CN105267210A - Application of Hypodematine in preparation of drugs resistant to human body fungi - Google Patents
Application of Hypodematine in preparation of drugs resistant to human body fungi Download PDFInfo
- Publication number
- CN105267210A CN105267210A CN201510733823.XA CN201510733823A CN105267210A CN 105267210 A CN105267210 A CN 105267210A CN 201510733823 A CN201510733823 A CN 201510733823A CN 105267210 A CN105267210 A CN 105267210A
- Authority
- CN
- China
- Prior art keywords
- hypodematine
- human body
- preparation
- fungi
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to an application of Hypodematine in the preparation of drugs resistant to human body fungi and belongs to the field of medicine. Hypodematine is highly inhibitory on Trichophyton rubrum, Microsporum lanosum or Trichophyton tonsurans, thus Hypodematine can serve as a compound resistant to human body fungi and is expected to be applied in the preparation of related drugs.
Description
Technical field
The present invention relates to the novelty teabag of compound H ypodematine, particularly relate to the application of Hypodematine in preparation anti-human fungi medicine.
Background technology
The health and lives of the mankind in pathomycete serious threat, antifungal drug is used widely as routine administration, the antimicrobial agent used clinically is at present (as ketoconazole, amikacin, gentamycin, voriconazole, itraconazole, terbinafine, amphotericin, fluconazol etc.) better to the curative effect of skin and superficial place infection, but the cumulative toxicity of these antibacterials is stronger, usually cause lesions of liver and kidney, digestive tract stimulates, dizzy, irritated etc., so the novel antifungal drugs finding mechanism of action uniqueness becomes one of focus of current medicament research and development.
The compound H ypodematine that the present invention relates to is one and delivers (Zhi-YunKang in 2013, etal., Thetotalsynthesisofhypodematine.JournalofAsiannaturalpro ductsresearch, 2013, 15 (8): 840-848.) noval chemical compound, this compound has brand-new framework types, current purposes only relates to vertigo (Zhi-YunKang, etal., Thetotalsynthesisofhypodematine.JournalofAsiannaturalpro ductsresearch, 2013, 15 (8): 840-848.), the purposes of the Hypodematine that the present invention relates in preparation anti-human fungi medicine belongs to first public.
Summary of the invention
The object of the invention is to not find that it has the present situation of the report of human body fungi activity according in existing Hypodematine research, provide the application of Hypodematine in preparation anti-human fungi medicine.
Described compound H ypodematine, structure is as shown in formula I:
Hypodematine has very strong suppression red hair moss bacterium, microsporum canis or the disconnected effect sending out moss bacterium, so Hypodematine can be used as the compound with the effect of human body fungus, and is expected to be applied in preparation anti-human fungi medicine.
The purposes of the Hypodematine that the present invention relates in preparation treatment anti-human fungi medicine belongs to first public, because framework types belongs to brand-new framework types, and it is unexpectedly strong for Human Fungi inhibit activities, there is not the possibility being provided any enlightenment by other compounds, possess outstanding substantive distinguishing features, the control simultaneously infected for Human Fungi obviously has significant progress.
Detailed description of the invention
The preparation method of compound H ypodematine involved in the present invention is see document (Zhi-YunKang, etal., Thetotalsynthesisofhypodematine.JournalofAsiannaturalpro ductsresearch, 2013,15 (8): 840-848.)
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by any restriction of specific embodiment, but be limited by claim.
Embodiment 1: the preparation of compound H ypodematine tablet involved in the present invention:
Get 5 g of compound Hypodematine, add 195 grams, dextrin, mixing, Conventional compression makes 1000.
Embodiment 2: the preparation of compound H ypodematine capsule involved in the present invention:
Get 5 g of compound Hypodematine, add starch 195 grams, mixing, encapsulatedly makes 1000.
Its pharmaceutically active is further illustrated below by pharmacodynamic experiment.
Experimental example 1:Hypodematine human body fungi activity
The experiment of human body fungi activity is the method for employing concentration dilution, and in triplicate, test pathogen has red hair moss bacterium, microsporum canis and a disconnected moss bacterium to each mensuration, and bacterial concentration is 105/mL.Hypodematine initial concentration is 50.0 μ g/mL (5% dimethyl sulfoxide DMSO), gradient dilution to 0.098 μ g/mL, the bacterium liquid of equivalent volumes and test sample Mixed culture are in 96 orifice plates, Human Fungi cultivation temperature is respectively 28 DEG C, observe after incubation time 24h, if find, when not having bacterium colony to be formed be the minimum human body fungi concentration of sample, i.e. MIC value.This experiment positive control is ketoconazole, and Hypodematine human body fungus the results are shown in Table 1.
Table 1Hypodematine human body fungus MIC value (μ g/mL)
Conclusion: Hypodematine has very strong human body fungi activity, and therefore Hypodematine of the present invention is expected to be used to prepare novel anti-human fungi medicine.
Claims (1)
- The application of 1.Hypodematine in anti-human fungi medicine, described compound H ypodematine structure is as shown in formula I:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510733823.XA CN105267210A (en) | 2015-11-02 | 2015-11-02 | Application of Hypodematine in preparation of drugs resistant to human body fungi |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510733823.XA CN105267210A (en) | 2015-11-02 | 2015-11-02 | Application of Hypodematine in preparation of drugs resistant to human body fungi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105267210A true CN105267210A (en) | 2016-01-27 |
Family
ID=55137613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510733823.XA Withdrawn CN105267210A (en) | 2015-11-02 | 2015-11-02 | Application of Hypodematine in preparation of drugs resistant to human body fungi |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105267210A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872059A (en) * | 2012-10-26 | 2013-01-16 | 吴俊华 | Application of Gypensapogenin B to preparing drugs for resisting human funguses |
| CN103479608A (en) * | 2013-10-10 | 2014-01-01 | 高伟 | Application of Scopariusins in preparation of antihuman fungal medicines |
-
2015
- 2015-11-02 CN CN201510733823.XA patent/CN105267210A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872059A (en) * | 2012-10-26 | 2013-01-16 | 吴俊华 | Application of Gypensapogenin B to preparing drugs for resisting human funguses |
| CN103479608A (en) * | 2013-10-10 | 2014-01-01 | 高伟 | Application of Scopariusins in preparation of antihuman fungal medicines |
Non-Patent Citations (1)
| Title |
|---|
| 陈亚民，等: "用二维核磁共振法研究肿足蕨碱的结构", 《药学学报》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103479608B (en) | Application of Scopariusins in preparation of antihuman fungal medicines | |
| CN103393692B (en) | The application of compound in preparation anti-human fungi medicine | |
| CN105267210A (en) | Application of Hypodematine in preparation of drugs resistant to human body fungi | |
| CN105534989A (en) | Applications of Trigonoliimines C in preparation of anti-fungal medicines for human bodies | |
| CN103446135B (en) | The application of Lycojaponicumin A in preparation anti-human fungi medicine | |
| CN103463029B (en) | Application of Lycojaponicumin B in human fungus resisting medicine | |
| CN103479636B (en) | The application of Lycojaponicumin C in preparation anti-human fungi medicine | |
| CN102872059B (en) | Application of Gypensapogenin B to preparing drugs for resisting human funguses | |
| CN103393696B (en) | Application of Chukrasone A for preparing antifungal drugs for human body | |
| CN103372004B (en) | Application of Chukrasone B in preparation of medicines for resisting human body fungi | |
| CN102861087B (en) | Application of Houttuynoid D in anti-human fungi medicine | |
| CN102861083B (en) | Application of Houttuynoid B in anti-human fungi medicine | |
| CN105412100A (en) | Application of Racemulsonine in preparing medicine for resisting human body fungi | |
| CN105412063A (en) | Application of Kanshone C to preparing drug for resisting human body fungi | |
| CN102872145B (en) | Application of Houttuynoid C in anti-human fungal drugs | |
| CN105343037A (en) | Application of Heyneanones D in preparing human body fungus resisting medicine | |
| CN103446115A (en) | Applications of Sarcaboside A in medicament against human fungus | |
| CN105434425A (en) | Applications of Rhodomicranols A in preparing drugs used for inhibiting human body fungi | |
| CN103462968B (en) | Incarviatone A is preparing the application in anti-bacterial drug | |
| CN102872133B (en) | Application of Houttuynoid E in anti-human fungal drugs | |
| CN103462989A (en) | Application of Lycojaponicumin B in preparation of medicines for resisting human body fungi | |
| CN102872007A (en) | Application of Eryngiolide A in medicaments resisting human body fungi | |
| CN102861027B (en) | Application of Gypensapogenin A in medicine for preventing human fungi | |
| CN106474114A (en) | Application of the Ternatusine A in anti-human fungi medicine is prepared | |
| CN106309426A (en) | Application of Fistulains B in human fungus resisting drugs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160127 |