CN105362787A - Traditional Chinese medicine preparation for treating sciatica as well as preparation method and application of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating sciatica as well as preparation method and application of traditional Chinese medicine preparation Download PDFInfo
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- CN105362787A CN105362787A CN201510974227.0A CN201510974227A CN105362787A CN 105362787 A CN105362787 A CN 105362787A CN 201510974227 A CN201510974227 A CN 201510974227A CN 105362787 A CN105362787 A CN 105362787A
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Abstract
The invention discloses traditional Chinese medicine preparation for treating sciatica as well as a preparation method and application of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation adopts raw materials of ficus pumila, macleaya cordata, saccharum arundinaceum, radix angelicae pubescentis, fructus psoraleae, corydalis tuber, crotalaria assamica, thin evodia root, myrrh, perilla leaf and chloranthus serratus root, and is added with one or more of filling agents, a disintegrating agent and a flavoring agent when being prepared, wherein the filling agent(s) is/are one or more of xylitol, microcrystalline cellulose and dextrin, the disintegrating agent is sodium carboxymethyl starch or low-substituted hydroxypropyl cellulose, and the flavoring agent is orange peel syrup or aspartame. The synergistic effect of the raw medical materials plays the functions of quick effect, exact curative effect, high safety and high simplicity in medication, the preparation process is simple, the environment can be protected, symptoms of aching lumbar and leg pain, muscle atrophy and the like caused by sciatica can be effectively relieved, toxic and side effects are avoided, and a new selection is provided for clinically relieving various symptoms caused by sciatica.
Description
Technical field
The present invention relates to medical applications technical field, specifically a kind of Chinese medicine preparation for the treatment of sciatica and its production and use.
Background technology
Sciatica refers to sciatic nerve path and distributed areas thereof the syndrome based on pain, can be caused by Different types of etiopathogenises.Sciatica has constitutional and the large class of Secondary cases two.Primary sciatica and sciatic neuritis, rare clinically; Secondary Sciatic Pain is common, mainly because sciatic nerve path is affected by adjacent tissue's pathological changes.Its clinical main manifestations is lumbago and skelalgia, and have a strong impact on the quality of life of patient, the lighter is handicapped, if pain recurrent exerbation, with the passing of time there will be the atrophy of Ipsilateral lower limb muscles, or occurs walking lamely, severe one lower extremity paralysis.Constitutional sciatic neuritis, onset is often acute or subacute, history of catching a cold of can catching cold; The Secondary Sciatic Pain cause of disease is more, the most common with prolapse of lumbar intervertebral disc, its clinical manifestation is that pain is mainly limited to sciatic nerve areal area, as outside after back of thighs, shank and foot outside, the patient of sharp ache can be peculiar posture: waist flexing, pain lateroflexion hip, go down on one's knees, toe lands.As pathological changes be positioned at nerve root time, often because of cough, the action that sneeze, firmly stool etc. increase abdominal pressures makes that intraspinal tube pressure increases and the pain increased.Some patients can have suffering limb muscular strength to go down.Primary disease belongs to the category of motherland's medical science " arthromyodynia ", " lumbago and skelalgia ", " muscular rheumatism ".The generation of primary disease, can because of deficiency of kidney-QI, and the heresy that affection of exogenous wind-cold is damp and hot or fall is winked and the many factors such as to be frustrated and cause.
The non-operative treatment of current western medical treatment sciatica generally adopts Adrenal Glucocorticoid or non-when body class anti-inflammation analgesia medicine.This symptom formula therapy only can alleviating pain, can not tackle the problem at its root, and there will be the side effect such as headache, dyspepsia, digestive tract ulcer, osteoporosis.And compare doctor trained in Western medicine, Chinese medicine make simple, to have no adverse reaction and cure rate is high, patient is easy to accept, and it is very necessary for therefore furtheing investigate based on traditional medicine sciatica and treat.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of sciatica and its production and use.
For achieving the above object, the invention provides following technical scheme:
Treat a Chinese medicine preparation for sciatica, be made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 30-40 part, Herba Macleayae Cordatae 30-40 part, Radix sacchari arundinacei 20-40 part, Radix Angelicae Pubescentis 20-30 part, Fructus Psoraleae 10-20 part, Rhizoma Corydalis 10-20 part, Caulis et Folium Crotalariae Assamicae 5-15 part, Radix Evodiae Leptae 5-15 part, Myrrha 8-12 part, Folium Perillae 8-12 part, Radix Chloranthi Serrati root 5-10 part.
As the further scheme of the present invention: the Chinese medicine preparation of described treatment sciatica, is made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 32-38 part, Herba Macleayae Cordatae 32-38 part, Radix sacchari arundinacei 25-35 part, Radix Angelicae Pubescentis 22-28 part, Fructus Psoraleae 12-18 part, Rhizoma Corydalis 12-18 part, Caulis et Folium Crotalariae Assamicae 8-12 part, Radix Evodiae Leptae 8-12 part, Myrrha 9-11 part, Folium Perillae 9-11 part, Radix Chloranthi Serrati root 6-9 part.
As the further scheme of the present invention: the Chinese medicine preparation of described treatment sciatica, is made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 35 parts, Herba Macleayae Cordatae 35 parts, Radix sacchari arundinacei 30 parts, Radix Angelicae Pubescentis 25 parts, Fructus Psoraleae 15 parts, Rhizoma Corydalis 15 parts, Caulis et Folium Crotalariae Assamicae 10 parts, Radix Evodiae Leptae 10 parts, Myrrha 10 parts, Folium Perillae 10 parts, Radix Chloranthi Serrati root 8 parts.
The preparation method of the Chinese medicine preparation of described treatment sciatica, concrete steps are as follows:
(1) take each raw material according to weight portion, mixing Caulis fici pumilae (Fructus Fici Pumilae), Herba Macleayae Cordatae, Radix sacchari arundinacei, Radix Angelicae Pubescentis and Fructus Psoraleae, obtain the first medical material group, and mixing Rhizoma Corydalis, Caulis et Folium Crotalariae Assamicae, Myrrha, Radix Chloranthi Serrati root obtain the second medical material group;
(2) Radix Evodiae Leptae is put into pot, fry to surface in coke yellow with slow fire, taking-up cools rear pulverizing and grinds into powder, crosses 120 order fine powders, for subsequent use;
(3) the first medical material group is put into container, add the water of quintuple, after soaking 12-14h, get immersion; In remaining medicinal residues, add the water of four times amount again, after soaking 6-8h, get immersion; Merge twice gained immersion, heating evaporation is the thick paste of relative density 1.15-1.20 under 60 DEG C of environment, for subsequent use;
(4) the second medical material group is put into container, add the ethanol of four times amount, after soaking 5-7h, get immersion; In remaining medicinal residues, add the ethanol of triplication again, after soaking 2-4h, get immersion; Merge the immersion of twice gained, heating evaporation is the thick paste of relative density 1.05-1.10 under 60 DEG C of environment, for subsequent use;
(5) Folium Perillae crocus cloth is wrapped put into doubling dose mature vinegar, after soaking 2-3h, get immersion; After adding the mature vinegar immersion 1-2h of a times amount again, get immersion; Merge twice immersion, heating evaporation is the thick paste of relative density 1.20-1.25 under 50 DEG C of environment, for subsequent use;
(6), after the thick paste mix homogeneously obtained in Radix Evodiae Leptae fine powder, step (3)-(4), various required dosage form after absorb fillers, disintegrating agent and correctives, is conventionally made.
As the further scheme of the present invention: described filler is one or more in xylitol, microcrystalline Cellulose, dextrin.
As the further scheme of the present invention: described disintegrating agent is carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose.
As the further scheme of the present invention: described disintegrating agent is carboxymethyl starch sodium.
As the further scheme of the present invention: described correctives is orange syrup or aspartame.
As the further scheme of the present invention: described dosage form is capsule, tablet, oral liquid, pill, powder or granule.
As the present invention's further scheme: the application of described Chinese medicine preparation in preparation treatment sciatica medicine.
Compared with prior art, the invention has the beneficial effects as follows:
In the present invention, each crude drug synergism plays and has the high and medication of rapid-action, determined curative effect, safety and simply act on, preparation technology is simple, environmentally friendly, effectively can alleviate the symptom such as waist and leg ache, amyotrophy that sciatica causes, do not have toxic and side effects, the various symptoms caused for clinical remission sciatica provide a newly selection.
Detailed description of the invention
Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.
Embodiment 1
Treat a Chinese medicine preparation for sciatica, be made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 30 parts, Herba Macleayae Cordatae 30 parts, Radix sacchari arundinacei 20 parts, Radix Angelicae Pubescentis 20 parts, Fructus Psoraleae 10 parts, Rhizoma Corydalis 10 parts, Caulis et Folium Crotalariae Assamicae 5 parts, Radix Evodiae Leptae 5 parts, Myrrha 8 parts, Folium Perillae 8 parts, Radix Chloranthi Serrati root 5 parts.
The preparation method of the Chinese medicine preparation of described treatment sciatica, concrete steps are as follows:
(1) take each raw material according to weight portion, mixing Caulis fici pumilae (Fructus Fici Pumilae), Herba Macleayae Cordatae, Radix sacchari arundinacei, Radix Angelicae Pubescentis and Fructus Psoraleae, obtain the first medical material group, and mixing Rhizoma Corydalis, Caulis et Folium Crotalariae Assamicae, Myrrha, Radix Chloranthi Serrati root obtain the second medical material group;
(2) Radix Evodiae Leptae is put into pot, fry to surface in coke yellow with slow fire, taking-up cools rear pulverizing and grinds into powder, crosses 120 order fine powders, for subsequent use;
(3) the first medical material group is put into container, add the water of quintuple, after soaking 12h, get immersion; In remaining medicinal residues, add the water of four times amount again, after soaking 6h, get immersion; Merge twice gained immersion, heating evaporation is the thick paste of relative density 1.15 under 60 DEG C of environment, for subsequent use;
(4) the second medical material group is put into container, add the ethanol of four times amount, after soaking 5h, get immersion; In remaining medicinal residues, add the ethanol of triplication again, after soaking 2h, get immersion; Merge the immersion of twice gained, heating evaporation is the thick paste of relative density 1.05 under 60 DEG C of environment, for subsequent use;
(5) Folium Perillae crocus cloth is wrapped put into doubling dose mature vinegar, after soaking 2h, get immersion; After adding the mature vinegar immersion 1h of a times amount again, get immersion; Merge twice immersion, heating evaporation is the thick paste of relative density 1.20 under 50 DEG C of environment, for subsequent use;
(6), after the thick paste mix homogeneously obtained in Radix Evodiae Leptae fine powder, step (3)-(4), after being added to xylitol, carboxymethyl starch sodium and orange syrup, conventionally capsule is made.
Usage and dosage: oral.A 3-5g, 3 times on the one.
Embodiment 2
Treat a Chinese medicine preparation for sciatica, be made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 32 parts, Herba Macleayae Cordatae 32 parts, Radix sacchari arundinacei 25 parts, Radix Angelicae Pubescentis 22 parts, Fructus Psoraleae 12 parts, Rhizoma Corydalis 12 parts, Caulis et Folium Crotalariae Assamicae 8 parts, Radix Evodiae Leptae 8 parts, Myrrha 9 parts, Folium Perillae 9 parts, Radix Chloranthi Serrati root 6 parts.
The preparation method of the Chinese medicine preparation of described treatment sciatica, concrete steps are as follows:
(1) take each raw material according to weight portion, mixing Caulis fici pumilae (Fructus Fici Pumilae), Herba Macleayae Cordatae, Radix sacchari arundinacei, Radix Angelicae Pubescentis and Fructus Psoraleae, obtain the first medical material group, and mixing Rhizoma Corydalis, Caulis et Folium Crotalariae Assamicae, Myrrha, Radix Chloranthi Serrati root obtain the second medical material group;
(2) Radix Evodiae Leptae is put into pot, fry to surface in coke yellow with slow fire, taking-up cools rear pulverizing and grinds into powder, crosses 120 order fine powders, for subsequent use;
(3) the first medical material group is put into container, add the water of quintuple, after soaking 12.5h, get immersion; In remaining medicinal residues, add the water of four times amount again, after soaking 6.5h, get immersion; Merge twice gained immersion, heating evaporation is the thick paste of relative density 1.16 under 60 DEG C of environment, for subsequent use;
(4) the second medical material group is put into container, add the ethanol of four times amount, after soaking 5.5h, get immersion; In remaining medicinal residues, add the ethanol of triplication again, after soaking 2.5h, get immersion; Merge the immersion of twice gained, heating evaporation is the thick paste of relative density 1.06 under 60 DEG C of environment, for subsequent use;
(5) Folium Perillae crocus cloth is wrapped put into doubling dose mature vinegar, after soaking 2.2h, get immersion; After adding the mature vinegar immersion 1.2h of a times amount again, get immersion; Merge twice immersion, heating evaporation is the thick paste of relative density 1.21 under 50 DEG C of environment, for subsequent use;
(6), after the thick paste mix homogeneously obtained in Radix Evodiae Leptae fine powder, step (3)-(4), after being added to xylitol, low-substituted hydroxypropyl cellulose and aspartame, conventionally tablet is made.
Usage and dosage: oral.A 3-5g, 3 times on the one.
Embodiment 3
Treat a Chinese medicine preparation for sciatica, be made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 35 parts, Herba Macleayae Cordatae 35 parts, Radix sacchari arundinacei 30 parts, Radix Angelicae Pubescentis 25 parts, Fructus Psoraleae 15 parts, Rhizoma Corydalis 15 parts, Caulis et Folium Crotalariae Assamicae 10 parts, Radix Evodiae Leptae 10 parts, Myrrha 10 parts, Folium Perillae 10 parts, Radix Chloranthi Serrati root 8 parts.
The preparation method of the Chinese medicine preparation of described treatment sciatica, concrete steps are as follows:
(1) take each raw material according to weight portion, mixing Caulis fici pumilae (Fructus Fici Pumilae), Herba Macleayae Cordatae, Radix sacchari arundinacei, Radix Angelicae Pubescentis and Fructus Psoraleae, obtain the first medical material group, and mixing Rhizoma Corydalis, Caulis et Folium Crotalariae Assamicae, Myrrha, Radix Chloranthi Serrati root obtain the second medical material group;
(2) Radix Evodiae Leptae is put into pot, fry to surface in coke yellow with slow fire, taking-up cools rear pulverizing and grinds into powder, crosses 120 order fine powders, for subsequent use;
(3) the first medical material group is put into container, add the water of quintuple, after soaking 13h, get immersion; In remaining medicinal residues, add the water of four times amount again, after soaking 7h, get immersion; Merge twice gained immersion, heating evaporation is the thick paste of relative density 1.18 under 60 DEG C of environment, for subsequent use;
(4) the second medical material group is put into container, add the ethanol of four times amount, after soaking 6h, get immersion; In remaining medicinal residues, add the ethanol of triplication again, after soaking 3h, get immersion; Merge the immersion of twice gained, heating evaporation is the thick paste of relative density 1.08 under 60 DEG C of environment, for subsequent use;
(5) Folium Perillae crocus cloth is wrapped put into doubling dose mature vinegar, after soaking 2.5h, get immersion; After adding the mature vinegar immersion 1.5h of a times amount again, get immersion; Merge twice immersion, heating evaporation is the thick paste of relative density 1.23 under 50 DEG C of environment, for subsequent use;
(6), after the thick paste mix homogeneously obtained in Radix Evodiae Leptae fine powder, step (3)-(4), after being added to dextrin, carboxymethyl starch sodium and orange syrup, conventionally oral liquid is made.
Usage and dosage: oral.A 3-5g, 3 times on the one.
Embodiment 4
Treat a Chinese medicine preparation for sciatica, be made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 38 parts, Herba Macleayae Cordatae 38 parts, Radix sacchari arundinacei 35 parts, Radix Angelicae Pubescentis 28 parts, Fructus Psoraleae 18 parts, Rhizoma Corydalis 18 parts, Caulis et Folium Crotalariae Assamicae 12 parts, Radix Evodiae Leptae 12 parts, Myrrha 11 parts, Folium Perillae 11 parts, Radix Chloranthi Serrati root 9 parts.
The preparation method of the Chinese medicine preparation of described treatment sciatica, concrete steps are as follows:
(1) take each raw material according to weight portion, mixing Caulis fici pumilae (Fructus Fici Pumilae), Herba Macleayae Cordatae, Radix sacchari arundinacei, Radix Angelicae Pubescentis and Fructus Psoraleae, obtain the first medical material group, and mixing Rhizoma Corydalis, Caulis et Folium Crotalariae Assamicae, Myrrha, Radix Chloranthi Serrati root obtain the second medical material group;
(2) Radix Evodiae Leptae is put into pot, fry to surface in coke yellow with slow fire, taking-up cools rear pulverizing and grinds into powder, crosses 120 order fine powders, for subsequent use;
(3) the first medical material group is put into container, add the water of quintuple, after soaking 13.5h, get immersion; In remaining medicinal residues, add the water of four times amount again, after soaking 7.5h, get immersion; Merge twice gained immersion, heating evaporation is the thick paste of relative density 1.19 under 60 DEG C of environment, for subsequent use;
(4) the second medical material group is put into container, add the ethanol of four times amount, after soaking 6.5h, get immersion; In remaining medicinal residues, add the ethanol of triplication again, after soaking 3.5h, get immersion; Merge the immersion of twice gained, heating evaporation is the thick paste of relative density 1.09 under 60 DEG C of environment, for subsequent use;
(5) Folium Perillae crocus cloth is wrapped put into doubling dose mature vinegar, after soaking 2.8h, get immersion; After adding the mature vinegar immersion 1.8h of a times amount again, get immersion; Merge twice immersion, heating evaporation is the thick paste of relative density 1.24 under 50 DEG C of environment, for subsequent use;
(6), after the thick paste mix homogeneously obtained in Radix Evodiae Leptae fine powder, step (3)-(4), after being added to xylitol, low-substituted hydroxypropyl cellulose and aspartame, conventionally pill is made.
Usage and dosage: oral.A 3-5g, 3 times on the one.
Embodiment 5
Treat a Chinese medicine preparation for sciatica, be made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 40 parts, Herba Macleayae Cordatae 40 parts, Radix sacchari arundinacei 40 parts, Radix Angelicae Pubescentis 30 parts, Fructus Psoraleae 20 parts, Rhizoma Corydalis 20 parts, Caulis et Folium Crotalariae Assamicae 15 parts, Radix Evodiae Leptae 15 parts, Myrrha 12 parts, Folium Perillae 12 parts, Radix Chloranthi Serrati root 10 parts.
The preparation method of the Chinese medicine preparation of described treatment sciatica, concrete steps are as follows:
(1) take each raw material according to weight portion, mixing Caulis fici pumilae (Fructus Fici Pumilae), Herba Macleayae Cordatae, Radix sacchari arundinacei, Radix Angelicae Pubescentis and Fructus Psoraleae, obtain the first medical material group, and mixing Rhizoma Corydalis, Caulis et Folium Crotalariae Assamicae, Myrrha, Radix Chloranthi Serrati root obtain the second medical material group;
(2) Radix Evodiae Leptae is put into pot, fry to surface in coke yellow with slow fire, taking-up cools rear pulverizing and grinds into powder, crosses 120 order fine powders, for subsequent use;
(3) the first medical material group is put into container, add the water of quintuple, after soaking 14h, get immersion; In remaining medicinal residues, add the water of four times amount again, after soaking 8h, get immersion; Merge twice gained immersion, heating evaporation is the thick paste of relative density 1.20 under 60 DEG C of environment, for subsequent use;
(4) the second medical material group is put into container, add the ethanol of four times amount, after soaking 7h, get immersion; In remaining medicinal residues, add the ethanol of triplication again, after soaking 4h, get immersion; Merge the immersion of twice gained, heating evaporation is the thick paste of relative density 1.10 under 60 DEG C of environment, for subsequent use;
(5) Folium Perillae crocus cloth is wrapped put into doubling dose mature vinegar, after soaking 3h, get immersion; After adding the mature vinegar immersion 2h of a times amount again, get immersion; Merge twice immersion, heating evaporation is the thick paste of relative density 1.25 under 50 DEG C of environment, for subsequent use;
(6), after the thick paste mix homogeneously obtained in Radix Evodiae Leptae fine powder, step (3)-(4), after being added to microcrystalline Cellulose, carboxymethyl starch sodium and orange syrup, conventionally granule is made.
Usage and dosage: oral.A 3-5g, 3 times on the one.
Comparative example 1
Treat a Chinese medicine preparation for sciatica, be made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 32 parts, Herba Macleayae Cordatae 32 parts, Radix sacchari arundinacei 25 parts, Radix Angelicae Pubescentis 22 parts, Fructus Psoraleae 12 parts, Rhizoma Corydalis 12 parts, Caulis et Folium Crotalariae Assamicae 8 parts, Myrrha 9 parts, Folium Perillae 9 parts, Radix Chloranthi Serrati root 6 parts.
The preparation method of the Chinese medicine preparation of described treatment sciatica, concrete steps are as follows:
(1) take each raw material according to weight portion, mixing Caulis fici pumilae (Fructus Fici Pumilae), Herba Macleayae Cordatae, Radix sacchari arundinacei, Radix Angelicae Pubescentis and Fructus Psoraleae, obtain the first medical material group, and mixing Rhizoma Corydalis, Caulis et Folium Crotalariae Assamicae, Myrrha, Radix Chloranthi Serrati root obtain the second medical material group;
(2) the first medical material group is put into container, add the water of quintuple, after soaking 12.5h, get immersion; In remaining medicinal residues, add the water of four times amount again, after soaking 6.5h, get immersion; Merge twice gained immersion, heating evaporation is the thick paste of relative density 1.16 under 60 DEG C of environment, for subsequent use;
(3) the second medical material group is put into container, add the ethanol of four times amount, after soaking 5.5h, get immersion; In remaining medicinal residues, add the ethanol of triplication again, after soaking 2.5h, get immersion; Merge the immersion of twice gained, heating evaporation is the thick paste of relative density 1.06 under 60 DEG C of environment, for subsequent use;
(4) Folium Perillae crocus cloth is wrapped put into doubling dose mature vinegar, after soaking 2.2h, get immersion; After adding the mature vinegar immersion 1.2h of a times amount again, get immersion; Merge twice immersion, heating evaporation is the thick paste of relative density 1.21 under 50 DEG C of environment, for subsequent use;
(5), after the thick paste mix homogeneously obtained step (3)-(4), after being added to xylitol, low-substituted hydroxypropyl cellulose and aspartame, conventionally tablet is made.
Usage and dosage: oral.A 3-5g, 3 times on the one.
Comparative example 2
Treat a Chinese medicine preparation for sciatica, be made up of the raw material of following weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 38 parts, Herba Macleayae Cordatae 38 parts, Radix sacchari arundinacei 35 parts, Radix Angelicae Pubescentis 28 parts, Fructus Psoraleae 18 parts, Rhizoma Corydalis 18 parts, Caulis et Folium Crotalariae Assamicae 12 parts, Radix Evodiae Leptae 12 parts, Myrrha 11 parts, Radix Chloranthi Serrati root 9 parts.
The preparation method of the Chinese medicine preparation of described treatment sciatica, concrete steps are as follows:
(1) take each raw material according to weight portion, mixing Caulis fici pumilae (Fructus Fici Pumilae), Herba Macleayae Cordatae, Radix sacchari arundinacei, Radix Angelicae Pubescentis and Fructus Psoraleae, obtain the first medical material group, and mixing Rhizoma Corydalis, Caulis et Folium Crotalariae Assamicae, Myrrha, Radix Chloranthi Serrati root obtain the second medical material group;
(2) Radix Evodiae Leptae is put into pot, fry to surface in coke yellow with slow fire, taking-up cools rear pulverizing and grinds into powder, crosses 120 order fine powders, for subsequent use;
(3) the first medical material group is put into container, add the water of quintuple, after soaking 13.5h, get immersion; In remaining medicinal residues, add the water of four times amount again, after soaking 7.5h, get immersion; Merge twice gained immersion, heating evaporation is the thick paste of relative density 1.19 under 60 DEG C of environment, for subsequent use;
(4) the second medical material group is put into container, add the ethanol of four times amount, after soaking 6.5h, get immersion; In remaining medicinal residues, add the ethanol of triplication again, after soaking 3.5h, get immersion; Merge the immersion of twice gained, heating evaporation is the thick paste of relative density 1.09 under 60 DEG C of environment, for subsequent use;
(5), after the thick paste mix homogeneously obtained in Radix Evodiae Leptae fine powder, step (3)-(4), after being added to xylitol, low-substituted hydroxypropyl cellulose and aspartame, conventionally pill is made.
Usage and dosage: oral.A 3-5g, 3 times on the one.
Embodiment 6
Clinical trial
(1) subjects: adopt the present invention to treat 260 routine patients altogether; The oldest person 54 years old, age reckling 21 years old;
(2) diagnostic criteria: diagnose with reference to " practical traditional Chinese medical science rheumatology ";
1) clinical symptoms feature: be apt to occur in person between twenty and fifty, how acute, subacute and chronic disease; How one-sided lower waist, buttocks morbidity, along sciatic nerve distributed areas conduction radiated pain; The all pressure pain points of common sciatic nerve path are positive; Because standing, walk, bend over, cough, sneeze, defecation are held one's breath etc., and action that abdominal pressure increases makes that the pain increased; Often have special subtract pain posture;
2) the impaired sign of sciatic nerve: buttocks, thigh, Calf muscle tension force decline, of flaccid muscles or slight atrophy; Little leg outer side and the instep pain sensation, hypopselaphesia or disappearance, or other sciatic nerves domination region paraesthesia; Ankle, toe reflex weaken or disappear;
3) straight-leg raising test is with reinforcement test, La Saigezheng, popliteal nest nerve compression test, straight lower limb cross matching, sciatic stretch test, pressure measurement by compression of neck is levied, neck sign is levied, pelvis separation test positive;
4) etiological diagnosis clinical characters: prolapse of lumbar intervertebral disc, lumbar spinal stenosis, intraspinal tumor, sacrum condyle arthritis, sciatic nerve Outlet of The Pelvic Cavity are narrow, pyriformis syndrome.
(3) exclusion standard: Acute onset, pain is limited to sciatic nerve path and distributed areas, be everlasting bend over, excessive heavy burden, after wound of falling, unexpected lumbago is as folding, then pain is radiated rapidly under lateral after patient's buttocks, thigh and shank, when abdominal pressure such as cough sneeze, straining at stool etc. increases, pain all can be made to increase the weight of, the straight-leg raising test positive, Lase&2&gue sign are positive.
(4) Therapeutic Method: 260 routine patients are equally divided into five groups, often group man 28 example, female 24 example, one group, two groups and three groups are test group, one group, two groups and three components do not take the Chinese medicine preparation of the treatment sciatica of the present invention that embodiment 1-embodiment 3 prepares, four groups and five groups is matched group, and four groups and the five groups Chinese medicine preparation taken comparative example 1 and comparative example 2 respectively and prepare, using method is oral.A 3-5g, 3 times on the one 1 week is a course for the treatment of.
(5) standard for the treatment of is with reference to the standard envisages in Ministry of Public Health " new Chinese medicine guideline of clinical investigations ".
Cure: symptom and sign disappears completely, play the functional activities such as crouching, walking normal, routine work is lived all without impact, Negative straight-leg raising test.
Effective: symptom and sign is clearly better, play the functional activities such as crouching, walking normal, routine work life is unaffected, and the straight-leg raising test positive is not obvious.
Effective: symptom and sign takes a turn for the better, play the functional activities such as crouching, walking slightly limited, have impact to routine work life.
Invalid: symptom and sign is without being clearly better or self termination treatment.
(6) therapeutic outcome: how to take effect after a week after taking medicine in the routine case of patient 260,2-3 the course for the treatment of cures; Wherein cure 99 examples, effective 61 examples, effective 61 examples, invalid 39, total effective rate reaches 85%, and therapeutic outcome is as shown in table 1:
Table 1: clinical trial therapeutic outcome
As shown in Table 1, the average effectiveness level adopting the Chinese medicine preparation for the treatment of sciatica of the present invention to carry out treating reaches 96.1%, the effective percentage of the pharmaceutical composition adopting comparative example to prepare only has 68.3%, therefore, between medicine of the present invention, there is synergistic function, add the effective percentage of Chinese medicine preparation.
Model case:
(1) week so-and-so, man, 49 years old, main suit its suffer from sciatica oneself 6 years, on the left of it, pain is radiated to foot downwards by arm, with shank and foot feeling of numbness, when coughing, sneeze time, can make that the pain increased, in order to ease the pain, the normal lateral bending of spinal column, knee slightly bent during bed.Lassitude loin and legs is weak, and muscle arteries and veins has traction contracture sometimes, difficulty of walking: overwork, pain increases the weight of, alleviation of pain time sleeping, when mood is irritated, has night sweat and produce, feel dizzy, tinnitus sometimes, nocturia is more, defecate drier and harder, period once ate ibuprofen and carried out hormone therapy, also repeatedly adopted massage, acupuncture and moxibustion therapy, but all do not fully recover, often recur.Its thready and rapid pulse, the few tongue of red tongue, is diagnosed as deficiency of the liver and kindey pattern of syndrome sciatica.Take the present invention according to the obtained Chinese medicine of embodiment 1, after three days, pain subtract to some extent through, seven days obviously take effect afterwards, and after taking 20 days, the symptom such as pain and other signs all disappears, recovery from illness.Consolidate again and taken a course for the treatment of, follow up a case by regular visits to and do not recur for 1 year.
(2) Zheng, female, 36 years old, conductor, its flank pain 12 years, tired and rain back lumbar part pain is fiercer, by checking the sciatica of examining as prolapse of lumbar intervertebral disc brings out, there is obvious tenderness lumbar spinal column both sides, and sciatic nerve path has many places tenderness; Adopt Chinese medicine preparation of the present invention to treat, after seven days, leg pain disappears, and flank pain alleviates, and continues to take three courses for the treatment of, and sciatica symptom is thoroughly cured, and can normally work; Check after 1 year, without any exception, without recurrence.
(3) section, man, 42 years old.Main suit's right lower extremity pain, from waist buttocks downwards in radioactivity, continues one month.Fear of cold, xerostomia is heavier, dyschesia.Patient takes anti-inflammation analgesic always, but cures the symptoms, not the disease.Lumbar vertebra CT shows: lumbar vertebra hyperosteogeny, waist 3/4,4/5 prolapse of intervertebral disc 4-5 millimeter, haves a medical check-up: right lower extremity straight-leg raising test is positive.Diagnosis: intervertebral disc of lumbar vertebra deviates from disease, lumbar vertebra hyperosteogeny, right sciatic nerves pain.After using a course for the treatment of of Chinese medicine preparation of the present invention, pain is slight, and Working Life recovers normal, then take two the course for the treatment of consolidate curative effect.
(4) Ma, female, 46 years old, be primary sciatica after diagnosing, show as lumbar vertebra abnormal change, pain is had a surplus for 2 years, limitation of activity, morning deadlock, stupid fiber crops, have a dizzy spell, numbness of lower limbs.After taking a course for the treatment of of medicine provided by the present invention, symptom alleviates, then after taking three courses for the treatment of of medicine provided by the present invention, clinical symptom disappearance, without recurrence.
(5) bent certain, man, found before this to walk and motion time, left lower extremity has of short duration pain sometimes, progressively increases the weight of later and develops into and have an intense pain.Pain by waist, buttocks or marrow, downwards on rear side of thigh, little leg outer side and instep diffusion, on the basis of rest pain, what sometimes have a burst of aggravation burns sample, and night is even more serious, can not pitching, to change one's position inconvenience, see its tongue in purple dark-coloured, be diagnosed as sciatica.Period once took health product, and carried out physical therapy, but did not all cure.After take the obtained medicine Chinese medicine preparation of the embodiment of the present invention 3, after seven days, pain obviously alleviates, and after then taking again three courses for the treatment of, its pain symptom disappears completely, patient's freedom of movement, recovery from illness.
The present invention finds that in a large amount of clinical practices it has the effect of significant treatment sciatica, and existing by main effect experiment, details are as follows:
Pharmacodynamics test:
1. the antiinflammatory action of xylol induced mice inflammatory model:
Hydrocortisone has stronger anti-inflammatory activity, be synthetic be also naturally occurring glucocorticoid, after hydrocortisone enters cell, activate cytoplasmic receptor, nucleus is entered after allosteric, be combined with DNA response element, cause suppression or the induction of genetic transcription, the expression of inflammation related proteins is changed.
(1) test method:
50 KM mices, male and female half and half, body weight 25-30 gram, five groups are divided at random, i.e. dosage group in model control group, high dose group of the present invention, the present invention, low dose group of the present invention, positive controls by body weight, often organize 10, each administration group mice gives following medicine respectively:
Model control group: gavage gives the normal saline of same volume;
Positive controls: gavage gives the hydrocortisone drug solution of 5mg/kg;
Compositions high dose group: gavage gives 50mg/kg embodiment 1 Chinese medicine composition Chinese medicine composition by crude drug gauge;
Dosage group in compositions: gavage gives 20mg/kg embodiment 1 Chinese medicine composition, and Chinese medicine composition presses crude drug gauge;
Compositions low dose group: gavage gives 5mg/kg embodiment 1 Chinese medicine composition, and Chinese medicine composition presses crude drug gauge;
Each administration group is administered once every day, successive administration 7d.Get dimethylbenzene 20u1 after last administration, be applied to each mouse right ear.Get after 30 minutes and be respectively evenly applied to mouse right ear respectively by reagent 0.03ml, auris dextra is put to death after 3.5 hours to dimethylbenzene, measures each group of mice left and right ear method of double differences.Ear method of double differences assay method: place cuts two ears along auricle baseline, lays auricle with 8mm card punch at the same position of left and right ear, weighs, and the ear method of double differences=auris dextra sheet weighs a left auricle weight.The ear method of double differences can be used as evaluates antiinflammatory index,
(2) result of the test: antiinflammatory action effect is as shown in table 2.
The antiinflammatory action result of table 2 xylol induced mice of the present invention inflammatory model
Note: compare with model control group, * P<0.05; Compare with model control group, * * P<0.01; Compare with positive controls,
#p<0.05; Compare with positive controls,
##p<0.01.
As shown in Table 2, give positive drug and Chinese medicine composition of the present invention all can obtain significant antiphlogistic effects, wherein the antiphlogistic effects of high dose group of the present invention and positive controls have pole significant difference, low dose group of the present invention and positive controls have significant difference, and this shows that the antiphlogistic effects of high dose group of the present invention and low dose group of the present invention significantly will be better than positive controls.
2. mouse hot-plate analgesic is affected:
(1) mouse hot-plate pain model makes:
About body weight 20g female mice is placed on hot plate dolorimeter, screen qualified male mice 90 (to lick metapedes time <5s or >30s to throw aside, scald for preventing foot, also deadline should be established, be generally 60s), the incubation period of metapedes reaction is added for threshold of pain index with mice, get 70 jennies, be divided into five groups, 14/group, i.e. model control group, cydiodine group, the present invention (obtaining by embodiment 1 formula and preparation technology) low dose group, middle dosage group and high dose group.Each group is gastric infusion, and 1 times/day, dosage is as shown in table 3, and after successive administration 14d, after measuring last medicine, 1h, 2h add the time of foot reaction.
Table 3 the present invention affects result to mouse hot-plate analgesic
Note: compare with model control group, * P<0.05, * * P<0.01.
Sufficient response latency time showing is licked by table 3 small mouse, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than model group (P<0.05) incubation period of high dose group.What illustrate that this Chinese medicine composition of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug cydiodine group (P<0.05) also extends the incubation period that mice adds foot reaction, has certain analgesic activity, but its analgesic effect and model group there was no significant difference.
In the present invention, each crude drug synergism plays and has the high and medication of rapid-action, determined curative effect, safety and simply act on, preparation technology is simple, environmentally friendly, effectively can alleviate the symptom such as waist and leg ache, amyotrophy that sciatica causes, do not have toxic and side effects, the various symptoms caused for clinical remission sciatica provide a newly selection.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, various change can also be made under the prerequisite not departing from this patent aim.
Claims (10)
1. treat the Chinese medicine preparation of sciatica for one kind, it is characterized in that, be made up of the following raw material according to weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 30-40 part, Herba Macleayae Cordatae 30-40 part, Radix sacchari arundinacei 20-40 part, Radix Angelicae Pubescentis 20-30 part, Fructus Psoraleae 10-20 part, Rhizoma Corydalis 10-20 part, Caulis et Folium Crotalariae Assamicae 5-15 part, Radix Evodiae Leptae 5-15 part, Myrrha 8-12 part, Folium Perillae 8-12 part, Radix Chloranthi Serrati root 5-10 part.
2. the Chinese medicine preparation for the treatment of sciatica according to claim 1, it is characterized in that, be made up of the following raw material according to weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 32-38 part, Herba Macleayae Cordatae 32-38 part, Radix sacchari arundinacei 25-35 part, Radix Angelicae Pubescentis 22-28 part, Fructus Psoraleae 12-18 part, Rhizoma Corydalis 12-18 part, Caulis et Folium Crotalariae Assamicae 8-12 part, Radix Evodiae Leptae 8-12 part, Myrrha 9-11 part, Folium Perillae 9-11 part, Radix Chloranthi Serrati root 6-9 part.
3.
rootaccording to the Chinese medicine preparation for the treatment of sciatica according to claim 1, it is characterized in that, be made up of the following raw material according to weight portion: Caulis fici pumilae (Fructus Fici Pumilae) 35 parts, Herba Macleayae Cordatae 35 parts, Radix sacchari arundinacei 30 parts, Radix Angelicae Pubescentis 25 parts, Fructus Psoraleae 15 parts, Rhizoma Corydalis 15 parts, Caulis et Folium Crotalariae Assamicae 10 parts, Radix Evodiae Leptae 10 parts, Myrrha 10 parts, Folium Perillae 10 parts, Radix Chloranthi Serrati root 8 parts.
4. a preparation method for the Chinese medicine preparation of the treatment sciatica as described in as arbitrary in claim 1-2, it is characterized in that, concrete steps are as follows:
(1) take each raw material according to weight portion, mixing Caulis fici pumilae (Fructus Fici Pumilae), Herba Macleayae Cordatae, Radix sacchari arundinacei, Radix Angelicae Pubescentis and Fructus Psoraleae, obtain the first medical material group, and mixing Rhizoma Corydalis, Caulis et Folium Crotalariae Assamicae, Myrrha, Radix Chloranthi Serrati root obtain the second medical material group;
(2) Radix Evodiae Leptae is put into pot, fry to surface in coke yellow with slow fire, taking-up cools rear pulverizing and grinds into powder, crosses 120 order fine powders, for subsequent use;
(3) the first medical material group is put into container, add the water of quintuple, after soaking 12-14h, get immersion; In remaining medicinal residues, add the water of four times amount again, after soaking 6-8h, get immersion; Merge twice gained immersion, heating evaporation is the thick paste of relative density 1.15-1.20 under 60 DEG C of environment, for subsequent use;
(4) the second medical material group is put into container, add the ethanol of four times amount, after soaking 5-7h, get immersion; In remaining medicinal residues, add the ethanol of triplication again, after soaking 2-4h, get immersion; Merge the immersion of twice gained, heating evaporation is the thick paste of relative density 1.05-1.10 under 60 DEG C of environment, for subsequent use;
(5) Folium Perillae crocus cloth is wrapped put into doubling dose mature vinegar, after soaking 2-3h, get immersion; After adding the mature vinegar immersion 1-2h of a times amount again, get immersion; Merge twice immersion, heating evaporation is the thick paste of relative density 1.20-1.25 under 50 DEG C of environment, for subsequent use;
(6), after the thick paste mix homogeneously obtained in Radix Evodiae Leptae fine powder, step (3)-(4), various required dosage form after absorb fillers, disintegrating agent and correctives, is conventionally made.
5. the preparation method of the Chinese medicine preparation for the treatment of sciatica according to claim 4, is characterized in that, described filler is one or more in xylitol, microcrystalline Cellulose, dextrin.
6. the preparation method of the Chinese medicine preparation for the treatment of sciatica according to claim 4, is characterized in that, described disintegrating agent is carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose.
7. the preparation method of the Chinese medicine preparation for the treatment of sciatica according to claim 6, is characterized in that, described disintegrating agent is carboxymethyl starch sodium.
8. the preparation method of the Chinese medicine preparation for the treatment of sciatica according to claim 4, is characterized in that, described correctives is orange syrup or aspartame.
9. the preparation method of the Chinese medicine preparation for the treatment of sciatica according to claim 4, is characterized in that, described dosage form is capsule, tablet, oral liquid, pill, powder or granule.
10. one kind as arbitrary in claim 1-2 as described in the application of Chinese medicine preparation in preparation treatment sciatica medicine.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940817A (en) * | 2012-12-12 | 2013-02-27 | 黄韶华 | Pill for treating sciatica |
| CN103751626A (en) * | 2014-02-19 | 2014-04-30 | 王海霞 | Traditional Chinese medicine preparation for treating sciatica and preparation method |
| CN104958416A (en) * | 2015-07-28 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | Chinese medicinal preparation for treating sciatica and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940817A (en) * | 2012-12-12 | 2013-02-27 | 黄韶华 | Pill for treating sciatica |
| CN103751626A (en) * | 2014-02-19 | 2014-04-30 | 王海霞 | Traditional Chinese medicine preparation for treating sciatica and preparation method |
| CN104958416A (en) * | 2015-07-28 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | Chinese medicinal preparation for treating sciatica and preparation method thereof |
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