CN105395215A - Ultrasonic imaging device and method - Google Patents

Abstract

The invention relates to an ultrasonic imaging device and method. The device comprises a motion control platform used for controlling the image scanning path, an amplitude modulation ultrasonic transmitting system used for transmitting ultrasonic excitation signals, a data acquiring and processing system used for receiving and processing echo signals, a computer imaging and displaying system used for reconstruction imaging of echo signals which are fed back, and an ultrasonic transducer used for sending and receiving ultrasonic waves acting on a phantom. The device and method have the advantages that more contrast medium microbubbles are adsorbed by the vascular wall through radial force generated after the amplitude modulation ultrasonic transmitting system acts on low-frequency ultrasound transmitted by the ultrasonic transducer, the imaging signal intensity of tissue is improved, high-resolution ultrasonic imaging is achieved through a high-frequency component, the imaging resolution ratio and the imaging depth are both considered, and a clearer image is provided for ultrasonic diagnosis.

Description

A kind of supersonic imaging device and method thereof

Technical field

The present invention relates to a kind of diagnostic ultrasound equipment, Ultrasonographic device, and medical diagnostic imaging apparatus, refer more particularly to a kind of ultrasound wave blur-free imaging device, and use the method for this imaging device.

Background technology

Various different disease, comprises cancer, hypertension and coronary heart disease etc., all can cause the morbid state in microcirculqtory system, as blood vessels caliber, microvessel density and the isoparametric change of Ink vessel transfusing blood flow rate.Therefore, blood vessel imaging has extremely important effect for the early diagnosis and therapy of various diseases especially malignant disease.

Along with the development of medical ultrasonic, utilize ultra sonic imaging to carry out medical consultations and be widely used, and become an irreplaceable method of diagnosis disease.Low frequency ultrasound has less SATT, realizes deeper imaging, but it applies the restriction be still subject to compared with low spatial resolution.High frequency ultrasound imaging can improve the resolution of imaging, but because of the acoustic attenuation of biological tissue, limits the degree of depth that high frequency acoustic imaging wave penetrates.

In recent years, the development of acoustic contrast agent and application, for high frequency ultrasound imaging provides technological approaches, but by the restriction of contrast agent microbubble size, be difficult to be applied to the ultrasonic image-forming system that frequency is greater than 15MHz.Because " when system operating frequency is near microvesicle natural frequency, can produce stronger first-harmonic and the scattering of second harmonic ", and conventional microbubble contrast agent diameter is 0.8-4 μm, and its resonant frequency is 14-1.5MHz.Therefore, need to provide a kind of new ultrasonic imaging method and imaging device, take into account the degree of depth and the imaging resolution of imaging, to be adapted to deeper blood capillary imaging.

Chinese patent publication No. CN102247171A discloses diagnostic ultrasound equipment, Ultrasonographic device, and medical diagnostic imaging apparatus, it is by thinking imaging, the change of dynamic blood flow can be observed simply by high visual identity degree, the information such as fine angioarchitecture, its scheme adopted is: comprise data acquisition unit in diagnostic ultrasound equipment, to have dropped into the 3D region in the subject of contrast agent with ultrasonic scanning in whole specified time limit, and obtain the ultrasound data relevant with above-mentioned 3D region in above-mentioned whole specified time limit, volume data generation unit, the ultrasound data relevant with above-mentioned 3D region during whole parsing in during using afore mentioned rules, the first volume data in each phase in during generating above-mentioned parsing, and generate 3rd volume data of expression for the contrast agent characteristic quantity of each position of the above-mentioned 3D region during the 2nd volume data of the contrast agent temporal information during above-mentioned parsing and the above-mentioned parsing of expression, image generation unit, use above-mentioned 2nd volume data and above-mentioned 3rd volume data, generate projected image.This technical scheme is only the feature solving image imaging, and it does not solve the defect of clear picture imaging.

Chinese patent publication No. CN1550217A discloses a kind of ultrasonic diagnostic equipment and image processing equipment, it is by strengthening the switching of the predetermined instant in ultra sonic imaging, perform high sound pressure and low acoustic pressure transonic, and will obtain depressing in a low voice to propagate, the compensation image of the real time communication as film, with low acoustic pressure transonic that high sound pressure propagates obtains just will switching to, the pre-exposure image Concurrent Display shown with static pictorial manner, thus make operator understand the structure of capillary vessel level, in addition, the low acoustic pressure that this equipment can also show any time propagate obtain by the image selected, instead of pre-exposure image.The defect of this device is the image that can not show blood vessel wall clearly.

Chinese patent application publication No. CN103876776A discloses a kind of ultrasonic contrast imaging method and device, for carrying out ultrasonic contrast development to the detected body of throwing in Contrast agent bubbles, it comprises initial step, obtain the original contrastographic picture of N frame, N is the totalframes in video picture cycle, projection imaging step, the projection result image obtaining the original contrastographic picture of described N frame is projected to the original contrastographic picture of described N frame, wherein, for the original contrastographic picture of N frame in the original contrastographic picture of described N frame, by original for N group contrastographic picture with any frame in the original contrastographic picture of described N group for projection template project, obtain the projection result image of the original contrastographic picture of described N frame, n is the positive integer being more than or equal to 1 and being less than or equal to N, described n-th group of original contrastographic picture is within the projection cycle and comprises the original contrastographic picture of some frames of the original contrastographic picture of described N frame, the described projection cycle is the fixed value being less than the described video picture cycle, display storing step, show or store the projection result image of the original contrastographic picture of described N frame.In a kind of ultrasonic contrast imaging method of embodiment, also comprised before the described projection imaging step of execution: motion registration step, motion registration is carried out to each two field picture in the original contrastographic picture of described N frame.

Such scheme also provides a kind of ultrasonic contrast imaging device, comprise original image acquisition module, for launching ultrasonic pulse to object to be detected, receive the ultrasound echo signal that target to be detected returns, the original contrastographic picture of N frame is obtained after signal processing is carried out to the ultrasound echo signal received, N is the totalframes in video picture cycle, projection imaging module, for to the original contrastographic picture of N frame in the original contrastographic picture of described N frame, by n-th group of original contrastographic picture with any frame in described n-th group of original contrastographic picture for projective module projects soon, obtain the projection result image of the original contrastographic picture of described n-th frame, n is the positive integer being more than or equal to 1 and being less than or equal to N, described n-th group of original contrastographic picture is within the default projection cycle and comprises some two field picture original images of the original contrastographic picture of described n-th frame, the described default projection cycle is the fixed value being less than the described video picture cycle, display memory module, for showing or store the projection result image of the original contrastographic picture of described N frame, a kind of ultrasonic contrast imaging device of embodiment also comprises motion registration module, for carrying out motion registration to the image of each in the original contrastographic picture of described N frame before the described projection imaging module of execution.But definition and the resolution of this device imaging are lower, can not meet the requirement of medical science.

Summary of the invention

For the defect that prior art exists, the invention provides a kind of supersonic imaging device and method thereof, to improve the imaging signal intensity of tissue, and realize high-resolution ultra sonic imaging.

In order to realize above-mentioned technical purpose, the invention provides a kind of supersonic imaging device, it comprises:

Motion Control Platform, described Motion Control Platform is used for being controlled to picture scanning pattern;

Amplitude modulation ultrasound emission system, described amplitude modulation ultrasound emission system is for launching ultrasonic excitation signal;

Data Collection & Processing System, described data Collection & Processing System is used for receiving and back-end processing echo-signal;

Computer controls and imaging system, and described computer controls to be used for carrying out reestablishment imaging to the echo-signal fed back with imaging system;

Ultrasonic transducer, described ultrasonic transducer is for sending and receive the ultrasound wave acted on imitative body.

Further technical scheme is, described Motion Control Platform is servo control platform, and described servo control platform is the controlled 3D control station of speed.

Further technical scheme is, described 3D control station is by fixture operation ultrasonic transducer.

Further technical scheme is, described servo control platform comprises servo control card, servomotor, is realized the motion of 3D control station by described servo control card control and driving servomotor.

Further technical scheme is, described servo control platform is imitated body by the coordinate figure that position, motor point file provides to target and scanned, and position, described motor point file is imported by drawing.

Further technical scheme is, is also provided with power amplifier between described amplitude modulation ultrasound emission system and ultrasonic transducer, amplifies ultrasonic excitation signal by described power amplifier.

Further technical scheme is, the ultrasonic excitation signal that described amplitude modulation ultrasound emission system produces is divided into and frequency high frequency ultrasound and difference frequency low frequency ultrasound, described and frequency high frequency ultrasound is used for realizing high-resolution ultra sonic imaging, and the radiant force that described difference frequency low frequency ultrasound produces is for improving the imaging signal intensity of blood vessel wall.

Further technical scheme is, the expression formula of the ultrasonic excitation signal of described amplitude modulation ultrasound emission system is cos Δ ω tcos ω t.

Further technical scheme is, when described amplitude modulation ultrasound emission system is with the amplitude modulation ultrasonic excitation signal of cos Δ ω tcos ω t excitation ultrasonic transducer, ultrasonic transducer will produce two ultrasonic signals simultaneously: with such as formula (1 and (2).

Namely by modulating wave: v ₀=V ₀cos Δ ω t and carrier wave: v ₁=V ₁cos ω t (1)

Obtain following amplitude-modulated wave:

$\begin{array}{c}{v}_{AM}\left(t\right)=V_m\left(t\right)cos\mathrm{\Δ}\mathrm{\ω}t=V_0(1+m_{a}cos\mathrm{\ω}t)cos\mathrm{\Δ}\mathrm{\ω}t\\ =V_0\[\cos \mathrm{\Δ}\mathrm{\ω}t+\frac{1}{2}{m}_a\cos \left(\mathrm{\ω}+\mathrm{\Δ}\mathrm{\ω}\right)t+\frac{1}{2}{m}_a\cos \left(\mathrm{\ω}-\mathrm{\Δ}\mathrm{\ω}\right)t\]\end{array}---\left(2\right)$

Further technical scheme is, described data Collection & Processing System is built-in with capture card.

Further technical scheme is, has contrast agent in the imitative body of described supersonic imaging device effect.

Further technical scheme is, described contrast agent has nonlinear scattering, its produce frequency be 2 ω be the difference frequency low frequency ultrasound of 2 Δ ω with frequency high frequency ultrasound and frequency.

Further technical scheme is, described contrast agent can produce the bubble of suspension in imitative body to be detected, and described bubble is astable in time domain, it can produce vibration under strong ultrasound wave drives, when drive quite rate and intensity suitable time, can resonance be formed, thus show non-linear.

Further technical scheme is, described low frequency ultrasound produces on radiant force vasoactive wall and adsorbs microvesicle.

Further technical scheme is, when to enter acoustic pressure be the sound field of P (t) for the microvesicle of contrast agent, it will make forced vibration under ultrasonication, and its radius R (t) meets RPNNP equation:

$\begin{array}{c}\mathrm{\ρ}R\frac{d^{2}R}{{\mathrm{dt}}^2}+\mathrm{\ρ}\frac{3}{2}{\left(\frac{dR}{dt}\right)}^2=P_v+P_{g0}{\left(\frac{R_0}{R}\right)}^{3\mathrm{\γ}}-P_0-\\ P\left(t\right)-\frac{2\mathrm{\δ}}{R}-\frac{4\mathrm{\μ}}{R}\left(\frac{dR}{dt}\right)\end{array}---\left(3\right)$

In formula: μ and ρ is the coefficient of viscosity and the density of liquid respectively; γ is the polytropic index of gas in bubble.

The present invention also provides a kind of ultrasonic imaging method, and wherein, the step that described formation method comprises has:

A), input instruction and enter computer control and imaging system;

B), computer controls and imaging system forms drawing file according to instruction, is determined the scanning pattern of 3D control station by software algorithm identification drawing file;

C), 3D control station controls the fortune merit of ultrasonic transducer by the fixture on it;

D), the ultrasound wave acted on imitative body is transmitted and received by ultrasonic transducer, for showing the state of imitative body;

E), ultrasonic transducer receives echo-signal, then gathers echo-signal by Data collection and precessing system, feeds back to computer further and to control and in imaging system, for showing the state of imitative body inside.

Further technical scheme is, described step also comprises:

(a'), amplitude-modulated signal emission system produces amplitude modulation ultrasonic excitation signal cos Δ ω tcos ω t by virtual instrument software Labview.

(b'), amplitude modulation ultrasonic excitation signal carries out signal source amplification by power amplifier;

(c'), described amplitude modulation ultrasonic excitation signal acts on ultrasonic transducer and will produce two ultrasonic signals simultaneously: with such as formula (1 and (2).

Namely by modulating wave: v ₀=V ₀cos Δ ω t and carrier wave: v ₁=V ₁cos ω t (1)

Obtain following amplitude-modulated wave:

$\begin{array}{c}{v}_{AM}\left(t\right)=V_m\left(t\right)cos\mathrm{\Δ}\mathrm{\ω}t=V_0(1+m_{a}cos\mathrm{\ω}t)cos\mathrm{\Δ}\mathrm{\ω}t\\ =V_0\[\cos \mathrm{\Δ}\mathrm{\ω}t+\frac{1}{2}{m}_a\cos \left(\mathrm{\ω}+\mathrm{\Δ}\mathrm{\ω}\right)t+\frac{1}{2}{m}_a\cos \left(\mathrm{\ω}-\mathrm{\Δ}\mathrm{\ω}\right)t\]\end{array}---\left(2\right)$

(d'), amplitude-modulated signal emission system carries out the signal feedback of amplitude modulation ultrasonic excitation signal to feed back and signal processing to Data collection and precessing system simultaneously;

(e'), Data collection and precessing system controls the data feedback obtained with in imaging system, for ultra sonic imaging and display to computer.

The invention has the beneficial effects as follows: the nonlinear characteristic utilizing acoustic contrast agent, amplitude-modulated signal excitation is adopted to produce and frequency high frequency ultrasound component and difference frequency low frequency ultrasound component, high fdrequency component is used for realizing high-resolution ultrasound imaging, low frequency component, for improving the imaging signal intensity of tissue, takes into account imaging depth and resolution.

Accompanying drawing explanation

Fig. 1 is structure flow chart of the present invention.

Fig. 2 is the amplitude modulation excitation electric signal graph in the present invention.

Fig. 3 is the amplitude-modulated wave spectrogram in the present invention.

Fig. 4 is R (t) frequency spectrum in the present invention.

The operation principle schematic diagram of Fig. 5 when to be that the present invention is ultrasonic do not start.

Fig. 6 be the present invention ultrasonic start time operation principle schematic diagram.

Detailed description of the invention

Describe embodiments of the present invention in order to clearer, below in conjunction with accompanying drawing, the present invention is described further.

With reference to shown in Fig. 1, a kind of supersonic imaging device, it comprises: 3D control station, the ultrasonic transducer be connected with 3D control station, wherein, ultrasonic transducer 1 is arranged on 3D control station by fixture, 3D control station controls by computer control system, computer control system is also provided with imaging software for display, be integrated into computer to control and imaging system, supersonic imaging device is also provided with Data collection and precessing system, by the echo-signal of Data collection and precessing system acquisition and processing ultrasonic transducer, Data collection and precessing system and computer control to be connected with imaging system, the structure and the flow regime that show imitative body interior detail cell space with imaging system images is controlled by computer.Supersonic imaging device is also provided with amplitude-modulated signal emission system, amplitude-modulated signal emission system can launch ultrasonic excitation signal, ultrasonic excitation signal carries out signal amplification by power amplifier, act on ultrasonic transducer, improve effect of ultrasonic transducer, amplitude-modulated signal emission system is connected with data collecting system, and the ultrasonic excitation signal sent by data collecting system feedback amplitude-modulated signal emission system is controlled with in imaging system to computer, and controls to show with imaging system by computer.

With reference to shown in Fig. 1, a kind of supersonic imaging device, it comprises: 3D control station, wherein, 3D control station adopts servo control platform, servo control platform is used for being controlled to picture scanning pattern, servo control platform comprises servo control card, servomotor, servo control platform drives servomotor by servo control card, the coordinate figure provided according to position, motor point file is imitated body to target and is scanned, scan-data imports computer into through Data collection and precessing system and controls and imaging system, then pass through image reconstruction algorithm, form 3-D view.Wherein, motion control card, with dynamic link library file, during use, only need carry out Initialize installation to motion control card.Position, described motor point file is imported by drawing, and namely described Initialize installation arranges motor pattern, movement velocity and distance etc.

With reference to shown in Fig. 2 and Fig. 3, the amplitude modulation ultrasound emission system that supersonic imaging device is built-in, described amplitude modulation ultrasound emission system is for launching ultrasonic excitation signal, and when encouraging a ultrasonic transducer with the amplitude modulated electric signals of cos Δ ω tcos ω t, ultrasonic transducer will produce two ultrasonic signals simultaneously:

with such as formula (1 and (2)

Namely by modulating wave: v ₀=V ₀cos Δ ω t and carrier wave: v ₁=V ₁cos ω t (1)

Following amplitude-modulated wave can be obtained:

$\begin{array}{c}{v}_{AM}\left(t\right)=V_m\left(t\right)cos\mathrm{\Δ}\mathrm{\ω}t=V_0(1+m_{a}cos\mathrm{\ω}t)cos\mathrm{\Δ}\mathrm{\ω}t\\ =V_0\[\cos \mathrm{\Δ}\mathrm{\ω}t+\frac{1}{2}{m}_a\cos \left(\mathrm{\ω}+\mathrm{\Δ}\mathrm{\ω}\right)t+\frac{1}{2}{m}_a\cos \left(\mathrm{\ω}-\mathrm{\Δ}\mathrm{\ω}\right)t\]\end{array}---\left(2\right)$

Due to the nonlinear scattering of acoustic contrast agent, create frequency be 2 ω be the difference frequency low frequency ultrasound of 2 Δ ω with frequency high frequency ultrasound and frequency, the radiant force that difference frequency low frequency ultrasound produces makes blood vessel wall adsorb more microvesicle, improve the imaging signal intensity of tissue, and be used for realizing high-resolution ultra sonic imaging with the high fdrequency component in frequency high frequency ultrasound.

Amplitude modulation ultrasound emission system produces and frequency high frequency ultrasound and difference frequency low frequency ultrasound, and wherein, and frequency high frequency ultrasound is used for realizing high-resolution ultra sonic imaging, and the radiant force that low frequency ultrasound produces is for improving the imaging signal intensity of blood vessel wall.

With reference to shown in Fig. 1, data Collection & Processing System, the echo-signal that described data Collection & Processing System receives for receiving and process ultrasonic transducer, data Collection & Processing System is built-in with data collecting card, coding is had in data collecting card, echo-signal and ultrasonic excitation signal is collected by data collecting card, to go forward side by side row operation and process, echo-signal after treatment, feeding back to computer controls with imaging system, thus manifest structure and the flow regime of imitative body, reach the object of diagnostic medical.

Computer controls and imaging system, and described computer controls to be used for carrying out three dimensional reconstructive CT to echo-signal with imaging system.

In human body, capillary blood vessel diameter is about 9 μm, and venule and small artery are about 20 μm and 37 μm respectively, therefore, realize blur-free imaging to blood capillary, and must adopt high frequency ultrasound, frequency is higher, and resolution is better, to obtain high-resolution; But blood capillary is but in away from the darker position of skin layer in general human body, if to its imaging, need penetrate certain degree of depth, now can only pass through the ultrasonic realization of low-frequency range, frequency is higher, decays larger, cannot realize Depth Imaging.Therefore, for blood capillary imaging in body, on imaging depth and resolution, there is contradiction in the two.In an embodiment of the present invention, reestablishment imaging adopts the method for the three-dimensional reconstruction of feature based, the steps include:

First be specified to the architectural feature on picture Target organ surface, secondly carry out three-dimensional reconstruction to these features, in reconstructing blood vessel, be regarded as the pipeline that a class is special, it is formed by the ball rolling envelope of the centre of sphere along axis that the surface of this pipeline can look at.Therefore, from mathematical modeling, according to scanning the blood vessel two-dimensional image sequence that obtain, rolling radius and spatial axis equation can be tried to achieve, and be that the sphere of r to roll envelope along spatial axis with radius, the form of blood vessel can be reconstructed in three dimensions.

Ultrasonic transducer, described ultrasonic transducer, for transmitting and receiving the ultrasound wave acted on imitative body, by hyperacoustic radiant force, can show the state of imitative body inside.

In the present invention, imitative body is the object or sick body, such as blood vessel that need to detect.

Due to the restriction by contrast agent microbubble size, be difficult to be applied to the ultrasonic image-forming system that frequency is greater than 15MHz, because " when system operating frequency is near microvesicle natural frequency; stronger first-harmonic and the scattering of second harmonic can be produced ", and conventional microbubble contrast agent diameter is 0.8-4 μm, its resonant frequency is 14-1.5MHz.According to the shortcoming that prior art exists, in an embodiment of the present invention, as shown in Figure 4,

The principle producing stronger first-harmonic and second harmonic scatrering is provided with acoustic contrast agent in imitative body.When to enter acoustic pressure be the sound field of P (t) for the microvesicle of contrast agent, it will make forced vibration under ultrasonication, and its radius R (t) meets RPNNP equation:

$\begin{array}{c}\mathrm{\ρ}R\frac{d^{2}R}{{\mathrm{dt}}^2}+\mathrm{\ρ}\frac{3}{2}{\left(\frac{dR}{dt}\right)}^2=P_v+P_{g0}{\left(\frac{R_0}{R}\right)}^{3\mathrm{\γ}}-P_0-\\ P\left(t\right)-\frac{2\mathrm{\δ}}{R}-\frac{4\mathrm{\μ}}{R}\left(\frac{dR}{dt}\right)\end{array}---\left(3\right)$

In formula: μ and ρ is the coefficient of viscosity and the density of liquid respectively; γ is the polytropic index of gas in bubble.

In Matlab, adopt fourth-order Runge-Kutta method to solve the R (t) in formula (3), and Fourier transformation is done to solving result, the fundamental frequency of R (t) and the frequency spectrum of higher order harmonics component can be obtained, can show from Fig. 4, the nonlinear motion of bubble can produce the multistage higher hamonic wave vibration except first-harmonic.

The nonlinear characteristic of contrast agent, adopt amplitude modulation ultrasonic action, the high frequency making it produce and frequency component and low frequency difference frequency component, the radiant force that low frequency ultrasound produces makes the principle that blood vessel wall adsorbs more contrast agent microbubble be, if there is acoustic characteristic in sound bearing medium has different, as the another kind of medium of the velocity of sound, density etc., when sound wave is propagated wherein, will occur to launch or scattering.In other words, another kind of medium can be detected from the sound wave of reflection or scattering, and difference is larger, is more easily detected.Ultrasonic contrast imaging is exactly based on this principle, acoustic characteristic with tissue there is the material of larger difference, as contrast agent injects human body position to be checked, increase difference between position to be checked and surrounding tissue artificially, thus make the ultrasonoscopy of acquisition seem more clear

Contrast agent nonlinear characteristic is, the glassware for drinking water of bubbles has very strong nonlinear acoustics characteristic.Acoustic contrast agent then can produce a large amount of suspended bubbles in fluid media (medium) such as blood.This bubble is astable in time domain.It can produce vibration under strong hyperacoustic driving, when the quite rate driven and intensity suitable time, can resonance be formed, thus show very strong non-linear.

When ultrasound wave is propagated in media as well, produce a kind of active force by the microgranule existed in medium, microgranule is subjected to displacement along sonic propagation direction, this active force produced by incident acoustic wave is called ultrasonic radiation force.

When the supersonic frequency acting on contrast agent microbubble is lower, more easily produce cavitation, because in low frequency situation, the compression be subject in blood and rarefaction have longer interval, microvesicle is made to reach by force larger size breaking, cavitation intensity increases greatly, then produces powerful microjet, impels more microvesicle to flow to blood vessel wall.

With reference to shown in Fig. 5, when ultrasound wave is propagated in media as well, produce a kind of active force by the microgranule existed in medium, microgranule is subjected to displacement along sonic propagation direction, this active force produced by incident acoustic wave is called ultrasonic radiation force.

When the supersonic frequency acting on contrast agent microbubble is lower, more easily produce cavitation, because in low frequency situation, the compression be subject in blood and rarefaction have longer interval, microvesicle is made to reach by force larger size breaking, cavitation intensity increases greatly, then produces powerful microjet, impels more microvesicle to flow to blood vessel wall.

With reference to shown in Fig. 5 and 6, on ultrasonic transducer 1 vasoactive wall 2, the hemocyte 4 in microscope 5 observable blood vessel wall 2 and the kinestate of contrast agent 3.

With reference to shown in Fig. 5, when the ultrasound wave of ultrasonic transducer 1 does not start, observed by microscope 5, the hemocyte 4 in blood vessel wall 2 and contrast agent 3 are in the kinestate of a non-rule.

With reference to shown in Fig. 6, when the ultrasound wave of ultrasonic transducer 1 starts, observed by microscope 5, hemocyte 4 in blood vessel wall 2 and contrast agent 3 are under the effect of ultrasonic radiation force, act on the supersonic frequency of contrast agent microbubble lower time, more easily produce cavitation, because in low frequency situation, the compression be subject in blood and rarefaction have longer interval, microvesicle is made to reach by force larger size breaking, cavitation intensity increases greatly, then produces powerful microjet, impels more microvesicle to flow to blood vessel wall.Low frequency ultrasound produces radiant force vasoactive wall absorption microvesicle.

In an embodiment of the present invention, supersonic imaging device adopts modular instrument to form, the signal that amplitude-modulated signal emission system produces is through power amplifier rear drive ultrasonic transducer, radiation blood vessel imitates body and intravital blood vessel, the echo-signal produced is by receive MUT, after broadband signal receptor amplifies, access data acquisition system, and be stored in computer.

The present invention also provides a kind of formation method of supersonic imaging device, and the step that this formation method comprises has:

A), input manual operation instruction and enter computer control and imaging system;

B), computer controls and imaging system forms drawing file according to the instruction manually inputted, and is determined the scanning pattern of 3D control station by software algorithm identification drawing file;

C), 3D control station controls the fortune merit of ultrasonic transducer by the fixture on it;

D), the ultrasound wave acted on imitative body is transmitted and received by ultrasonic transducer, for feeding back the state of imitative body;

E), ultrasonic transducer receive echo-signal by data collecting system feed back to computer control and imaging system, by computer control and imaging system for showing the structure of the interior vessel of imitative body.

The step that a kind of formation method of supersonic imaging device also comprises has:

(a'), amplitude-modulated signal emission system produces amplitude modulation ultrasonic excitation signal cos Δ ω tcos ω t by virtual instrument software Labview.

(b'), amplitude modulation ultrasonic excitation signal carries out signal amplification by power amplifier;

(c'), acted on ultrasonic transducer by amplitude modulation ultrasonic excitation signal and will produce two ultrasonic signals simultaneously: with such as formula (1 and (2).

Namely by modulating wave: v ₀=V ₀cos Δ ω t and carrier wave: v ₁=V ₁cos ω t (1)

Obtain following amplitude-modulated wave:

$\begin{array}{c}{v}_{AM}\left(t\right)=V_m\left(t\right)cos\mathrm{\Δ}\mathrm{\ω}t=V_0(1+m_{a}cos\mathrm{\ω}t)cos\mathrm{\Δ}\mathrm{\ω}t\\ =V_0\[\cos \mathrm{\Δ}\mathrm{\ω}t+\frac{1}{2}{m}_a\cos \left(\mathrm{\ω}+\mathrm{\Δ}\mathrm{\ω}\right)t+\frac{1}{2}{m}_a\cos \left(\mathrm{\ω}-\mathrm{\Δ}\mathrm{\ω}\right)t\]\end{array}$

(d'), amplitude-modulated signal emission system also feeds back to data collecting system the signal source of amplitude modulation ultrasonic excitation signal simultaneously.

(e'), data collecting system acts on computer control with on imaging device, for ultra sonic imaging and display effect the data obtained.

By amplitude modulation ultrasound emission system, produce and frequency high frequency ultrasound and difference frequency low frequency ultrasound, the radiant force that low frequency ultrasound produces makes blood vessel wall adsorb more contrast agent microbubble, improve the imaging signal intensity of tissue, and high fdrequency component is used for realizing high-resolution ultra sonic imaging.So this Vltrasonic device can take into account imaging resolution and imaging depth simultaneously, can be ultrasonic diagnosis and image is more clearly provided.

The above embodiment only have expressed embodiments of the present invention, and it describes comparatively detailed, as long as those skilled in the art is after viewing embodiments of the invention, under not departing from the prerequisite of the present invention's design, the change made all belongs to protection scope of the present invention.But embodiment as herein described can not be interpreted as and limit protection scope of the present invention.

Claims (17)

1. a supersonic imaging device, is characterized in that, described imaging device comprises:

Motion Control Platform, described Motion Control Platform is used for being controlled to picture scanning pattern;

Amplitude modulation ultrasound emission system, described amplitude modulation ultrasound emission system is for launching ultrasonic excitation signal;

Data Collection & Processing System, described data Collection & Processing System is used for receiving and back-end processing echo-signal;

Computer controls and imaging system, and described computer controls to be used for carrying out reestablishment imaging to the echo-signal fed back with imaging system;

Ultrasonic transducer, described ultrasonic transducer is for sending and receive the ultrasound wave acted on imitative body.

2. supersonic imaging device according to claim 1, is characterized in that, described Motion Control Platform is servo control platform, and described servo control platform is the controlled 3D control station of speed.

3. supersonic imaging device according to claim 2, is characterized in that, described 3D control station is by fixture operation ultrasonic transducer.

4. supersonic imaging device according to claim 2, is characterized in that, described servo control platform comprises servo control card, servomotor, is realized the motion of 3D control station by described servo control card control and driving servomotor.

5. supersonic imaging device according to claim 4, is characterized in that, described servo control platform is imitated body by the coordinate figure that position, motor point file provides to target and scanned, and position, described motor point file is imported by drawing.

6. supersonic imaging device according to claim 1, is characterized in that, is also provided with power amplifier between described amplitude modulation ultrasound emission system and ultrasonic transducer, amplifies ultrasonic excitation signal by described power amplifier.

7. supersonic imaging device according to claim 6, it is characterized in that, the ultrasonic excitation signal that described amplitude modulation ultrasound emission system produces is divided into and frequency high frequency ultrasound and difference frequency low frequency ultrasound, described and frequency high frequency ultrasound is used for realizing high-resolution ultra sonic imaging, and the radiant force that described difference frequency low frequency ultrasound produces is for improving the imaging signal intensity of blood vessel wall.

8. supersonic imaging device according to claim 7, is characterized in that, the expression formula of the ultrasonic excitation signal of described amplitude modulation ultrasound emission system is cos Δ ω tcos ω t.

9. supersonic imaging device according to claim 8, is characterized in that, when described amplitude modulation ultrasound emission system is with the amplitude modulation ultrasonic excitation signal of cos Δ ω tcos ω t excitation ultrasonic transducer, ultrasonic transducer will produce two ultrasonic signals simultaneously: with such as formula (1 and (2).

Namely by modulating wave: ν ₀=V ₀cos Δ ω t and carrier wave: ν ₁=V ₁cos ω t (1) obtains following amplitude-modulated wave:

。

10. supersonic imaging device according to claim 1, is characterized in that, described data Collection & Processing System is built-in with capture card.

11., according to described supersonic imaging device arbitrary in claim 1 ~ 10, is characterized in that there is contrast agent in the imitative body of described supersonic imaging device effect.

12. supersonic imaging devices according to claim 11, is characterized in that, described contrast agent has nonlinear scattering, its produce frequency be 2 ω be the difference frequency low frequency ultrasound of 2 Δ ω with frequency high frequency ultrasound and frequency.

13. supersonic imaging devices according to claim 12, it is characterized in that, described contrast agent can produce the bubble of suspension in imitative body to be detected, described bubble is astable in time domain, it can produce vibration under strong ultrasound wave drives, when drive quite rate and intensity suitable time, can resonance be formed, thus show non-linear.

14. supersonic imaging devices according to claim 13, is characterized in that, described low frequency ultrasound produces on radiant force vasoactive wall and adsorbs microvesicle.

15. according to described supersonic imaging device arbitrary in claim 12 ~ 14, it is characterized in that, when to enter acoustic pressure be the sound field of P (t) for the microvesicle of contrast agent, it will make forced vibration under ultrasonication, and its radius R (t) meets RPNNP equation:

In formula: μ and ρ is the coefficient of viscosity and the density of liquid respectively; γ is the polytropic index of gas in bubble.

16. 1 kinds of ultrasonic imaging methods, is characterized in that, the step that described formation method comprises has:

A), input instruction and enter computer control and imaging system;

B), computer controls and imaging system forms drawing file according to instruction, is determined the scanning pattern of 3D control station by software algorithm identification drawing file;

C), 3D control station controls the fortune merit of ultrasonic transducer by the fixture on it;

D), the ultrasound wave acted on imitative body is transmitted and received by ultrasonic transducer, for showing the state of imitative body;

E), ultrasonic transducer receives echo-signal, then gathers echo-signal by Data collection and precessing system, feeds back to computer further and to control and in imaging system, for showing the state of imitative body inside.

17. ultrasonic imaging methods according to claim 16, is characterized in that, described step also comprises:

(a'), amplitude-modulated signal emission system produces amplitude modulation ultrasonic excitation signal cos Δ ω tcos ω t by virtual instrument software Labview;

(b'), amplitude modulation ultrasonic excitation signal carries out signal source amplification by power amplifier;

(c'), described amplitude modulation ultrasonic excitation signal acts on ultrasonic transducer and will produce two ultrasonic signals simultaneously:

with such as formula (1 and (2)

Namely by modulating wave: ν ₀=V ₀cos Δ ω t and carrier wave: ν ₁=V ₁cos ω t (1)

Obtain following amplitude-modulated wave:

(d'), amplitude-modulated signal emission system carries out the signal feedback of amplitude modulation ultrasonic excitation signal to feed back and signal processing to Data collection and precessing system simultaneously;

(e'), Data collection and precessing system controls the data feedback obtained with in imaging system, for ultra sonic imaging and display to computer.