CN105232658A - Stasis removing and pain relieving traditional Chinese medicine preparation for treating glioma and preparation method thereof - Google Patents
Stasis removing and pain relieving traditional Chinese medicine preparation for treating glioma and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a stasis removing and pain relieving traditional Chinese medicine preparation for treating glioma and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations for treating the glioma. According to the technical scheme, the stasis removing and pain relieving traditional Chinese medicine preparation for treating the glioma is prepared from, by weight, 8%-15% of rhizoma chuanxiong, 8%-15% of lumbricus, 15%-25% of cortex albiziae, 15%-20% of java brucea fruits, 15%-25% of marsdenia tenacissima, 8%-15% of radix paeoniae rubra, 8%-15% of ligusticum sinense oliver and 8%-15% of radix angelicae. The stasis removing and pain relieving traditional Chinese medicine preparation are excellent in effect of removing stasis removing, relieving pain and detoxifying and can effectively treat a headache symptom caused by a nerve compressive syndrome and act on multiple visceral organs of the whole body, the unique understanding of traditional Chinese medicine on the organic whole of a human body is fully embodied, and the anti-tumor purpose is achieved by regulating the functions of the whole body. The stasis removing and pain relieving traditional Chinese medicine preparation for treating the glioma has the advantages of being exact in treatment effect, wide in medicine source, low in cost, convenient to produce and take and significant in effect on treating the glioma.
Description
Technical field
The present invention relates to a kind of removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma and preparation method thereof, belong to treatment glioma technical field of traditional Chinese medicine preparation.
Background technology
Glioma is commonly encountered diseases, frequently-occurring disease in central nerve neuroma, and Chinese glioma annual morbidity is 3-6 people/100,000 people.In recent years, glioma morbidity in rejuvenation trend, was olderly more common between 20 ~ 50 years old, with 30 ~ 40 years old for summit, also more common about 10 years old child in addition, in the whole world, had 18 ~ 600,000 young and middle-aged glioblastoma patients to lose valuable life every year.The first-selected surgical healing of glioma, but due to glioma be infiltrative growth, operation thoroughly can not remove glioma cell, therefore postoperatively easily recurs in a short time.At present, Treatment for Glioma method still based on excision, combined with chemotherapy, radiotherapy and immunotherapy, but all do not reach desirable effect, and side effect is large, medical expense is expensive.
Summary of the invention
The object of the invention is to provide a kind of removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma and preparation method thereof, clear curative effect, and medicine source is wide, with low cost, produce and taking convenience, can solve the problems referred to above existed in background technology.
Technical scheme of the present invention is:
The removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma, be made up of Rhizoma Chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae, Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, the Radix Angelicae Dahuricae, the percentage by weight of each Chinese medicinal components is: Rhizoma Chuanxiong 8-15%, Pheretima 8-15%, Cortex Albiziae 15-25%, Fructus Bruceae 15-20%, Caulis Marsdeniae Tenacissimae 15-25%, Radix Paeoniae Rubra 8-15%, Rhizoma Ligustici 8-15%, Radix Angelicae Dahuricae 8-15%.
The preparation method of the removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma, comprises following processing step: select chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae, Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, the Radix Angelicae Dahuricae, cleans, breaks into powder; According to percentage by weight preparation and decoction, the percentage by weight of each Chinese medicinal components is Rhizoma Chuanxiong 8-15%, Pheretima 8-15%, Cortex Albiziae 15-25%, Fructus Bruceae 15-20%, Caulis Marsdeniae Tenacissimae 15-25%, Radix Paeoniae Rubra 8-15%, Rhizoma Ligustici 8-15%, Radix Angelicae Dahuricae 8-15%; Decoct with water, filter, decocted with water by medicinal residues again, filter, water-bath concentrates, and becomes paste, dry, grinds, and makes the removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma.
The removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma can make capsule, tablet, powder etc. as required.
Processing step more specifically: adopt gauze to filter impurity, add 5 times of soak by water 1 hour, filter with gauze, medicinal residues are decocted with water 30 minutes again, merging filtrate, water-bath is condensed into paste, put plate glass, dry in 80 DEG C of baking boxs; Be ground into fine powder, by 60 mesh sieves, by weight subpackage, make capsule.
The present invention, by Rhizoma Chuanxiong, Pheretima, Cortex Albiziae, Radix Paeoniae Rubra, Rhizoma Ligustici, Radix Angelicae Dahuricae grass compatibility, based on removing obstruction for relieving pain, is equipped with Fructus Bruceae, the Caulis Marsdeniae Tenacissimae composition with detoxicating functions.
Rhizoma Chuanxiong, acrid in the mouth, warm in nature; Wind-expelling pain-stopping.Research shows, Rhizoma Chuanxiong water solublity crude preparation by using damages the radiation exposure of rat, mice and dog and chlormethine all has protective effect.Comparatively mice is good, comparatively intramuscular injection is good again for lumbar injection to the anti-radiation effect of rat for Rhizoma Chuanxiong, and intramuscular injection is more oral good again.These product are pointed out to can be used as the radiocurable complementary therapy of tumor patient, to alleviate its toxic and side effects.Chuanxiong rhizome oral has certain Accommodation to immune system, and gamma globulin can be made to raise, and to T lymphocyte, low person is improved effect.In addition, Rhizoma Chuanxiong also has certain antitumaous effect, has certain inhibitory action to leukaemia.
Pheretima, salty in the mouth cold in nature; Heat clearing away, dredging collateral.Modern pharmacology research report is pointed out, Pheretima extracting solution has good anticoagulation in vitro, can make the equal significant prolongation of the clotting time of blood, thrombin time, prothrombin time, and in pronounced amount effect relationship; Blood viscosity can be reduced, inhibition thrombosis.Its anticoagulant mechanism is that it has direct inhibitory action to thrombin-fibrinogen reaction.Pheretima still has fibrinolysis activity, can make established thromboembolism.Show that it can promote that cancerous protuberance blood stasis dissipates.
Cortex Albiziae, nature and flavor are sweet, flat; Mind calming, subduing inflammation.Contained by Cortex Albiziae, Polysaccharides on Mice transplanted tumor S180 suppression ratio is 73%.The human microvascular endothelial cell (mvec) that Cortex Albiziae can significantly suppress epidermal growth factor to be induced is bred, move and become pipe.In addition, Cortex Albiziae effectively can also suppress intrusion and the vascularization of vitro invasion model mice endotheliocyte.Namely Cortex Albiziae can suppress the angiogenesis that epidermal growth factor is induced, inhibition tumor cell propagation and transfer.
Fructus Bruceae, bitter in the mouth, cold in nature; Removing toxic substances.Oleum Fructus Bruceae vein emulsion can suppress Mouse Ehrlich Carcinoma Cells and ascites hepatoma cells in vitro; In bulk testing, oil-in-water vein emulsion has better anticancer effect to mice ehrlich carcinoma, also has certain curative effect to sarcoma topical.There is obvious destruction to ehrlich ascites cell structure, be mainly the destruction of biofilm structure.The lighter, cell membrane is complete, and nuclear structures exists, rarely seen core peripheral clearance is broadening, mitochondrial swelling, cavitation, and dilatation of rough endoplasmic reticula is from local threshing, severe one, the serious cavitation of cell membrane defect, mitochondrion and the complete disintegrate of part cell, reach antineoplastic object with this.
Caulis Marsdeniae Tenacissimae, acrid in the mouth, is slightly cold; Heat-clearing and toxic substances removing.Research finds, the Caulis Marsdeniae Tenacissimae of high concentration to the suppression ratio of stomach cancer cell and hydroxy camptothecin similar, the stomach cancer cell caryoplasm scale smaller after Caulis Marsdeniae Tenacissimae effect, G0/G1 phase cell proportion increases, and presents differentiation-inducing trend.Caulis Marsdeniae Tenacissimae can be the activity of dose-dependent inhibition lung adenocarcinoma cell, and inducing cell Mitochondria becomes circle and breaks, induction Apoptosis of Lung Adenocarcinoma Cell.
Radix Paeoniae Rubra, bitter in the mouth, cold nature, returns Liver Channel; Eliminating stasis to stop pain.Research shows, Radix Paeoniae Rubra and effective ingredient thereof have the effect such as antiplatelet aggregation, anti-ex vivo thrombosis.Radix Paeoniae Rubra all can make KPTT, PT and TT all extend in vitro and in vivo, illustrate its to endogenous and exogenous cruor pathway all inhibited, its effect link may be common pathway at both, namely to the activity of antithrombase.
Rhizoma Ligustici, acrid in the mouth, property are wet; Dispersing cold for relieving pain.The arthralgia that rheumatic and rheumatoid causes can be treated, joint stuffiness, the diseases such as numb limbs and tense tendons; Because of the headache that anemofrigid cold causes, chest pain, toothache, aversion to cold, heat radiation of can dispeling cold, anti-inflammatory analgetic; Migraine and general headache, nasal obstruction brain is vexed; Rheumatism sufferings, wind syndrome of head order swells, malaria of having loose bowels dysentery; The stomach spasm that cold syndrome of the stomach causes, stomachache, flatulence, the diseases such as dyspepsia.
The Radix Angelicae Dahuricae, warm in nature, acrid in the mouth, gas fragrance, micro-hardship.To invigorate blood circulation evacuation of pus, granulation promoting pain relieving.The Radix Angelicae Dahuricae can act on Hela cell, by cell block in S phase and cell death inducing.
Prescription knot, pain relieving, detoxicating functions are excellent, effectively can treat the headache syndromes because nerve compression symptom causes, act on the multiple internal organs of whole body, fully demonstrate Chinese medicine and the uniqueness of human body organic whole is familiar with, by regulating whole body function, reach antineoplastic object.
Good effect of the present invention is: clear curative effect, and medicine source is wide, with low cost, produce and taking convenience, treatment glioma Be very effective.
Accompanying drawing explanation
Fig. 1 be in C6 glioma cell of the present invention PI3K/AKT/mTOR signaling pathway protein and Atg7 protein expression level affect schematic diagram;
What Fig. 2 was the present invention on PI3K/AKT/mTOR signaling pathway protein in C6 glioma cell and Atg7 protein expression level affects schematic diagram;
Fig. 3 is that the present invention affects schematic diagram to C6 glioma cell apoptosis level;
Fig. 4 is that the present invention affects schematic diagram to C6 glioma cell apoptosis level;
Fig. 5 is that the present invention affects schematic diagram to C6 invasion of glioma cells;
In figure: C: blank group; CHI1: Rhizoma Chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae group; CHI2: Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, Radix Angelicae Dahuricae group; T: of the present invention group.
Detailed description of the invention
The invention will be further described by the following examples.
The removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma, be made up of Rhizoma Chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae, Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, the Radix Angelicae Dahuricae, the percentage by weight of each Chinese medicinal components is: Rhizoma Chuanxiong 8-15%, Pheretima 8-15%, Cortex Albiziae 15-25%, Fructus Bruceae 15-20%, Caulis Marsdeniae Tenacissimae 15-25%, Radix Paeoniae Rubra 8-15%, Rhizoma Ligustici 8-15%, Radix Angelicae Dahuricae 8-15%.
The preparation method for the treatment of glioma removing obstruction for relieving pain Chinese medicine preparation, comprises following processing step: select chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae, Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, the Radix Angelicae Dahuricae, cleans, break into powder; According to percentage by weight preparation and decoction, the percentage by weight of each Chinese medicinal components is Rhizoma Chuanxiong 8-15%, Pheretima 8-15%, Cortex Albiziae 15-25%, Fructus Bruceae 15-20%, Caulis Marsdeniae Tenacissimae 15-25%, Radix Paeoniae Rubra 8-15%, Rhizoma Ligustici 8-15%, Radix Angelicae Dahuricae 8-15%; Decoct with water, filter, decocted with water by medicinal residues again, filter, water-bath is condensed into paste, dry, grinds, and makes the removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma.
Each important component percentage by weight of specific embodiment sees the following form:
The present invention is studied by cell experiment, obtains Preferred effects, obtains following Main Conclusions:
1. the present invention finds through radioimmunology experiment, and the present invention significantly suppresses C6 glioma cell to discharge TNF-α;
2. the present invention is detected by Westernblotting method and shows, the present invention significantly can raise the expression of PI3K/AKT/mTOR signaling pathway protein in C6 glioma cell, significantly upper expression of lowering Atg7 albumen in C6 glioma cell;
3. the present invention is detected by AnnexinV-FITC and finds, the present invention can obviously promote C6 glioma cell apoptosis;
4. the present invention is found by crystal violet staining assay, and the present invention significantly can suppress the aggressive of C6 glioma cell;
5. the present invention is by suppressing C6 glioma cell release TNF-α, and causes tumor cell autophagy by PI3K/AKT/mTOR signal path, and then causes the aggressive of apoptosis and Tumor suppression.
The present invention suppresses the experimental studies results of glioma:
(1) the present invention and the side of tearing open thereof are on the impact of TNF-alpha content in C6 glioma cell culture fluid.(see table 1)
Note: CHI1: Rhizoma Chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae group; CHI2: Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, Radix Angelicae Dahuricae group; T: of the present invention group.Same concentration suppression ratio compares: compare with of the present invention group, *
p<0.05;
△ p<0.01.
Result is pointed out, two side's of tearing open groups increase with drug level, in culture fluid, TNF-alpha content also increases, there is obvious dose-dependence, it causes TNF-alpha content peak in culture fluid can be reached for 23.9 μ g/L and 26.52 μ g/L, and of the present invention group promotes that the effect of glioma cell release TNF-α is better than two side's of tearing open groups, have significant difference, 38.38 μ g/L can be reached, prove that two side's of tearing open groups have synergism.
(2) the present invention and the side of tearing open are on the impact (see accompanying drawing 1,2) of PI3K/AKT/mTOR signaling pathway protein and Atg7 protein expression level in C6 glioma cell.
In accompanying drawing: C: blank group; CHI1: Rhizoma Chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae group; CHI2: Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, Radix Angelicae Dahuricae group; T: of the present invention group.
The C6 glioma cell of the present invention and the side's of tearing open process, the protein band of PI3K/AKT/mTOR signaling pathway protein all strengthens compared with matched group, illustrate that the present invention and the side of tearing open expression to these signaling pathway proteins has facilitation, facilitation power is followed successively by: T > CH2 > CH1 > C.And the expression of autophagy proteins Atg7 all weakens compared with matched group, illustrate that the present invention and the side of tearing open expression to Atg7 albumen is inhibited, inhibitory action power is followed successively by: T > CH2 > CH1 > C.
The formation of cell to autophagy has meticulous adjustment, there is the participation of several genes, these genes are generically and collectively referred to as autophagy related gene (autophagyrelatedgene, ATG), the albumen of their codings participates in the induction of autophagy, generation, maturation and recirculation, while autophagy be also subject to some signal pathways as PI3K/AKT/mTOR and
The regulation and control of p38-MAPK etc.
Phosphinositides-3 kinases (phosphatidylinositol-3-kinase, PI3K), is present in cytoplasmic complex, is that a kind of energy can the lipid kinase of catalyze phospholipid acyl inositol D3 position phosphorylation.After cell stimulates by various somatomedin etc., the activation of PI3K will cause 3,4-diphosphonic acid phosphatidylinositols (PIP2) to be converted into 3,4,5-triphosphoric acid phosphatidylinositols (PIP3).As PIP3 reactivation many downstreams albumen of second message,second messenger.Akt is one of PI3K downstream key protein, is a kind of serine/threonine protein kitase of upper high conservative of evolving.Akt albumen after activation, again in endochylema or in karyon, by a series of for phosphorylation substrate, and then plays effect such as promotion cell proliferation, anti-apoptotic etc.
Mammal rapamycin target protein (mammaliantargetofrapamycin, mTOR) is one of PI3K signal path downstream molecules.MTOR participates in the autophagy of cell.Autophagy (autophagy), also known as autophagy, is that cell utilizes some impaired organelles of lysosomal degradation self and macromolecular substances process, regulates cell.MTOR, as a kind of conservative serine/threonine protein kitase, is the point regulating the upstream passages such as Growth of Cells, propagation, motion, survival and autophagy, and mTOR, as key regulator startup stage of autophagy, can suppress the generation of autophagy after its activation.Wherein PI3K/AKT/mTOR is the signal path suppressing autophagy, and it can be activated in many tumors.
In this experiment, we are with the protein expression of PI3K/AKT/mTOR signal protein in Westernblot method detection matched group and the present invention and the side's of tearing open group.After the full side of result display application the present invention and two sides of tearing open process C6 glioma cell, each protein expression has and strengthens to some extent compared with matched group, and complete square acting on is better than the side of tearing open.And the expression of autophagygene protein A tg7 is just in time contrary with the protein expression of PI3K/AKT/mTOR signal protein, after the full side of application the present invention and two sides of tearing open process C6 glioma cell, each protein expression has and weakens to some extent compared with matched group, and full side's inhibitory action is better than the side of tearing open.Experimental result illustrates that the present invention treats the active component of glioma at removing obstruction for relieving pain class medicine.
Research proves, each herbal medicine in the present invention links closely just, and the glioma stagnation of QI hinders network, blood deficiency holds the pathogenesis that the stasis of blood stops up brain under the arm, is that primary efficacy treats glioma with removing obstruction for relieving pain.
(3) the present invention and the side of tearing open are on the impact (see accompanying drawing 3,4) of C6 glioma cell apoptosis level.
In accompanying drawing: C: blank group; CHI1: Rhizoma Chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae group; CHI2: Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, Radix Angelicae Dahuricae group; T: of the present invention group.
It is an important step that glioma prevents and treats apoptosis of tumor cells in Mechanism Study.In this experiment, detect apoptosis by AnnexinV-FITC, after the present invention of result display application and the side's of tearing open process C6 glioma cell, each group of Level of Apoptosis all has and increases compared with matched group, and wherein the effect of full side is the strongest, and two sides of tearing open are slightly weak.Experimental result illustrates that the present invention suppresses the invasive mechanism of glioma apoptosis-related with promotion, and its active component produces under removing obstruction for relieving pain class drug synergism.
(4) the present invention and the side of tearing open are on the impact (see accompanying drawing 5) of C6 invasion of glioma cells.
The treatment of glioma is based on operative treatment, but because glioma has high invasive feature, therefore can not accomplish in art that pathology thoroughly excise, postoperative patient often Preventive in a short time, have a strong impact on the quality of life of patient, namely severe one causes death in a short time, and therefore, the postoperative routine of patients with gliomas will carry out the auxiliary treatment such as chemotherapy.The physical weakness of tumor patient own, often can not the chemicals of tolerate treatment dosage, causes postoperative chemotherapy effect unsatisfactory.If the overall angle improving immunity can be implemented from the angle of the traditional Chinese medical science to body treat, the effect of getting twice the result with half the effort may be reached.After use the present invention and the side of tearing open thereof act on C6 glioma cell, find the present invention and tear Fang Junneng open to reduce glioma aggressive, 3 groups of medicines are followed successively by C6 glioma cell anti-invasion effect power: > Caulis Marsdeniae Tenacissimae of the present invention, Radix Paeoniae Rubra, Rhizoma Ligustici, Radix Angelicae Dahuricae group > Rhizoma Chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae group.
Claims (3)
1. treat the removing obstruction for relieving pain Chinese medicine preparation of glioma for one kind, it is characterized in that: be made up of Rhizoma Chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae, Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, the Radix Angelicae Dahuricae, the percentage by weight of each Chinese medicinal components is: Rhizoma Chuanxiong 8-15%, Pheretima 8-15%, Cortex Albiziae 15-25%, Fructus Bruceae 15-20%, Caulis Marsdeniae Tenacissimae 15-25%, Radix Paeoniae Rubra 8-15%, Rhizoma Ligustici 8-15%, Radix Angelicae Dahuricae 8-15%.
2. treat a preparation method for the removing obstruction for relieving pain Chinese medicine preparation of glioma, it is characterized in that comprising following processing step:
Select chuanxiong, Pheretima, Cortex Albiziae, Fructus Bruceae, Caulis Marsdeniae Tenacissimae, Radix Paeoniae Rubra, Rhizoma Ligustici, the Radix Angelicae Dahuricae, clean, break into powder; According to percentage by weight preparation and decoction, the percentage by weight of each Chinese medicinal components is Rhizoma Chuanxiong 8-15%, Pheretima 8-15%, Cortex Albiziae 15-25%, Fructus Bruceae 15-20%, Caulis Marsdeniae Tenacissimae 15-25%, Radix Paeoniae Rubra 8-15%, Rhizoma Ligustici 8-15%, Radix Angelicae Dahuricae 8-15%; Decoct with water, filter, decocted with water by medicinal residues again, filter, water-bath concentrates, and becomes paste, dry, grinds, and makes the removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma.
3. the preparation method of the removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma according to claim 2, is characterized in that: the removing obstruction for relieving pain Chinese medicine preparation for the treatment of glioma makes capsule, tablet, powder.
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