CN105326857B - A kind of tophus resolvent and preparation method thereof - Google Patents
A kind of tophus resolvent and preparation method thereof Download PDFInfo
- Publication number
- CN105326857B CN105326857B CN201510907115.3A CN201510907115A CN105326857B CN 105326857 B CN105326857 B CN 105326857B CN 201510907115 A CN201510907115 A CN 201510907115A CN 105326857 B CN105326857 B CN 105326857B
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- Prior art keywords
- tophus
- resolvent
- sodium dihydrogen
- dihydrogen phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of tophus resolvent, it is made up of the component of content once：0.1~0.2g of sodium dihydrogen phosphate dihydrate, 6~7g of disodium hydrogen phosphate dodecahydrate, ultra-pure water 100ml, each 1000ml of disodium phosphate soln of 0.2mol/L sodium dihydrogen phosphate and 0.2mol/L is prepared respectively, sodium dihydrogen phosphate 5.3ml is chosen by automatical potentiometric titrimeter, both 0.2mol/L disodium phosphate soln 94.7ml are mixed, it is thoroughly mixed, and basifier is added into it, it is 8 to regulate and control pH value by PH test paper, the tophus resolvent that the present invention mentions is easy to use, securely and reliably, on cytoactive without influence, the damage of soft tissue will not be caused.Tophus can be fast and effectively dissolved, operating time can be shortened and improve operative effect, or even can be treated by local injection, avoids performing the operation.
Description
Technical field
The present invention relates to a kind of irrigation, and in particular to a kind of tophus resolvent and preparation method thereof.
Background technology
In the pathogenic process of gout patients, it may appear that a kind of tubercle as hard as flint, it is referred to as " tophus ", also known as gout
Tubercle.This is Monosodium urate crystallization deposition in soft tissue, causes chronic inflammation and tophus that proliferation of fibrous tissue is formed.On pain
The arthritic pathogenesis of wind, many scholars generally believe relevant with polymorphonuclear white blood cell.During gout, synovial tissue and joint
The sodium urate crystals of cartilage release are swallowed by the white blood cell of joint fluid, and white blood cell ruptures again discharges protease and inflammatory factor enters
Enter synovia.Enzyme inflammatory factor makes the leukocytosis in joint, then there is more white blood cell phases for having swallowed urate crystal
Enzyme is discharged after rupture and inflammatory component forms vicious circle, further results in acute synovitis and articular cartilage damage.
Tophus is most commonly in helix, also the Metatarsophalangeal joint of Duo Jian Yu Hallux toes, refer to, wrist, elbow and knee joint etc.,
Sclerotin is invaded in the bone of juxtra-articular.Skeleton deformity is formed, or is damaged sclerotin, it is long to influence joint motion, need to perform the operation
Treatment.But tophus Chang great Liang, infiltrative growth, it is serious with mucous membrane adhesion, and be attached on bone face, such as pursue and thoroughly remove pain
Wind stone, operative treatment are likely to cause the damage of soft tissue, nerve, can more likely cause the destruction of sclerotin, form new bone
Folding.Therefore, operative treatment is difficult thorough removing tophus at this stage, ineffective.
The content of the invention
(1) technical problems to be solved
In order to overcome prior art insufficient, the present invention proposes a kind of tophus for efficiently, quickly dissolving tophus and dissipated
Agent and preparation method thereof, for being rinsed in art, can rapidly, effectively dissolve tophus, so as to improve operative effect, or even can pass through
Local injection is treated, and avoids performing the operation.
(2) technical scheme
The present invention is achieved through the following technical solutions：The present invention proposes a kind of tophus resolvent, by content once
Component forms：
Sodium dihydrogen phosphate 0.1~0.2g of dihydrate,
Disodium hydrogen phosphate 6~7g of dodecahydrate,
Ultra-pure water 100ml.
Preferably, a kind of tophus resolvent, is made up of the component of content once：
Sodium dihydrogen phosphate dihydrate 0.165g,
Disodium hydrogen phosphate dodecahydrate 6.78g,
Ultra-pure water 100ml.
A kind of preparation method of tophus resolvent, it is characterised in that：Comprise the following steps：
1), weigh sodium dihydrogen phosphate dihydrate 31.2g and add ultra-pure water to 1000ml dissolvings, it is standby；
2), weigh disodium hydrogen phosphate dodecahydrate 71.632g and add ultra-pure water to 1000ml dissolvings, it is standby；
3) it is, mixed by both the resulting solution 5.3ml of automatical potentiometric titrimeter selecting step 1, step 2 resulting solution 94.7ml
Close, be thoroughly mixed, and basifier is added into it, it is 8 to regulate and control pH value by PH test paper.
Preferably, the basifier is sodium bicarbonate solution.
(3) beneficial effect
A kind of tophus resolvent that the present invention mentions and preparation method thereof, its is easy to use, and securely and reliably, cell is lived
Property will not cause the damage of soft tissue without influence.Tophus can be fast and effectively dissolved, operating time can be shortened and improve operation
Curative effect, or even can avoid performing the operation.
Embodiment
In order that the object, technical solution and advantage of invention are more clearly understood, with reference to embodiments, the present invention is entered
Row is further described.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit
The fixed present invention.
A kind of tophus resolvent is prepared, is made up of the component of content once：
Sodium dihydrogen phosphate dihydrate 0.165g,
Disodium hydrogen phosphate dodecahydrate 6.78g,
Ultra-pure water 100ml.
Its preparation method comprises the following steps：
1), weigh sodium dihydrogen phosphate dihydrate 31.2g and add ultra-pure water to 1000ml dissolvings, it is standby；
2), weigh disodium hydrogen phosphate dodecahydrate 71.632g and add ultra-pure water to 1000ml dissolvings, it is standby；
3) it is, mixed by both the resulting solution 5.3ml of automatical potentiometric titrimeter selecting step 1, step 2 resulting solution 94.7ml
Close, be thoroughly mixed, and basifier is added into it, it is 8 to regulate and control pH value by PH test paper.
Specifically observation solute effect when, the present inventor from sodium bicarbonate solution, hydrogen peroxide, physiological saline alkaline solution with
It is specific as follows and several clinical conventional several tophus lytic agents of glucose solution alkaline solution are as a comparison：
1), the optimal dissolution conditions of tophus resolvent of the present invention：Solvent 80ml, temperature 50 C, PH 8, stirring rate 100
Turn/Min, 7 minutes time, dissolution rate 78%.Condition of the same race but not stirring, dissolution rate is between 40%-50%；
2), the optimal dissolution conditions of sodium bicarbonate solution are：80ml distilled water, it is 8 to add sodium acid carbonate regulation PH, temperature 50
DEG C, stir speed (S.S.) 100L/Min, dissolution time is 7 minutes, dissolution rate 57%；
3), hydrogen peroxide：Without obvious solute effect；
4), the optimal dissolution conditions of physiological saline alkaline solution are：Physiological saline 80ml, it is 8 to add sodium acid carbonate regulation PH, temperature
50 DEG C of degree, stir speed (S.S.) 100L/Min, dissolution time is 7 minutes, dissolution rate 50%；
5), the optimal dissolution conditions of glucose solution alkaline solution are：80ml glucose solutions, add sodium acid carbonate, regulation
PH is 8, stir speed (S.S.) 100L/Min, and dissolution time is 7 minutes, dissolution rate 46%.
Can be seen that a kind of tophus resolvent mentioned in the present invention by as above contrast effect can efficiently, quickly
Dissolve tophus, for being rinsed in art, can rapidly, effectively dissolve tophus, so as to improve operative effect, or even part can be passed through
Injection treatment, avoids performing the operation.
Above-mentioned embodiment is only the preferred embodiment of the present invention, it is impossible to the scope of protection of the invention is limited with this,
The change and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed scope.
Claims (4)
- A kind of 1. tophus resolvent, it is characterised in that：It is made up of the component of following content：
- A kind of 2. tophus resolvent according to claim 1, it is characterised in that：It is made up of the component of following content：
- A kind of 3. preparation method of tophus resolvent according to claim 1 or 2, it is characterised in that：Including following step Suddenly：1), weigh sodium dihydrogen phosphate dihydrate 31.2g and add ultra-pure water to 1000ml dissolvings, it is standby；2), weigh disodium hydrogen phosphate dodecahydrate 71.632g and add ultra-pure water to 1000ml dissolvings, it is standby；3), mixed by both the resulting solution 5.3ml of automatical potentiometric titrimeter selecting step 1, step 2 resulting solution 94.7ml, It is thoroughly mixed, and basifier is added into it, it is 8 to regulate and control pH value by PH test paper.
- A kind of 4. preparation method of tophus resolvent according to claim 1, it is characterised in that：The basifier is carbon Sour hydrogen sodium solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510907115.3A CN105326857B (en) | 2015-12-10 | 2015-12-10 | A kind of tophus resolvent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510907115.3A CN105326857B (en) | 2015-12-10 | 2015-12-10 | A kind of tophus resolvent and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105326857A CN105326857A (en) | 2016-02-17 |
| CN105326857B true CN105326857B (en) | 2018-02-27 |
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| GB201720992D0 (en) * | 2017-12-15 | 2018-01-31 | Hooper Mark | A medical use |
| CN108014329A (en) * | 2018-01-19 | 2018-05-11 | 汪群力 | It is a kind of to aid in removing composition of remaining and infiltration type ventilation calculus and preparation method thereof in operation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1063305C (en) * | 1998-08-15 | 2001-03-14 | 深圳市华为电气股份有限公司 | Secondary power tube driving circuit for medium and large power ringing current converter |
| US6654120B2 (en) * | 2001-08-23 | 2003-11-25 | Quantimetrix Corporation | Synovial fluid control |
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2015
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Non-Patent Citations (4)
| Title |
|---|
| 尿酸结石发病机理及其治疗进展;罗洪，等;《黔南民族医专学报》;19961231;第9卷(第2期);第1-3页 * |
| 手术切除联合加热5% 碳酸氢钠溶液冲洗治疗手部痛风石的试验和应用研究;梁庆晨，孙强;《中华临床医师杂志》;20130131;第7卷(第1期);第393-395页 * |
| 手部痛风石的手术治疗体会;詹海华，等;《中国矫形外科杂志》;20140831;第22卷(第15期);第1433-1436页 * |
| 老年手部痛风石患者25 例手术治疗的疗效;王振兴，等;《中国老年学杂志》;20120531;第32卷;第1920-1921页 * |
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Granted publication date: 20180227 Termination date: 20181210 |