CN105229131A - 用于生产高度纯化的多不饱和脂肪酸的色谱方法 - Google Patents

用于生产高度纯化的多不饱和脂肪酸的色谱方法 Download PDF

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Publication number
CN105229131A
CN105229131A CN201480029096.2A CN201480029096A CN105229131A CN 105229131 A CN105229131 A CN 105229131A CN 201480029096 A CN201480029096 A CN 201480029096A CN 105229131 A CN105229131 A CN 105229131A
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CN
China
Prior art keywords
chromatographic separation
stream
eluent
eluent stream
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480029096.2A
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English (en)
Chinese (zh)
Inventor
E·瓦勒里
P·阿黛姆
J·布莱休伊特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Groupe Novasep SAS
Original Assignee
Groupe Novasep SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP13305596.2A external-priority patent/EP2801604B1/en
Priority claimed from US13/897,056 external-priority patent/US8802880B1/en
Priority claimed from US14/149,420 external-priority patent/US9428711B2/en
Application filed by Groupe Novasep SAS filed Critical Groupe Novasep SAS
Priority to CN201811593375.8A priority Critical patent/CN109679768A/zh
Publication of CN105229131A publication Critical patent/CN105229131A/zh
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterised by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds or centrifugal chromatography
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/08—Refining

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Sustainable Development (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Fats And Perfumes (AREA)
  • Liquid Carbonaceous Fuels (AREA)
CN201480029096.2A 2013-05-07 2014-04-23 用于生产高度纯化的多不饱和脂肪酸的色谱方法 Pending CN105229131A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811593375.8A CN109679768A (zh) 2013-05-07 2014-04-23 用于生产高度纯化的多不饱和脂肪酸的色谱方法

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361820459P 2013-05-07 2013-05-07
EP13305596.2A EP2801604B1 (en) 2013-05-07 2013-05-07 Chromatographic process for the production of highly purified polyunsaturated fatty acids
US61/820,459 2013-05-07
EP13305596.2 2013-05-07
US13/897,056 US8802880B1 (en) 2013-05-07 2013-05-17 Chromatographic process for the production of highly purified polyunsaturated fatty acids
US13/897,056 2013-05-17
US14/149,420 US9428711B2 (en) 2013-05-07 2014-01-07 Chromatographic process for the production of highly purified polyunsaturated fatty acids
US14/149,420 2014-01-07
PCT/EP2014/058166 WO2014180654A1 (en) 2013-05-07 2014-04-23 Chromatographic process for the production of highly purified polyunsaturated fatty acids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811593375.8A Division CN109679768A (zh) 2013-05-07 2014-04-23 用于生产高度纯化的多不饱和脂肪酸的色谱方法

Publications (1)

Publication Number Publication Date
CN105229131A true CN105229131A (zh) 2016-01-06

Family

ID=51866832

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201480029096.2A Pending CN105229131A (zh) 2013-05-07 2014-04-23 用于生产高度纯化的多不饱和脂肪酸的色谱方法
CN201811593375.8A Pending CN109679768A (zh) 2013-05-07 2014-04-23 用于生产高度纯化的多不饱和脂肪酸的色谱方法

Family Applications After (1)

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CN201811593375.8A Pending CN109679768A (zh) 2013-05-07 2014-04-23 用于生产高度纯化的多不饱和脂肪酸的色谱方法

Country Status (9)

Country Link
EP (1) EP2994523B1 (https=)
JP (3) JP6546911B2 (https=)
KR (1) KR102263760B1 (https=)
CN (2) CN105229131A (https=)
CA (1) CA2911273C (https=)
CL (1) CL2015003247A1 (https=)
GB (1) GB2528618B (https=)
PE (2) PE20200389A1 (https=)
WO (1) WO2014180654A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107556187A (zh) * 2017-08-31 2018-01-09 江苏科技大学 β‑环糊精包埋联合模拟移动床色谱分离法制备高纯度α‑亚麻酸的方法
CN107586259A (zh) * 2017-07-10 2018-01-16 乔璞科技有限公司 纯化不饱和脂肪酸以及二十碳五烯酸的方法
CN112592268A (zh) * 2020-12-18 2021-04-02 江苏汉邦科技有限公司 一种利用连续色谱系统分离鱼油中epa的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104529772B (zh) * 2014-12-17 2016-12-07 浙江大学 一种模拟移动床色谱制备高纯度epa酯和dha酯单体的方法

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US20030222024A1 (en) * 2002-02-22 2003-12-04 Novasep Chromatography method and device with recovery of solvent
CN102285880A (zh) * 2011-06-14 2011-12-21 国家海洋局第三海洋研究所 Epa乙酯和dha乙酯的制备方法
CN102811781A (zh) * 2009-12-30 2012-12-05 巴斯夫制药（卡兰尼什）公司 用于纯化多不饱和脂肪酸的模拟移动床色谱分离方法
CN102921192A (zh) * 2012-05-16 2013-02-13 中国计量科学研究院 一种制备高纯度单不饱和脂肪酸的方法

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JPH0746097B2 (ja) 1988-05-17 1995-05-17 三菱化成エンジニアリング株式会社 クロマト分離法
US5102553A (en) 1988-12-16 1992-04-07 The Amalgamated Sugar Company Time variable simulated moving bed process
DK0697034T3 (da) * 1993-04-29 1997-07-14 Norsk Hydro As Fremgangsmåder til kromatografisk fraktionering af fedtsyrer og deres derivater
US5630943A (en) 1995-11-30 1997-05-20 Merck Patent Gesellschaft Mit Beschrankter Haftung Discontinuous countercurrent chromatographic process and apparatus
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FR2785196B1 (fr) 1998-10-29 2000-12-15 Inst Francais Du Petrole Procede et dispositif de separation avec des zones chromatographiques a longueur variable
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CN102811781A (zh) * 2009-12-30 2012-12-05 巴斯夫制药（卡兰尼什）公司 用于纯化多不饱和脂肪酸的模拟移动床色谱分离方法
CN102285880A (zh) * 2011-06-14 2011-12-21 国家海洋局第三海洋研究所 Epa乙酯和dha乙酯的制备方法
CN102921192A (zh) * 2012-05-16 2013-02-13 中国计量科学研究院 一种制备高纯度单不饱和脂肪酸的方法

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107586259A (zh) * 2017-07-10 2018-01-16 乔璞科技有限公司 纯化不饱和脂肪酸以及二十碳五烯酸的方法
CN107556187A (zh) * 2017-08-31 2018-01-09 江苏科技大学 β‑环糊精包埋联合模拟移动床色谱分离法制备高纯度α‑亚麻酸的方法
CN112592268A (zh) * 2020-12-18 2021-04-02 江苏汉邦科技有限公司 一种利用连续色谱系统分离鱼油中epa的方法
CN112592268B (zh) * 2020-12-18 2022-12-09 江苏汉邦科技股份有限公司 一种利用连续色谱系统分离鱼油中epa的方法

Also Published As

Publication number Publication date
JP2020090680A (ja) 2020-06-11
GB2528618A (en) 2016-01-27
KR20160005046A (ko) 2016-01-13
EP2994523B1 (en) 2024-02-21
WO2014180654A1 (en) 2014-11-13
KR102263760B1 (ko) 2021-06-11
CA2911273A1 (en) 2014-11-13
GB201520373D0 (en) 2016-01-06
PE20251531A1 (es) 2025-06-05
JP6546911B2 (ja) 2019-07-17
JP6867524B2 (ja) 2021-04-28
JP2016523826A (ja) 2016-08-12
CA2911273C (en) 2021-04-27
EP2994523A1 (en) 2016-03-16
JP2018141168A (ja) 2018-09-13
PE20200389A1 (es) 2020-02-24
CN109679768A (zh) 2019-04-26
CL2015003247A1 (es) 2016-05-27
GB2528618B (en) 2020-12-23

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Application publication date: 20160106