber dressing and preparation method thereof |
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| CN204352015U (en) * | 2014-12-22 | 2015-05-27 | 中国人民解放军第四军医大学 | Skin care dressing after a kind of rear quarters deepⅱdegreeburn healing |
| CN104874010A (en) * | 2015-05-28 | 2015-09-02 | 深圳市源兴纳米医药科技有限公司 | Composite zinc silver antibacterial agent contained chitosan fiber dressing and preparation method thereof |
| CN205163386U (en) * | 2015-11-03 | 2016-04-20 | 中国人民解放军第四军医大学 | Special dressing behind burn wound mesh grafting |
-
2015
- 2015-11-03 CN CN201510744119.4A patent/CN105395315A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN2897209Y (en) * | 2006-04-26 | 2007-05-09 | 冯君 | Medical bandage |
| CN201414876Y (en) * | 2009-05-14 | 2010-03-03 | 武汉华纳联合药业有限公司 | Compound chitosan dressing |
| CN102600013A (en) * | 2012-03-21 | 2012-07-25 | 苏州博创同康生物工程有限公司 | Medical flocking hemostasis material, preparation thereof and application |
| CN202699681U (en) * | 2012-04-26 | 2013-01-30 | 青岛明药堂医药科技开发有限公司 | Composite biological dressing of carboxymethyl chitosan and calcium alginate |
| CN103239755A (en) * | 2013-05-15 | 2013-08-14 | 东华大学 | Method for preparing multi-layer composite functional surgical dressing |
| CN103394117A (en) * | 2013-08-28 | 2013-11-20 | 广东泰宝医疗科技股份有限公司 | Self-adhesive type composite active carbon fiber dressing and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110475531A (en) * | 2017-04-05 | 2019-11-19 | 墨尼克医疗用品有限公司 | Composite material for fluid flow pipe reason |
| CN107397974A (en) * | 2017-09-11 | 2017-11-28 | 北京煜煌科技有限公司 | A kind of wound patch for treating chronic trauma |
| CN107898489A (en) * | 2017-12-04 | 2018-04-13 | 泰州市人民医院 | One kind skin-grafting packing fixed structure and fixing means |
| CN108309565A (en) * | 2018-02-07 | 2018-07-24 | 苏州元禾医疗器械有限公司 | A kind of adhesive dressing |
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| C06 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160316 |
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| RJ01 | Rejection of invention patent application after publication |