CN105214008A - A kind of Chinese medicine oral liquid and preparation method for the treatment of bile reflux gastritis - Google Patents

Abstract

The present invention discloses a kind of Chinese medicine oral liquid and preparation method for the treatment of bile reflux gastritis, is made up of following raw material: Rhizoma Et Radix Notopterygii 13-17 part, Fructus Aurantii 7-11 part, Radix Aucklandiae 7-11 part, Rhizoma Curcumae 18-22 part, Herba Taraxaci 38-42 part, Radix Et Rhizoma Nardostachyos 10-14 part, Flos Rosae Rugosae 13-17 part, Radix Codonopsis 18-22 part, Endothelium Corneum Gigeriae Galli 13-17 part, Radix Bupleuri 10-14 part, Fructus Evodiae 4-8 part, Caulis Perillae 6-10 part, Fructus Citri Sarcodactylis 13-17 part, Aspongopus 8-12 part, Herba Belladonnae 4-8 part.The present invention has effect of depressed liver-energy dispersing and QI regulating, normalizing the stomach by guiding QI downward, clearing away heat-damp and promoting diuresis, function of gallbladder promoting purging FU-organs, and be a kind of safe and reliable, without any side effects, effective ingredient utilization rate is high, the Chinese medicine composition of instant effect.

Description

A kind of Chinese medicine oral liquid and preparation method for the treatment of bile reflux gastritis

Technical field

The present invention relates to a kind of Chinese medicine oral liquid for the treatment of bile reflux gastritis, belong to the field of Chinese medicines.

Background technology

Bile reflux gastritis is also known as alkaline reflux gastritis, refer to that reducing the reasons such as the operation of pylorus peristaltic function by sphincter of pylorus functional disorder or row causes containing the duodenum such as bile, pancreatic juice content inflow stomach, gastric mucosa is made to produce inflammation, erosion and hemorrhage etc., weaken gastric mucosal barrier function, H+ disperse is caused to increase, and the gastric mucosa chronic inflammatory disease caused, clinical manifestation: one, abdominal distention: this is than one of major symptom, show as distended tummy discomfort, middle upper abdomen continues burn feeling, also can show as pain after breastbone, can increase the weight of after the meal; Two, heartburn: there is burning sensation in portion, even some esophageal patient also has burn feeling, usually, loss of appetite smooth with belch, acid regurgitation, Nausea and vomiting, borborygmus, defecation and the phenomenon such as to become thin; Three, gastrorrhagia: heavy patients with bile reflux gastritis also there will be the situation of gastrorrhagia, some patient stool present black, have plenty of hematemesis; Four, vomit: in gastric emptying disorder, vomiting generally occurs in night or midnight, blood is with in some patient's vomitus, the western medical treatment Main Means taked this disease at present takes antibiotic, but western medicine is temporary transient symptom management mostly, and it is harmful unhelpful to take too many antibiotic, immune function of human body goes down, and causes Relapse rate difficulty more.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine oral liquid for the treatment of bile reflux gastritis, it has depressed liver-energy dispersing and QI regulating, normalizing the stomach by guiding QI downward, clearing away heat-damp and promoting diuresis, function of gallbladder promoting purging FU-organs

Effect.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine oral liquid for bile reflux gastritis, be made up of following raw material: Rhizoma Et Radix Notopterygii 13-17 part, Fructus Aurantii 7-11 part, Radix Aucklandiae 7-11 part, Rhizoma Curcumae 18-22 part, Herba Taraxaci 38-42 part, Radix Et Rhizoma Nardostachyos 10-14 part, Flos Rosae Rugosae 13-17 part, Radix Codonopsis 18-22 part, Endothelium Corneum Gigeriae Galli 13-17 part, Radix Bupleuri 10-14 part, Fructus Evodiae 4-8 part, Caulis Perillae 6-10 part, Fructus Citri Sarcodactylis 13-17 part, Aspongopus 8-12 part, Herba Belladonnae 4-8 part.

Preferably, each parts by weight of raw materials is: Rhizoma Et Radix Notopterygii 15 parts, Fructus Aurantii 9 parts, the Radix Aucklandiae 9 parts, Rhizoma Curcumae 20 parts, Herba Taraxaci 40 parts, Radix Et Rhizoma Nardostachyos 12 parts, Flos Rosae Rugosae 15 parts, Radix Codonopsis 20 parts, Endothelium Corneum Gigeriae Galli 15 parts, Radix Bupleuri 12 parts, Fructus Evodiae 6 parts, Caulis Perillae 8 parts, Fructus Citri Sarcodactylis 15 parts, Aspongopus 10 parts, Herba Belladonnae 6 parts.

Pharmacological action:

Rhizoma Et Radix Notopterygii: nature and flavor with return through: pungent, bitter, temperature; Return bladder, kidney channel, function with cure mainly: cold expelling, dispel the wind, dehumidifying, pain relieving; For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.

Fructus Aurantii: nature and flavor with return through: bitter, pungent, sour, temperature; Return spleen, stomach warp, function with cure mainly: regulating the flow of QI to ease the stomach, row stagnant relieving distension; For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.

The Radix Aucklandiae: nature and flavor with return through: pungent, bitter, temperature; Return spleen, stomach, large intestine, three burnt, gallbladder meridians, function with cure mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia; The real intestinal antidiarrheal of Radix Aucklandiae (roasted); For stomachache of having loose bowels.

Rhizoma Curcumae: nature and flavor with return through: pungent, bitter, temperature; Return liver, spleen channel, function with cure mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving; For note of the ancient Chinese abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.

Herba Taraxaci: nature and flavor with return through: bitter, sweet, cold; Return liver, stomach warp, function with cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome; For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Radix Et Rhizoma Nardostachyos: nature and flavor with return through acrid, sweet, warm; Return spleen, stomach warp, function with cure mainly: regulating QI to relieve pain, relieving stagnation and activating the spleen; For distension and fullness in the abdomen, inappetence, vomiting; External treatment is had a toothache, swelling of the feet.

Flos Rosae Rugosae: nature and flavor with return through sweet, micro-hardship, temperature; Return liver, spleen channel, function with cure mainly: promoting QI circulation for relieving depression, and blood, pain relieving; For stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia, falls and flutters the pain of injury.

Radix Codonopsis: nature and flavor with return through: sweet, flat; Return spleen, lung meridian, function with cure mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Endothelium Corneum Gigeriae Galli: nature and flavor with return through: sweet, flat; Return spleen, stomach, small intestinal, urinary bladder channel, function with cure mainly: invigorating the stomach and promoting digestion, arresting seminal emission; Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.

Radix Bupleuri: nature and flavor with return through: bitter, be slightly cold; Return liver, gallbladder meridian, function with cure mainly: reconciling superficies and interior, soothing the liver, yang invigorating; For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.

Fructus Evodiae: nature and flavor with return through: pungent, bitter, heat; Slightly poisonous; Return liver, spleen, stomach, kidney channel, function with cure mainly: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal; For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.

Caulis Perillae: nature and flavor with return through: pungent, temperature; Return lung, spleen channel, function with cure mainly: regulating the flow of QI to ease the stomach, pain relieving, antiabortive; Vexed for chest and diaphragm painful abdominal mass, gastralgia, belch is vomitted, frequent fetal movement.

Fructus Citri Sarcodactylis: nature and flavor with return through: pungent, bitter, sour, warm; Return liver, spleen, lung meridian, function with cure mainly: liver-smoothing, qi-regulating, and stomach and alleviating pain; For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.

Aspongopus: nature and flavor with return through: salty, temperature; Return liver,spleen,kidney warp, function with cure mainly: regulating QI to relieve pain, warming middle-JIAO is supporing yang; For cold syndrome of the stomach distending pain, stomachache due to hyperactive liver-QI attacking the stomach, impotence due to deficiency of the kidney, soreness of waist and knee joint.

Herba Belladonnae: meridian distribution of property and flavor: bitter, pungent, temperature, kidney, stomach two warp; Effect: inducing diuresis to remove edema, wind-expelling pain-stopping; For edema, dysuria, oliguria, rheumatic arthritis, toothache, orchitis.

Another technical problem to be solved by this invention is to provide a kind of preparation method preparing above-mentioned Chinese medicine oral liquid.

Another technical problem to be solved by this invention is achieved through the following technical solutions:

Treat a preparation method for the Chinese medicine oral liquid of bile reflux gastritis, be prepared from by following methods:

(1) get raw material Rhizoma Et Radix Notopterygii, Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(2) get raw material Herba Taraxaci, Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(3) Rhizoma Et Radix Notopterygii after pulverizing in step (1), Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus are added above-mentioned raw materials weight and 8-13 water doubly, decoct 2-3 hour, release medicinal liquid; Herba Taraxaci after pulverizing in step (2), Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1-2 hour doubly after twice medicinal residues merges, release medicinal liquid; Merge the medicinal liquid decocted for three times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;

(4) gained filtrate in step (3) is added the ethanol of filtrate weight 1.5-2 times 95%, leave standstill 20-24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;

(5) filter in step (4) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;

(6) gained filtrate in step (5) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;

(7) gained clear paste in step (6) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat the Chinese medicine oral liquid of bile reflux gastritis.

Preferably, a kind of preparation method for the treatment of the Chinese medicine oral liquid of bile reflux gastritis, is prepared from by following methods:

(1) get raw material Rhizoma Et Radix Notopterygii, Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;

(2) get raw material Herba Taraxaci, Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;

(3) Rhizoma Et Radix Notopterygii after pulverizing in step (1), Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus are added the water of above-mentioned raw materials weight and 13 times, decocts 2 hours, releasing medicinal liquid; Herba Taraxaci after pulverizing in step (2), Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae are added the soak by water 2 hours of above-mentioned raw materials weight and 12 times, release medicinal liquid; Twice medicinal residues add the soak by water 1.5 hours of its weight 8 times after merging, release medicinal liquid; Merge the medicinal liquid decocted for three times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;

(4) gained filtrate in step (3) is added the ethanol of 95% of filtrate weight 1.5 times, leave standstill 24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane aperture of described leaf filter is 0.8 μm, in the process of filtering, pressure limit is 0.15MPa, face discharge is 1.5T/h, obtains filtrate, for subsequent use;

(5) filter in step (4) in gained filtrate feeding leaf filter, the filter membrane aperture of described leaf filter is 0.8 μm, and in the process of filtering, pressure limit is 0.15MPa, and face discharge is 0.8T/h, obtains filtrate, for subsequent use;

(6) gained filtrate in step (5) is sent into traditional Chinese drug inspissation machine, when being evaporated to 60 DEG C in thickener, the clear paste of relative density 1.05, obtains clear paste, for subsequent use;

(7) gained clear paste in step (6) is statically placed in 24 hours under the condition of 6 DEG C, by sodium hydroxide solution adjust ph to 6.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20min is irradiated in ultraviolet wavelength 254nm sterilizing, packs to obtain finished product, must treat the Chinese medicine oral liquid of bile reflux gastritis.

Beneficial effect: the present invention has effect of depressed liver-energy dispersing and QI regulating, normalizing the stomach by guiding QI downward, clearing away heat-damp and promoting diuresis, function of gallbladder promoting purging FU-organs, be a kind of safe and reliable, without any side effects, effective ingredient utilization rate is high, the Chinese medicine composition of instant effect.

The present invention adopts pure Chinese medicine to be raw material, according to pathogenic factor and the Clinical symptoms of bile reflux gastritis, under instruction of Chinese Medicine theory, carry out prescription be prepared from the basis not being raw-material activity, show through clinical efficacy, this medicine has definite curative effect to bile reflux gastritis, is a kind of ideal treatment medication of patients with bile reflux gastritis.

Model case

Case 1: Mrs Wang, 35 years old, medical history: upper abdomen distension pain, nearly 1 year, through western medicines in treatment in many ways, have no improvement, heart sense is burnt in existing sense, poor appetite, examine as bile reflux gastritis, take Drug therapy of the present invention course for the treatment of, after treatment, patient's subjective symptoms obviously alleviates, after taking two courses for the treatment of, patient's above-mentioned symptom disappears completely, follows up a case by regular visits to 1 year without recurrence.

Case 2: Mr. Ou, 45 years old, medical history: patient had gastritis medical history more than 3 years, hospital gastroscope inspection is bile reflux gastritis, patient comes here and goes to a doctor, and patient's bitter taste is uncomfortable in chest, acid regurgitation, have dull pain, take a course for the treatment of of Drug therapy of the present invention, after treatment, patient's subjective symptoms obviously alleviates, after taking two courses for the treatment of again, patient's above-mentioned symptom disappears completely, follows up a case by regular visits to 1 year without recurrence.

Case 3: Mrs Bi, 30 years old, medical history: patient has gastritis medical history three months, hospital gastroscope inspection is bile reflux gastritis, complexion is normal, tongue fur turns white, and main suit gets up a little bitter in the mouth morning, not acid regurgitation, appetite is normal, refuse cold drinks and snachs, do not vomit, after having a meal, digestion is not so good, defecation is normal, but times of defecation is many, the breast side of body is sometimes swollen, somewhat swollen after meal, take a course for the treatment of of Drug therapy of the present invention, after treatment, patient's subjective symptoms obviously alleviates, and after taking two courses for the treatment of, patient's above-mentioned symptom disappears completely, follows up a case by regular visits to 1 year without recurrence.

Case 4: Xiang Mr., 55 years old, medical history: patient's bitter taste, dry pharynx, abdominal distention are felt sick existing more than 2 years.After patient's private prosecution anger, or greasy thing of taking food causes nausea nausea, abdominal distention, does not feel like a meal, fatigue and weak, sometimes be hard and dry, feed postemphasis admission, checks that gastroscope shows: bile reflux gastritis, take a course for the treatment of of Drug therapy of the present invention, after treatment, patient's subjective symptoms obviously alleviates, then after taking two courses for the treatment of, patient's above-mentioned symptom disappears completely, follows up a case by regular visits to 1 year without recurrence.

Case 5: Mr. Zhang, 37 years old, medical history: patient suffers from bile reflux gastritis existing 5 years, come here to go to a doctor, patient is symptom at that time: scorching hot is back dull pain sometimes, uncomfortable in chestly to have the hiccups, eat meal just to have the hiccups, support swollen not sleep well in sleep in evening sensation stomach, particularly to morning, stomach support of waking up the morning of waking up is swollen, defecate, just feel better after having separated, defecate rare bad, almost every day is all like this, take a course for the treatment of of Drug therapy of the present invention, after treatment, patient's subjective symptoms obviously alleviates, after taking three courses for the treatment of again, patient's above-mentioned symptom disappears completely, follow up a case by regular visits to 1 year without recurrence.

Case 6: Mr. Wang, 41 years old, medical history: patient suffers from gastropathy existing 3 years, and hospital gastroscope is diagnosed: superficial gastritis companion bile reflux.The current symptom belch of patient's readme, stomach fiber crops pain, dizzy, not sleep well, take a course for the treatment of of Drug therapy of the present invention, after treatment, patient's subjective symptoms obviously alleviates, then after taking three courses for the treatment of, patient's above-mentioned symptom disappears completely, follows up a case by regular visits to 1 year without recurrence.

Case 7: Mr. Qian, 51 years old, medical history: patient suffers from bile reflux gastritis, one year about half, eat a lot of Chinese medicine Western medicine, effect is not very remarkable, bad during fashion, take a course for the treatment of of Drug therapy of the present invention, after treatment, patient's subjective symptoms obviously alleviates, after taking two courses for the treatment of, patient's above-mentioned symptom disappears completely, follows up a case by regular visits to 1 year without recurrence.

Clinical data

Physical data: reflux gastritis patient 50 example, man 27 example, female 23 example, age 23-60 year, the course of disease three months to 6 years.

Diagnostic criteria: the diagnosis of bile reflux gastritis and main gastroscopy and the stomach function regulating aspirate of relying on of discriminating measure, and isotope assay can understand reflux degree.

Therapeutic Method: take oral liquid of the present invention, every day 3 times, each 30ml, 10 days 1 courses for the treatment of.

Curative effect determinate standard: recovery from illness: each transference cure of patient, recovers normal through gastroscope and the inspection of stomach aspirate; Effective: each symptom of patient takes an evident turn for the better, and takes an evident turn for the better through places such as gastroscopy gastric mucosa, pyloric ostiums; Invalid: each disease of patient is without any improvement.

Therapeutic outcome: by this side treatment patients with bile reflux gastritis 50 example, recovery from illness 39 example, effective 11 examples, invalid 0 example, total effective rate 100%.

Detailed description of the invention

Embodiment 1

The present invention treats the preparation of bile reflux gastritis Chinese medicine oral liquid, and the weight portion of each raw material is: Rhizoma Et Radix Notopterygii 17 parts, Fructus Aurantii 11 parts, the Radix Aucklandiae 11 parts, Rhizoma Curcumae 22 parts, Herba Taraxaci 42 parts, Radix Et Rhizoma Nardostachyos 14 parts, Flos Rosae Rugosae 17 parts, Radix Codonopsis 22 parts, Endothelium Corneum Gigeriae Galli 17 parts, Radix Bupleuri 14 parts, Fructus Evodiae 8 parts, Caulis Perillae 10 parts, Fructus Citri Sarcodactylis 17 parts, Aspongopus 12 parts, Herba Belladonnae 8 parts;

Be prepared from by following methods:

(1) get raw material Rhizoma Et Radix Notopterygii, Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(2) get raw material Herba Taraxaci, Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(3) Rhizoma Et Radix Notopterygii after pulverizing in step (1), Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus are added above-mentioned raw materials weight and 8-13 water doubly, decoct 2-3 hour, release medicinal liquid; Herba Taraxaci after pulverizing in step (2), Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1-2 hour doubly after twice medicinal residues merges, release medicinal liquid; Merge the medicinal liquid decocted for three times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;

(4) gained filtrate in step (3) is added the ethanol of filtrate weight 1.5-2 times 95%, leave standstill 20-24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;

(5) filter in step (4) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;

(6) gained filtrate in step (5) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;

(7) gained clear paste in step (6) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat the Chinese medicine oral liquid of bile reflux gastritis.

Usage: take oral liquid of the present invention, every day 3 times, each 30ml.

Embodiment 2

The present invention treats the preparation of bile reflux gastritis Chinese medicine oral liquid, and the weight portion of each raw material is: Rhizoma Et Radix Notopterygii 15 parts, Fructus Aurantii 9 parts, the Radix Aucklandiae 9 parts, Rhizoma Curcumae 20 parts, Herba Taraxaci 40 parts, Radix Et Rhizoma Nardostachyos 12 parts, Flos Rosae Rugosae 15 parts, Radix Codonopsis 20 parts, Endothelium Corneum Gigeriae Galli 15 parts, Radix Bupleuri 12 parts, Fructus Evodiae 6 parts, Caulis Perillae 8 parts, Fructus Citri Sarcodactylis 15 parts, Aspongopus 10 parts, Herba Belladonnae 6 parts;

Be prepared from by following methods:

(1) get raw material Rhizoma Et Radix Notopterygii, Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(2) get raw material Herba Taraxaci, Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(3) Rhizoma Et Radix Notopterygii after pulverizing in step (1), Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus are added above-mentioned raw materials weight and 8-13 water doubly, decoct 2-3 hour, release medicinal liquid; Herba Taraxaci after pulverizing in step (2), Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1-2 hour doubly after twice medicinal residues merges, release medicinal liquid; Merge the medicinal liquid decocted for three times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;

(4) gained filtrate in step (3) is added the ethanol of filtrate weight 1.5-2 times 95%, leave standstill 20-24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;

(5) filter in step (4) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;

(6) gained filtrate in step (5) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;

(7) gained clear paste in step (6) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat the Chinese medicine oral liquid of bile reflux gastritis.

Usage: take oral liquid of the present invention, every day 3 times, each 30ml.

Embodiment 3

The present invention treats the preparation of bile reflux gastritis Chinese medicine oral liquid, and the weight portion of each raw material is: Rhizoma Et Radix Notopterygii 13 parts, Fructus Aurantii 7 parts, the Radix Aucklandiae 7 parts, Rhizoma Curcumae 18 parts, Herba Taraxaci 38 parts, Radix Et Rhizoma Nardostachyos 10 parts, Flos Rosae Rugosae 13 parts, Radix Codonopsis 18 parts, Endothelium Corneum Gigeriae Galli 13 parts, Radix Bupleuri 10 parts, Fructus Evodiae 4 parts, Caulis Perillae 6 parts, Fructus Citri Sarcodactylis 13 parts, Aspongopus 8 parts, Herba Belladonnae 4 parts;

Be prepared from by following methods:

(1) get raw material Rhizoma Et Radix Notopterygii, Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(2) get raw material Herba Taraxaci, Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(3) Rhizoma Et Radix Notopterygii after pulverizing in step (1), Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus are added above-mentioned raw materials weight and 8-13 water doubly, decoct 2-3 hour, release medicinal liquid; Herba Taraxaci after pulverizing in step (2), Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1-2 hour doubly after twice medicinal residues merges, release medicinal liquid; Merge the medicinal liquid decocted for three times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;

(4) gained filtrate in step (3) is added the ethanol of filtrate weight 1.5-2 times 95%, leave standstill 20-24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;

(5) filter in step (4) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;

(6) gained filtrate in step (5) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;

(7) gained clear paste in step (6) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat the Chinese medicine oral liquid of bile reflux gastritis.

Usage: take oral liquid of the present invention, every day 3 times, each 30ml.

Claims (6)

1. treat a Chinese medicine oral liquid for bile reflux gastritis, it is characterized in that: be made up of following raw material: Rhizoma Et Radix Notopterygii 13-17 part, Fructus Aurantii 7-11 part, Radix Aucklandiae 7-11 part, Rhizoma Curcumae 18-22 part, Herba Taraxaci 38-42 part, Radix Et Rhizoma Nardostachyos 10-14 part, Flos Rosae Rugosae 13-17 part, Radix Codonopsis 18-22 part, Endothelium Corneum Gigeriae Galli 13-17 part, Radix Bupleuri 10-14 part, Fructus Evodiae 4-8 part, Caulis Perillae 6-10 part, Fructus Citri Sarcodactylis 13-17 part, Aspongopus 8-12 part, Herba Belladonnae 4-8 part.

2. a kind of Chinese medicine oral liquid for the treatment of bile reflux gastritis according to claim 1, is characterized in that: the weight portion of each raw material is: Rhizoma Et Radix Notopterygii 15 parts, Fructus Aurantii 9 parts, the Radix Aucklandiae 9 parts, Rhizoma Curcumae 20 parts, Herba Taraxaci 40 parts, Radix Et Rhizoma Nardostachyos 12 parts, Flos Rosae Rugosae 15 parts, Radix Codonopsis 20 parts, Endothelium Corneum Gigeriae Galli 15 parts, Radix Bupleuri 12 parts, Fructus Evodiae 6 parts, Caulis Perillae 8 parts, Fructus Citri Sarcodactylis 15 parts, Aspongopus 10 parts, Herba Belladonnae 6 parts.

3. a kind of Chinese medicine oral liquid for the treatment of bile reflux gastritis according to claim 1, is characterized in that: the weight portion of each raw material is: Rhizoma Et Radix Notopterygii 17 parts, Fructus Aurantii 11 parts, the Radix Aucklandiae 11 parts, Rhizoma Curcumae 22 parts, Herba Taraxaci 42 parts, Radix Et Rhizoma Nardostachyos 14 parts, Flos Rosae Rugosae 17 parts, Radix Codonopsis 22 parts, Endothelium Corneum Gigeriae Galli 17 parts, Radix Bupleuri 14 parts, Fructus Evodiae 8 parts, Caulis Perillae 10 parts, Fructus Citri Sarcodactylis 17 parts, Aspongopus 12 parts, Herba Belladonnae 8 parts.

4. a kind of Chinese medicine oral liquid for the treatment of bile reflux gastritis according to claim 1, is characterized in that: the weight portion of each raw material is: Rhizoma Et Radix Notopterygii 13 parts, Fructus Aurantii 7 parts, the Radix Aucklandiae 7 parts, Rhizoma Curcumae 18 parts, Herba Taraxaci 38 parts, Radix Et Rhizoma Nardostachyos 10 parts, Flos Rosae Rugosae 13 parts, Radix Codonopsis 18 parts, Endothelium Corneum Gigeriae Galli 13 parts, Radix Bupleuri 10 parts, Fructus Evodiae 4 parts, Caulis Perillae 6 parts, Fructus Citri Sarcodactylis 13 parts, Aspongopus 8 parts, Herba Belladonnae 4 parts.

5. a kind of preparation method for the treatment of the Chinese medicine oral liquid of bile reflux gastritis according to claim 1 and 2, is characterized in that: be prepared from by following methods:

(1) get raw material Rhizoma Et Radix Notopterygii, Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(2) get raw material Herba Taraxaci, Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(3) Rhizoma Et Radix Notopterygii after pulverizing in step (1), Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus are added above-mentioned raw materials weight and 8-13 water doubly, decoct 2-3 hour, release medicinal liquid; Herba Taraxaci after pulverizing in step (2), Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1-2 hour doubly after twice medicinal residues merges, release medicinal liquid; Merge the medicinal liquid decocted for three times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;

(4) gained filtrate in step (3) is added the ethanol of filtrate weight 1.5-2 times 95%, leave standstill 20-24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;

(5) filter in step (4) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;

(6) gained filtrate in step (5) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;

(7) gained clear paste in step (6) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat the Chinese medicine oral liquid of bile reflux gastritis.

6. a kind of preparation method for the treatment of the Chinese medicine oral liquid of bile reflux gastritis according to claim 1 and 2, is characterized in that: be prepared from by following methods:

(1) get raw material Rhizoma Et Radix Notopterygii, Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;

(2) get raw material Herba Taraxaci, Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;

(3) Rhizoma Et Radix Notopterygii after pulverizing in step (1), Fructus Aurantii, the Radix Aucklandiae, Rhizoma Curcumae, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli, Radix Bupleuri, Fructus Evodiae, Caulis Perillae, Fructus Citri Sarcodactylis, Aspongopus are added the water of above-mentioned raw materials weight and 13 times, decocts 2 hours, releasing medicinal liquid; Herba Taraxaci after pulverizing in step (2), Flos Rosae Rugosae, Radix Codonopsis, Herba Belladonnae are added the soak by water 2 hours of above-mentioned raw materials weight and 12 times, release medicinal liquid; Twice medicinal residues add the soak by water 1.5 hours of its weight 8 times after merging, release medicinal liquid; Merge the medicinal liquid decocted for three times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;

(4) gained filtrate in step (3) is added the ethanol of 95% of filtrate weight 1.5 times, leave standstill 24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane aperture of described leaf filter is 0.8 μm, in the process of filtering, pressure limit is 0.15MPa, face discharge is 1.5T/h, obtains filtrate, for subsequent use;

(5) filter in step (4) in gained filtrate feeding leaf filter, the filter membrane aperture of described leaf filter is 0.8 μm, and in the process of filtering, pressure limit is 0.15MPa, and face discharge is 0.8T/h, obtains filtrate, for subsequent use;

(6) gained filtrate in step (5) is sent into traditional Chinese drug inspissation machine, when being evaporated to 60 DEG C in thickener, the clear paste of relative density 1.05, obtains clear paste, for subsequent use;

(7) gained clear paste in step (6) is statically placed in 24 hours under the condition of 6 DEG C, by sodium hydroxide solution adjust ph to 6.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20min is irradiated in ultraviolet wavelength 254nm sterilizing, packs to obtain finished product, must treat the Chinese medicine oral liquid of bile reflux gastritis.