CN105326562A - Catheter device for regulating renal nerves - Google Patents

Catheter device for regulating renal nerves Download PDF

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Publication number
CN105326562A
CN105326562A CN201410287025.4A CN201410287025A CN105326562A CN 105326562 A CN105326562 A CN 105326562A CN 201410287025 A CN201410287025 A CN 201410287025A CN 105326562 A CN105326562 A CN 105326562A
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China
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electrode
portion
shape
electrodes
adjusting
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CN201410287025.4A
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Chinese (zh)
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汪立
秦杰
盛卫文
王震
王国辉
朱平
吴艳雪
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上海安通医疗科技有限公司
泰尔茂(中国)投资有限公司
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Priority to CN201410287025.4A priority Critical patent/CN105326562A/en
Publication of CN105326562A publication Critical patent/CN105326562A/en

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Abstract

A catheter device for regulating renal nerves comprises a regulating assembly, a rigid part and a conveying part. The regulating assembly comprises an electrode bearing portion and a plurality of electrodes; the electrodes are arranged to transmit regulating energy to nerves; the electrode bearing portion is arranged to bear the plurality of electrodes; the conveying part is arranged to convey the regulating assembly to a position close to the nerves; the rigid part is arranged inside the conveying part. The electrode bearing portion is flexible and pre-treated to have a first shape; when the rigid part is inserted into the electrode bearing portion, the electrode bearing portion is kept in a second shape corresponding to the rigid part; when the rigid part is removed from the electrode bearing portion, the electrode bearing portion restores to the first shape. The rigid part simple to manufacture, lower in cost and convenient to operate is used for controlling the shape of the electrode bearing portion, thus enabling the catheter device to move in a vessel or transmit the regulating energy.

Description

一种用于调节肾神经的导管装置 A catheter apparatus for regulating renal nerves

技术领域 FIELD

[0001] 本发明涉及电外科,尤其涉及一种用于调节肾神经的导管装置。 [0001] The present invention relates to electrosurgery and more particularly to catheter devices for regulating renal nerves.

背景技术 Background technique

[0002] 顽固性高血压,即使用3种或以上药物(都已经使用一个利尿剂)仍然难以控制的高血压(sBP彡160mmHg),在临床上较常见,其致病因素众多,发病机制不明确,药物治疗效果很差,诊断和治疗技术仍不够成熟,成为高血压治疗的重大难题之一。 [0002] resistant hypertension, that is, using three or more drugs (both have used a diuretic) hypertension (sBP San 160mmHg) is still difficult to control, more common in clinical practice, many of its risk factors, pathogenesis is not clear, poor drug treatment, diagnosis and treatment technology is still not mature enough to become one of the major problem of the treatment of hypertension.

[0003] 最新的动物及临床实验数据证明对肾神经的调节(例如去交感神经)可以显著持久地减低顽固性高血压,例如最近发展出的肾动脉射频消融术。 [0003] The latest animal experiments and clinical data demonstrate the regulation of renal nerves (such as sympathetic denervation) can significantly reduce permanently resistant hypertension, renal artery such as a recent development of radiofrequency ablation. 肾动脉射频消融术是一种通过将电极导管经血管送入肾动脉内特定部位,释放射频电流导致肾动脉交感神经局部凝固性坏死,达到去神经的介入性技术。 Radiofrequency ablation renal artery by a catheter through a blood vessel into the electrodes within a particular portion of the renal artery, renal artery leading to the release of the RF current local sympathetic coagulation necrosis, interventional techniques to achieve denervation. 射频电流损伤范围小,不会造成机体危害,因此肾动脉射频消融术已经成为一种有效的去除肾动脉交感神经的方法。 RF current is small damage range, will not cause harm to the body, so the renal artery radiofrequency ablation has become an effective method for the removal of the renal arteries sympathetic.

[0004] 另外,对肾神经的调节被证明对多种与肾脏相关的疾病有一定效果,特别是肾交感神经过度活化导致的相关疾病。 [0004] In addition, the regulation of renal nerves proved to have some effect on a variety associated with kidney disease, especially renal sympathetic nerve-related diseases caused by excessive activation. 例如,充血性心力衰竭(CHF)可以导致异常高的肾交感神经活化,从而导致从身体除去的水和钠的减少,并增加肾素的分泌。 For example, congestive heart failure (CHF) may result in abnormally high sympathetic activation of the kidneys, resulting in reduced removal of water and sodium from the body, and increased renin secretion. 增加的肾素分泌导致肾血管收缩,引起肾血流量的降低。 Increased renin secretion lead to renal vasoconstriction, caused by decrease in renal blood flow. 从而,肾对于心力衰竭的反应可以使心力衰竭病症的螺旋下降延长。 Thus, for renal failure of the reaction can decrease the helical extension failure condition.

[0005] 尽管相关文献或专利中有报道用于调节肾动脉交感神经的相关器械,但目前现有的器械具有操作不便、制作成本高或效率低下等缺陷。 [0005] Despite reports related equipment for modulating sympathetic nerve renal artery literature or patents, but conventional equipment having a maneuver, or the high manufacturing cost and low efficiency defects.

[0006] 因此,本发明提供一种新型的用于调节肾神经的导管装置。 [0006] Accordingly, the present invention provides a novel catheter device for adjusting the renal nerves.

发明内容 SUMMARY

[0007] 有鉴于现有技术的上述缺陷,本发明所要解决的技术问题是提供一种操作方便、制作成本低的用于调节肾神经而治疗相关疾病的导管装置。 [0007] In view of the above drawbacks of the prior art, the present invention is to solve the technical problem to provide a convenient operation, low production costs for adjusting the renal nerves treating a disease associated conduit means. 肾神经为位于人肾动脉上的肾交感神经,本发明中的调节肾神经是指通过损伤或非损伤的方式除去或降低所述神经的活化,本发明提供了一种用于调节肾神经的导管装置,通过进入血管,释放调节能量来调节肾动脉上的肾交感神经。 Renal sympathetic renal nerve is located on human renal artery, renal nerves regulating means in the present invention by way of injury or damage to remove or reduce the activation of the nerve, the present invention provides a method for regulating renal nerves conduit means into the vessel through the release of energy to adjust the regulation of renal sympathetic nerve renal artery.

[0008] 为实现上述目的,本发明提供了一种用于调节肾神经的导管装置,包括调节组件和输送部件; [0008] To achieve the above object, the present invention provides a catheter device for adjusting the renal nerves, including adjustment assembly and conveying member;

[0009] 所述调节组件包括电极承载部和多个电极;所述多个电极被设置为将调节能量传递到神经;所述电极承载部被设置为承载所述多个电极; [0009] The adjustment assembly includes an electrode supporting portion and a plurality of electrodes; a plurality of electrodes is arranged to adjust the energy delivered to the nerve; the electrode carrier is arranged to carry a portion of the plurality of electrodes;

[0010] 所述电极与导线相连; [0010] The electrode lead wire is connected;

[0011] 所述输送部件被设置为将所述调节组件输送到靠近所述神经的位置; [0011] The conveying means is arranged to adjust the transport assembly to a position close to the nerve;

[0012] 其特征在于, [0012] wherein,

[0013] 所述电极承载部为挠性的,且被预处理为具有第一形状; [0013] The carrier portion of the electrode is flexible, and is pre-treated to have a first shape;

[0014] 所述导管装置还包括设置在所述输送部件内的刚性部件;当所述刚性部件插入所述电极承载部时,所述电极承载部保持与所述刚性部件相应的第二形状;当所述刚性部件从所述电极承载部抽离时,所述电极承载部回复为所述第一形状; [0014] The conduit means further comprises a rigid member disposed in said conveying member; when the rigid member is inserted into the electrode-bearing portion of the electrode carrier holding portion and the rigid member corresponding to the second shape; when detached from the rigid member portion of the electrode carrier, the electrode carrier portion reply to the first shape;

[0015] 在所述第一形状下,所述电极承载部被设置为适于通过所述多个电极将调节能量传递到所述神经;在所述第二形状下,所述电极承载部被设置为适于在血管中移动。 [0015] In the first shape, the electrode portion is arranged to the carrier by a plurality of electrodes adapted to adjust the energy delivered to the nerve; in the second shape, the portion of the electrode carrier set adapted to move in a blood vessel.

[0016] 进一步地,所述刚性部件的所述插入和所述抽离是由刚性部件运动控制机构控制的. [0016] Further, the rigidity of the insertion member and the disengagement is controlled by the motion control mechanism of the rigid member.

[0017] 进一步地,所述刚性部件为金属丝。 [0017] Furthermore, the rigid member is a metal wire.

[0018] 所述金属丝优选为NiTi合金。 [0018] The wire is preferably NiTi alloy.

[0019] 进一步地,所述电极承载部采用记忆合金制成。 [0019] Further, the electrode-bearing portion made of shape memory alloy.

[0020] 进一步地,所述电极承载部的所述第一形状为螺旋形或者近似螺旋形。 [0020] Further, the shape of the electrode-bearing portion of a first spiral or approximately spiral shape.

[0021] 进一步地,所述电极承载部的所述第二形状为直的或者近似直的。 [0021] Further, the shape of the second electrode-bearing portion of a straight or nearly straight.

[0022] 进一步地,所述第一形状的直径为4_12mm。 [0022] Further, the first shape having a diameter of 4_12mm.

[0023] 进一步地,多个所述电极能够单独控制释放能量。 [0023] Further, the plurality of electrodes can be individually controlled release of energy. 即一个电极是否将调节能量传递到神经,与其他电极是否将调节能量传递到神经无关;可以仅有一个电极传递调节能量。 I.e. whether to adjust one of the electrodes to the nerves energy transfer, whether to adjust the other electrodes to the nerve independent energy transfer; transmitting electrode may be only a regulation of energy.

[0024] 进一步地,多个所述电极同时控制释放能量。 [0024] Further, the plurality of electrodes while controlling the release of energy. 即部分电极或所有电极同时传递调节能量,每个电极是否传递调节能量的状态是彼此独立的。 That portion of the electrode or all the electrodes simultaneously adjust the energy transfer, whether each electrode is adjusted transmission energy states are independent of each other.

[0025] 进一步地,所述电极的横截面为环形。 [0025] Further, the cross section of the electrode is annular.

[0026] 进一步地,所述电极的数目为2-6个,当所述电极承载部处于第一形状时,相邻的电极之间的距离为4-15mm。 [0026] Further, the number of electrodes is 2-6, when the electrode-bearing portion is in the first shape, the distance between adjacent electrodes is 4-15mm.

[0027] 进一步地,所述电极的数目为4个。 [0027] Further, the number of electrodes is four.

[0028] 进一步地,所述电极采用钼铱合金材质。 [0028] Further, the molybdenum electrode is iridium alloy.

[0029] 进一步地,所述电极使用粘结剂粘结于所述电极承载部。 [0029] Further, the use of adhesive bonding the electrode to the electrode-bearing portion.

[0030] 所述粘结剂优选为UV固化胶或环氧树脂胶。 [0030] The binder is preferably a UV curable glue or epoxy glue.

[0031] 进一步地,每一个所述电极在其内表面具有为其提供能量的单独的导线。 [0031] Further, each of said electrodes having to provide a separate energy conductors on its inner surface.

[0032] 进一步地,所述导线焊接于所述电极的内表面。 [0032] Further, the wire bonding to the inner surface of the electrode.

[0033] 进一步地,所述导线设置在所述电极承载部与所述输送部件的外部,并由第一绝缘层包覆所述电极承载部和所述输送部件。 [0033] Further, the wire electrode disposed on the carrier and the external portion of the conveying member by a first insulating layer covering the electrode carrier and the portion of the conveying member.

[0034] 进一步地,所述电极承载部与所述输送部件的外部具有第二绝缘层,所述导线设置在所述第一绝缘层的外部,并被所述第二绝缘层包覆。 [0034] Furthermore, the electrode carrier and the outer portion of the conveying member having a second insulating layer, the outer conductor disposed on the first insulating layer, and the second insulating cover layer.

[0035] 进一步地,所述第一绝缘层和/或所述第二绝缘层为热缩高分子材料形成。 [0035] Further, the first insulating layer and / or said second insulating layer is formed of heat shrink polymeric material.

[0036] 进一步地,所述高分子材料为PET/FEP/PTFE/TPU。 [0036] Further, the polymer material is PET / FEP / PTFE / TPU.

[0037] 进一步地,所述电极承载部的远端设置用于减少或避免血管壁损伤的保护部件。 [0037] Further, the distal end portion of the electrode carrier is provided for reducing or avoiding the protective member vessel wall injury.

[0038] 进一步地,所述保护部件为软头。 [0038] Further, the protective member is a soft head.

[0039] 进一步地,所述保护部件由橡胶、硅胶或热塑性弹性体材料制成。 [0039] Further, the protective member is made of rubber, silicone or a thermoplastic elastomeric material.

[0040] 进一步地,所述保护部件的长度为3_50mm。 [0040] Further, the length of the guard member is 3_50mm.

[0041] 进一步地,所述输送部件与所述电极承载部是一体的。 [0041] Further, the conveying carrier member and the electrode portion are integral.

[0042] 进一步地,所述输送部件的远端与所述电极承载部的近端相连。 [0042] Further, a proximal end connected to the distal end of the electrode bearing portion of the delivery member.

[0043] 进一步地,所述输送部件设置为管状。 [0043] Further, the conveying member to the tubular.

[0044] 进一步地,所述输送部件的外径为0.5-1.0mm,壁厚为0.05-0.15mm。 [0044] Further, the outer diameter of the conveying member is of 0.5-1.0 mm, a wall thickness of 0.05-0.15mm.

[0045] 进一步地,所述输送部件采用N1-Ti合金制作。 [0045] Further, the conveying member using N1-Ti alloy production.

[0046] 进一步地,所述导管装置还包括用于握持的手柄,所述手柄与所述输送部件的近端连接,所述导线与所述手柄连接。 [0046] Further, the catheter apparatus further comprises a handle for gripping the handle connected to the proximal end of the conveying member, the connecting wires and the handle.

[0047] 进一步地,所述刚性部件运动控制机构安装于所述手柄内,所述刚性部件运动控制机构通过齿轮控制所述刚性部件的运动。 [0047] Furthermore, the rigid member is attached to the motion control mechanism within the handle, the movement control means moving the rigid member of the rigid member through the gear control.

[0048] 进一步地,所述刚性部件运动控制机构位于所述手柄外,直接通过手动操作来控制所述刚性部件的运动。 [0048] Furthermore, the rigid member motion control mechanism located outside of the handle directly to control the movement of the rigid member by a manual operation.

[0049] 进一步地,所述调节能量为射频、热量、冷量、电磁能、超声波、微波或光能中一种或几种。 [0049] Further, the adjusted RF energy, heat, cold, electromagnetic, ultrasonic, microwave, or optical energy of one or more.

[0050] 进一步地,所述电极承载部的表面被切割。 [0050] Further, the surface of the electrode carrier portion is cut.

[0051] 进一步地,所述电极承载部表面按照切割角度切割成直线槽。 [0051] Further, the electrode-bearing surface was cut into the linear groove portion in accordance with the cutting angle.

[0052] 进一步地,所述电极承载部表面按照切割角度切割成多个柱形槽。 [0052] Further, a surface portion of the electrode carrier into a plurality of cylindrical grooves cut in accordance with the angle.

[0053] 进一步地,所述切割角度在30°〜80°之间。 [0053] Further, the cutting angle is between 30 ° ~80 °.

[0054] 进一步地,所述直线槽在所述电极承载部表面的所述切割角度是相同的。 [0054] Further, the linear cutting grooves in the bearing surface of the electrode is the same angle.

[0055] 进一步地,所述直线槽在所述电极承载部表面的所述切割角度是不同的,所述直线槽在所述电极承载部远端的所述切割角度大于在所述电极承载部近端的所述切割角度。 [0055] Further, the linear cutting grooves in the bearing surface of the electrode is different from an angle, the linear groove portion in the distal end of the electrode carrier of the cutting angle is greater than the electrode carrier portion the proximal end of the cutting angle.

[0056] 进一步地,相邻的所述柱形槽之间的切割间隔相同。 [0056] Further, the cutting between the adjacent grooves spaced the same column.

[0057] 本发明提供的用于调节神经的导管装置,使用制作简单、成本较低、便于操作的支撑结构来控制电极承载部的形状,从而实现导管装置在血管内的移动或传递调节能量。 [0057] The present invention provides catheter devices for adjusting nerves, making use of simple, low cost, ease of operation of the support structure to control the shape of the electrode-bearing portion, in order to achieve a catheter or delivery means for moving the regulation of energy within a blood vessel. 采用本发明公开的用于调节神经的导管装置,无需使用导引导丝,操作更加简便,大大减少了医务人员的工作量,也为手术争取了宝贵的时间,大大增大了手术的成功几率,具有很强的临床实用性。 Using the apparatus of the present invention discloses a catheter for adjusting nerves, without using a guide wire, more convenient operation, greatly reducing the workload of medical staff, but also for the precious time of surgery, greatly increasing the probability of success of surgery, It has a strong clinical utility.

[0058] 本发明提供的用于调节神经的导管装置,每个电极单独控制,任何一个电极的工作状态都不受其他电极的影响,医务人员可以根据实际需要,选择一个、部分或全部电极释放调节能量。 [0058] The present invention provides catheter devices for adjusting nerve, each individual control electrode, a working electrode state of any other electrodes are not affected, according to actual needs medical personnel, to select one, some or all of the electrodes release regulate energy. 本发明所提供的用于调节神经的装置操作便利,能够同时对多个神经位点进行调节或者对某些神经位点进行选择性调节,从而提高工作效率,并进一步提高治疗的准确度,并且在某些电极故障的情况下,医务人员可以灵活的选择工作电极,大大提交了设备意外故障的处理能力,保障手术的正常进行,具有重要的临床意义。 Facilitate the operation of the present invention provides apparatus for adjusting the nerves, can simultaneously adjust a plurality of neural sites or sites of certain nerve selectively adjusted, thereby improving efficiency and further improve the accuracy of the treatment, and in the case of certain electrode failure, the medical staff the flexibility to choose the working electrode, greatly submitted a processing capacity of unexpected failure of equipment to ensure the normal operation, has important clinical significance.

[0059] 本发明中,用到的缩写: [0059] the present invention, the abbreviations used:

[0060] PTFE 指聚四氟乙烯,即Polytetrafluoroethylene ; [0060] PTFE refers to polytetrafluoroethylene, i.e., Polytetrafluoroethylene;

[0061] FEP 指氟化乙烯丙烯共聚物,即Fluorinated ethylene propylene ; [0061] FEP refers to fluorinated ethylene propylene copolymer, i.e., Fluorinated ethylene propylene;

[0062] TPU指热塑性聚氨酯弹性体橡胶,即Thermoplastic polyurethanes ; [0062] TPU thermoplastic polyurethane elastomer means rubber, i.e. Thermoplastic polyurethanes;

[0063] PET 指聚对苯二甲酸乙二醇酯,即Polyethylene terephthalate。 [0063] PET refers to polyethylene terephthalate, i.e. Polyethylene terephthalate.

[0064] 为了便于说明,本发明中将装置或部件的靠近使用者(或手柄)或远离需要调节的神经位点的一端称为“远端”,将装置或部件的远离使用者(或手柄)或靠近需要调节的神经位点的一端称为“近端”。 [0064] For convenience of explanation, in the present invention is closer to the user device or component (or handle), or needs to be adjusted away from the nerve site remote from the end user is called "distal", the device or component (or handle ) or near one end of the nerve to be adjusted site referred to as "proximal end."

[0065] 以下将结合附图对本发明的构思、具体结构及产生的技术效果作进一步说明,以充分地了解本发明的目的、特征和效果。 [0065] Hereinafter, in conjunction with the accompanying drawings of the inventive concept, the specific structure and technical effect produced is further described to fully understand the objects, features and advantages of the present invention.

附图说明 BRIEF DESCRIPTION

[0066] 图1是人肾的结构示意图; [0066] FIG. 1 is a schematic structural diagram of human kidney;

[0067] 图2是人肾动脉的结构示意图; [0067] FIG. 2 is a schematic diagram of the structure of human renal artery;

[0068] 图3是本发明的一个实施例的用于调节神经的导管装置处于第一形状结构示意图; [0068] FIG. 3 is a schematic view of a first conduit means for adjusting the shape and structure of a neural embodiment of the present invention in;

[0069] 图4是图3所示的导管装置处于第二形状结构示意图; [0069] FIG. 4 is a catheter device shown in FIG. 3 is a schematic view of a second shape of the structures;

[0070] 图5是电极承载部表面的切割角度相同的直线槽的示意图; [0070] FIG. 5 is a schematic view of the same cutting angle of the electrode bearing surface of the grooved portion;

[0071] 图6是电极承载部表面的切割角度不同的直线槽的示意图; [0071] FIG. 6 is a schematic view of different cutting angles of the electrode-bearing surface of the grooved portion;

[0072] 图7是电极承载部表面被切割角度不同的直线槽的示意图; [0072] FIG. 7 is a schematic view of a different portion of the electrode-bearing surface of the cutting angle of the straight groove;

[0073] 图8是电极承载部表面被切割为多个柱形槽的示意图。 [0073] FIG. 8 is an electrode-bearing surface is cut into a plurality of cylindrical grooves FIG.

具体实施方式 Detailed ways

[0074] 图1、图2示出了人肾、人肾动脉的结构。 [0074] FIG 1, FIG 2 shows a human kidney, human kidney arteries structure.

[0075] 如图1所示,人肾在解剖学上包括肾1,肾动脉2经由腹部的主动脉连接到心脏,含氧的血液通过肾动脉2供给肾I ;脱氧的血液经由肾静脉3和下腔静脉4从肾I流到心脏。 [0075] As shown, in the human renal anatomy includes kidneys 1, 2 are connected via the renal artery of the abdominal aorta to the heart, oxygenated blood through the renal artery supplying renal 2 I; deoxygenated blood via the renal vein 3 4 from the inferior vena cava and renal I flow to the heart.

[0076] 如图2所示,肾神经21沿着肾动脉2的轴向延伸,肾神经21 —般在肾动脉2的外膜内。 [0076] As shown in FIG 2, the renal nerves 21 extending axially along the renal artery 2, the renal nerves 21 - as in the renal artery within the adventitia 2.

[0077] 本实施例中用于调节神经的导管装置,用于调节位于肾动脉2上的肾神经21,所述的调节是指通过损伤或非损伤的方式除去或降低肾神经21的活化。 [0077] In the present embodiment the conduit means for adjusting the nerves embodiment, for adjusting the renal nerves located on the renal artery 221, the adjustment means by using damage or injury remove or reduce the activation of the renal nerves 21. 如果需要调节其它部位的神经(例如,心脏相关神经),或者需要其它的调节方式(例如,需要提高神经的活化),本领域技术人员可以根据本发明做出合理预期的、不需要付诸创造性劳动的调整。 If necessary to adjust other parts of the nerve (e.g., cardiac-related neurological), or other adjustment required manner (e.g., the need to improve the activation of nerves), those skilled in the art can be made reasonably expected according to the present invention, no inventive into adjustment of labor.

[0078] 本实施例中用于调节神经的导管装置,包括用于调节所述神经的调节组件5,输送所述调节组件5的输送部件6 ;调节组件5包括用于将调节能量传递到肾神经的电极51以及用于承载电极51的电极承载部52,电极承载部52具有第一形状和第二形状。 [0078] The conduit means for adjusting the neural embodiment of the present embodiment, comprises means for adjusting said neural adjustment assembly 5, the conveying member conveying the adjustment assembly 5 6; 5 adjustment assembly comprises means for adjusting the energy delivered to the kidney nerve electrode 51 and the electrode for carrying the carrier portion 52 of the electrode 51, the electrode carrier having a first portion 52 and second shapes. 图3和图4分别示出了电极承载部52的第一形状和第二形状。 Figures 3 and 4 show a first and second shapes electrode portion 52 of the carrier. 在第一形状下,调节组件5的至少一个电极51可将调节能量传递到肾神经的位置,在第二形状下,调节组件5用于在血管中移动;导管装置还包括刚性部件9,刚性部件9设置为可支撑电极承载部52处于第二形状。 In a first form, the at least one electrode 5 adjustment assembly 51 may be adjusted to the position of the energy delivery renal nerves, in the second shape, 5 for moving the adjustment assembly in a blood vessel; catheter device further comprises a rigid member 9, the rigid member 9 may be provided to support the electrode-bearing portion 52 is in the second shape.

[0079] 本实施例中,电极51传递调节能量给需要调节的肾神经位点的方式为:经由血管进入人体,通过肾动脉内壁靠近神经位点。 [0079] In the present embodiment, the electrodes 51 pass renal nerve sites to adjust the power to be adjusted as: enter the body through a blood vessel, near the nerve site by the inner wall of the renal artery. 因此需要解决的技术问题是:既要实现电极51能够紧贴血管内壁作用于相应位置的神经,又需要电极51在血管中方便地移动,不损伤血管壁。 Thus the technical problem to be solved are: to achieve both the electrode 51 can act on the nervous against the vessel wall of the corresponding position, and electrode 51 need to be easily moved in the vessel without damaging the vessel wall.

[0080] 电极承载部52采用记忆材料制成,并预先热处理成第一形状,且具有空腔。 [0080] The electrode-bearing portion 52 made of memory material, and pre-heat treatment into a first shape, and has a cavity.

[0081] 如图3所示,本实施例中,电极承载部52的第一形状整体为螺旋形,在血管的径向上,电极承载部52的最宽处比第二形状大,这样可以使承载的电极51靠近或接触血管壁,从而靠近肾神经。 [0081] As shown in FIG. 3, in this embodiment, the shape of the first electrode portion 52 is integrally carrying a spiral shape in the radial direction of the vessel, the width of the electrode-bearing portion 52 is larger than the second shape, this could make carrying electrode 51 close to or in contact with the vascular wall so close to renal nerves.

[0082] 考虑到血管具有一定的弹性,电极承载部52的螺旋形的直径设置为4_12mm。 [0082] Considering the vessel has a certain elasticity, the helical portion 52 of the diameter of the electrode carrier to 4_12mm. 针对肾动脉内径较小的个体,例如内径为4_左右,可以将电极承载部52的螺旋形的直径设置为5-6mm左右;针对肾动脉内径较大的个体,例如内径为7mm左右,可以将螺旋的直径设置为8-9_左右。 Renal artery diameter for smaller individuals, for example, an inner diameter of about 4_, helical diameter of the electrode-bearing portion 52 may be about 5-6mm; for large individual renal artery diameter, for example, an inner diameter of approximately 7mm, can the diameter of the spiral is about 8-9_.

[0083] 电极承载部52的第一形状也可以为其它形状,例如具有圆滑的弯曲的无规则形状,只要是当所述电极承载部在血管中时,电极处于接触血管壁的位置即可。 [0083] The shape of the electrode carrier first portion 52 may be other shapes, for example having a curved rounded irregularly shaped, so long as when the electrode-bearing portion in the blood vessel when the electrode is in a position to contact the vessel wall.

[0084] 如图4所示,刚性部件9插入电极承载部52,电极承载部52处于第二形状,抽离电极承载部52,电极承载部52处于第一形状。 [0084] As shown in FIG 4, the rigid member 9 is inserted electrode carrier portion 52, the electrode shape in the second bearing portion 52, bearing portions 52 pulled the electrode, the electrode supporting portion 52 is in the first shape. .

[0085] 刚性部件9的插入和抽离由刚性部件运动控制机构10控制。 [0085] The rigid part 9 is inserted and pulled out by the control means 10 controls the movement of the rigid member.

[0086] 在本发明的一个优选实施例中,刚性部件9为金属丝。 [0086] In a preferred embodiment of the present invention, the rigid member 9 is a metal wire.

[0087] 所述金属丝优选为N1-Ti合金。 The [0087] preferably the wire N1-Ti alloy.

[0088] 电极承载部52为热处理成具有空腔的螺旋结构。 [0088] The electrode-bearing portion 52 having a helical structure to a heat treatment cavity.

[0089] 电极承载部52的第一形状为螺旋形或者近似螺旋形;电极承载部52的第二形状为直形或者近似直形。 [0089] The shape of the first electrode bearing portion 52 is a spiral or approximately spiral; electrode-bearing portions of the second shape 52 is straight or approximately straight shape. 当电极承载部52为第一形状时,调节组件5的至少一个电极可将调节能量传递到肾神经的位置;当电极承载部52为第二形状时,电极承载部52承载着电极51在血管中移动。 When the electrode supporting portion 52 of the first shape, the at least one electrode assembly 5 may be adjusted to adjust the position of energy delivery to the renal nerves; when the electrode-bearing portion 52 to a second shape, the electrode bearing portion 52 carries an electrode 51 in the vessel China mobile.

[0090] 如图4所示,本实施例中,电极承载部52的第二形状为直或接近直,也可以是细长状或纤维状或丝状,该条形的横截面优选为圆形或近似圆形,横截面的最宽处小于血管的内直径。 [0090] As shown in FIG. 4, in this embodiment, the shape of the second electrode-bearing portion 52 is straight or nearly straight, and may be elongated or fibrous or filamentous, the strip is preferably a circular cross-section or approximately circular shape, the widest cross-section smaller than the inner diameter of the blood vessel. 这样,在第二形状下,当调节组件5在血管中移动时,调节组件5不会损伤血管壁。 Thus, in the second shape, when the adjustment assembly 5 moves in a blood vessel, adjustment assembly 5 will not damage the vessel wall. 当需要对肾动脉上的神经进行调节时,由于人肾动脉的内直径一般为4-7_,因此,调节组件5在肾动脉的径向上的最大尺寸不大于4mm,最好设置为l_2mm,既可以满足在血管内方便移动,又具有足够的刚性并且便于制作,并可以减小患者的伤口的尺寸。 When it is desired to nerves regulating renal artery, renal artery since the inner diameter of the person generally 4-7_, therefore, adjustment assembly 5 in the radial direction on the renal artery largest dimension no greater than 4mm, preferably set l_2mm, both satisfy facilitate movement in the blood vessel, but also has sufficient rigidity and ease of fabrication, and can reduce the size of the wound of the patient. 作为该具体实施方式的变化,第二形状也可以允许一定的弯曲或者波浪形的弯曲,其横截面也可以为其它形状,只要其表面光滑,能够方便地在血管内移动而不损伤血管壁即可。 As a variation of this particular embodiment, the second shape can also allow some bending or undulating curved, the cross section may be, as long as a smooth surface, can be easily moved within the blood vessel without damage to the vessel wall shapes other i.e. can.

[0091] 本实施例中用于调节肾神经的导管装置的工作过程如下: [0091] The working process of the present embodiment, conduit means for adjusting the renal nerves embodiment is as follows:

[0092] I先将刚性部件9插入电极承载部52,使得电极承载部52由预成形的第一形状变为第二形状; [0092] I first rigid member 9 is inserted electrode carrier portion 52, so that the electrode 52 carried by the first portion of the preformed shape to a second shape;

[0093] 2移动导管装置到人体肾动脉上的肾交感神经处; [0093] 2 is moved to the conduit means at renal sympathetic nerve renal artery in the human body;

[0094] 3将刚性部件9抽离电极承载部52,电极承载部52由直的变为螺旋形,即由第二形状回复为第一形状,此时,电极承载部52上的电极51,紧贴血管内壁作用于相应位置的神经,释放一定的能量从而起到调节该神经位点(例如,降低或消除交感神经的活化)的作用; [0094] 3 bearing the electrode portion 9 pulled rigid member 52, the electrode 52 carried by the straight portion becomes helical, i.e. a reply to the second shape as the first shape, this time, the electrode 51 on the electrode-bearing portion 52, close to the vessel wall act on the nervous respective position, whereby a constant energy release can modulate the nerve site (e.g., reduce or eliminate sympathetic activation) action;

[0095] 4将刚性部件9插入电极承载部52,电极承载部件52再次由第一形状转变为第二形状; [0095] 4 rigid member 9 is inserted electrode carrier portion 52, the electrode carrying member 52 again transitions from a first shape to a second shape;

[0096] 5将导管装置移出人体。 [0096] 5 out of the body of the catheter apparatus.

[0097] 电极51与输送调节能量的导线相连,每一个电极51独立工作,分别具有单独的导线。 [0097] 51 and the electrode wires connected to the regulation of energy delivery, working independently of each electrode 51, each having a separate wire. 一个电极是否释放调节能量,与其他电极无关;可以仅有一个或部分电极传递调节能量,也可以所有电极同时工作,传递调节能量;每个电极是否传递调节能量的状态是彼此独立的。 An electrode whether to release regulation of energy, regardless of the other electrodes; or may be only a portion of the electrode regulation of energy transfer, all the electrodes may be operated simultaneously, the regulation of energy delivery; whether each electrode transmission adjustment power state independent of each other. 电极51的内表面具有为其提供能量的导线。 Electrode 51 having an inner surface to provide energy conductor. 电极承载部52与输送部件6的外部具有第一绝缘层,导线设置在第一绝缘层的外部,并在导线和第一绝缘层的外部包覆第二绝缘层。 External electrode-bearing portion 52 of the conveying member 6 having a first insulating layer, the outer conductor disposed on the first insulating layer, and a second insulating layer covering the outer conductor and the first insulating layer.

[0098] 当电极51靠近需要调节的神经位点时,电极51释放一定的能量并作用于该神经位点,从而起到调节该神经位点(例如,降低或消除交感神经的活化)的作用。 [0098] When the electrode 51 is adjusted to be near the site of the nerve, electrode 51 and release a certain energy to act on the nerve site, and thus play a regulating the nerve site (e.g., reduce or eliminate sympathetic activation) effect .

[0099] 电极51可以通过将热量传递到该神经位点而实现该目的。 [0099] The electrode 51 may be achieved by transferring heat to the object of the nerve site. 例如,用于神经调节的传热加热机制可以包括热消融和非消融的热变或损伤,例如,可以将靶神经纤维的温度升高超过所需阈值以实现非消融的热变,或超过更高的温度以实现消融的热变。 For example, a heating mechanism for heat transfer neuromodulation may include thermal ablation and non-ablative thermal alteration or the damage, e.g., temperature of the target neural fibers may be elevated above a desired threshold to achieve non-ablative thermal alteration of, or more than high temperatures to effect the thermal ablation. 例如,靶温度可以在大约37°C_45°C (用于非热消融的热变温度),或者,所述靶温度可以在大约45°C或更高,以用于消融的热变。 For example, the target temperature may be from about 45 ° C or higher for thermal ablation becomes about 37 ° C_45 ° C (for non-thermal ablation thermal transition temperature), or the target temperature.

[0100] 电极51也可以通过将冷却传递到该神经位点而实现该目的。 [0100] electrodes 51 of the object can also be achieved by passing the cooling to the nerve site. 例如,将靶神经纤维的温度降低到约20°C以下以实现非冷冻的热变,或者将靶神经纤维的温度降低到约0°C以下以实现冷冻的热变。 For example, the temperature of the target nerve fibers was reduced to about below 20 ° C in order to achieve a non-freezing thermal denaturation, the temperature of the target neural fibers or decreased to below 0 ° C to about achieve heat becomes frozen.

[0101] 电极51还可以通过将能量场施加到靶神经纤维来实现。 [0101] electrode 51 is also achieved to the target nerve fibers can be applied by the energy field. 该能量场可以包括:电磁能、射频、超声波(包括高强度聚焦超声波)、微波、光能(包括激光、红外线和近红外线)等。 The energy field may comprise: an electromagnetic energy, radio frequency, ultrasound (including high intensity focused ultrasound), microwave, light (including laser, infrared and near infrared) and the like. 例如,热诱导的神经调节可以通过将脉冲的或连续的热能场递送到靶神经纤维而实现。 For example, thermally-induced neuromodulation may be achieved by field or thermal energy delivered to the target successive pulses of the nerve fibers. 其中,一种比较优选的能量方式是脉冲射频电场或其它类型的脉冲热能。 Wherein, in a more preferred embodiment pulse energy of radio frequency electric field or other types of energy pulses. 脉冲射频电场或其它类型的脉冲热能可以促成更大的热量级别、更长的总持续时间和/或更好的受控的血管内肾神经调节治疗。 Pulsed RF fields, or other types of pulse energy can contribute to greater levels of heat, longer total duration and / or better controlled intravascular renal neuromodulation therapy.

[0102] 无论通过何种能量方式实现调节神经的目的,当使用者使用本实施例中用于调节神经的导管装置进行工作时,电极需要与产生该能量(例如射频仪)或使电极51本身产生该能量的设备进行电连接。 [0102] Whether the purposes of regulating neuronal energy by way of which, when the user uses the present embodiment of the catheter device embodiment for adjusting the neural work, the electrode needs to generate energy (e.g. radio frequency meter) or the electrode 51 itself the energy generating device is electrically connected. 这些设备以及电极与这些设备的连接为本领域技术人员所熟知的现有技术(例如,在本发明装置中设置用于连接这些设备的接口,使用时可实现即插即用),这里不再详细叙述。 These prior art devices and devices connected to these electrodes and the person skilled in the art (e.g., in the apparatus of the present invention is provided for interfacing these devices, may be implemented using a Plug and Play), where no detail.

[0103] 为了更好的传递调节能量,电极51的横截面为环状。 [0103] For a better regulation of energy transfer, the cross-section of the electrode 51 is annular. 当所述电极承载部处于第一形状时,即当在肾动脉内电极承载部52为螺旋形时,电极承载部52上的电极51处于接触肾动脉内壁的位置,即靠近肾神经,这样就可以进行调节工作。 When the electrode-bearing portion is in the first shape, i.e. when the electrode carrier within the renal artery helical portion 52, the electrode 51 on the electrode-bearing portion 52 is in a position in contact with the inner wall of the renal artery, that is, near the renal nerves, so that It can be adjusted to work.

[0104] 本实施例中,电极51的数目为四个,当电极承载部52处于第一形状(螺旋状)时,相邻的电极51在血管的轴向上的距离为4-15mm。 [0104] In this embodiment, the number of electrode 51 is four, when the electrode-bearing portion 52 is in the first shape (helical), the distance between adjacent electrodes 51 in the axial direction of the blood vessel is 4-15mm. 一般说来,进行肾神经消融手术时,需要对肾神经的3-8个位点进行消融。 In general, the renal nerve ablation surgery, the need for 3-8 loci renal nerve ablation. 因此,使用本实施例中的导管装置进行消融手术时,一次调节组件5的定位(使电极51接触血管内壁)可以完成四个位点的消融,而完成整个消融手术只需要进行两次调节组件5的定位。 Thus, when using the device in a catheter ablation procedure performed embodiment, a positioning assembly 5 is adjusted (the electrode 51 in contact with the blood vessel wall) to complete four ablation site, and to complete the ablation procedure requires only two adjustment assembly positioning 5. 电极51的数目也可以设置为2-6个,但如果数目过多,会增加导管装置的制作成本;而数目较少,会降低消融手术的工作效率。 The number of electrodes 51 may be set to 2-6, but if the number is too large, the manufacturing cost increases conduit means; the smaller number will reduce the efficiency of the ablation procedure.

[0105] 电极51的材料可采用生物相容性较好或比较稳定的金属或金属合金,例如钼族金属,本实施例中的电极51采用钼铱合金制作。 Materials [0105] electrode 51 is preferably biocompatible or can be a relatively stable metal or metal alloy, such as molybdenum metal, the present embodiment the electrode 51 in Example molybdenum iridium alloy production.

[0106] 为了使电极51牢固的安装在电极承载部52上,并尽量减少对血管壁的损伤,可使用胶水将电极51粘结于电极承载部52上,并形成电极51与电极承载部52间的平滑过渡。 [0106] In order to secure the electrode 51 is mounted on the electrode-bearing portion 52, and to minimize damage to the vessel wall, the electrode 51 may be used to glue bonded to the electrode-bearing portion 52, and forming electrode 51 and the electrode supporting portion 52 smooth transition between. 胶水可选用UV固化胶、环氧树脂胶或其混合物,这样既具有能达到医疗用途的生物相容性,又对金属合金和高分子材料都有一定的粘结力。 Optional UV curable adhesive glue, epoxy, or mixtures thereof, so that both can be achieved with a biocompatible medical use, but also of metal alloys, and polymeric materials have a certain adhesion.

[0107] 导线连接到能量产生设备,例如射频仪,焊接在电极51的内表面,导线设置于电极承载部52与输送部件6的外部。 [0107] conductors connected to the energy generating device, such as radio frequency device, the inner surface of the welding electrode 51, electrode wires disposed in the outer bearing portion 52 of the conveying member 6. 设置多个电极时,需要设置多根导线分别将多个电极连接到能量产生设备。 When a plurality of electrodes, a plurality of wires need to set the plurality of electrodes respectively connected to the energy generating device.

[0108] 电极承载部52上还可以设置用于测量温度的元件,例如热电偶,以及相应的导线。 [0108] The upper electrode portion bearing member 52 may also be provided for the measurement of temperature, such as a thermocouple, and the corresponding wires.

[0109] 电极承载部52的远端设置用于减少或避免血管壁损伤的保护部件,保护部件的一个作用是减少或避免血管壁损伤,碰触到血管壁时,因为自身足够柔软且能够迅速回弹,不会对血管造成损失;保护部件的另一个作用是对整个导管装置起到导向作用,当遇到血管的弯折处时,自身能够根据血管的弯折度弯曲,从而引导整个导管装置顺利通过血管的弯折处。 When [0109] the distal end portion of the electrode carrier 52 is provided for reducing or avoiding the protective member vessel wall injury, the effect of a protective member is to reduce or avoid damage to the vessel wall, touches the vessel wall, and because of their flexible enough to quickly rebound, without causing damage to the blood vessel; another role is to play a protective member contribution to the overall catheter guide means when the vessel encounters the bend itself can be bent according to the bending of the blood vessel so as to guide the entire catheter means at the vessel by bending smoothly.

[0110] 保护部件是相对较软部件,可以是材质相对较软的高分子材料制作的部件,本实施例中,保护部件为软头8,如图3和图4所示,避免电极承载部52的远端损伤血管;软头采用弹性材料制作,弹性材料为橡胶、硅胶或热塑性弹性体;软头的长度为3-15mm,最大直径小于1.33_。 [0110] protective member is relatively soft member, the material may be a relatively soft polymer material member, the soft head of this embodiment, the protective member 8, as shown in FIGS. 3 and 4, electrode-bearing portion to avoid the distal end 52 of the vascular injury; head soft elastic material, the elastic material is rubber, silicone or a thermoplastic elastomer; soft head length of 3-15mm, a maximum diameter of less than 1.33_.

[0111] 保护部件也可以是弹簧,设置于电极承载部52的远端,弹簧采用N1-Ti合金或不锈钢制作,螺距是紧密螺旋的,能够满足弹性要求。 [0111] protective member may be a spring, disposed on the distal end portion of the electrode carrier 52, the spring using N1-Ti alloy or stainless steel, the spiral pitch is tight, it is possible to meet compliance requirements. 弹簧的长度为25-50_,螺旋外径为0.25-0.6mm,弹簧丝的直径为0.045-0.12mm。 25-50_ length of the spring of the coil outer diameter of 0.25-0.6mm, the diameter of the spring wire is 0.045-0.12mm.

[0112] 输送部件6与所述电极承载部52可以是一体的。 [0112] the conveying member 6 and the carrier portion of the electrode 52 may be integral.

[0113] 输送部件6与所述电极承载部52也可以是分体的,输送部件6的远端与电极承载部52的近端相连。 [0113] the conveying member 6 and the carrier portion of the electrode 52 may be a separate body connected to the proximal end of the distal end portion 52 of the electrode carrier conveying member 6.

[0114] 输送部件6为管状,外径为0.5mm-1.0mm,壁厚为0.05-0.15mm ;采用N1-Ti合金制作;外表面热缩一层高分子材料;高分子材料为PET/FEP/PTFE/TPU。 [0114] the conveying member 6 is tubular, an outer diameter of 0.5mm-1.0mm, a wall thickness of 0.05-0.15 mm; using N1-Ti alloy production; outer surface layer of heat shrinkable polymer material; polymer material is PET / FEP / PTFE / TPU.

[0115] 为了便于使用刚性部件9改变电极承载部的形状52,电极承载部52的表面被切害I]。 [0115] For ease of changing the shape of a rigid member 9 bearing the electrode portion 52, the surface electrode portion 52 are cut bearing damage I]. 刚性部件9控制电极承载部52,使其具有第一形状或第二形状,在刚性部件9插入电极承载部52时,电极承载部52由螺旋形变为直形,即从第一形状变为第二形状;当刚性部件9抽离电极承载部52时,电极承载部52由直形变为螺旋形,即从第二形状回复为第一形状。 A rigid carrier member 9 controls the electrode unit 52 so as to have a first shape or the second shape, the rigid member 9 is inserted 52, the electrode portion 52 carrying a helical electrode carrier becomes straight portion, i.e. from a first shape to a second second shape; pull away the electrode bearing portion 9 when the rigid member 52, the electrode 52 carried by the straight portion becomes helical, i.e., return to the first shape from the second shape.

[0116] 电极承载部52的表面按照切割角度、从电极承载部52的远端向电极承载部52的近端,被切割成直线槽或多个柱形槽,具体如图5-图8所示。 [0116] surface of the bearing portion 52 of the electrode according to the cutting angle from the distal end portion of the electrode carrier the electrode carrier 52 to the proximal end portion 52, is cut into a straight groove or a plurality of cylindrical grooves, specifically 5 through 8 in FIG. shows. 水平放置电极承载部52,若是被切割为直线槽,切割角度就是直线与水平方向的夹角ct ;若是被切割为多个柱形槽,切割角度就是多个柱形槽的中心点之间的连线与水平方向上的夹角ct。 Horizontally disposed electrode-bearing portion 52, if a linear groove is cut, the cutting angle is the angle between the straight line and the horizontal ct; if it is cut into a plurality of cylindrical grooves, the cutting angle is the center point between a plurality of cylindrical grooves ct on the connection angle with the horizontal direction.

[0117] 在本发明的一个较佳实施例中,电极承载部表面按照切割角度切割成直线槽,具体如图5、图6和图7所示。 [0117] In a preferred embodiment of the present invention, electrode-bearing surface was cut into the linear groove portion in accordance with a cutting angle, particularly FIGS. 5, 6 and 7 shown in FIG.

[0118] 在电极承载部的表面,图5所示的直线槽是以a =53°的切割角度、从电极承载部的远端开始到电极承载部的近端、按照直线进行连续切割形成的。 [0118] bearing surface of the electrode portion, the linear grooves shown in Figure 5 is a = 53 ° angle cut, according to a straight line cut is formed continuously from the distal end portion of the electrode carrier the electrode carrier beginning portion to the proximal end . 其中,直线槽的切割宽度在0.2449mm〜0.6566mm之间,图5所示的直线槽在电极承载部上的切割角度是一致的。 Wherein the cutting width of the linear groove between 0.2449mm~0.6566mm, cutting angle linear groove shown in FIG. 5 on the electrode portion of the carrier is the same.

[0119] 图6所示的直线槽分为两部分:一部分是以a =53°的切割角度、从电极承载部的远端开始、按照直线连续切割形成的;另一部分是当靠近电极承载部近端时,逐步减小切割角度(a '),并按照逐步减小的切割角度(a ')、直至电极承载部的近端、按照直线连续切割形成的。 Straight groove shown in [0119] FIG 6 is divided into two parts: one is a cutting angle a = 53 °, starting from the distal end portion of the electrode carrier, formed by cutting a continuous straight line; the other is close to the electrodes when the carrier portion when the proximal end, and gradually reduced cutting angle (a '), and in accordance with the cutting angle (a progressively smaller'), until the proximal end portion of the electrode carrier, formed by cutting a continuous straight line.

[0120] 图7所示的直线槽分为两部分:一部分是以a =53°的切割角度、从电极承载部的远端开始、按照直线间断切割形成的;另一部分是当靠近电极承载部近端时,逐步减小切割角度(a '),并按照逐步减小的切割角度(a ')、直至电极承载部的近端、按照直线间断切割形成的。 Straight groove shown in [0120] FIG. 7 is divided into two parts: one is a cutting angle a = 53 °, starting from the distal end portion of the electrode carrier, cutting in a straight line intermittently formed; the other is close to the electrodes when the carrier portion when the proximal end, and gradually reduced cutting angle (a '), and in accordance with the cutting angle (a progressively smaller'), until the proximal end of the electrode-bearing portions, formed by cutting in a straight line intermittently. 其中,直线槽的切割宽度在0.2449mm〜0.6566mm之间。 Wherein the width of the linear groove is cut between 0.2449mm~0.6566mm.

[0121] 在本发明的又一个较佳实施例中,电极承载部表面按照切割角度切割成多个柱形槽,如图8所示,在电极承载部52上,多个柱形槽是以30°的切割角度、按照0.7150mm的切割间隔(相邻两个柱形槽中心的水平间隔)、从电极承载部52的远端向近端切割形成的。 [0121] In a further preferred embodiment of the present invention, the electrode-bearing surface a plurality of cylindrical grooves cut in accordance with cutting angle, as shown in FIG. 8, on the electrode-bearing portion 52, a plurality of cylindrical grooves are 30 ° angle cut, according to cutting intervals 0.7150mm (two cylindrical grooves adjacent the center horizontal separation), from the distal portion 52 of the electrode carrier formed by cutting proximally. 每一个槽形花纹与水平正方向夹角为120°。 Each sipe positive direction and the horizontal angle of 120 °.

[0122] 导管装置还包括用于使用者握持的手柄7。 [0122] 7 conduit means further comprises a handle for gripping the user. 输送部件6与手柄7相连。 A handle connected to the conveying member 6 and 7. 导线安装在手柄7上。 Wire 7 mounted on the handle. 手柄7与外部能量发生器的连接电缆设置为一体,或设置为通过转换端口连接的两部分,导线通过手柄7与外部能量发生器的连接电缆相连。 7 handle connecting cable is provided with an external power generator as one, two, or set by the conversion port portion, a wire connected to the handle by a connection cable 7 external energy generator.

[0123] 刚性部件运动控制机构10可以设置在手柄7内,由手柄7通过齿轮操控刚性部件9的抽离和插入。 [0123] rigid member motion control mechanism 10 may be disposed within the handle 7, controlled by the handle 7 by a rigid member 9 and the gear disengagement inserted. 刚性部件运动控制机构10也可设置在手柄7外部,通过手动直接控制刚性部件9的抽离和插入。 Rigid member motion control mechanism 10 may be provided on the external handle 7, the rigid member is directly controlled by manual insertion and disengagement of 9. 在本实施例中,如图3和图4所示,刚性部件运动控制机构10是设置在手柄7的外部,通过手动抽离或插入刚性部件。 In the present embodiment, as shown in FIGS. 3 and 4, the rigid member motion control mechanism 10 is disposed on the outside of the handle 7 by a rigid member is inserted into or pulled out manually.

[0124] 以上详细描述了本发明的较佳具体实施例。 [0124] or more specifically described in detail preferred embodiments of the present invention. 应当理解,本领域的普通技术无需创造性劳动就可以根据本发明的构思作出诸多修改和变化。 It should be understood that the art of ordinary skill may be made without inventive labor many modifications and variations of the inventive concept. 因此,凡本技术领域中技术人员依本发明的构思在现有技术的基础上通过逻辑分析、推理或者有限的实验可以得到的技术方案,皆应在由权利要求书所确定的保护范围内。 Therefore, any person skilled in the art under this inventive concept on the basis of prior art technical solutions through logical analysis, reasoning or limited experiments can be obtained, are to be within the scope defined by the claims in.

Claims (10)

1.一种用于调节肾神经的导管装置,包括调节组件和输送部件; 所述调节组件包括电极承载部和多个电极;所述多个电极被设置为将调节能量传递到神经;所述电极承载部被设置为承载所述多个电极; 所述电极与导线相连; 所述输送部件被设置为将所述调节组件输送到靠近所述神经的位置; 其特征在于, 所述电极承载部为挠性的,且被预处理为具有第一形状; 所述导管装置还包括设置在所述输送部件内的刚性部件;当所述刚性部件插入所述电极承载部时,所述电极承载部保持与所述刚性部件相应的第二形状;当所述刚性部件从所述电极承载部抽离时,所述电极承载部回复为所述第一形状; 在所述第一形状下,所述电极承载部被设置为适于通过所述多个电极将调节能量传递到所述神经;在所述第二形状下,所述电极承载部被设置为适于在血管中 CLAIMS 1. A catheter device for adjusting the renal nerves, including adjustment assembly and conveying member; said adjustment assembly includes an electrode supporting portion and a plurality of electrodes; a plurality of electrodes is arranged to adjust the energy delivered to the nerve; the the electrode carrier is arranged to carry a portion of the plurality of electrodes; and electrodes connected to the lead; the conveying means is arranged to adjust the transport assembly to a position close to the nerve; characterized in that the electrode carrier portion is flexible, and is pre-treated to have a first shape; said conduit means further comprises a rigid member disposed in said conveying member; when the rigid member is inserted into the electrode-bearing portion of the electrode carrier portion maintaining the second shape corresponding to said rigid member; when detached from the rigid member portion of the electrode carrier, the electrode carrier portion reply to the first shape; in the first shape, the electrode-bearing portions are provided by said plurality of electrodes adapted to adjust the energy delivered to the nerve; in the second shape, the electrode-bearing portion adapted to be disposed in a blood vessel 动。 move.
2.如权利要求1所述的用于调节肾神经的导管装置,其特征在于,所述刚性部件的插入和抽离是由刚性部件运动控制机构控制的。 2. The catheter device for adjusting the renal nerves according to claim 1, wherein said rigid member is inserted into and pulled out of a rigid member is controlled by the motion control mechanism.
3.如权利要求2所述的用于调节肾神经的导管装置,其特征在于,所述刚性部件为金属丝。 Conduit means for adjusting the renal nerves according to claim 2, wherein said rigid member is a metal wire.
4.如权利要求3所述的用于调节肾神经的导管装置,其特征在于,所述金属丝为NiTi口ο 4. The catheter device for adjusting the renal nerves according to claim 3, characterized in that the metal is NiTi wire port ο
5.如权利要求2所述的用于调节肾神经的导管装置,其特征在于,所述电极承载部采用记忆合金制成。 5. A catheter as claimed in claim adjusting means for renal nerves claim 2, wherein the electrode-bearing portion using memory alloy.
6.如权利要求2所述的用于调节肾神经的导管装置,其特征在于,所述电极承载部的所述第一形状为螺旋形或者近似螺旋形。 Conduit means for adjusting the renal nerves according to claim 2, wherein said first portion of the electrode carrier to form a spiral or approximately spiral shape.
7.如权利要求2所述的用于调节肾神经的导管装置,其特征在于,所述电极承载部的所述第二形状为直的或者近似直的。 7. A catheter as claimed in claim adjusting means for renal nerves claim 2, wherein said bearing portion of said second electrode have a straight or nearly straight.
8.如权利要求6所述的用于调节肾神经的导管装置,其特征在于,所述第一形状的直径为4_12mm。 8. A catheter as claimed in claim means for adjusting the renal nerves according to claim 6, wherein the first shape having a diameter of 4_12mm.
9.如权利要求1所述的用于调节肾神经的导管装置,其特征在于,多个所述电极单独控制释放能量。 Conduit means for adjusting the renal nerves according to claim 1, wherein said plurality of electrodes individually controlled release energy.
10.如权利要求2所述的用于调节肾神经的导管装置,其特征在于,多个所述电极同时控制释放能量。 10. A catheter as claimed in claim adjusting means for renal nerves claim 2, wherein the plurality of electrodes while controlling the release of energy.
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9554848B2 (en) 1999-04-05 2017-01-31 Medtronic, Inc. Ablation catheters and associated systems and methods
US9675413B2 (en) 2002-04-08 2017-06-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US9707035B2 (en) 2002-04-08 2017-07-18 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9855096B2 (en) 2012-05-11 2018-01-02 Medtronic Ardian Luxembourg S.A.R.L. Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods
US9888961B2 (en) 2013-03-15 2018-02-13 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
US10076382B2 (en) 2010-10-25 2018-09-18 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1549694A (en) * 2001-05-01 2004-11-24 咖帝玛股份有限公司 Helically shaped electrophysiology catheter
CN101528145A (en) * 2005-12-29 2009-09-09 韦伯斯特生物官能公司;塞思·J·沃尔利 Deflectable catheter with a flexibly attached tip section
CN202437329U (en) * 2012-01-10 2012-09-19 上海安通医疗科技有限公司 Manipulative radiofrequency catheter electrode device
CN102846374A (en) * 2011-06-30 2013-01-02 韦伯斯特生物官能(以色列)有限公司 Catheter with variable arcuate distal section
CN102908191A (en) * 2012-11-13 2013-02-06 陈绍良 Multipolar synchronous pulmonary artery radiofrequency ablation catheter
CN102940525A (en) * 2012-10-17 2013-02-27 上海安通医疗科技有限公司 Multi-pole helicoidal radiofrequency ablation conduit
CN203280485U (en) * 2013-04-12 2013-11-13 上海微创电生理医疗科技有限公司 Multi-electrode ablation catheter
US20140088585A1 (en) * 2012-09-26 2014-03-27 Boston Scientific Scimed, Inc. Catheter having rib and spine structure supporting multiple electrodes for renal nerve ablation
CN203935269U (en) * 2014-06-24 2014-11-12 上海安通医疗科技有限公司 Catheter device for adjusting renal nerves

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1549694A (en) * 2001-05-01 2004-11-24 咖帝玛股份有限公司 Helically shaped electrophysiology catheter
CN101528145A (en) * 2005-12-29 2009-09-09 韦伯斯特生物官能公司;塞思·J·沃尔利 Deflectable catheter with a flexibly attached tip section
CN102846374A (en) * 2011-06-30 2013-01-02 韦伯斯特生物官能(以色列)有限公司 Catheter with variable arcuate distal section
CN202437329U (en) * 2012-01-10 2012-09-19 上海安通医疗科技有限公司 Manipulative radiofrequency catheter electrode device
US20140088585A1 (en) * 2012-09-26 2014-03-27 Boston Scientific Scimed, Inc. Catheter having rib and spine structure supporting multiple electrodes for renal nerve ablation
CN102940525A (en) * 2012-10-17 2013-02-27 上海安通医疗科技有限公司 Multi-pole helicoidal radiofrequency ablation conduit
CN102908191A (en) * 2012-11-13 2013-02-06 陈绍良 Multipolar synchronous pulmonary artery radiofrequency ablation catheter
CN203280485U (en) * 2013-04-12 2013-11-13 上海微创电生理医疗科技有限公司 Multi-electrode ablation catheter
CN203935269U (en) * 2014-06-24 2014-11-12 上海安通医疗科技有限公司 Catheter device for adjusting renal nerves

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9554848B2 (en) 1999-04-05 2017-01-31 Medtronic, Inc. Ablation catheters and associated systems and methods
US9675413B2 (en) 2002-04-08 2017-06-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US9707035B2 (en) 2002-04-08 2017-07-18 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10076382B2 (en) 2010-10-25 2018-09-18 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods
US9855096B2 (en) 2012-05-11 2018-01-02 Medtronic Ardian Luxembourg S.A.R.L. Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods
US9888961B2 (en) 2013-03-15 2018-02-13 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode

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