CN1052864C - Qianguohua lead removing liquid - Google Patents
Qianguohua lead removing liquid Download PDFInfo
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- CN1052864C CN1052864C CN97109256A CN97109256A CN1052864C CN 1052864 C CN1052864 C CN 1052864C CN 97109256 A CN97109256 A CN 97109256A CN 97109256 A CN97109256 A CN 97109256A CN 1052864 C CN1052864 C CN 1052864C
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Abstract
The present invention relates to Qianguohua liquid for removing lead. Kelp immersion liquid, edible aminofusin, Chinese gooseberry extract rich in Vitamins C, and sunflower seed extract containing zinc are used as principal raw materials, proteoglycan, sugar, citric acid and table salt are added, and thus, colorless or light yellow brown transparent liquid conforming to the standard of a health-care beverage is made. The Qianguohua liquid has the advantages of no off-flavor and sour and sweet taste. The content of zinc in the health-care beverage is from 5 mg/100 ml to 10 mg/100 ml, the content of the zinc in oral liquid is from 20 mg/100 ml to 30 mg/100 ml, the content of amino acid containing sulfur is more than 2 mg/100 ml, the pH value is more than 6, and the content of carbon dioxide in the beverage is more than 2. The health-care liquid can effectively activate enzyme systems in vivo, can accelerate the removal of body fluid and lead which is accumulated in tissue cells, and can also reduce the absorption of lead. The Qianguohua liquid has the function of body-health protection.
Description
The invention belongs to quicken body fluid and be accumulated in eliminating plumbous in the histocyte plumbous liquid and preparation method thereof falls.
Lead is a kind of metallic poison, because factors such as motor vehicle exhaust emission and industrial coal cause plumbous environmental pollution to be tending towards seriously, human body is produced potential hazard.How lead poisoning and the unusual crowd of plumbous absorption prevent and treat the key subjects that become worldwide medical research, the many physicians in various countries just actively open up the new method that the non-medicine of research is got rid of body lead, but do not see the research that success is arranged so far as yet, some study report, to eliminate the environment lead contamination, reduce the danger that daily suction is poisoned, control concentrates on the adjusting living and diet, help the plumbous metabolism of body to discharge, the similar dietotherapy of its method, " the The role of nutrition in the prevention of load poisoning in children " that the Sargent JD worker of Lebanon delivered in 1994 (pediatr Ann 1,994 23 (11) 636-42 both at home and abroad medical literature 1985-96) recently is exactly an example.China had not before also had the natural drink product of special efficacy lead discharging, and the health products of the plumbous harm of exploitation control certainly will be asked.
The objective of the invention is from natural fruit thing, to extract composition, be deployed into the plumbous non-pharmaceutical preparation that falls, and its compound method is provided based on the natural goods composition with lead-expelling function.
Lead enters in the body, does not have structural change, has only discharge can remove its toxic action.Because of the plumbous metabolism of body is subjected to multiple factor affecting, but accumulate in vivo and short plumbous the drainage as the anti-lead of zinc tangerine, take in sufficient protein, the nutrient such as vitamin and an amount of cellulose of taking food all can influence and plumbously absorb and discharge, in view of the above, the technical scheme that realizes the object of the invention is: fall plumbous liquid with kelp extract, contain zinc sunflower seed extract, be rich in ascorbic Chinese gooseberry extract, commercially available edible compound amino acid such as silkworm chrysalis hydrolysis compound amino acid are primary raw material, be equipped with cystine, cysteine and flavouring low-ester pectin (polygalacturonic acid), albumen sugar, sugar, citric acid, salt, be deployed into colourless or fallow transparent liquid, its zinc, sulfur-bearing amino, pH value, the carbon dioxide component content is:
The composition beverage and oral liquid
Zinc (in Zn mg/100ml) 5-10 20-30
Sulfur-containing amino acid (mg/100ml)＞22
PH value＜66
Carbon dioxide＞2-its lead, arsenic, mercury, the food additives amount meets national health beverages standard, plumbous in Pb＜0.5mg/l, arsenic is in As＜0.3mg/l, mercury must not detect in Hg, food additives meet GB2760, microbiological indicator meets sanitary standard, total plate count (clump count)＜100/ml, coliform＜6/100ml, pathogenic bacteria duodenum 12 road pathogenic bacteria, pathogenic coccus must not detect, mould, saccharomycete＜10/ml meet No. 099 Q/QGH001-95 operative norm of hygienic food and health number (1997).
The plumbous beverage and the oral liquid method of inspection are originally fallen, the organoleptic indicator is undertaken by GB/T10792, zinc by GB5009,14 carry out, sulfur-containing amino acid is with PICO-TAC type amino acid analysis system measurement, pH value is undertaken by GB9724, lead is undertaken by GB5009,12, arsenic is undertaken by GB5009,11, and microorganism is undertaken by national GB4789.
Compound method of falling plumbous liquid of the present invention: albumen sugar is 36 parts at first by ratio of weight and the number of copies, 5.6 parts of compound amino acids, 36 parts of vitamin Cs, 1.6 parts on zinc, 0.34 part of cystine, 0.34 part of cysteine, low-ester pectin 0-0.5 part, calculate each raw material aequum, undertaken by following program then, with sunflower seed extract and compound amino acid, cystine, cysteine mixes, the low-ester pectin that adds the 0.1-0.5% of above-mentioned these raw mix weight, do not add when joining oral liquid, add the immersion liquid of part sea-tangle and transfer and mix the composition mother liquor, be generally 120 ℃ after 30 minutes through high-temperature sterilization, again with sea-tangle immersion liquid allotment concentration, add albumen sugar then, the Chinese gooseberry extract, citric acid, PH＜6, sour-sweet flavor are arrived in the salt seasoning, after component content reaches standard, uniform filtration, filling and sealing, high-temperature sterilization, check.
Producing of its sunflower seed extract: sunflower seed are removed degrease with milling process, also excessive 10-30% water is most to being ground to smoothly to add water-wet with 60% ethanol and sub-benevolence slag, heating and refluxing extraction liquid, decompression recycling ethanol, filtration, concentrated filtrate is made material liquid fully and is used to containing zinc 〉=158mg/100ml.
Sea-tangle leaching liquor preparation method, commercially available dried sea-tangle was immersed in 2% acetic acid 20 minutes, propose to place 〉=8 hours, with the flushing deacidification of 4% saline solution, add the water infusion and removed raw meat in 1 hour after, chopping adds 3000ml cold water dipping 〉=24 hours by 120g raw material sea-tangle, filter, filtrate is concentrated into 1/5 volume, add ethanol and separate out the protein foreign material, behind the decompression filtrate recycling ethanol, filtration, filtrate get leaching liquor with activated carbon decolorizing.
The preparation of Chinese gooseberry extract: extracting juice, water-bath heating destructive enzyme are cleaned, pressed to bright Kiwi berry berry, adding 90% ethanol is stirred to precipitation and filters fully, behind the decompression filtrate recycling ethanol, repeat 1-2 stand at low temperature 〉=24 hour, filter, filtrate is decoloured with charcoal absorption, analyzes to such an extent that contain the extract of Catergen .4g/100ml.
Its compound amino acid, cystine, cysteine, low-ester pectin polygalacturonic acid, citric acid, albumen sugar, sugar, salt all are commercially available edible product.
Below by embodiment, toxicology safety test, human experiment experiment, quality stability test and hygiene test further specify performance of falling plumbous liquid of the present invention.
Embodiment 1
Get the sunflower seed extract 1540ml that contains zinc 158.4mg/100ml, silkworm chrysalis hydrolysis compound amino acid dry powder 5.75g, edible cystine and each 0.34g of cysteine, adding low-ester pectin 2g mixes, the kelp extract 5000ml that adding obtains by preceding method, through 120 ℃ of sterilizations 30 minutes, add albumen sugar 36g again, the Kiwi berry extract 1510ml that contains Catergen .4g/100ml, add white granulated sugar 30g, salt 10g, add kelp extract 1850ml and transfer ratio, adding citric acid is transferred Pb≤6, obtains 10000ml in 30 minutes through high-temperature sterilization and falls plumbous liquid.Record this liquid by the aforesaid method of inspection and contain zinc 16.5mg/100ml, sulfur-containing amino acid 6.8mg/100ml, PH=6, plumbous (in Pb)＜0.5mg/l, arsenic (in As)＜0.3mg/L, mercury does not detect, copper (in Cu)＜0.5mg/100ml, total number of bacteria＜10/ml, coliform＜3/100ml, pathogenic bacteria do not detect.
Embodiment 2, the toxicology safety test
Send Hubei Prov. Health ﹠ Epidemic Prevention Station to carry out the toxicology safety test the plumbous liquid of falling of example 1, press toxicological evaluation of food safety procedure GB15193.3-94 method of inspection operation, the Kunming mouse that provides with this epidemic prevention station animal center, 20 of the healthy mices of body weight 18-20g, male and female half and half are irritated stomach 0.2ml by every 10g body weight, stop eating 16 hours before the filling stomach, a per os filling stomach Cmax reaches 20g/kg as a result, observe a week, animal all survives, and is movable normal, do not see any poisoning symptom, LD
50＞15g/kg.Press acute toxicity grading criteria, this is tried thing and falls plumbous health care liquid and belong to nontoxic level class material.
Embodiment 3, originally fall the lead thing that surges and drink test.
Select 30 of the Spraguo-Dewley white mouse of body weight in the 110-190g scope for use, wherein female 18, male 12, male and female grouping random sampling are divided into three groups of control group A, plumbous material group B and experimental group C, raise with the stainless steel metabolic cage respectively, the A group is raised with basal feed, the B group adds 2% lead acetate in basal feed, the C group adds 2% lead acetate and drinks and originally fall plumbous beverage in basal feed, A, B drink distilled water for two groups, and ad lib was fed three months.
Experiment is weighed for the 1st, 2,3 the end of month before experiment, and blood sampling is collected every animal excrement, urine, experiment in 24 hours respectively through the stainless steel metabolic cage and adopted femoral artery blood eventually, collects brain, liver, kidney, femur and marrow.
Detection method:
1, doctor's type scale weighing apparatus method, standard weights are proofreaied and correct.
2, lead, copper, zinc, manganese content are reported spectrometry with the single sweep oscillography in brain, liver, kidney, femur, blood, urine, the excrement.
3, hemoglobin, high ferro cyaniding 721 spectrophotometers.
4, marrow PCE Giemsa staining.
The B treated animal is because of being subjected to the infringement of lead poisoning as a result, and body weight and hemoglobin obviously descend, and the C group is fallen plumbous liquid owing to having drunk simultaneously; though raise to measure plumbous feed together; but body weight is consistent with hemoglobin and control group, and the lead discharging effect of this beverage is described, and hematopoiesis function has been played protective effect.B treated animal blood lead and liver lead level apparently higher than control group, and are respectively 2.3 times and 6 times of C treated animal, and significant differences is arranged.The plumbous amount of the lead in urine of C group and excrement obviously is in high level simultaneously, and the result has affirmed the lead discharging effect of falling plumbous liquid.By to the Zn in animal liver, kidney, bone, the brain, Cu, Fe, Mn trace element testing result, show and originally fall plumbous liquid in vivo lead discharging the time, do not influence the metabolism utilization of other element in the body.
Embodiment 4, fall the experiment of plumbous liquid human experiment, People's Hospital, Hubei Province carries out on the basis of routine physical examination in that 400 lead joints of certain factory are touched the workman, has selected 58 lead in urine＞0.07mg/L, and the lead joint that does not have other illness touches the experimenter of workman as this experiment, and wherein the women is 9.58 experimenters are age-based, be divided into two groups after the existing stratified random smapling in the length of service, be 24 of 34 of experimental group and control groups, tested two months that experimental group is drunk and originally fallen plumbous beverage, control group is drunk lichee carbonated drink, take 350ml * 2 bottle respectively every day, two groups of beverages adopt double-blind study by the same processes supply of a Soft Drinks Plant to the experimenter, respectively at experiment first day and experiment bimestrial last day of twice collection blood and urine sample, detect index.
Blood: HB: high ferro cyaniding.
ZPP:XY-A type ZPP blood fluor tester.
δ-AL, AD:721 colorimetric method.
Pb, Zn, Cu: atomic absorption spectrophotometer.
Urine:
δ-ALA: ethyl acetate extraction paradime thylaminobenzaldehyde colorimetric method.
Flesh liver: picric acid colorimetric method.
Pb, Zn, Cu atomic absorption spectrophotometer.
Testing result is as follows:
| Group | Survey the number people | Hb(g/dl) | δ-ALAD activity (Lu/L) | Zpp(μg/gHb | |||
| Beginning | The end | Beginning | The end | Beginning | The end | ||
| Experimental group | 34 | 13.1±2.4 | 13.5±1.9* | 57.8±50.7 | 113.5±62.2* | 6.3±2.9 | 5.3±2.3* |
| Control group | 24 | 12.4±2.7 | 12.0±2.5 | 64.7±49.6 | 64.7±48.4 | 6.5±3.6 | 6.5±4.0 |
| * P | ＜0.05 | ＜0.01 | ＜0.01 | ||||
The Hb testing result has significant difference for two groups, and experimental group Hb level is in rising trend.Though experimental group δ-ALAD in latter stage does not reach normal reference value (141.8-271.21Lu/L) and drinks and fall behind the plumbous liquid δ-ALAD activity and have obviously and increase, test highly significant difference is arranged the whole story, the Zpp amount of testing latter stage, experimental group experimenter obviously reduces, and testing has significant differences P＜0.01 whole story.
(μ g/ml) is as follows for blood Pb, Zn, Cu content:
| Project | Beginning | The end | ||
| Pb | Experimental group 31.7 ± 13.10 | Control group 31.93 ± 17.34 | Experimental group 23.54 ± 11.85* | Control group 30.04 ± 11.09 |
| Zn | 6.88±1.46 | 7.07±1.43 | 6.80±1.34** | 6.70±2.12 |
| CU | 1.45±0.33 | 1.50±0.34 | 1.33±0.30** | 1.33±0.30 |
| * P＜0.02 ** P＞0.05 | ||||
The visible experimental group blood lead content of result obviously descends latter stage, and experiment has significant difference P＜0.02 whole story, but Zn, Cu content there was no significant difference P＞0.05,
Urine δ-ALA value experiment has obvious decline latter stage, and testing has utmost point significant difference P＜0.01 whole story.
Urine Pb, Zn, Co content (mg/g) creatinine is as follows:
| Project | Beginning | The end | ||
| Pb | Experimental group | Control group | Experimental group | Control group |
| 353.08±3.30 (33) | 356.94±3.29 (22) | 159.45±9.00* (26) | 233.13±7.44 (16) | |
| Zn | 8.14±3.02 (29) | 7.14±4.21 (23) | 10.91±9.00 (25) | 1.09±0.50 (15) |
| CU | 1.18±0.64 (32) | 1.36±0.93 (24) | 1.09±0.50 (27) | 1.12±0.56 (16) |
Be experiment number P＜0.05 in the bracket
The experimental group lead in urine has obvious decline latter stage, and there is significant difference (P＜0.05) at experiment beginning, end.
The result shows: originally fall the activity that plumbous liquid can increase δ-ALAD, thereby the effect that improves hematopoiesis function in the human body is arranged, blood lead, lead in urine load obviously reduce in the body, and the lead discharging effect affirms that after the experiment periods, Zn, Cu constituent content are stablized.Experimental session, the experimenter does not have any bad reaction.
Embodiment 5, originally fall the main quality index stability test of plumbous liquid.
By Ministry of Agriculture food quality supervision verification test center, academy of agricultural sciences, Hubei Province test center is with reference to the regulation of health ministry about health food hygienic requirements and stability test, with State Standard of the People's Republic of China GB5009, pertinent regulations such as GB4789, the main component of originally falling plumbous liquid is carried out the stability experiment of accelerated test and reserved sample observing, method (increased the sunflower seed extract and reduced cystine and cysteine amount) by embodiment 1 makes, lot number is 960804,960806,960,808 3 batch samples, plastic bottle, put relative humidity and be in 75% the drier, then drier is put into 37 ℃ of insulating boxs, heating is three months continuously, sampling 0 regularly, 1,2, March, according to product company standard regulation part index number is measured, in trimestral accelerated test, obvious variation does not take place in every index, extrapolates thus, and the room temperature of this product kept sample the phase greater than 2 years.This product is more stable to light ratio, and is more stable to ratio of specific heat.
Claims (5)
1, a kind of plumbous liquid falls, it is characterized in that by the sea-tangle immersion liquid, edible compound amino acid, be rich in ascorbic Chinese gooseberry extract, containing zinc sunflower seed extract is primary raw material, with addition of albumen sugar, sugar, citric acid, salt, low-ester pectin flavouring are formed, and its zinc, sulfur-containing amino acid, PH, carbon dioxide component content are:
The composition beverage and oral liquid
Zinc is in Zn mg/100ml 5-10 20-30
Sulfur-containing amino acid mg/100ml＞22
PH value＜66
Carbon dioxide＞2-
2, compound method of falling plumbous liquid as claimed in claim 1, it is characterized in that by ratio of weight and the number of copies 36 parts of albumen sugar, 5.6 parts of compound amino acids, 36 parts of vitamin Cs, 1.6 parts on zinc, 0.34 part of cystine, 0.34 part of cysteine, pectin 0-0.5 part calculates each raw material aequum, undertaken by following program then, with sunflower seed extract and compound amino acid cystine, cysteine mixes, and the 0.1-0.5% low-ester pectin that adds above-mentioned these raw mix weight mixes, and does not add pectin when joining oral liquid, add part sea-tangle immersion liquid accent and mix the composition mother liquor, behind high-temperature sterilization, with sea-tangle immersion liquid allotment concentration, add albumen sugar again, the Chinese gooseberry extract, citric acid, salt transfers to PH＜6, after the analysis component content reaches standard, uniform filtration, filling and sealing, sterilization, check.
3, compound method of falling plumbous liquid as claimed in claim 2, it is characterized in that producing of sunflower seed extract, be that sunflower seed are removed degrease with milling process, add water-wet to being ground to smoothly to the greatest extent with 60% ethanol and sub-benevolence slag, heating and refluxing extraction liquid, decompression recycling ethanol, filtration, concentrated filtrate is to containing zinc 〉=158mg/100ml.
4, compound method of falling plumbous liquid as claimed in claim 2, it is characterized in that producing of Chinese gooseberry extract, be that extracting juice, water-bath heating destructive enzyme are cleaned, pressed to bright Kiwi berry berry, add 90% ethanol and be stirred to precipitation fully, filter, behind the decompression filtrate recycling ethanol, repeats 1-2 stand at low temperature 〉=24 hour, filtration, filtrate is decoloured with charcoal absorption, analyzes to such an extent that contain the extract of Catergen .4g/100ml.
5, compound method of falling plumbous liquid as claimed in claim 2, it is characterized in that the preparation of sea-tangle leaching liquor, be that commercially available dried sea-tangle was immersed in 2% acetic acid 20 minutes, propose to place 〉=8 hours, with the flushing deacidification of 4% saline solution, add the water infusion and removed raw meat in 1 hour after, chopping adds 3000ml cold water dipping 〉=24 hours, filtration, filtrate by the dried sea-tangle of 120g amount and is concentrated into 1/5 volume, adds ethanol and separates out the protein foreign material, behind the decompression filtrate recycling ethanol, filtered fluid gets final product with activated carbon decolorizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97109256A CN1052864C (en) | 1997-09-26 | 1997-09-26 | Qianguohua lead removing liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97109256A CN1052864C (en) | 1997-09-26 | 1997-09-26 | Qianguohua lead removing liquid |
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| Publication Number | Publication Date |
|---|---|
| CN1179280A CN1179280A (en) | 1998-04-22 |
| CN1052864C true CN1052864C (en) | 2000-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97109256A Expired - Fee Related CN1052864C (en) | 1997-09-26 | 1997-09-26 | Qianguohua lead removing liquid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349124A (en) * | 2013-07-22 | 2013-10-16 | 北京绿源求证科技发展有限责任公司 | Food type health tea electuary capable of promoting lead discharge |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087611C (en) * | 1998-08-20 | 2002-07-17 | 萧师惠 | Oral nutrient lead-expelling powdered granules |
| CN105286015A (en) * | 2015-11-05 | 2016-02-03 | 叶芳 | Composite fruit and vegetable beverage capable of promoting lead in human bodies to be discharged |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087269A (en) * | 1992-11-23 | 1994-06-01 | 梁东东 | Health care oral liquid and compound method thereof |
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1997
- 1997-09-26 CN CN97109256A patent/CN1052864C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087269A (en) * | 1992-11-23 | 1994-06-01 | 梁东东 | Health care oral liquid and compound method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349124A (en) * | 2013-07-22 | 2013-10-16 | 北京绿源求证科技发展有限责任公司 | Food type health tea electuary capable of promoting lead discharge |
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| Publication number | Publication date |
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| CN1179280A (en) | 1998-04-22 |
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