CN105338996A - α胸腺肽用于脓毒症治疗的用途 - Google Patents

α胸腺肽用于脓毒症治疗的用途 Download PDF

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Publication number
CN105338996A
CN105338996A CN201380028974.4A CN201380028974A CN105338996A CN 105338996 A CN105338996 A CN 105338996A CN 201380028974 A CN201380028974 A CN 201380028974A CN 105338996 A CN105338996 A CN 105338996A
Authority
CN
China
Prior art keywords
sepsis
administered
days
alpha thymosin
thymosin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380028974.4A
Other languages
English (en)
Chinese (zh)
Inventor
管向东
吴健锋
C·塔特希尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
First Affiliated Hospital of Sun Yat Sen University
Sciclone Pharmaceuticals LLC
Original Assignee
First Affiliated Hospital of Sun Yat Sen University
Sciclone Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by First Affiliated Hospital of Sun Yat Sen University, Sciclone Pharmaceuticals LLC filed Critical First Affiliated Hospital of Sun Yat Sen University
Priority to CN201710735183.5A priority Critical patent/CN107519483A/zh
Publication of CN105338996A publication Critical patent/CN105338996A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380028974.4A 2012-03-30 2013-03-28 α胸腺肽用于脓毒症治疗的用途 Pending CN105338996A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710735183.5A CN107519483A (zh) 2012-03-30 2013-03-28 α胸腺肽用于脓毒症治疗的用途

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261618563P 2012-03-30 2012-03-30
US61/618,563 2012-03-30
US201261643824P 2012-05-07 2012-05-07
US61/643,824 2012-05-07
US13/835,107 2013-03-15
US13/835,107 US20130296223A1 (en) 2012-03-30 2013-03-15 Use of thymosin alpha for the treatment of sepsis
PCT/US2013/034394 WO2013149030A2 (en) 2012-03-30 2013-03-28 Use of thymosin alpha for the treatment of sepsis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710735183.5A Division CN107519483A (zh) 2012-03-30 2013-03-28 α胸腺肽用于脓毒症治疗的用途

Publications (1)

Publication Number Publication Date
CN105338996A true CN105338996A (zh) 2016-02-17

Family

ID=49261395

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201710735183.5A Pending CN107519483A (zh) 2012-03-30 2013-03-28 α胸腺肽用于脓毒症治疗的用途
CN201380028974.4A Pending CN105338996A (zh) 2012-03-30 2013-03-28 α胸腺肽用于脓毒症治疗的用途

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201710735183.5A Pending CN107519483A (zh) 2012-03-30 2013-03-28 α胸腺肽用于脓毒症治疗的用途

Country Status (8)

Country Link
US (5) US20130296223A1 (enExample)
EP (2) EP3741386A1 (enExample)
JP (6) JP2015514093A (enExample)
KR (1) KR20150048663A (enExample)
CN (2) CN107519483A (enExample)
CA (1) CA2866435A1 (enExample)
HK (1) HK1246694A1 (enExample)
WO (1) WO2013149030A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3180620B1 (en) * 2014-08-12 2020-01-01 X4 Pharmaceuticals (Austria) GmbH Predicting s. aureus disease
WO2019028448A1 (en) * 2017-08-04 2019-02-07 The Johns Hopkins University APPLICATION FOR EARLY PREDICTION OF SEPTIC SHOCK WAITING
US11504071B2 (en) * 2018-04-10 2022-11-22 Hill-Rom Services, Inc. Patient risk assessment based on data from multiple sources in a healthcare facility
PL3781210T3 (pl) * 2018-04-20 2024-11-12 Combioxin Sa Leczenie niedociśnienia w przypadku sepsy lub wstrząsu septycznego
US20240293424A1 (en) 2021-07-12 2024-09-05 2N Pharma Aps Carnitine-palmitoyl-transferase-1 (cpt-1) inhibitors for use in a method of preventing or treating sepsis in a mammalian subject

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009647A1 (en) * 1993-10-07 1995-04-13 The George Washington University Medical Center METHOD OF TREATING SEPTIC SHOCK USING THYMOSIN-α¿1?
CN101020048A (zh) * 2007-02-12 2007-08-22 广东天普生化医药股份有限公司 一种用于治疗脓毒症的药物组合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4079127A (en) 1976-10-28 1978-03-14 Board Of Regents Of The University Of Texas Thymosin alpha 1
TW252045B (enExample) * 1993-10-07 1995-07-21 Allan L Goldstein
US5972933A (en) * 1998-01-08 1999-10-26 Ed. Geistlich Sohne Ag Fur Chemische Industrie Method of treating microbial infections
UA80957C2 (en) 2001-11-01 2007-11-26 Sciclone Pharmaceuticals Inc Method of administering a thymosin alpha 1 peptide
BR0316646A (pt) * 2002-11-25 2005-10-11 Sciclone Pharmaceuticals Inc Método de proteção contra os danos causados pela radiação utilizando timosina alfa
EP1928410A2 (en) * 2005-09-29 2008-06-11 Nektar Therapeutics Antibiotic formulations, unit doses, kits, and methods
WO2008115951A1 (en) * 2007-03-21 2008-09-25 Bausch & Lomb Incorporated Fluoroquinolones for treating, reducing, ameliorating, or preventing infections caused by antibacterial drug-resistant bacteria
AU2008335840A1 (en) * 2007-12-12 2009-06-18 Sciclone Pharmaceuticals, Inc. Treatment of melanoma with alpha thymosin peptides in combination with antibodies against cytotoxic T lymphocyte-associated antigen 4 (CTLA4)
CN101514228A (zh) * 2008-02-21 2009-08-26 张卓兵 N-端修饰的人胸腺肽α1复合物及其制备方法
US8716012B2 (en) * 2009-05-08 2014-05-06 Sciclone Pharmaceuticals, Inc. Alpha thymosin peptides as vaccine enhancers
JP2013520475A (ja) * 2010-02-25 2013-06-06 アゲンニックス・アーゲー 重症敗血症の治療における経口ラクトフェリン
EP2675272A4 (en) * 2011-02-09 2015-03-11 Sciclone Pharmaceuticals Inc THYMOSINE ALPHA PEPTIDE FOR THE PREVENTION, TREATMENT AND TREATMENT OF INFECTIONS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009647A1 (en) * 1993-10-07 1995-04-13 The George Washington University Medical Center METHOD OF TREATING SEPTIC SHOCK USING THYMOSIN-α¿1?
CN101020048A (zh) * 2007-02-12 2007-08-22 广东天普生化医药股份有限公司 一种用于治疗脓毒症的药物组合物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
SUN YAT-SEN UNIVERSITY: "Efficacy of Thymosin alpha1 for Severe Sepsis (ETASS) NCT00711620", 《HTTPS://CLINICALTRIALS.GOV/CT2/SHOW/NCT00711620》 *
吴建浓等: "胸腺肽α1 对严重脓毒症患者的免疫调理作用", 《中国急救医学》 *
程爱斌等: "胸腺肽α1对严重脓毒症患者细胞免疫功能的影响", 《江苏医药》 *
陈小莉等: "胸腺肽α1对脓毒症患者T细胞亚群的影响", 《中国实用医药》 *

Also Published As

Publication number Publication date
JP2015514093A (ja) 2015-05-18
EP2841088A4 (en) 2015-10-14
US20130296223A1 (en) 2013-11-07
JP2022176345A (ja) 2022-11-25
US20210106656A1 (en) 2021-04-15
HK1207314A1 (en) 2016-01-29
CA2866435A1 (en) 2013-10-03
US20150024994A1 (en) 2015-01-22
JP2019156854A (ja) 2019-09-19
CN107519483A (zh) 2017-12-29
KR20150048663A (ko) 2015-05-07
EP2841088B1 (en) 2020-06-17
WO2013149030A2 (en) 2013-10-03
JP2017214377A (ja) 2017-12-07
JP2025107346A (ja) 2025-07-17
EP3741386A1 (en) 2020-11-25
US20180236036A1 (en) 2018-08-23
JP2021100983A (ja) 2021-07-08
HK1246694A1 (zh) 2018-09-14
EP2841088A2 (en) 2015-03-04
US20240091314A1 (en) 2024-03-21

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Application publication date: 20160217

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