CN105326655B - 一种叶酸无硅油洗发水及其制备方法 - Google Patents
一种叶酸无硅油洗发水及其制备方法 Download PDFInfo
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- CN105326655B CN105326655B CN201510825020.7A CN201510825020A CN105326655B CN 105326655 B CN105326655 B CN 105326655B CN 201510825020 A CN201510825020 A CN 201510825020A CN 105326655 B CN105326655 B CN 105326655B
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- Prior art keywords
- folic acid
- shampoo
- silicone oil
- hair
- sodium
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- 239000002453 shampoo Substances 0.000 title claims abstract description 68
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 235000019152 folic acid Nutrition 0.000 title claims abstract description 39
- 239000011724 folic acid Substances 0.000 title claims abstract description 39
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000008367 deionised water Substances 0.000 claims abstract description 18
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 15
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- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims description 14
- 229940048848 lauryl glucoside Drugs 0.000 claims description 14
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 14
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- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 claims description 6
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
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- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 3
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Abstract
本发明公开了一种叶酸无硅油洗发水及其制备方法。它包括下述质量百分比的原料：两性表面活性剂30～60％，非离子表面活性剂6～10％，调理剂0.1～5％，叶酸0.005～0.10％，植物提取物0.30～3％，防腐剂0～0.50％，香精0～0.30％，去离子水余量。该洗发水不含硅油，具有良好的调理性能，可减少断发和脱发，安全清洁头发，适合备孕、怀孕及产后女性使用。
Description
技术领域
本发明属于日用化学品领域。更具体地，涉及一种添加叶酸、不含硅油的洗发水及其制备方法。
背景技术
洗发水是生活中保持头发和头皮清洁健康的重要发用清洁用品。随着洗发水配方和工艺的发展，洗发水已经不再局限清洁目的，还需要具有良好的梳理性及柔软顺滑的感觉。上世纪70年代，硅油产品被广泛应用于洗发水与护发产品中。2000年前后，硅油开始被国际日化品牌产品带入中国市场并被广泛使用。在洗发过程中，硅油会附着在头发毛鳞片的空隙中，填平头发表面，带来发质的“修复”效果，头发摸起来就会很柔顺。目前中国市场上，含硅油的洗发产品比例达到了90％以上。
但是，硅油中会含有少量D4(环四聚二甲基硅氧烷)，其作为杂质被携带加入到洗发水中。一些硅油产品中D4含量甚至高达1％以上。D4作为环状硅油的一种，其挥发性强，易被人体吸入。据报告称D4可能会影响人体的生殖能力，但目前还没有长期的研究数据能100％支持这个结论。目前，化妆品界一直在行动，欧洲在对硅油及D4进行进一步的安全评估。各大化妆品公司会在一些硅油原料中要求原料商提供D4的残留量，并对原料进行D4残留的标准控制。近几年，无硅油洗发水越来越受到消费者的注意，产品和数量也一直呈上升趋势。不过如果保证洗发水在不含硅油的情况下，仍然具有良好的调理性能，是目前洗发产品开发上的一个技术难点。
此外，备孕、怀孕和产后女性是一类特殊群体，更要特别注意化妆品的安全性。在洗发水选择上，不仅要满足良好的清洁与调理功能，还要保证产品具有安全性。孕期由于体内雌激素作用，延长了头发生长期，原本在正常休止期的头发不再脱落，发量浓密；加之孕期营养充足，容易出现发质油腻。洗发次数亦不会减少，若长时间使用含硅油洗发产品，硅油会吸附在头发表面，日益累积会导致发丝变粗，重量变大影响发型，同时会导致毛囊堵塞，头皮发痒、头皮屑增多，甚至可能出现掉发、脱发等问题。同时硅油中的D4可能会对健康带来不利影响。此外，传统的表面活性剂如AES(脂肪醇聚氧乙烯醚硫酸钠)等容易导致头皮干燥、造成头皮敏感，还有可能通过头皮被身体吸收，进入肝脏，且不能通过新陈代谢排出体外，此类原料的安全性目前也引起越来越多的争议。因此，我们日常可以使用的洗发水并不真正适合备孕、怀孕和产后女性。急需发明一种既能安全清洁头发，又具有良好调理性能，还适合备孕、怀孕和产后女性的洗发水。
发明内容
本发明的第一个目的是提供一种氨基酸体系的叶酸无硅油洗发水，该洗发水不含硅油，配方中的叶酸和特定调理剂协同作用能达到良好的调理性能，此外，该洗发水采用氨基酸类两性表面活性剂，可安全清洁头发，对头皮无刺激，减少断发和脱发，适合备孕、怀孕及产后女性使用。
本发明的第二个目的是提供一种氨基酸体系叶酸无硅油洗发水的制备方法。
为达到上述目的，本发明采用下述技术方案：
一种叶酸无硅油洗发水，它包括下述质量百分比的原料：两性表面活性剂30～60％，非离子表面活性剂6～10％，调理剂0.1～5％，叶酸0.005～0.1％，植物提取物0.30～3％，防腐剂0～0.50％，香精0～0.30％，去离子水余量。
其中，叶酸(FolicAcid)也叫维生素B9，是一种水溶性维生素，存在于小到病毒、细菌，大到人类的所有生命系统中。叶酸是胎儿生长发育不可缺少的营养素。孕妇缺乏叶酸有可能导致胎儿出生时出现低体重、唇腭裂、心脏缺陷等。如果在怀孕头3个月内缺乏叶酸，可引起胎儿神经管发育缺陷，而导致畸形。准备怀孕的女性，可在怀孕前就开始每天服用400微克叶酸。叶酸在制造核酸(核糖核酸、脱氧核糖核酸)上也扮演着重要的角色，是机体细胞生长和繁殖所必须的物质，叶酸帮助蛋白质代谢，可缓解头皮紧张，促进细胞再生，使头皮更健康，同时具有消炎、镇痛的作用。在本发明的配方中，叶酸除了满足孕期女性方便补充维生素的需要，还可以与配方中的特定调理剂协同作用，替代硅油，达到良好的调理性能，且修复发质、滋养头皮、维持发丝和头皮的健康。
进一步地，在本发明的配方中，所述两性表面活性剂优选使用氨基酸类两性表面活性剂。其中，所述氨基酸类两性表面活性剂选自椰油酰基谷氨酸TEA盐、椰油酰甘氨酸钠、月桂酰基甲基氨基丙酸钠和月桂酰肌氨酸钠中的一种或几种。此外，在本发明的具体实施方案中，两性表面活性剂还可以包括椰油酰胺丙基甜菜碱和/或椰油酰两性基二乙酸二钠。
进一步地，在本发明配方中，所述非离子表面活性剂为椰油酰胺DEA和/或月桂基葡糖苷。
本发明不能添加传统阴离子表面活性剂，这样可减少产品对头皮的刺激。另外，相对传统的洗发原料，本发明配方中以氨基酸类两性表面活性剂为主，此类表面活性剂的合成原料均采用谷氨酸、肌氨酸、冬氨酸等氨基酸与长链的脂肪酸缩合而成，这些氨基酸本身就是生物体内、人体皮肤中含有的天然物质，并且其合成工艺均采用脂肪酶和蛋白酶进行酶催化反应，因此不会产生对人体有毒有害的副产物，具有非常高的安全性，是目前已知最温和的一类表面活性剂，同时它的生物相容性强、环境友好，更加符合未来的化妆品的趋势。非离子表面活性剂，发泡性能优良，稳泡和去污能力出色，生物降解性能好，对皮肤温和、低刺激，是理想的洗涤原料。
在本发明的配方中，所述调理剂选自聚季铵盐、瓜儿胶羟丙基三甲基氯化铵、酪梨油、阿甘油、水解胶原蛋白和泛醇中的一种或几种。其中，瓜儿胶羟丙基三甲基氯化铵、酪梨油和阿甘油是耐高温调理剂；而水解胶原蛋白、聚季铵盐和泛醇属于低温调理剂，在低温时加入。
在本发明的配方中，所述植物提取物包括春黄菊提取液、枸杞提取液、母菊提取液和人参提取液中的一种或几种。这些植物提取物可以有效滋养头发。
进一步地，在本发明的配方中，所述防腐剂是食品级的或是非传统防腐剂，例如1,2-己二醇/辛甘醇/环庚三烯酚酮的混合物或苯甲酸钠。其中，1,2-己二醇/辛甘醇/环庚三烯酚酮的混合物为非传统防腐剂，虽然有助于产品的防腐保存，但是它不像传统防腐剂一样容易引起皮肤的不良反应。
所述香精优选低刺激，安全性高的，且不含有26种致敏原的香精，例如，德国德乐满香精公司的FRAG 86433287、FRAG 86429603等。本发明所述的26种过敏原包括：戊基肉桂醛、苯甲醇、肉桂醇、柠檬醛、丁子香酚、羟基香茅醛、异丁子香酚、α-戊基肉桂醇、水杨酸苄酯、肉桂醛、香豆素、香叶醇、新铃兰醛、对甲氧基苄醇、肉桂酸苄酯、法尼醇、铃兰醛、芳樟醇、苯甲酸苄酯、香茅醇、α-已基桂醛、右旋萜二烯、庚炔羧酸甲酯、异甲基-α-紫罗兰酮、橡苔和树苔提取物、树苔提取物。
本发明还提供了一种叶酸无硅油洗发水的制备方法，该方法包括：将去离子水加入主罐，升温至65℃～75℃，加入耐高温的调理剂、两性表面活性剂、非离子表面活性剂搅拌均匀，然后降温至35℃～45℃，加入叶酸、植物提取物、低温调理剂、防腐剂、香精搅拌均匀即可，形成溶液，即得。
本发明的有益效果如下：
本发明提供的叶酸无硅油洗发水虽然没有添加硅油，但由于配方中添加了叶酸和特定的调理剂，两者协同作用，使得产品依然具有良好的调理性能，同时，通过配方中其它原料成分的严格筛选，使得该洗发水安全、无刺激，在深层清洁的同时能保持头皮本身的正常状态，并且能让头皮恢复到健康状态，更适用于备孕、怀孕及产后女性。
具体实施方式
为了更清楚地说明本发明，下面结合优选实施例对本发明做进一步的说明。本领域技术人员应当理解，下面所具体描述的内容是说明性的而非限制性的，不应以此限制本发明的保护范围。
实施例1
配方组成：以100g原料计：
椰油酰基谷氨酸TEA盐30g，椰油酰胺DEA 3g，月桂基葡糖苷3g，瓜尔胶羟丙基三甲基氯化铵0.1g，叶酸0.005g，春黄菊提取液0.30g(购自CHEMYUNION QUIMICA LTDA)，苯甲酸钠0.50g，香精0.30g，去离子水余量。
制备工艺：
将去离子水加入反应釜中，加热至75℃，加入瓜尔胶羟丙基三甲基氯化铵溶解均匀后、加入椰油酰基谷氨酸TEA盐、椰油酰胺DEA、月桂基葡糖苷搅拌均匀，后降温至45℃，加入叶酸、春黄菊提取液、苯甲酸钠、香精搅拌均匀，形成溶液，即得。
实施例2
配方组成：以100g原料计：
椰油酰甘氨酸钠50g，椰油酰胺丙基甜菜碱10g，月桂基葡糖苷10g，聚季铵盐5g，叶酸0.1g，人参提取液3g(购自湖州珍露生物制品有限公司)，1,2-己二醇/辛甘醇/环庚三烯酚酮混合物0.5g(非传统防腐剂，购自德之馨)，去离子水余量。
制备工艺：
将去离子水加入反应釜中，加热至65℃，加入椰油酰甘氨酸钠、椰油酰胺丙基甜菜碱、月桂基葡糖苷搅拌均匀，后降温至35℃，加入叶酸、人参提取液、聚季铵盐、1,2-己二醇/辛甘醇/环庚三烯酚酮混合物搅拌均匀，形成溶液，即得。
实施例3
配方组成：以100g原料计：
椰油酰两性基二乙酸二钠10g，月桂酰基甲基氨基丙酸钠20g,月桂酰肌氨酸钠10g,椰油酰胺DEA 2g，月桂基葡糖苷5g，阿甘油0.5g，泛醇0.5g，叶酸0.005g，母菊提取液0.30g(购自湖州珍露生物制品有限公司)，苯甲酸钠0.50g，香精0.10g，去离子水余量。
制备工艺：
将去离子水加入反应釜中，加热至70℃，加入椰油酰两性基二乙酸二钠、月桂酰基甲基氨基丙酸钠、月桂酰肌氨酸钠、椰油酰胺DEA、月桂基葡糖苷、阿甘油、搅拌均匀，后降温至38℃，加入叶酸、苯甲酸钠、泛醇、母菊提取液、香精搅拌均匀，形成溶液，即得。
实施例4
配方组成：以100g原料计：
椰油酰两性基二乙酸二钠10g，月桂酰基甲基氨基丙酸钠20g，椰油酰甘氨酸钠10g，月桂基葡糖苷8g，酪梨油0.5g，水解胶原蛋白0.30g，叶酸0.005g，苯甲酸钠0.50g，香精0.10g，去离子水余量。
制备工艺：
将去离子水加入反应釜中，加热至70℃，加入椰油酰两性基二乙酸二钠、月桂酰基甲基氨基丙酸钠、椰油酰甘氨酸钠、月桂基葡糖苷、酪梨油、搅拌均匀，后降温至38℃，加入叶酸、苯甲酸钠、水解胶原蛋白、香精搅拌均匀，形成溶液，即得。
对比例1
配方组成：以100g原料计：
椰油酰基谷氨酸TEA盐30g，椰油酰胺DEA 3g，月桂基葡糖苷3g，二甲基硅油1g，春黄菊提取液0.30g(购自CHEMYUNION QUIMICA LTDA)，苯甲酸钠0.50g，香精0.30g，去离子水余量。
制备工艺：
将去离子水加入反应釜中，加热至75℃，加入椰油酰基谷氨酸TEA盐、椰油酰胺DEA、月桂基葡糖苷、二甲基硅油搅拌均匀，后降温至45℃，加入春黄菊提取液、苯甲酸钠、香精搅拌均匀，形成溶液，即得。
对比例2
配方组成：以100g原料计：
椰油酰基谷氨酸TEA盐30g，椰油酰胺DEA 3g，月桂基葡糖苷3g，瓜尔胶羟丙基三甲基氯化铵0.105g，春黄菊提取液0.30g(购自CHEMYUNION QUIMICA LTDA)，苯甲酸钠0.50g，香精0.30g，去离子水余量。
制备工艺：
将去离子水加入反应釜中，加热至75℃，加入瓜尔胶羟丙基三甲基氯化铵溶解均匀后、加入椰油酰基谷氨酸TEA盐、椰油酰胺DEA、月桂基葡糖苷搅拌均匀，后降温至45℃，加入春黄菊提取液、苯甲酸钠、香精搅拌均匀，形成溶液，即得。
对比例3
脂肪醇醚硫酸酯钠10g，月桂基硫酸钠5g，氯化钠0.8g，瓜儿胶羟丙基三甲基氯化铵0.5g，椰油酰胺DEA 5g，聚季铵盐2g，柠檬酸0.1g，食品香精(料)0.3g，苯甲酸钠0.5g，叶酸0.01g，去离子水余量。
制备工艺：
将去离子水加入反应釜中，加热至80-90℃，加入柠檬酸保温10min，后降温至75℃后再加入脂肪醇醚硫酸酯钠、月桂基硫酸钠，搅拌至完全溶解，加入椰油酰胺DEA、瓜儿胶羟丙基三甲基氯化铵搅拌分散均匀，搅拌均匀，降温至42℃，加入食品香精(料)，苯甲酸钠，叶酸、氯化钠、聚季铵盐搅拌均匀、形成溶液，即得。
试验例1
以实施例1和对比例1生产的洗发水，选取备孕、怀孕阶段和产后女性进行洗发效果评价。
试验人群：选取的98名女性，其中
1、长发52人，短发46人，长短发比例各占约一半。
2、处于备孕期17人，怀孕1-3个月孕妇16人，怀孕3-6月孕妇20人，怀孕6-9个月孕妇21人，哺乳期女性24人。
试验样品：实施例1洗发水为1号样品，对比例1洗发水为2号样品。
使用方法：
将头发梳顺，润湿，从头部中间位置分为两部分，左边使用1号洗发水，右边使用等量的2号洗发水，轻轻按摩头皮，用清水分别冲洗两部分。对比干湿梳性、柔顺效果、头发蓬松高度、发重感、头皮滋润度和缓解头痒情况。
本发明叶酸无硅油洗发水，其头发干湿梳性、柔顺效果、头发蓬松度、、发重感、头皮滋润度和缓解头痒效果得到了试用证实，使用人数为98人，试验数据如下：
使用1号洗发水和2号洗发水评价结果
| 序号 | 性能指标 | 优于 | 相当 | 差于 | 好评率 |
| 1 | 干湿梳性 | 50 | 28 | 20 | 51.0％ |
| 2 | 柔顺效果 | 63 | 28 | 7 | 64.3％ |
| 3 | 头发蓬松度 | 82 | 14 | 2 | 83.7％ |
| 4 | 发重感 | 95 | 3 | 0 | 96.9％ |
| 5 | 头皮滋润度 | 89 | 6 | 3 | 90.8％ |
| 6 | 缓解头痒 | 91 | 7 | 0 | 92.9％ |
注：“优于”：1号洗发水性能指标效果优于2号洗发水；“相当”：1号洗发水和2号洗发水性能指标效果相当；“差于”：1号洗发水性能指标效果差于2号洗发水。
试验例2
以实施例1和对比例2生产的洗发水，选取备孕、怀孕阶段和产后女性进行洗发效果评价。
试验人群：选取的98名女性，其中
1、长发52人，短发46人，长短发比例各占约一半。
2、处于备孕期17人，怀孕1-3个月孕妇16人，怀孕3-6月孕妇20人，怀孕6-9个月孕妇21人，哺乳期女性24人。
试验样品：实施例1洗发水为1号样品，对比例2洗发水为3号样品。
使用方法：
将头发梳顺，润湿，从头部中间位置分为两部分，左边使用1号洗发水，右边使用等量的3号洗发水，轻轻按摩头皮，用清水分别冲洗两部分。对比干湿梳性、柔顺效果、头发的光泽度、头皮滋润度。
本发明叶酸无硅油洗发水，其头发干湿梳性、柔顺效果、头发的光泽度和头皮滋润度得到了试用证实，使用人数为98人，试验数据如下：
使用1号洗发水和3号洗发水评价结果
| 序号 | 性能指标 | 优于 | 相当 | 差于 | 好评率 |
| 1 | 干湿梳性 | 54 | 37 | 7 | 55.1％ |
| 2 | 柔顺效果 | 67 | 25 | 6 | 68.4％ |
| 3 | 头发光泽度 | 89 | 9 | 0 | 90.8％ |
| 4 | 头皮滋润度 | 91 | 5 | 2 | 92.9％ |
注：“优于”：1号洗发水性能指标效果优于3号洗发水。“相当”：1号洗发水和3号洗发水性能指标效果相当。“差于”：1号洗发水性能指标效果差于3号洗发水。
试验例3
以实施例2和对比例3生产的洗发水，选取备孕、怀孕阶段和产后女性进行洗发效果评价。
试验人群：选取的98名女性，其中
1、长发52人，短发46人，长短发比例各占约一半。
2、处于备孕期17人，怀孕1-3个月孕妇16人，怀孕3-6月孕妇20人，怀孕6-9个月孕妇21人，哺乳期女性24人。
试验样品：实施例2洗发水为5号样品，对比例3洗发水为4号样品。
使用方法：
将头发梳顺，润湿，从头部中间位置分为两部分，左边使用5号洗发水，右边使用等量的4号洗发水，轻轻按摩头皮，用清水分别冲洗两部分。对比干湿梳性、柔顺效果、头发蓬松度、头皮干痒缓解程度、头皮滋润度。
本发明氨基酸体系、叶酸无硅油洗发水，其头发干湿梳性、柔顺效果、头发蓬松度、头皮干痒缓解程度和头皮滋润度还得到了试用证实，使用人数为98人，试验数据如下：
| 序号 | 性能指标 | 优于 | 相当 | 差于 | 好评率 |
| 1 | 干湿梳性 | 96 | 2 | 0 | 98.0％ |
| 2 | 柔顺效果 | 93 | 3 | 2 | 94.9％ |
| 3 | 头发蓬松度 | 89 | 9 | 0 | 90.8％ |
| 4 | 头皮干痒缓解程度 | 95 | 3 | 0 | 96.9％ |
| 5 | 头皮滋润度 | 90 | 5 | 3 | 91.8％ |
注：“优于”：5号洗发水性能指标效果优于4号洗发水；“相当”：5号洗发水和4号洗发水性能指标效果相当；“差于”：5号洗发水性能指标效果差于4号洗发水。
结论：
氨基酸体系、含叶酸无硅油洗发水的干湿梳性、柔顺效果、头发蓬松度、发重感、头皮滋润度要稍好于含硅油洗发水及含硅油非氨基酸体系的洗发水。
显然，本发明的上述实施例仅仅是为清楚地说明本发明所作的举例，而并非是对本发明的实施方式的限定，对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动，这里无法对所有的实施方式予以穷举，凡是属于本发明的技术方案所引伸出的显而易见的变化或变动仍处于本发明的保护范围之列。
Claims (5)
1.一种叶酸无硅油洗发水，其特征在于，它包括下述质量百分比的原料：两性表面活性剂30~60%，非离子表面活性剂6~10%，调理剂0.1~5%，叶酸0.005~0.10%，植物提取物0.30~3%，防腐剂0~0.50%，香精0~0.30%，去离子水余量，其中，
所述两性表面活性剂包括氨基酸类两性表面活性剂，其中，所述氨基酸类两性表面活性剂选自椰油酰基谷氨酸 TEA 盐、椰油酰甘氨酸钠、月桂酰基甲基氨基丙酸钠和月桂酰肌氨酸钠中的一种或几种；
所述调理剂选自瓜儿胶羟丙基三甲基氯化铵。
2.根据权利要求1所述的叶酸无硅油洗发水，其特征在于，所述两性表面活性剂还包括椰油酰胺丙基甜菜碱和/或椰油酰两性基二乙酸二钠。
3.根据权利要求1所述的叶酸无硅油洗发水，其特征在于，所述非离子表面活性剂为椰油酰胺 DEA和/或月桂基葡糖苷。
4.根据权利要求1所述的叶酸无硅油洗发水，其特征在于，所述植物提取物包括春黄菊提取液、枸杞提取液、母菊提取液和人参提取液中的一种或几种。
5.根据权利要求1所述的叶酸无硅油洗发水，其特征在于，所述防腐剂为1,2-己二醇/辛甘醇/环庚三烯酚酮的混合物或苯甲酸钠。
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| CN106176285A (zh) * | 2016-08-25 | 2016-12-07 | 天津郁美净集团有限公司 | 一种适用于儿童使用的无硅洗发沐浴组合物及其制备方法 |
| CN106361660B (zh) * | 2016-10-14 | 2020-06-16 | 广州澳希亚实业有限公司 | 一种不含硫酸盐阴离子表面活性剂的无硅油洗发组合物 |
| CN106473994A (zh) * | 2016-12-12 | 2017-03-08 | 德阳力久云智知识产权运营有限公司 | 一种无硅油防脱发洗发水及其制备方法 |
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Denomination of invention: Silicone-oil-free folic acid shampoo and preparation method thereof Effective date of registration: 20200122 Granted publication date: 20180417 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2020990000097 |
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Date of cancellation: 20210818 Granted publication date: 20180417 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2020990000097 |
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Denomination of invention: The invention relates to a folic acid silicone free shampoo and a preparation method thereof Effective date of registration: 20210818 Granted publication date: 20180417 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2021990000732 |
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Date of cancellation: 20230330 Granted publication date: 20180417 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2021990000732 |