CN105341684A - Folium mori fine dried noodles capable of decreasing blood sugar and preparation method thereof - Google Patents
Folium mori fine dried noodles capable of decreasing blood sugar and preparation method thereof Download PDFInfo
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- 241000209219 Hordeum Species 0.000 claims abstract description 16
- 235000007340 Hordeum vulgare Nutrition 0.000 claims abstract description 16
- 229930013930 alkaloid Natural products 0.000 claims abstract description 15
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- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 abstract description 2
- 229920002498 Beta-glucan Polymers 0.000 abstract description 2
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 2
- 230000002929 anti-fatigue Effects 0.000 description 2
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- 229920002678 cellulose Polymers 0.000 description 2
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- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses folium mori fine dried noodles capable of decreasing blood sugar and belongs to the technical field of food processing. The folium mori fine dried noodles are prepared from, by weight, 0.1-1% of folium mori extract and 99-99.9% of barley flour, wherein the folium mori extract comprises folium mori flavone element extract, folium mori alkaloid compound extract and folium mori polysaccharide extract. The invention further discloses a preparation method of the folium mori fine dried noodles. According to the folium mori fine dried noodles capable of decreasing blood sugar, after the folium mori fine dried noodles are prepared ready, the health care effects of decreasing blood sugar, lowering the blood pressure, reducing blood fat, resisting to fatigue and the like are achieved, and the noodles are extremely good in mouthfeel and convenient to eat; according to the method for preparing the folium mori fine dried noodles, the folium mori extract is directly added to the barley flour, the content of effective constituents in the fine dried noodles is raised, the effective constituents are directly absorbed and utilized by the human body, viscosity of chyme can be increased by beta-glucan in barley, time of the human body for absorbing the effective constituents is prolonged, thereby the drug absorption status is improved, and the drug absorption and utilization rate is greatly raised.
Description
Technical field
The invention belongs to food processing technology field, be specifically related to mulberry leaf dried noodles with function of blood sugar reduction and preparation method thereof.
Background technology
Mulberry leaf have long history in the application of China, and Shennong's Herbal claims mulberry leaf to be " mulberry leaf ", has nourishing yin and supplementing blood, dispelling wind and heat from the body, beneficial liver ventilation, effect of antihypertensive diuretic.Compendium of Material Medica is recorded mulberry leaf and can only be quenched one's thirst (diabetes being equivalent to modern medicine), the effects such as antihypertensive diuretic.Modern study to show in mulberry leaf containing abundant amino acid, cellulose, vitamin, mineral matter and several physiological active substances, the various health care functions such as have hypoglycemic, hypotensive, reducing blood lipid, delay senility.Mulberry leaf are medicine and food raw materials of Ministry of Public Health's approval, have high nutrition and health value.
The metabolic disease of diabetes (diabetesmellitus, DM) to be one group with hyperglycaemia be feature.Whole world number of the infected about has 3.82 hundred million, and China about has 9,800 ten thousand people to suffer from diabetes, accounts for 1/4th of global number of patients, and the onset diabetes rate of China presents ascendant trend.At present, but the very high diagnosis and treatment rate of China's onset diabetes rate is very low.For a long time, dietary factor is considered to there is relation with diabetes always, develops to have to control the expectation that metabolism of blood glucose functional food is numerous diabetic.
Barley (HordeumvulgareL.), another name tries to gain wheat, meal wheat, barebacked wheat, be similar to, but content of cellulose is slightly high with the nutritional labeling of wheat, extensive in the plantation of China's scope." not Lu ": " mainly to quench one's thirst, heat extraction, beneficial gas, in tune ".Barley food therapy value is huge, is mainly used in weakness of the spleen and the stomach, and dyspepsia is full, it is vexed to rise; Dysphoria with smothery sensation is thirsty; Difficult urination.Also can be used for gastroduodenal ulcer, chronic gastritis etc.
Summary of the invention
Goal of the invention: the invention provides the mulberry leaf dried noodles with function of blood sugar reduction, this mulberry leaf dried noodles has the health-care efficacies such as hypoglycemic, hypotensive, reducing blood lipid, antifatigue after making, and excellent taste, instant edible; The invention also discloses the preparation method of this mulberry leaf dried noodles.
Technical scheme: for achieving the above object, the present invention adopts following technical scheme:
Have the mulberry leaf dried noodles of function of blood sugar reduction, it is obtained by the raw material of following percentage by weight: mulberry-leaf extract 0.1-1% and barley flour 99-99.9%.
Described mulberry-leaf extract comprises flavones in mulberry leaves component extract, Folium Mori alkaloid compounds extract and mulberry leaf polysaccharide class extract.
The method with the mulberry leaf dried noodles of function of blood sugar reduction described in preparation, comprises the following steps:
1) Mulberry Leaf is prepared for subsequent use;
2) flavones in mulberry leaves component extract is prepared
Adopt supercritical CO
2abstraction technique extraction flavones in mulberry leaves component extract, extraction temperature is 40-50 DEG C, and extracting pressure is 9-12Mpa, and extraction time is 5-7h, and wherein, Mulberry Leaf and entrainer mass volume ratio are 1:1;
3) mulberry leaf polysaccharide class extract is prepared
Adopt water extraction to extract mulberry leaf polysaccharide class extract, to concentrated after Mulberry Leaf water extraction, add isopyknic absolute ethyl alcohol precipitate polysaccharides, sediment dry for standby, obtain mulberry leaf polysaccharide class extract;
4) Folium Mori alkaloid compounds extract is prepared
By step 3) in after Mulberry Leaf water extraction the concentrated supernatant obtained cationic ion-exchange resin 0.5M ammoniacal liquor wash-out, it is for subsequent use that eluent concentrate drying obtains Folium Mori alkaloid compounds extract;
5) by step 2)-4) the above-mentioned flavones in mulberry leaves component extract, Folium Mori alkaloid compounds extract and the mulberry leaf polysaccharide class extract that obtain be mixed into mulberry-leaf extract, barley flour is mixed according to the ratio that percentage by weight is mulberry-leaf extract 0.1-1% and barley flour 99-99.9% with mulberry-leaf extract, adopt conventional method compacting vermicelli, packaging can obtain the mulberry leaf dried noodles with function of blood sugar reduction.
Step 1) in, preparing mulberry leaf powder is select eugonic complete great Ye in August, and remove pollutant and dry rear pulverizing, cross 80 mesh sieves, sterilization treatment is for subsequent use.
Step 2) in, entrainer is the ethanol of concentration 80%.
Wherein, step 2) and step 3) in prepare the Mulberry Leaf of flavones in mulberry leaves component extract and to prepare the Mulberry Leaf quality of mulberry leaf polysaccharide class extract equal.
Beneficial effect: compared with prior art, the mulberry leaf dried noodles with function of blood sugar reduction of the present invention, this mulberry leaf dried noodles has the health-care efficacies such as hypoglycemic, hypotensive, reducing blood lipid, antifatigue after making, and excellent taste, instant edible; The method of this mulberry leaf dried noodles of preparation of the present invention directly adds mulberry-leaf extract by adopting in barley flour, improve the content of active ingredient in vermicelli, body directly absorbs active ingredient, beta glucan in barley can make the viscosity of chyme increase, increase the time that body absorbs active ingredient, thus improve drug absorption situation, drug absorption utilization rate is improved greatly.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1
Eugonic complete great Ye, removed pollutant and dried rear pulverizing preferred August, and mistake 80 mesh sieves, sterilization treatment is for subsequent use.Accurately take 1kg Mulberry Leaf, supercritical CO
2extraction is 45 DEG C according to extraction temperature, and extracting pressure is 10Mpa, and extraction time is 6h, and entrainer and Mulberry Leaf ratio are 1:1, with 80% ethanol for entrainer.
Experimental result is: mulberry leaf extract yield is 0.0815%.In mulberry leaf extract, general flavone content reaches 48.3%.Mulberry Leaf 1kg, concentrated after adopting water extraction, add 95% ethanol and make content reach 50% precipitate polysaccharides, sediment dry for standby.0.5M ammoniacal liquor wash-out after resin cation purifying crossed by supernatant, and it is for subsequent use that eluent concentrate drying obtains alkaloid position.Above-mentioned flavone extract, polysaccharide extract and alkaloids extract are mixed into mulberry-leaf extract 29.165g
Embodiment 2
Eugonic complete great Ye, removed pollutant and dried rear pulverizing preferred August, and mistake 80 mesh sieves, sterilization treatment is for subsequent use.Accurately take 1kg Mulberry Leaf, supercritical CO
2extraction is 40 DEG C according to extraction temperature, and extracting pressure is 9Mpa, and extraction time is 5h, and entrainer and Mulberry Leaf ratio are 1:1, with 80% ethanol for entrainer.
Experimental result is: mulberry leaf extract yield is 0.074%.In mulberry leaf extract, general flavone content reaches 43.5%.Mulberry Leaf 1kg, concentrated after adopting water extraction, add 95% ethanol and make content reach 50% precipitate polysaccharides, sediment dry for standby.0.5M ammoniacal liquor wash-out after resin cation purifying crossed by supernatant, and it is for subsequent use that eluent concentrate drying obtains alkaloid position.Above-mentioned flavone extract, polysaccharide extract and alkaloids extract are mixed into mulberry-leaf extract 28.415g
Embodiment 3
Eugonic complete great Ye, removed pollutant and dried rear pulverizing preferred August, and mistake 80 mesh sieves, sterilization treatment is for subsequent use.Accurately take 1kg Mulberry Leaf, supercritical CO
2extraction is 50 DEG C according to extraction temperature, and extracting pressure is 12Mpa, and extraction time is 7h, and entrainer and Mulberry Leaf ratio are 1:1, with 80% ethanol for entrainer.
Experimental result is: mulberry leaf extract yield is 0.077%.In mulberry leaf extract, general flavone content reaches 45.7%.Mulberry Leaf 1kg, concentrated after adopting water extraction, add 95% ethanol and make content reach 50% precipitate polysaccharides, sediment dry for standby.0.5M ammoniacal liquor wash-out after resin cation purifying crossed by supernatant, and it is for subsequent use that eluent concentrate drying obtains alkaloid position.Above-mentioned flavone extract, polysaccharide extract and alkaloids extract are mixed into mulberry-leaf extract 28.715g
Proportionally (mulberry leaf mixture is respectively 5g, 25g, 50g, and barley flour is respectively 4995g, 4975g, 4950g, and it is 0.1%, 0.5%, 1% that mulberry leaf mixture accounts for sum-rate will to choose high-quality barley flour and mulberry-leaf extract.) mix, conventionally suppress vermicelli after the assay was approved, packaging can obtain the mulberry leaf dried noodles of function of blood sugar reduction.
Embodiment 4
Reagent and material: four oxygen crash smack one's lips, the U.S. produces blood sugar test paper, the steady prompt type blood sugar test paper of Johnson & Johnson of the U.S., and U.S.'s work is produced.Barley flour, country people shop, Shandong, Jinan, Shandong Province.Common wheat powder, south of the River flour mill of Jiangsu Danyang City produces.Mulberry leaf dried noodles, laboratory is made by oneself.
The foundation of diabetes (DM) mouse model: select healthy qualified Kunming small white mouse 100, about 8 weeks, body weight (20 ± 2) g, point cage, mark, weigh.After fasting 12h, alloxan 0.9%NaCl solution preparation becomes the solution of 1%, presses the dosage intraperitoneal injection of mice of 200mg/kg every day, continuous two days.After 3 days, tail point gets hematometry fasting blood-glucose, with blood glucose value on 12.00mmol/L, and there is many foods, many drinks, diuresis symptom continuously, be defined as diabetic mice.This time modeling altogether 84 qualified diabetic mices.
Grouping and process: be divided into 9 groups, Normal group 10, model control group 10, intact animal administration group 10, mulberry leaf dried noodles low dose group (100mg/kg) 10, middle dosage group (500mg/kg) 10, high dose group (1000mg/kg) 10, mulberry leaf wheat flour low dose group (100mg/kg) 10, middle dosage group (500mg/kg) 10, high dose group (1000mg/kg) 10.Mulberry leaf dried noodles is used grinder mill powdered, the wheat flour of purchase and mulberry-leaf extract are proportionally mixed into reference substance, mulberry leaf dried noodles and reference substance distilled water are configured to respectively the solution of 500mg/L.Normal group and model control group give isopyknic distilled water gavage.Intact animal administration group gives 500mg/kg mulberry leaf dried noodles.Mulberry leaf dried noodles low dose group 100mg/kg (0.1%), middle dosage group 500mg/kg (0.5%), high dose group 1000mg/kg (1%), mulberry leaf wheat flour low dose group 100mg/kg (0.1%), middle dosage group 500mg/kg (0.5%), high dose group 1000mg/kg (1%) gastric infusion, successive administration one week, measure fasting blood sugar, and calculate blood sugar inhibiting rate.
Result of the test is as shown in table 1, and as can be seen from Table 1, mulberry leaf dried noodles has significant hypoglycemic activity compared with Normal group, and along with the increase of dosage, hypoglycemic activity obviously increases.Mulberry leaf dried noodles compared with mulberry leaf wheat flour mixture, the hypoglycemic activity a little higher than mulberry leaf wheat flour blood sugar reducing function of mulberry leaf dried noodles group.Table 1 mulberry leaf dried noodles is to the hypoglycemic activity of diabetic mice
Claims (6)
1. there is the mulberry leaf dried noodles of function of blood sugar reduction, it is characterized in that: it is obtained by the raw material of following percentage by weight: mulberry-leaf extract 0.1-1% and barley flour 99-99.9%.
2. the mulberry leaf dried noodles with function of blood sugar reduction according to claim 1, is characterized in that: described mulberry-leaf extract comprises flavones in mulberry leaves component extract, Folium Mori alkaloid compounds extract and mulberry leaf polysaccharide class extract.
3. prepare the method with the mulberry leaf dried noodles of function of blood sugar reduction described in claim 1, it is characterized in that: comprise the following steps:
1) Mulberry Leaf is prepared for subsequent use;
2) flavones in mulberry leaves component extract is prepared
Adopt supercritical CO
2abstraction technique extraction flavones in mulberry leaves component extract, extraction temperature is 40-50 DEG C, and extracting pressure is 9-12Mpa, and extraction time is 5-7h, and wherein, Mulberry Leaf and entrainer mass volume ratio are 1:1;
3) mulberry leaf polysaccharide class extract is prepared
Adopt water extraction to extract mulberry leaf polysaccharide class extract, to concentrated after Mulberry Leaf water extraction, add isopyknic absolute ethyl alcohol precipitate polysaccharides, sediment dry for standby, obtain mulberry leaf polysaccharide class extract;
4) Folium Mori alkaloid compounds extract is prepared
By the supernatant obtained concentrated after Mulberry Leaf water extraction in step 3) cationic ion-exchange resin 0.5M ammoniacal liquor wash-out, it is for subsequent use that eluent concentrate drying obtains Folium Mori alkaloid compounds extract;
5) by step 2)-4) the above-mentioned flavones in mulberry leaves component extract, Folium Mori alkaloid compounds extract and the mulberry leaf polysaccharide class extract that obtain be mixed into mulberry-leaf extract, barley flour is mixed according to the ratio that percentage by weight is mulberry-leaf extract 0.5-10% and barley flour 99.5-90% with mulberry-leaf extract, adopt conventional method compacting vermicelli, packaging can obtain the mulberry leaf dried noodles with function of blood sugar reduction.
4. the preparation method with the mulberry leaf dried noodles of function of blood sugar reduction according to claim 3, it is characterized in that: in step 1), preparing mulberry leaf powder is select eugonic complete great Ye in August, removes pollutant and dries rear pulverizing, cross 80 mesh sieves, sterilization treatment is for subsequent use.
5. the preparation method with the mulberry leaf dried noodles of function of blood sugar reduction according to claim 3, is characterized in that: step 2) in, entrainer is the ethanol of concentration 80%.
6. the preparation method with the mulberry leaf dried noodles of function of blood sugar reduction according to claim 3, it is characterized in that: wherein, step 2) and step 3) in prepare the Mulberry Leaf of flavones in mulberry leaves component extract and to prepare the Mulberry Leaf quality of mulberry leaf polysaccharide class extract equal.
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| CN201510896695.0A CN105341684A (en) | 2015-12-08 | 2015-12-08 | Folium mori fine dried noodles capable of decreasing blood sugar and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105962071A (en) * | 2016-04-29 | 2016-09-28 | 安徽恋尚你食品有限公司 | Fast noodles made from freeze-dried horseradish tree leaves and making method |
| CN107439946A (en) * | 2017-09-20 | 2017-12-08 | 南昌大学 | A kind of mulberry leaf noodles for reducing uric acid |
-
2015
- 2015-12-08 CN CN201510896695.0A patent/CN105341684A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105962071A (en) * | 2016-04-29 | 2016-09-28 | 安徽恋尚你食品有限公司 | Fast noodles made from freeze-dried horseradish tree leaves and making method |
| CN107439946A (en) * | 2017-09-20 | 2017-12-08 | 南昌大学 | A kind of mulberry leaf noodles for reducing uric acid |
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