CN105259146A - Method and system for quantitatively detecting narcotics - Google Patents
Method and system for quantitatively detecting narcotics Download PDFInfo
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- CN105259146A CN105259146A CN201510740579.XA CN201510740579A CN105259146A CN 105259146 A CN105259146 A CN 105259146A CN 201510740579 A CN201510740579 A CN 201510740579A CN 105259146 A CN105259146 A CN 105259146A
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Abstract
The invention relates to the technical field of narcotics detection and especially relates to a method for quantitatively detecting narcotics. The method comprises the following steps: collecting a biological tissue sample of the quantitatively detected narcotics; performing light stimulation on the biological tissue sample; collecting a delayed luminescence parameter of the biological tissue sample after light stimulation; analyzing the acquired delayed luminescence parameter and confirming the content of the narcotics in the sample. According to the method provided by the invention, the to-be-detected sample is subjected to light induction and delayed lighting is collected and analyzed, so that the content of the narcotics in the to-be-detected sample is acquired, quantitative detection for the narcotics is realized, the operation is simple and the sample is free from being pretreated. During the detection, the sample is not directly contacted, so that the damage to the sample is small, the measuring sensitivity is higher, the error is better controlled and the method is especially fit for detection for the narcotics in the biological sample.
Description
Technical field
The present invention relates to illicit drugs inspection technical field, particularly a kind of drugs quantitative detecting method and system.
Background technology
Drug abuse and Drug-related crimes form serious threat to national public safety, and the prohibition of drug has become global common recognition.Illicit drugs inspection is requisite important component part in banning drugs work, and testing result is the important evidence of procuratorate's prosecution, law court's measurement of penalty judgement.The banning drugs work that develops into of illicit drugs inspection technology provides powerful guarantee.
The illicit drugs inspection technology of current widespread use is chemical measure, immunoassay and chromatography.Chemical measure utilizes the chemical reactions such as specific chemical reagent and drugs sample develop the color, precipitation to identify the kind of drugs, simple to operate, reaction velocity is fast, but chemical measure sensitivity is low, not easily detect the drugs that structure is similar, therefore chemical measure is only applicable to the primary dcreening operation experiment of on-the-spot drug testing and laboratory inspection, and just have eliminating, screening and direction action, its assay can not directly use as the positive proof of court.
Chromatography is a kind of method for separating and analyzing, has very high sensitivity and specificity, once can analyze several samples and required sample size is few, and analysis efficiency is high.Chromatography is the authenticity method in illicit drugs inspection field, and its testing result can use as court evidence.And chromatography needs the pre-service carrying out series of complex to sample just can carry out the separation andpreconcentration of sample, and detection time is longer, testing process relative complex, needs professional and technical personnel to operate.
Immunoassay utilizes the specificity of antigen-antibody reaction and susceptibility to detect the drugs in sample to be tested, and the testing process time is short, easy and simple to handle, have higher sensitivity.Immunoassay depends on antibody, antigen, immunoassay must biochemical reagents under normal temperature condition, easily lose biologically active, this makes the external condition such as temperature, humidity easily cause interference to immunoassay process, affect the accuracy of its testing result, therefore, immunoassay can only as a kind of preliminary screening protocol of drugs, and its testing result needs again to be confirmed by other detection method.
Given this, explore a kind of detection method that is quick, sensitive, septicemia product that accuracy rate is high and put, carrying out smoothly banning drugs work, significant.
Summary of the invention
Based on above-mentioned situation, be necessary to provide easy and simple to handle, highly sensitive, the drugs quantitative detecting method that the testing process time is short and system.
A kind of drugs quantitative detecting method, comprises the steps:
A. the biological organization sample needing drugs quantitatively to detect is gathered;
B. carry out illumination to this biological organization sample to excite;
C. the delayed luminescence parameter that described illumination excites artifact tissue samples is gathered;
D. analyzing and processing is carried out to described delayed luminescence parameter, determine the content of drugs in this biological organization sample.
Further, also step g is comprised between described step a and step b: comprise and pre-process is carried out to described biological organization sample; Described pre-process comprises the kind and drug species of determining described biological organization sample.
Improve as one, described steps d analyzing and processing specifically comprises: biological specimen kind to be measured, drug species and delayed luminescence parameter information and the table of comparisons preset are contrasted, determine the content of drugs in biological specimen to be measured;
Wherein, the described table of comparisons obtains according to following steps;
I. according to kind and the drug species of biological specimen, gradient demarcation is carried out to the content of drugs in biological specimen;
II. carry out illumination to the biological specimen demarcating drugs content to excite, and measure the delayed luminescence parameter of this content, described delayed luminescence parameter comprises luminous intensity and decay of luminescence;
III. the table of comparisons is formed; The described table of comparisons comprises the delayed luminescence parameter information of biological specimen kind, drug species, drugs content and correspondence.
Improve as another kind, described steps d specifically comprises: according to kind and the drug species of biological specimen, pre-set and organize quantitative function more; According to the described quantitative function pre-set, the luminous intensity and decay of luminescence information gathering biological specimen to be measured is calculated, obtains biological specimen drugs content to be measured;
Wherein, described quantitative function obtains according to following steps:
I. according to kind and the drug species of biological specimen, gradient demarcation is carried out to the content of drugs in biological specimen;
Ii. carry out illumination to the biological specimen demarcating drugs content to excite, and measure the delayed luminescence parameter of this content, described delayed luminescence parameter comprises luminous intensity and decay of luminescence;
Iii. the delayed luminescence parameter of measurement is normalized calculating, and the result after calculating is obtained delayed luminescence curvilinear function through over-fitting;
Iv. delayed luminescence curvilinear function and corresponding biological specimen drugs content are obtained the quantitative function under this biological specimen kind and drug species through matching again.
Further, between described step c and steps d, be also provided with step h: the biological organization sample kind determined according to step g and drug species, call the table of comparisons or quantitative function that mate with biological organization sample kind and drug species.
Further, described biological organization sample is serum, and described drug species is methamphetamine; Delayed luminescence parameter information containing methamphetamine serum to be measured and the methamphetamine content table of comparisons in the serum preset are contrasted, determines the content of methamphetamine in test serum;
In described serum, the methamphetamine content table of comparisons, comprises, and carries out gradient demarcation to the content of methamphetamine in serum, and carries out illumination according to the serum of different gradient methamphetamine content demarcated and excite and transfer delay luminous parameters, forms the methamphetamine content table of comparisons in serum.
Further, in described serum, the methamphetamine content table of comparisons is specially the methamphetamine content die-away curve table of comparisons in serum;
The methamphetamine content die-away curve table of comparisons in described serum, according to the delayed luminescence parameter of serum under the different gradient methamphetamine content of measurement, calculates the methamphetamine content die-away curve table of comparisons in serum through attenuation function;
Wherein, described attenuation function is:
Wherein, τ is luminescent lifetime, and m is constant.
Improve as one, described biological organization sample is serum, and described drug species is methamphetamine; The luminous intensity and decay of luminescence information methamphetamine content quantitative function in serum that gather test serum are calculated methamphetamine content in test serum; In described serum, methamphetamine content quantitative function is:
M＝10
(2-τ)/2.5
Wherein, M is methamphetamine content, and τ is luminescent lifetime.
A kind of drugs quantitative detection system, comprising:
Acquisition module, for gathering the biological organization sample needing drugs quantitatively to detect;
Light source module, excites for carrying out illumination to this biological organization sample;
Photon counting module, for gather illumination excite after the delayed luminescence parameter of biological organization sample;
Data processing module, for carrying out analyzing and processing to described delayed luminescence parameter, determines the content of drugs in this biological organization sample;
Improve as one, also comprise preposition analysis module, for carrying out preposition analysis to the biological organization sample of described collection, determining kind and the drug species of described biological organization sample, and the kind of this biological organization sample and drug species are transferred to data processing module.
A kind of drugs quantitative detecting method of the present invention, by carrying out photoinduction to sample to be tested, and gathers and analyzing and processing its delayed luminescence, thus obtains drugs content in sample to be tested.This can realize quantitatively detecting and bright simple to operate, without the need to carrying out pre-service to sample; Testing process does not directly contact with sample, very little to the infringement of sample, makes measurement sensistivity higher and error better controls, and is especially applicable to the detection of drugs in biological specimen.The present invention, in measuring process, can carry out sensitive, quick and Poul Dorset Sheep to drugs micro-in biological organization sample, be applicable to the micro-drugs detected in public safety field in blood.
Accompanying drawing explanation
Fig. 1 a is the delayed luminescence die-away curve schematic diagram of a kind of drugs quantitative detecting method of the present invention serum sample, methamphetamine and serum mixing sample;
Fig. 1 b is the 3.5ms place delayed luminescence die-away curve schematic diagram of a kind of drugs quantitative detecting method of the present invention serum sample, methamphetamine and serum mixing sample;
Fig. 2 a is the delayed luminescence die-away curve fitting effect contrast schematic diagram of a kind of drugs quantitative detecting method of the present invention serum sample;
Fig. 2 b is that the delayed luminescence die-away curve fitting effect of the present invention's a kind of drugs quantitative detecting method methamphetamine and serum mixing sample contrasts schematic diagram;
Fig. 3 is a kind of drugs quantitative detecting method methamphetamine of the present invention and serum mixing sample delayed luminescence life-span and methamphetamine relation with contents schematic diagram.
Embodiment
In order to make object of the present invention, technical scheme and advantage more clear, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
A kind of drugs quantitative detecting method is provided, comprises the steps:
A. the biological organization sample needing drugs quantitatively to detect is gathered;
G. for carry out pre-process to biological organization sample, described pre-process comprises the kind containing Poison in the kind and biological organization sample determining biological organization sample;
B. carry out illumination to this biological organization sample to excite;
C. gather illumination excite after the delayed luminescence parameter of biological organization sample;
H. be according to step g. the biological organization sample kind determined and drug species, call the analysis and processing method mated with biological organization sample kind and drug species;
D. carrying out analyzing and processing by measuring the delayed luminescence parameter obtained, determining the content of drugs in sample.
Wherein, steps d can have two kinds of analyzing and processing modes:
First kind of way is, biological specimen kind to be measured, drug species and delayed luminescence parameter information and the table of comparisons preset is contrasted, determines the content of drugs in biological specimen to be measured;
Wherein, the described table of comparisons obtains according to following steps;
I. according to kind and the drug species of biological specimen, gradient demarcation is carried out to the content of drugs in biological specimen;
II. carry out illumination to the biological specimen demarcating drugs content to excite, and measure the delayed luminescence parameter of this content, described delayed luminescence parameter comprises luminous intensity and decay of luminescence;
III. the table of comparisons is formed; The described table of comparisons comprises the delayed luminescence parameter information of biological specimen kind, drug species, drugs content and correspondence.The second way is, according to kind and the drug species of biological specimen, pre-sets and organizes quantitative function more; According to the described quantitative function pre-set, the luminous intensity and decay of luminescence information gathering biological specimen to be measured is calculated, obtains biological specimen drugs content to be measured;
Wherein, described quantitative function obtains according to following steps:
I. according to kind and the drug species of biological specimen, gradient demarcation is carried out to the content of drugs in biological specimen;
Ii. carry out illumination to the biological specimen demarcating drugs content to excite, and measure the delayed luminescence parameter of this content, described delayed luminescence parameter comprises luminous intensity and decay of luminescence;
Iii. the delayed luminescence parameter of measurement is normalized calculating, and the result after calculating is obtained delayed luminescence curvilinear function through over-fitting;
Iv. delayed luminescence curvilinear function and corresponding biological specimen drugs content are obtained the quantitative function under this biological specimen kind and drug species through matching again.
The content of drugs in output sample.
Concrete, due to choosing of sample, directly affect the accuracy of testing result.In public security enforcement of drug suppression, the illicit drugs inspection be accused of in drug addict's biological specimen (blood, urine, hair etc.) is an important content, and testing result directly affects the follow-up corresponding rehabilitation measure taked of drug addict.Drugs enter in drug addict's body, and when reaching steady state (SS), the bulk component content of septicemia product is relatively the highest; Secondly, the drugs content detected in blood, directly can show the physiological effect that misuser is subject to; Blood extracts in body, is not vulnerable to dye.At present, the therapeutic dose of medicine and poisonous substance, dosis toxica and lethal quantity are all demarcate with the content in blood, so blood is the first-selection of biological specimen sample.Therefore described biological organization sample is serum in the present embodiment, and described drug species is methamphetamine.
Obtain the delayed luminescence die-away curve of serum sample, methamphetamine and serum mixing sample (1 × 10-5mol/L) in measurement after, as shown in Fig. 1 (a).The characteristics of luminescence of delayed luminescence is reacted mainly through luminous intensity and decay of luminescence characteristic.Luminous intensity depends on the character with tested sample, simultaneously relevant with the external condition such as excitating light strength, sample content, environment temperature, humidity, and the biological information of decay of luminescence characteristic reactions sample intrinsic, only depend on the character of tested sample, do not disturb by external condition, therefore decay of luminescence characteristic more can react the characteristics of luminescence of sample.Therefore, in order to analyze the delayed luminescence attenuation characteristic of two kinds of samples better, by the experimental data in Fig. 1 (a) with intensity corresponding to respective 3.5ms place for standard is normalized calculating, result is as shown in Fig. 1 (b).Can find out, curve b is obviously fast damply than curve a, and this illustrates that the delayed luminescence rate of decay of methamphetamine and serum mixing sample is apparently higher than serum sample.Fig. 1 can distinguish serum sample and methamphetamine and serum mixing sample intuitively.
According to first kind of way, described biological organization sample is serum, and described drug species is methamphetamine; Delayed luminescence parameter information containing methamphetamine serum to be measured and the methamphetamine content table of comparisons in the serum preset are contrasted, determines the content of methamphetamine in test serum;
In described serum, the methamphetamine content table of comparisons, comprises, and carries out gradient demarcation to the content of methamphetamine in serum, and carries out illumination according to the serum of different gradient methamphetamine content demarcated and excite and transfer delay luminous parameters, forms the methamphetamine content table of comparisons in serum.
Further, in described serum, the methamphetamine content table of comparisons is specially the methamphetamine content die-away curve table of comparisons in serum;
The methamphetamine content die-away curve table of comparisons in described serum, according to the delayed luminescence parameter of serum under the different gradient methamphetamine content of measurement, in the serum that declines, methamphetamine content subtraction function calculates the methamphetamine content die-away curve table of comparisons in serum;
Wherein, in described serum, methamphetamine content attenuation function is:
Wherein, τ is luminescent lifetime, and m is constant.In described serum, the deduction process of methamphetamine content attenuation function is as follows:
The luminous intensity and decay of luminescence information that gather test serum are calculated methamphetamine content in test serum through quantitative function; Described quantitative function is, the serum delayed luminescence parameter of demarcating methamphetamine content gathered in advance; Relative luminous intensity I (t) can represent with following formula:
I(t)＝I
0e
-vt＝e
-vt(2)
In formula, t is the duration of sample luminescence after exciting light stops, and v is Acetone sensitization; Be rewritten as further:
F (ν) can be tried to achieve, namely by doing inverse laplace transform to I (t)
f(v)＝L
-1{I(t)}(4)
By following formula:
In above formula, t0, m are constants.
Can obtain:
Therefore the mathematical expectation of v and average rate constant vm are:
The then luminescent lifetime of sample:
τ＝1/v
m＝t
0/m(8)
Therefore t
0=m τ (9)
Can obtain:
As shown in Figure 2, utilize the delayed luminescence die-away curve of serum sample, methamphetamine and serum mixing sample in function model (9) formula matching Fig. 1 (b), obtain the parameter m of two kinds of samples and the numerical value of τ, list in table 1.
| Serum | Serum/MA | |
| τ(ms) | 38.4 | 14.2 |
| m | 189 | 102 |
Table 1
Table 1 is serum sample, methamphetamine compares with the parameter value of serum mixing sample, can find out compared with serum sample, the luminescent lifetime τ of methamphetamine and serum mixing sample reduces about 63%, this explanation, methamphetamine joins in serum, have impact on the luminous power of serum, make the faster of the decay of luminescence of serum.This is consistent with the conclusion intuitively drawn in Fig. 1.The methamphetamine of different content joins in serum, and whether the delayed luminescence characteristic of serum can be variant.The change in the delayed luminescence life-span of mixing sample when methamphetamine content is different, investigates delayed luminescence and whether has sensitive indicative function to the change of methamphetamine content in serum.
According to the second way, described biological organization sample is serum, and described drug species is methamphetamine; The luminous intensity and decay of luminescence information methamphetamine content quantitative function in serum that gather test serum are calculated methamphetamine content in test serum; In described serum, methamphetamine content quantitative function is:
M＝10
(2-τ)/2.5(10)
Wherein, M is methamphetamine content, and τ is luminescent lifetime.
The deduction process of described methamphetamine content quantitative function is as follows:
Measure the methamphetamine of different content and the delayed luminescence die-away curve of serum mixing sample, utilize function model (1) formula, all Fitting Analysis has been carried out to experimental data each time.Table 2 lists the numerical value to the luminescent lifetime τ obtained after each group data fitting.Result shows, and along with the increase of methamphetamine content, τ value is diminishing gradually, and this illustrates, methamphetamine content is higher, the delayed luminescence of mixing sample decay sooner, delayed luminescence ability declines gradually.There is association between the delayed luminescence life-span of mixing sample and methamphetamine content, if this association can be found out, just can extract the information of methamphetamine content by the delayed luminescence life-span of sample, realize the quantitative calculating of methamphetamine content in serum.
Table 2
When table 2 is methamphetamine content difference, the luminescent lifetime τ value of mixing sample, after methamphetamine content M (unit: mol/L) is taken the logarithm, obtain the corresponding relation of lgM and luminescent lifetime τ, as shown in black broken line in Fig. 3, can intuitively find, methamphetamine content and luminescent lifetime are roughly linear, therefore, we have carried out linear fit to raw data, as shown in straight line red in figure.Result shows, the matching degree of fitting function and raw data is fine, and degree of fitting is 99.2%.Fitting function expression formula is:
τ＝2-2.5lg(M)(11)
Therefore the content of methamphetamine in mixing sample:
M＝10
(2-τ)/2.5(10)
Formula (10) shows, as long as matching obtains the luminescent lifetime of mixed sample, can calculate the content of methamphetamine in mixing sample, thus realizes the quantitative calculating of methamphetamine content in serum.
Fundamental purpose of the present invention is to provide a kind of method quantitatively detected based on the septicemia product of photoinduction delayed luminescence technology, has high sensitivity (1 × 10-8mol/L).
A kind of drugs quantitative detection system, comprising:
Acquisition module, for gathering the biological organization sample needing drugs quantitatively to detect;
Light source module, excites for carrying out illumination to this biological organization sample;
Photon counting module, for gather illumination excite after the delayed luminescence parameter of biological organization sample, described delayed luminescence parameter comprises luminous intensity and decay of luminescence;
Data processing module, for carrying out analyzing and processing by measuring the delayed luminescence parameter obtained, determines the content of drugs in sample;
Result output module, for the content of drugs in output sample.
Also comprise preposition analysis module, described preposition analysis module is connected with acquisition module and data processing module respectively, for carrying out preposition analysis to the biological specimen gathered, determine biological organization sample kind and drug species information, and by this biological organization sample kind and drug species information transmission to data processing module.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a drugs quantitative detecting method, is characterized in that, comprises the steps:
A. the biological organization sample needing drugs quantitatively to detect is gathered;
B. carry out illumination to this biological organization sample to excite;
C. the delayed luminescence parameter that illumination excites rear described biological organization sample is measured;
D. analyzing and processing is carried out to described delayed luminescence parameter, determine the content of drugs in this biological organization sample.
2. drugs quantitative detecting method as claimed in claim 1, is characterized in that, also comprise step g between described step a and step b:
Comprise and pre-process is carried out to described biological organization sample; Described pre-process comprises the kind and drug species of determining described biological organization sample.
3. drugs quantitative detecting method as claimed in claim 2, it is characterized in that, described steps d specifically comprises: biological specimen kind to be measured, drug species and delayed luminescence parameter information and the table of comparisons preset are contrasted, determine the content of drugs in biological specimen to be measured;
Wherein, the described table of comparisons obtains according to following steps;
I. according to kind and the drug species of biological specimen, gradient demarcation is carried out to the content of drugs in biological specimen;
II. carry out illumination to the biological specimen demarcating drugs content to excite, and measure the delayed luminescence parameter of this content, described delayed luminescence parameter comprises luminous intensity and decay of luminescence;
III. form the table of comparisons, the described table of comparisons comprises the delayed luminescence parameter information of biological specimen kind, drug species, drugs content and correspondence.
4. drugs quantitative detecting method as claimed in claim 2, it is characterized in that, described steps d specifically comprises: according to kind and the drug species of biological specimen, pre-set and organize quantitative function more; According to the described quantitative function pre-set, the luminous intensity and decay of luminescence information gathering biological specimen to be measured is calculated, obtains biological specimen drugs content to be measured;
Wherein, described quantitative function obtains according to following steps:
I. according to kind and the drug species of biological specimen, gradient demarcation is carried out to the content of drugs in biological specimen;
Ii. carry out illumination to the biological specimen demarcating drugs content to excite, and measure the delayed luminescence parameter of this content, described delayed luminescence parameter comprises luminous intensity and decay of luminescence;
Iii. the delayed luminescence parameter of measurement is normalized calculating, and the result after calculating is obtained delayed luminescence curvilinear function through over-fitting;
Iv. delayed luminescence curvilinear function and corresponding biological specimen drugs content are obtained the quantitative function under this biological specimen kind and drug species through matching again.
5. the drugs quantitative detecting method as described in claim 3 or 4, it is characterized in that, also be provided with step h between described step c and steps d: the biological organization sample kind determined according to step g and drug species, call the table of comparisons or quantitative function that mate with biological organization sample kind and drug species.
6. drugs quantitative detecting method as claimed in claim 5, it is characterized in that, described biological organization sample is serum, and described drug species is methamphetamine; Delayed luminescence parameter information containing methamphetamine serum to be measured and the methamphetamine content table of comparisons in the serum preset are contrasted, determines the content of methamphetamine in test serum;
In described serum, the methamphetamine content table of comparisons, comprises, and carries out gradient demarcation to the content of methamphetamine in serum, and carries out illumination according to the serum of different gradient methamphetamine content demarcated and excite and transfer delay luminous parameters, forms the methamphetamine content table of comparisons in serum.
7. drugs quantitative detecting method as claimed in claim 6, it is characterized in that, in described serum, the methamphetamine content table of comparisons is specially the methamphetamine content die-away curve table of comparisons in serum;
The methamphetamine content die-away curve table of comparisons in described serum, according to the delayed luminescence parameter of serum under the different gradient methamphetamine content of measurement, calculates the methamphetamine content die-away curve table of comparisons in serum through attenuation function;
Wherein, described attenuation function is:
Wherein, τ is luminescent lifetime, and m is constant.
8. drugs quantitative detecting method as claimed in claim 4, it is characterized in that, described biological organization sample is serum, and described drug species is methamphetamine; The luminous intensity and decay of luminescence information methamphetamine content quantitative function in serum that gather test serum are calculated methamphetamine content in test serum; In described serum, methamphetamine content quantitative function is:
M＝10
(2-τ)/2.5
Wherein, M is methamphetamine content, and τ is luminescent lifetime.
9. a drugs quantitative detection system, is characterized in that, comprising:
Acquisition module, for gathering the biological organization sample needing drugs quantitatively to detect;
Light source module, excites for carrying out illumination to this biological organization sample;
Photon counting module, for gather illumination excite after the delayed luminescence parameter of biological organization sample;
Data processing module, for carrying out analyzing and processing to described delayed luminescence parameter, determines the content of drugs in this biological organization sample.
10. drugs quantitative detection system as claimed in claim 9, it is characterized in that, also comprise preposition analysis module, for carrying out preposition analysis to the biological organization sample of described collection, determine kind and the drug species of described biological organization sample, and the kind of this biological organization sample and drug species are transferred to data processing module.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112798578A (en) * | 2020-12-23 | 2021-05-14 | 中国人民公安大学 | Method for determining type of drug to be detected according to reaction color of drug detection test paper |
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Application publication date: 20160120 |