CN105384708B - It is a kind of（S）‑（+）‑1‑（2 piperidines phenyl）The preparation method of 3 methyl n-butylamines - Google Patents
It is a kind of（S）‑（+）‑1‑（2 piperidines phenyl）The preparation method of 3 methyl n-butylamines Download PDFInfo
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- CN105384708B CN105384708B CN201510692991.9A CN201510692991A CN105384708B CN 105384708 B CN105384708 B CN 105384708B CN 201510692991 A CN201510692991 A CN 201510692991A CN 105384708 B CN105384708 B CN 105384708B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract
The present invention provides a kind of（S）‑（+）‑1‑（2 piperidines phenyl）The preparation method of 3 methyl n-butylamines, the processing step of methods described is as follows：
Description
Technical field
The invention belongs to medicine intermediate preparation technology field, and in particular to a kind of（S）-（+）-1-（2- piperidines phenyl）-
The preparation method of 3- methyl n-butylamines.
Background technology
（S）-（+）-1-（2- piperidines phenyl）- 3- methyl n-butylamines are non-sulfonylureas Drugs Promoting Insulin Secretion Repaglinides
Key intermediate, its structural formula as shown in figure 1,（S）-（+）-1-（2- piperidines phenyl）The synthetic route master of -3- methyl n-butylamines
It is related to 3 kinds of methods：The chiral synthesis of chiral auxiliary control, is catalyzed asymmetric syntheses, Kinetic Resolution.
1. the chiral synthesis of chiral auxiliary control, reaction scheme are as shown in Fig. 2 2- chlorobenzaldehydes and chiral auxiliary D-
(-)-methacrylic borate tartar acid derivative ester obtains anti-with azide after 2, halo through asymmetric allylation
4 should be obtained, through catalytic hydrogenation obtain 5,5 with piperidines coupling obtain target product（S）-（+）-1-（2- piperidines phenyl）- 3- methyl
N-butylamine.This synthetic method step is more, and chiral reagent is expensive, it is impossible to reclaim, and total recovery is relatively low so that product cost compared with
It is high.
2. asymmetric syntheses, reaction scheme are catalyzed as shown in figure 3, the synthetic method is 1 and the reaction in the presence of acetic anhydride
Obtain 2,2 reduced under chiral catalyst effect 3, the hydrolysis of final step 3 obtains target product, and catalysis asymmetric syntheses is near
Study hotspot over year, but initiation material 1 is difficult to obtain in this method, it is desirable to have other compound synthesis.
3. Kinetic Resolution, reaction scheme are as shown in figure 4, the optical purity of the Kinetic Resolution product is high, but yield
It is low.
The content of the invention
The purpose of the present invention is precisely in order to solve above-mentioned the deficiencies in the prior art, and provide a kind of（S）-（+）-1-（2- piperazines
Pyridine phenyl）The novel preparation method of -3- methyl n-butylamines.
The present invention realizes that the technical scheme that above-mentioned purpose is used is a kind of（S）-（+）-1-（2- piperidines phenyl）- 3- methyl
The preparation method of n-butylamine, the process route chart of methods described is as shown in figure 5, the described method comprises the following steps：
1）It is 1 by mol ratio:1.1-1.2 3- methyl isophthalic acids-（2- piperidines phenyl）- 1- butanone and benzylamine mixture are dissolved in chlorine
It is imitative, wherein, chloroform and 3- methyl isophthalic acids-（2- piperidines phenyl）The constitution ratio of -1- butanone is 4:1；Add ammonium chloride, ammonium chloride and 3-
Methyl isophthalic acid-（2- piperidines phenyl）The mass ratio of -1- butanone is 1.1-1.2%：1；Heating reflux reaction 1.5 hours, is cooled to room
Temperature, added water washing, and organic layer is dried with anhydrous Na 2SO4, and filtering is evaporated to obtain the sticky crude product of shape compound 1；
2）It is 3 that compound 1 is dissolved in into volume ratio:1 methanol and the in the mixed solvent of dichloromethane, add RuCl3, (S)-
(-) -1,1'- binaphthols, tetraisopropyl titanate heats 60 DEG C of stirring reactions under 8bar hydrogen atmosphere, is reacted after 6 hours
Finish, by reaction solution evaporated under reduced pressure, residue is dissolved in ethyl acetate, and once, saturated aqueous common salt washed once, organic addition for washing
Anhydrous Na2SO4Dry, filter evaporated under reduced pressure, residue through silica gel column chromatography with purifying to obtain compound 2；
3）Compound 2 is dissolved in methanol, 20% dilute HCl is added, 60 DEG C of Pd-C catalysis heating is anti-under 5bar hydrogen atmosphere
Answer after 8 hours, reaction solution is cooled to room temperature, filter, filtrate is washed with methanol, the filtrate after washing adds saturation NaHCO3Water
Solution adjusts pH value of solution=8, and decompression boils off methanol, is extracted with ethyl acetate three times, merges organic layer, then uses saturated aqueous common salt
Washing, anhydrous Na2SO4Dry, filtering evaporated under reduced pressure is obtained（S）-（+）-1-（2- piperidines phenyl）- 3- methylbutylamines.
The beneficial effects of the invention are as follows：The present invention with 3- methyl isophthalic acids-（2- piperidines phenyl）- 1- butanone is raw material using catalysis
Dissymmetric synthesis is synthesized（S）-（+）-1-（2- piperidines phenyl）- 3- methyl n-butylamines；Raw material is easy to purchase in the synthetic method,
Synthetic route is shorter, high income.
Brief description of the drawings
Fig. 1 is（S）-（+）-1-（2- piperidines phenyl）The structural formula of -3- methylbutylamines.
Fig. 2 is the reaction scheme figure for the chiral synthesis that existing chiral auxiliary is controlled.
Fig. 3 is the existing reaction scheme figure for being catalyzed asymmetric syntheses.
Fig. 4 is the reaction scheme figure of existing Kinetic Resolution.
Fig. 5 is reaction scheme figure of the invention.
Embodiment
With reference to specific embodiment, the present invention is described further, but protection scope of the present invention is not limited in
This：
Embodiment 1：
One kind of the present invention（S）-（+）-1-（2- piperidines phenyl）The preparation method of -3- methylbutylamines comprises the following steps：
1）By 3- methyl isophthalic acids-（2- piperidines phenyl）- 1- butanone（10.0g, 40.7mmol), benzylamine（4.8g, 44.8mmol）
It is dissolved in chloroform（40 ml）, add ammonium chloride（0.11g, 2.0mmol）, heating reflux reaction 1.5 hours.Room temperature is cooled to, is added water
（20ml）Washing, organic layer anhydrous Na2SO4Dry, filtering is evaporated to obtain the sticky crude product of shape compound 1（13.0g, 96%）.
2）By compound 1（12.0g, 36.1mmol）It is dissolved in methanol and CH2Cl2Mixed solvent（3:1,30ml）In, plus
Enter RuCl3（0.15g, 0.72mmol）, (S)-(-) -1,1'- binaphthols（0.13g, 0.72mmol）, tetraisopropyl titanate
（0.10g, 0.36mmol）, in hydrogen atmosphere（8bar）60 DEG C of stirring reactions of lower heating, reaction is finished after 6 hours.By reaction solution
It is cooled to room temperature, residue is dissolved in ethyl acetate (30ml), once, saturated aqueous common salt washed once, organic for washing by evaporated under reduced pressure
It is added anhydrous Na2SO4Dry, filter evaporated under reduced pressure, residue is purified through silica gel column chromatography（Eluant, eluent：Ethyl acetate：Petroleum ether=
1:1）, obtain compound 2（11.3g, 93%）.
3）By compound 2（11.3g, 33.6mmol）Methanol (20ml) is dissolved in, 20% dilute HCl is added（6.7ml,
36.9mmol）, Pd-C（1.1g）, in hydrogen atmosphere（5bar）Lower 60 DEG C of reactions of heating, react after 8 hours and finish.By reaction solution
It is cooled to room temperature, filters, methanol washing, filtrate adds saturation NaHCO3The aqueous solution adjusts pH value of solution=8.Decompression boils off methanol, uses second
Acetoacetic ester is extracted three times, merges organic layer, saturated common salt water washing, anhydrous Na2SO4Dry, filtering evaporated under reduced pressure is obtained（S）-（+）-
1-（2- piperidines phenyl）- 3- methylbutylamines 4（7.8g, 94%, ee99.0%）.
Embodiment 2：
One kind of the present invention（S）-（+）-1-（2- piperidines phenyl）The preparation method of -3- methylbutylamines comprises the following steps：
1）By 3- methyl isophthalic acids-（2- piperidines phenyl）- 1- butanone（15.0g, 61.0mmol), benzylamine（7.2g, 67.2mmol）
It is dissolved in chloroform（60 ml）, add ammonium chloride（0.17g,3.0mmol）, heating reflux reaction 1.5 hours.Room temperature is cooled to, is added water
（30ml）Washing, organic layer anhydrous Na2SO4Dry, filtering is evaporated to obtain the sticky crude product of shape compound 1（19.8g, 97.5%）.
2）By compound 2（18.0g, 54.2mmol）It is dissolved in methanol and CH2Cl2Mixed solvent（3:Isosorbide-5-Nitrae 5ml）In, plus
Enter RuCl3（0.23g, 1.08mmol）, (S)-(-) -1,1'- binaphthols（0.20g, 1.08mmol）, tetraisopropyl titanate
（0.15g, 0.54mmol）, in hydrogen atmosphere（8bar）60 DEG C of stirring reactions of lower heating, reaction is finished after 6 hours.By reaction solution
It is cooled to room temperature, residue is dissolved in ethyl acetate (45ml), once, saturated aqueous common salt washed once, organic for washing by evaporated under reduced pressure
It is added anhydrous Na2SO4Dry, filter evaporated under reduced pressure, residue is purified through silica gel column chromatography（Eluant, eluent：Ethyl acetate：Petroleum ether=
1:1）, obtain compound 2（16.8g, 92.2%）.
3）By compound 2（16.5g, 49.1mmol）Methanol (30ml) is dissolved in, 20% dilute HCl is added（9.8ml,
54.0mmol）, Pd-C（1.6g）, in hydrogen atmosphere（5bar）Lower 60 DEG C of reactions of heating, react after 8 hours and finish.By reaction solution
It is cooled to room temperature, filters, methanol washing, filtrate adds saturation NaHCO3The aqueous solution adjusts pH value of solution=8.Decompression boils off methanol, uses second
Acetoacetic ester is extracted three times, merges organic layer, saturated common salt water washing, anhydrous Na2SO4Dry, filtering evaporated under reduced pressure is obtained（S）-（+）-
1-（2- piperidines phenyl）- 3- methylbutylamines 4（11.5g, 94.8%, ee99.0%）.
Claims (1)
1. it is a kind of（S）-（+）-1-（2- piperidines phenyl）The preparation method of -3- methyl n-butylamines, it is characterised in that：Methods described bag
Include following steps：
1）It is 1 by mol ratio:1.1-1.2 3- methyl isophthalic acids-（2- piperidines phenyl）- 1- butanone and benzylamine mixture are dissolved in chloroform,
Wherein, chloroform and 3- methyl isophthalic acids-（2- piperidines phenyl）The constitution ratio of -1- butanone is 4:1；Add ammonium chloride, ammonium chloride and 3- first
Base -1-（2- piperidines phenyl）The mass ratio of -1- butanone is 1.1-1.2%：1；Heating reflux reaction 1.5 hours, is cooled to room temperature,
Add water washing, organic layer anhydrous Na2SO4Dry, filtering is evaporated to obtain the sticky crude product of shape compound 1；
2）It is 3 that compound 1 is dissolved in into volume ratio:1 methanol and the in the mixed solvent of dichloromethane, add RuCl3, (S)-(-)-
1,1'- binaphthol, tetraisopropyl titanate heats 60 DEG C of stirring reactions under 8bar hydrogen atmosphere, reacted after 6 hours
Finish, by reaction solution evaporated under reduced pressure, residue is dissolved in ethyl acetate, and once, saturated aqueous common salt washed once, organic addition nothing for washing
Water Na2SO4Dry, filter evaporated under reduced pressure, residue through silica gel column chromatography with purifying to obtain compound 2；
3）Compound 2 is dissolved in methanol, 20% dilute HCl is added, 60 DEG C of reactions 8 of Pd-C catalysis heating under 5bar hydrogen atmosphere
After hour, reaction solution is cooled to room temperature, filtered, filtrate is washed with methanol, the filtrate after washing adds saturation NaHCO3It is water-soluble
Liquid adjusts pH value of solution=8, and decompression boils off methanol, is extracted with ethyl acetate three times, merges organic layer, is then washed with saturated common salt
Wash, anhydrous Na2SO4Dry, filtering evaporated under reduced pressure is obtained（S）-（+）-1-（2- piperidines phenyl）- 3- methylbutylamines.
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| CN201510692991.9A CN105384708B (en) | 2015-10-21 | 2015-10-21 | It is a kind of（S）‑（+）‑1‑（2 piperidines phenyl）The preparation method of 3 methyl n-butylamines |
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| CN201510692991.9A CN105384708B (en) | 2015-10-21 | 2015-10-21 | It is a kind of（S）‑（+）‑1‑（2 piperidines phenyl）The preparation method of 3 methyl n-butylamines |
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| CN105384708B true CN105384708B (en) | 2017-10-27 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7041830B2 (en) * | 2003-03-31 | 2006-05-09 | Council Of Scientific And Industrial Research | Process for preparing (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine |
| WO2007104359A1 (en) * | 2006-03-14 | 2007-09-20 | Jacobs University Bremen Ggmbh | Synthesis of amines with ytterbium lewis acids |
| EP2019097A1 (en) * | 2007-07-25 | 2009-01-28 | Aurobindo Pharma Limited | Process for preparing (alphaS)-alpha-(2-methylpropyl)-2-(1-piperidinyl)benzenemethanamine |
| CN101538253B (en) * | 2008-03-21 | 2012-03-21 | 江苏豪森医药集团连云港宏创医药有限公司 | Method for preparing repaglinide intermediate |
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