CN105362958A - Traditional Chinese medicine composition for preventing ABO hemolysis of fetuses and newborns - Google Patents

Traditional Chinese medicine composition for preventing ABO hemolysis of fetuses and newborns Download PDF

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CN105362958A
CN105362958A CN201510951935.2A CN201510951935A CN105362958A CN 105362958 A CN105362958 A CN 105362958A CN 201510951935 A CN201510951935 A CN 201510951935A CN 105362958 A CN105362958 A CN 105362958A
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chinese medicine
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别会荣
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing ABO hemolysis of fetuses and newborns. The traditional Chinese medicine composition is prepared from, by weight, 20-30 g of herba leonuri, 20-30 g of radix angelica sinensis tails, 20-30 g of white paeony roots, 10-20 g of radix aucklandiae, 10-20 g of achyranthes bidentata, 10-20 g of peach kernels, 5-10 g of leeches, 5-10 g of fried fructus aurantii immaturus and 5-10 g of rhizoma curcumae. The selected medicinal materials achieve the functions of promoting qi circulation to relieve pain, nourishing blood, retaining yin with astringent, promoting blood circulation to remove blood stasis, tonifying qi and achieving anti-abortion measuccessful gestation together. It is found through clinical application that the traditional Chinese medicine composition has the advantages of being rapid in effect, remarkable in treatment effect, low in cost and free of toxic and side effects.

Description

A kind of Chinese medicine composition preventing fetus, neonate ABO hemolytic disease
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine composition that can prevent fetus, neonate ABO hemolytic disease.
Background technology
Hemolytic disease of newborn refers to the isoimmunization haemolysis caused because of female, baby's blood group incompatibility.In China, maternal-fetal blood group incompatibility is the one of high risk pregnancy, is more common in ABO incompatibility, and hemolytic disease of newborn caused by ABO incompatibility is turned out to be the important disease of the one relevant with blood group by theory.The diseases such as miscarriage, stillborn fetus, stillbirth, severe anemia, bilirubin encephalopathy, mental retardation can be caused, be put into the important content of anemia of pregnant woman's perinatal care.
At present, hemolytic disease of newborn best bet is avoided to be prevention.Therefore, abo blood group mensuration is carried out to the pregnant Mr. and Mrs of blood group incompatibility and detects pregnancy serum antibody titer, understand the relation of tiring and between hemolytic disease of newborn sickness rate, determine whether fetus suffers from ABO hemolytic disease, and carry out prophylactic treatment in time with medicine, stop fetus, neonate occurs that ABO hemolytic disease seems very crucial.
At present, the medicine of prevention fetus, neonate ABO hemolytic disease is a lot, but Western medicine exists certain toxic and side effects mostly, easily affect the normal development of fetus health and organ in vivo, causes fetus to occur lopsided etc.; Chinese medicine exists that onset is slow, prevention and the defect such as cure rate is low.Therefore, need a kind of instant effect, short treating period, Chinese medicine composition cheap and without any side effects badly, effectively prevent fetus, neonate ABO hemolytic disease.
Summary of the invention
The invention solves the defect that current Chinese and western drugs exists in prevention fetus, neonate ABO hemolytic disease process, a kind of instant effect, short treating period, Chinese medicine composition cheap and without any side effects are provided.
The technical solution adopted in the present invention is: a kind of Chinese medicine composition preventing fetus, neonate ABO hemolytic disease, and it is characterized in that, described Chinese medicine composition is made up of the Chinese herb of following weight portion:
Herba Leonuri 20-30 gram, Radix Angelicae Sinensis 20-30 gram, Radix Paeoniae Alba 20-30 gram, Radix Aucklandiae 10-20 gram, Radix Achyranthis Bidentatae 10-20 gram, Semen Persicae 10-20 gram, Hirudo 5-10 gram, Fructus Aurantii Immaturus (parched) 5-10 gram, Rhizoma Curcumae 5-10 gram.
As this kind of prioritization scheme:
Described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
Herba Leonuri 20 grams, Radix Angelicae Sinensis 20 grams, the Radix Paeoniae Alba 20 grams, the Radix Aucklandiae 10 grams, Radix Achyranthis Bidentatae 10 grams, 10 grams, Semen Persicae, Hirudo 5 grams, Fructus Aurantii Immaturus (parched) 5 grams, Rhizoma Curcumae 5 grams.
As this kind of prioritization scheme:
Described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
Herba Leonuri 25 grams, Radix Angelicae Sinensis 25 grams, the Radix Paeoniae Alba 25 grams, the Radix Aucklandiae 15 grams, Radix Achyranthis Bidentatae 15 grams, 15 grams, Semen Persicae, Hirudo 8 grams, Fructus Aurantii Immaturus (parched) 7 grams, Rhizoma Curcumae 8 grams.
As this kind of prioritization scheme:
Described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
Herba Leonuri 30 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, the Radix Aucklandiae 20 grams, Radix Achyranthis Bidentatae 20 grams, 20 grams, Semen Persicae, Hirudo 10 grams, Fructus Aurantii Immaturus (parched) 10 grams, Rhizoma Curcumae 10 grams.
The instructions of taking of above-mentioned Chinese medicine composition is: after being mixed by the raw material Chinese medicine of above-mentioned weight proportion, traditionally the method for fried Chinese medicine gets its medicine juice, every secondary 150ml, starts to take, every day 1 time from gestation 4th month (17 weeks), until childbirth.
The raw material Chinese medicine of above-mentioned Chinese medicine composition:
Herba Leonuri, nature and flavor are bitter, pungent, are slightly cold; Return liver, pericardium channel.There is promoting blood flow to regulate menstruation, effect of inducing diuresis to remove edema.
Radix Angelicae Sinensis, sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, effect of menstruction regulating and pain relieving.
The Radix Paeoniae Alba, bitter in the mouth, acid, be slightly cold; Enter Liver Channel.There is the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain, effect of suppressing the hyperactive liver and subsiding YANG.
The Radix Aucklandiae, acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.There is warming middle-JIAO to promote flow of QI pain relieving, effect of strengthening the spleen to promote digestion intestinal stasis relieving.
Radix Achyranthis Bidentatae is bitter, sour, flat; Enter liver, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening; Inducing diuresis for treating stranguria syndrome; Effect of conducting blood to flow downwards.
Semen Persicae, nature and flavor are sweet flat, bitter; Return lung, liver, large intestine channel.There is blood circulation promoting and blood stasis dispelling, moisturize effect of laxation.
Hirudo, salty in the mouth; Bitter; Property is put down; Return Liver Channel.There is removing blood stasis; Effect of Tong Jing Xiao Disorder.
Fructus Aurantii Immaturus (parched), bitter, pungent, sour, temperature; Return spleen, stomach warp.There is effect of soothing the liver strongly fragrant, spleen invigorating kidney, qi and blood circulation promotion.
Rhizoma Curcumae, pungent, bitter, temperature; Return liver, spleen channel.There is removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, effect of expelling wind and removing dampness.
The traditional Chinese medical science is thought, haemolysis destroys erythrocyte and belongs to blood stasis phenomenon, can adopt blood circulation promoting and blood stasis dispelling and pleasant treatment of regulating the flow of vital energy, and then suppresses formation and the effect of blood group antibody.Chinese medicine composition of the present invention, Herba Leonuri can promoting blood flow to regulate menstruation, and Radix Angelicae Sinensis is enriched blood and invigorated blood circulation, and this two medicines compatibility can be enriched blood and be invigorated blood circulation, again can menstruction regulating and pain relieving; Semen Persicae blood circulation promoting and blood stasis dispelling, Hirudo removing blood stasis, the circulation of qi promoting of Rhizoma Curcumae removing blood stasis, this three tastes Chinese medicine can play removing blood stasis, the good effects of relieving pain of dysmenorrhea; Be equipped with the Radix Paeoniae Alba to nourish blood yin fluid astringing, Radix Aucklandiae warming middle-JIAO to promote flow of QI and Radix Achyranthis Bidentatae tonification gas-solid kidney, inducing diuresis for treating stranguria syndrome, effect of conducting blood to flow downwards, gather the antiabortive effect of blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, the yin fluid astringing that nourishes blood, QI invigorating altogether.
For investigating the clinical efficacy of medicine of the present invention further, we have selected 25 routine outpatient service anemia of pregnant woman and carry out clinical trial, between 19 ~ 38 years old age, 26.7 years old mean age, wherein anemia of pregnant woman is 0 type blood, and husband is A, B, AB type blood, all 1:64 is greater than through saline flowering in vitro antagonist bioactivity, and the baby of the ABO Hemolysis of all once gave a birth in the past jaundice or edema, incidence rate is 78.2%, and case fatality rate is 61.2%.
Criterion of therapeutical effect (adopting saline flowering in vitro anemia of pregnant woman to be carried out to the abo antibody bioactivity of the anti-A of IgG or anti-B):
Cure: antibody titer is less than 1: 64, birth normal fetal, no sequel.
Effective: clinical antibody titer detects and obviously improves, and smooth delivery produces baby.
Invalid: clinical antibody titer detects without improving, and dead fetuses by abortion aged, does not give a birth.
Therapeutic Method:
Treatment group takes the Chinese medicine composition of embodiment 2, and traditionally the method for fried Chinese medicine gets its medicine juice, every secondary 150ml, starts to take, every day 1 time from gestation 4th month (17 weeks), until childbirth.
Statistics patient on medication the results are shown in Table one.Patient starts to take from gestation 4th month (17 weeks), and after two weeks, through Clinical detection, antibody titer obviously improves, and after taking one month, antibody titer all recovers normal.Take continuously to a point puerperium, all patients produce baby all smoothly.Through health check-up, 21 routine neonates are normal, and physiologic jaundice appears in 4 examples, all fully recover through treatment.Without dead fetuses by abortion aged case.Neonate of giving a birth through following up a case by regular visits to, grow normal, equal no sequel.The hemolytic disease of newborn incidence rate 78.2% of in the past giving a birth and infant mortality rate 61.2% are compared, and this invention Chinese medicine composition has extremely significant curative effect to prevention fetus, neonate ABO hemolytic disease, significant.
Table one: the result table of statistics patient on medication
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine composition preventing fetus, neonate ABO hemolytic disease, chooses Herba Leonuri 20 grams, Radix Angelicae Sinensis 20 grams, the Radix Paeoniae Alba 20 grams, the Radix Aucklandiae 10 grams, Radix Achyranthis Bidentatae 10 grams, 10 grams, Semen Persicae, Hirudo 5 grams, Fructus Aurantii Immaturus (parched) 5 grams, Rhizoma Curcumae 5 grams.
Embodiment 2: a kind of Chinese medicine composition preventing fetus, neonate ABO hemolytic disease, chooses Herba Leonuri 25 grams, Radix Angelicae Sinensis 25 grams, the Radix Paeoniae Alba 25 grams, the Radix Aucklandiae 15 grams, Radix Achyranthis Bidentatae 15 grams, 15 grams, Semen Persicae, Hirudo 8 grams, Fructus Aurantii Immaturus (parched) 7 grams, Rhizoma Curcumae 8 grams.
Embodiment 3: a kind of Chinese medicine composition preventing fetus, neonate ABO hemolytic disease, chooses Herba Leonuri 30 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, the Radix Aucklandiae 20 grams, Radix Achyranthis Bidentatae 20 grams, 20 grams, Semen Persicae, Hirudo 10 grams, Fructus Aurantii Immaturus (parched) 10 grams, Rhizoma Curcumae 10 grams.
Below by concrete case, Chinese medicine composition curative effect of the present invention is verified further:
Case 1
Mrs Zhao, 28 years old, 0 type blood, husband was AB type blood.Because of blood group problem, past attempts was given a birth jaundice neonate, and by failing to respond to any medical treatment, patient is absorbed in deep misery, and stress is huge.After being introduced, gestation is after four months again, and start to take Chinese medicine composition of the present invention, Clinical detection antibody titer effectively improves, rear term labor, produces healthy boy baby one, follows up a case by regular visits to no sequel.
Case 2
Mrs Li, 32 years old, 0 type blood, husband was AB type blood.During gestation health check-up in 3 two months, find that antibody titer is greater than 1:64, suffer from ABO hemolytic disease, take Chinese medicine composition of the present invention continuously after two weeks, detect antibody titer and be less than 1:64, and continue to keep stable, rear full-term normal delivery healthy babies, follows up a case by regular visits to no sequel.
Case 3
Mrs Li, 31 years old, 0 type blood, husband was AB type blood.First tire, because checking to suffer from ABO hemolytic disease, is forced to have an abortion.Gestation is after 4 months again, checks that antibody titer is greater than 1:64, still suffers from this disease.Start to take Chinese medicine composition of the present invention after three weeks, antibody titer tends towards stability and is less than 1:64, and under rear term birth, healthy girl baby one, follows up a case by regular visits to no sequel.

Claims (4)

1. prevent a Chinese medicine composition for fetus, neonate ABO hemolytic disease, it is characterized in that, described Chinese medicine composition is made up of the Chinese herb of following weight portion:
Herba Leonuri 20-30 gram, Radix Angelicae Sinensis 20-30 gram, Radix Paeoniae Alba 20-30 gram, Radix Aucklandiae 10-20 gram, Radix Achyranthis Bidentatae 10-20 gram, Semen Persicae 10-20 gram, Hirudo 5-10 gram, Fructus Aurantii Immaturus (parched) 5-10 gram, Rhizoma Curcumae 5-10 gram.
2. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the Chinese herb of following weight portion:
Herba Leonuri 20 grams, Radix Angelicae Sinensis 20 grams, the Radix Paeoniae Alba 20 grams, the Radix Aucklandiae 10 grams, Radix Achyranthis Bidentatae 10 grams, 10 grams, Semen Persicae, Hirudo 5 grams, Fructus Aurantii Immaturus (parched) 5 grams, Rhizoma Curcumae 5 grams.
3. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the Chinese herb of following weight portion:
Herba Leonuri 25 grams, Radix Angelicae Sinensis 25 grams, the Radix Paeoniae Alba 25 grams, the Radix Aucklandiae 15 grams, Radix Achyranthis Bidentatae 15 grams, 15 grams, Semen Persicae, Hirudo 8 grams, Fructus Aurantii Immaturus (parched) 7 grams, Rhizoma Curcumae 8 grams.
4. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the Chinese herb of following weight portion:
Herba Leonuri 30 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, the Radix Aucklandiae 20 grams, Radix Achyranthis Bidentatae 20 grams, 20 grams, Semen Persicae, Hirudo 10 grams, Fructus Aurantii Immaturus (parched) 10 grams, Rhizoma Curcumae 10 grams.
CN201510951935.2A 2015-12-17 2015-12-17 Traditional Chinese medicine composition for preventing ABO hemolysis of fetuses and newborns Pending CN105362958A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107255727A (en) * 2017-07-07 2017-10-17 深圳优迪生物技术有限公司 Latex is than turbid freeze-dried reagent and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010013925A2 (en) * 2008-07-31 2010-02-04 Dong-A Pharmaceutical. Co., Ltd. Pharmacological composition for prevention and treatment of respiratory disease containing pyrazolopyrimidinone compound or pharmaceutically acceptable salts thereof
CN103784574A (en) * 2014-01-28 2014-05-14 济南伟传信息技术有限公司 Orally taken traditional Chinese medicine for preventing and treating hemolytic disease of newborn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010013925A2 (en) * 2008-07-31 2010-02-04 Dong-A Pharmaceutical. Co., Ltd. Pharmacological composition for prevention and treatment of respiratory disease containing pyrazolopyrimidinone compound or pharmaceutically acceptable salts thereof
CN103784574A (en) * 2014-01-28 2014-05-14 济南伟传信息技术有限公司 Orally taken traditional Chinese medicine for preventing and treating hemolytic disease of newborn

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Title
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107255727A (en) * 2017-07-07 2017-10-17 深圳优迪生物技术有限公司 Latex is than turbid freeze-dried reagent and preparation method thereof
CN107255727B (en) * 2017-07-07 2019-02-01 深圳优迪生物技术有限公司 Latex is than turbid freeze-dried reagent and preparation method thereof

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