CN105327330B - A kind of composition and preparation method thereof with antihypertensive effect - Google Patents
A kind of composition and preparation method thereof with antihypertensive effect Download PDFInfo
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- CN105327330B CN105327330B CN201510884909.2A CN201510884909A CN105327330B CN 105327330 B CN105327330 B CN 105327330B CN 201510884909 A CN201510884909 A CN 201510884909A CN 105327330 B CN105327330 B CN 105327330B
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- kudzu root
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- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of composition and preparation method thereof with antihypertensive effect, the composition is made of corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract, corn peptide 40-60 parts based on its parts by weight, 10-30 parts of dogbane leaf extractive, 20-40 parts of kudzu root extract, 15-45 parts of eucommia leaf extract, are obtained by hybrid mode；The composition utilizes small active peptides --- corn peptide combines the plant extracts of " integration of drinking and medicinal herbs ", each component synergistic effect, Nantural non-toxic, it is without side-effects while, there is apparent decompression, antioxidation；Preparation method is simple, is suitble to the demand of scale industrial production.
Description
Technical field
The present invention relates to a kind of composition and preparation method thereof, especially a kind of composition and its system with antihypertensive effect
Preparation Method.
Background technique
Hypertension is to cause heart failure, apoplexy, coronary heart disease and myocardial infarction principal element.Coronary heart disease is dead in the world
One of highest disease of rate.The balance of vasotonia system (RAS) adjustable blood pressure and blood flow plays in treatment coronary heart disease
Critically important effect.Angiotensin I intravascular angiotensin-converting enzyme (ACE) is sheared the amino acid residue of the end C- two and is formed
Angiotensin II, and then the synthesis of intense stimulus adrenal cortex glomerular zone cell and release aldosterone, it is rear to promote renal tubule pair
Na+Reabsorption, and then increase blood pressure.Angiotensin converting enzyme is distributed widely in each histoorgan of mammal,
It is mainly pulmonary capillary endothelial cells and the cell of other several types, such as digestive epithelium cell, neuro-epithelial cell etc..
Angiotensin converting enzyme (ACE) is a kind of multi-functional dipeptidyl carboxypeptidase, and can degrade bradykinin, is allowed to inactivate, and utilizes and swash
Peptide release enzyme-kinin system (KKS) reaches hypotensive activity.Ace inhibitory peptide is widely used in treating hypertension.Ace inhibitory peptide
By hindering conversion of the RAS system Angiotensin-Converting I to Angiotensin II, so that the strong contraction of anti-hemostatic tube, reaches
The effect to reduce blood pressure.Compared with chemically synthesized drug, since food-borne ace inhibitory peptide is from a wealth of sources, produce it is safer at
This is lower.Therefore it possesses the potentiality of powerful substitution synthetic drug.
Summary of the invention
Technical problem to be solved by the present invention lies in provide a kind of composition with antihypertensive effect.
Another technical problem to be solved by this invention is to provide the preparation side of the above-mentioned composition with antihypertensive effect
Method.
In order to solve the above technical problems, the technical scheme is that
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Take object to form, corn peptide 40-60 parts based on its parts by weight, 10-30 parts of dogbane leaf extractive, 20-40 parts of kudzu root extract,
15-45 parts of eucommia leaf extract.
Preferably, the above-mentioned composition with antihypertensive effect, 55 parts of corn peptide, Folium Apocyni Veneti extract based on its parts by weight
15 parts of object, 35 parts of kudzu root extract, 30 parts of eucommia leaf extract.
Preferably, the above-mentioned composition with antihypertensive effect, the dogbane leaf extractive are Folium Apocyni Veneti water extract.
Preferably, the above-mentioned composition with antihypertensive effect, the kudzu root extract are pueraria lobata alcohol extract.
Preferably, the above-mentioned composition with antihypertensive effect, the eucommia leaf extract are Cortex Eucommiae alcohol extracts from the leaves.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Above-mentioned preparation method resulting composition is irradiated sterilizing 1-2 days, with 0.5g/ filling capsules, plastic packaging of bottling, and inspection
It tests, finished product, storage, as finished product.In use process, usage amount is 1-2/day.
Beneficial effects of the present invention:
The above-mentioned composition with antihypertensive effect, utilizes small active peptides --- and corn peptide combines the plant of " integration of drinking and medicinal herbs "
Object extract, each component synergistic effect, Nantural non-toxic, it is without side-effects while, there is apparent decompression, antioxidation；Its
Preparation method is simple, is suitble to the demand of scale industrial production.
Specific embodiment
Technical solution of the present invention is further described combined with specific embodiments below.
Embodiment 1
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 55g, dogbane leaf extractive 15g, kudzu root extract 35g, eucommia leaf extract 30g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Embodiment 2
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 40g, dogbane leaf extractive 10g, kudzu root extract 20g, eucommia leaf extract 15g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Embodiment 3
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 40g, dogbane leaf extractive 20g, kudzu root extract 30g, eucommia leaf extract 30g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Embodiment 4
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 40g, dogbane leaf extractive 30g, kudzu root extract 40g, eucommia leaf extract 45g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Embodiment 5
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 50g, dogbane leaf extractive 10g, kudzu root extract 30g, eucommia leaf extract 45g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Embodiment 6
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 50g, dogbane leaf extractive 20g, kudzu root extract 40g, eucommia leaf extract 15g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Embodiment 7
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 50g, dogbane leaf extractive 30g, kudzu root extract 20g, eucommia leaf extract 30g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Embodiment 8
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 60g, dogbane leaf extractive 10g, kudzu root extract 40g, eucommia leaf extract 30g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Embodiment 9
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 60g, dogbane leaf extractive 20g, kudzu root extract 20g, eucommia leaf extract 45g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Embodiment 10
A kind of composition with antihypertensive effect, is mentioned by corn peptide, dogbane leaf extractive, kudzu root extract and folium cortex eucommiae
Object is taken to form, wherein corn peptide 60g, dogbane leaf extractive 30g, kudzu root extract 30g, eucommia leaf extract 15g.
The preparation method of the above-mentioned composition with antihypertensive effect, specific preparation process is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
Each component is commercial product in the above-mentioned composition with antihypertensive effect, wherein dogbane leaf extractive is sieve
Cloth sesame slices water extract, kudzu root extract are pueraria lobata alcohol extract, and eucommia leaf extract is Cortex Eucommiae alcohol extracts from the leaves.
Each component prescription analysis is as follows:
Corn peptide be using corn protein powder as substrate, it is small with the molecular weight obtained after corresponding protease hydrolytic and have certain
Active peptide molecule.The amino acid composition of corn functional peptides is parallel with zein, and branched-amino acid content is high, is a kind of
High F value peptide, the peptide is small, easy with molecular weight to be absorbed, improves liver function, and alleviating blood aromatic amino acid excessive concentration leads to liver
It goes into a coma, sober up, is antifatigue, is anti-oxidant, blood pressure lowering effect.
Dogbane leaf extractive is significant in efficacy in terms of having decompression, improving the symptoms such as dizziness, palpitaition, insomnia, proves effective fast.
Kudzu root extract can effectively adjust vessel retraction diastolic function, reduce the blood pressure of awake spontaneous hypertension rat and subtract
Slow heart rate inhibits renin-angiotensin system, reduces the content of catecholamine.
Eucommia leaf extract has calmness, analgesia, decompression, strengthen immunity, anti-inflammatory, anti-aging, improves glycometabolism, shadow
The effects of ringing uterine function, by promoting, endothelial cell discharges NO to Cortex Eucommiae alcohol extracts from the leaves and directly activation beta receptor generates diastole blood
Tube effect.
Each component is synergistic, can play significant antihypertensive effect.
Below by way of test example the present invention is further explained the antihypertensive effect with the working composition that reduces blood pressure.
There is 1 present invention of test example the composition of hypotensive activity to make to the blood pressure lowering of essential hypertension (SHR) rat
With
Test method: hypertensive SHR rats, half male and half female, are randomly divided into 4 groups, tested I, II by 60,250-280g
Group, positive drug control group and a model group, every group each 15.Composition described in the tested group of oral embodiment of the present invention 1；Sun
Property drug control group oral nifedipine piece (10mg/ piece)；Model control group takes orally same volume distilled water, once a day, continuous 3
Week.The systolic pressure of weekend measurement rat, each time point are measured 3 times, are averaged weekly after administration.Blood pressure determination after administration
It should start to measure after 2 hours upon administration, measure and complete in 4 hours.Experimental result is as shown in table 1.
Influence of the table 1 to SHR rat blood pressure
Test result shows: 2 various doses of composition (capsule) of the invention can reduce essential hypertension
(SHR) blood pressure of rat, antihypertensive effect is obvious, and after one week of dosing, blood pressure is begun to decline to continuous 3 weekend (P≤0.05).With it is right
Compare according to group, difference has significant meaning.
2 present invention of test example has the clinical observation of the composition antihypertensive effect for the effect that reduces blood pressure
80 subjects are observed, wherein male 40, women 40, average age 48.6 years old.The present invention takes in treatment group
Composition described in embodiment 1 daily once 1 tablet each time (0.5g/), is taken 3 months altogether；Control group is with taking nitre benzene
Plain film, daily a piece of (10mg/ piece).Test result is as shown in table 2.
Blood pressure after table 2 is treated 3 months
Test result shows that taking front and back blood pressure has apparent reduction.The blood pressure of tested crowd improves significantly, and takes
Do not occur significant discomfort symptom afterwards, shows that composition of the present invention has good blood pressure reduction effect, and take period not
See there is adverse reaction, clinical application safety is good.
The above-mentioned detailed description that a kind of composition with antihypertensive effect and preparation method thereof is carried out referring to embodiment,
It is illustrative without being restrictive, several embodiments can be enumerated according to limited range, therefore do not departing from this hair
Change and modification under bright general plotting should belong within protection scope of the present invention.
Claims (3)
1. a kind of composition with antihypertensive effect, it is characterised in that: by corn peptide, dogbane leaf extractive, kudzu root extract
It is formed with eucommia leaf extract, corn peptide 40-60 parts based on its parts by weight, 10-30 parts of dogbane leaf extractive, pueraria lobata extraction
20-40 parts of object, 15-45 parts of eucommia leaf extract, wherein the dogbane leaf extractive is Folium Apocyni Veneti water extract, the Pueraria lobota
Root extract is pueraria lobata alcohol extract, and the eucommia leaf extract is Cortex Eucommiae alcohol extracts from the leaves.
2. the composition according to claim 1 with antihypertensive effect, it is characterised in that: the corn peptide based on its parts by weight
55 parts, 15 parts of dogbane leaf extractive, 35 parts of kudzu root extract, 30 parts of eucommia leaf extract.
3. the preparation method of the composition as claimed in claim 1 or 2 with antihypertensive effect, it is characterised in that: specific preparation step
It is as follows:
(1) weighing corn peptide, dogbane leaf extractive, kudzu root extract and eucommia leaf extract by prescription amount is raw material；
(2) each raw material be added mix mixed in roller to get.
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| CN109876135B (en) * | 2019-04-25 | 2022-09-06 | 陈东良 | Eucommia ulmoides leaf and corn peptide composition capable of reducing blood pressure and blood fat and preparation method thereof |
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