CN105377354B - 用于向脑递送药物以治疗神经状况的装置、系统和方法 - Google Patents

用于向脑递送药物以治疗神经状况的装置、系统和方法 Download PDF

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Publication number
CN105377354B
CN105377354B CN201480015066.6A CN201480015066A CN105377354B CN 105377354 B CN105377354 B CN 105377354B CN 201480015066 A CN201480015066 A CN 201480015066A CN 105377354 B CN105377354 B CN 105377354B
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CN
China
Prior art keywords
brain
diffusion chamber
diffusion
drug
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480015066.6A
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English (en)
Chinese (zh)
Other versions
CN105377354A (zh
Inventor
M·伊姆兰
菲利普·摩根
本·特兰奇纳
保罗·斯菲尔
凯尔·霍伦
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Incube Laboratories LLC
Original Assignee
Incube Laboratories LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/827,468 external-priority patent/US10507313B2/en
Application filed by Incube Laboratories LLC filed Critical Incube Laboratories LLC
Publication of CN105377354A publication Critical patent/CN105377354A/zh
Application granted granted Critical
Publication of CN105377354B publication Critical patent/CN105377354B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/008—Strength or flexibility characteristics of the catheter tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3966—Radiopaque markers visible in an X-ray image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M2025/0042—Microcatheters, cannula or the like having outside diameters around 1 mm or less
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/008—Strength or flexibility characteristics of the catheter tip
    • A61M2025/0081—Soft tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36064—Epilepsy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201480015066.6A 2013-03-14 2014-03-12 用于向脑递送药物以治疗神经状况的装置、系统和方法 Expired - Fee Related CN105377354B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/827,468 US10507313B2 (en) 2009-01-26 2013-03-14 Apparatus, systems and methods for delivery of medication to the brain to treat neurological conditions
US13/827,468 2013-03-14
PCT/US2014/025018 WO2014159757A2 (en) 2013-03-14 2014-03-12 Apparatus, systems and methods for delivery of medication to the brain to treat neurological condidtions

Publications (2)

Publication Number Publication Date
CN105377354A CN105377354A (zh) 2016-03-02
CN105377354B true CN105377354B (zh) 2019-03-26

Family

ID=51625613

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480015066.6A Expired - Fee Related CN105377354B (zh) 2013-03-14 2014-03-12 用于向脑递送药物以治疗神经状况的装置、系统和方法

Country Status (5)

Country Link
EP (1) EP2968881B8 (https=)
JP (2) JP6449844B2 (https=)
CN (1) CN105377354B (https=)
AU (2) AU2014244437B9 (https=)
WO (1) WO2014159757A2 (https=)

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CA2739431C (en) 2008-10-01 2016-12-06 Sherwin Hua System and method for wire-guided pedicle screw stabilization of spinal vertebrae
US11331424B2 (en) 2009-01-26 2022-05-17 Incube Labs, Llc Apparatus, systems and methods for delivery of medication to the brain to treat neurological conditions
US9919146B2 (en) 2013-05-01 2018-03-20 Sherwin Hua Methods and systems for intraventricular brain stimulation
WO2018044933A1 (en) * 2016-08-30 2018-03-08 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
EP3654844A4 (en) * 2017-07-21 2021-04-14 Abbott Diabetes Care Inc. DEVICES, SYSTEMS AND METHODS FOR DISPENSING SOLID FORMULATIONS
AU2018308115B2 (en) * 2017-07-26 2023-12-14 Neuraptive Therapeutics, Inc. Device and method of creating a fluid containment field for administering therapeutics to a nerve
JP7101859B2 (ja) * 2018-07-02 2022-07-15 ミネトロニクス ニューロ インコーポレイテッド 中枢神経系に沿って治療するためのシステム、カテーテル、および方法
AU2020321382B2 (en) * 2019-08-01 2024-08-22 Theracle, Inc. Intracranial delivery of medicinal solution
CN121512655A (zh) 2019-11-27 2026-02-13 斯拜因23公司 治疗脊柱侧弯的系统、装置和方法
IL299826A (en) 2020-07-15 2023-03-01 Cerebral Therapeutics Inc A medical device with a non-filtered CSF withdrawal path
US12329930B2 (en) 2020-09-29 2025-06-17 Enclear Therapies, Inc. Subarachnoid fluid management method and system
CN115105675B (zh) * 2021-03-18 2025-12-05 上海微创神奕医疗科技有限公司 一种医疗装置
KR20240049213A (ko) 2021-05-12 2024-04-16 스파인23 인코포레이티드 척추뼈의 척추경 나사를 안정화시키기 위한 시스템 및 방법
US20230200707A1 (en) * 2021-12-29 2023-06-29 Cerebral Therapeutics, Inc. Ventricular drain or shunt asssembly with recording electrode
US12605537B2 (en) 2022-02-15 2026-04-21 Biogen Ma Inc. Implantable medical device for use with or having recording electrode
GB202211580D0 (en) * 2022-08-09 2022-09-21 Cambridge Entpr Ltd Implantable device
CN115591048B (zh) * 2022-12-16 2023-03-21 北京泰杰伟业科技有限公司 脑组织给药系统
US20240285854A1 (en) * 2023-02-28 2024-08-29 Enclear Therapies, Inc. Csf therapeutic delivery system
CN119565004A (zh) * 2024-11-14 2025-03-07 武汉衷华脑机融合科技发展有限公司 一种脑脊液置换装置

Citations (5)

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US5152744A (en) * 1990-02-07 1992-10-06 Smith & Nephew Dyonics Surgical instrument
US6458118B1 (en) * 2000-02-23 2002-10-01 Medtronic, Inc. Drug delivery through microencapsulation
US20050137579A1 (en) * 2003-12-23 2005-06-23 Medtronic, Inc. Permeable membrane catheters, systems, and methods
US20090131857A1 (en) * 2007-11-20 2009-05-21 Mark Geiger Method and apparatus for introducing a medicinal dose directly into a mammalian patient's cerebrospinal fluid
WO2012047931A1 (en) * 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Device for local drug delivery and treatment of cerebral edema and other brain-related diseases

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US4829070A (en) * 1982-05-18 1989-05-09 University Of Florida Novel redox carriers for brain-specific drug delivery
US5846220A (en) * 1996-04-30 1998-12-08 Medtronic, Inc. Therapeutic method for treatment of Alzheimer's disease
US9186175B2 (en) * 2004-10-28 2015-11-17 Nico Corporation Surgical access assembly and method of using same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5152744A (en) * 1990-02-07 1992-10-06 Smith & Nephew Dyonics Surgical instrument
US6458118B1 (en) * 2000-02-23 2002-10-01 Medtronic, Inc. Drug delivery through microencapsulation
US20050137579A1 (en) * 2003-12-23 2005-06-23 Medtronic, Inc. Permeable membrane catheters, systems, and methods
US20090131857A1 (en) * 2007-11-20 2009-05-21 Mark Geiger Method and apparatus for introducing a medicinal dose directly into a mammalian patient's cerebrospinal fluid
WO2012047931A1 (en) * 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Device for local drug delivery and treatment of cerebral edema and other brain-related diseases

Also Published As

Publication number Publication date
WO2014159757A3 (en) 2015-01-29
JP6449844B2 (ja) 2019-01-09
AU2014244437B2 (en) 2018-11-08
EP2968881B1 (en) 2019-05-01
CN105377354A (zh) 2016-03-02
AU2019200557A1 (en) 2019-02-14
JP2018102951A (ja) 2018-07-05
EP2968881A2 (en) 2016-01-20
AU2014244437A1 (en) 2015-09-24
EP2968881B8 (en) 2019-10-09
EP2968881A4 (en) 2016-12-14
AU2014244437B9 (en) 2019-05-02
WO2014159757A2 (en) 2014-10-02
JP2016515866A (ja) 2016-06-02

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Granted publication date: 20190326

Termination date: 20210312