CN105209410A - 自由基轨道转换 - Google Patents

自由基轨道转换 Download PDF

Info

Publication number
CN105209410A
CN105209410A CN201480019844.9A CN201480019844A CN105209410A CN 105209410 A CN105209410 A CN 105209410A CN 201480019844 A CN201480019844 A CN 201480019844A CN 105209410 A CN105209410 A CN 105209410A
Authority
CN
China
Prior art keywords
neg
rad
free radical
negatively charged
charged ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480019844.9A
Other languages
English (en)
Chinese (zh)
Inventor
米歇尔·路易丝·库特
加娜·格利奥威
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CONVENTION PATENT APPLICATION
Original Assignee
CONVENTION PATENT APPLICATION
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2013900371A external-priority patent/AU2013900371A0/en
Application filed by CONVENTION PATENT APPLICATION filed Critical CONVENTION PATENT APPLICATION
Publication of CN105209410A publication Critical patent/CN105209410A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
    • C07F9/65685—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine oxide or thioxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201480019844.9A 2013-02-06 2014-02-06 自由基轨道转换 Pending CN105209410A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2013900371A AU2013900371A0 (en) 2013-02-06 Radical orbital switching
AU2013900373 2013-02-06
AU2013900373A AU2013900373A0 (en) 2013-02-06 Radical orbital switching
AU2013900371 2013-02-06
PCT/AU2014/000085 WO2014121327A1 (en) 2013-02-06 2014-02-06 Radical orbital switching

Publications (1)

Publication Number Publication Date
CN105209410A true CN105209410A (zh) 2015-12-30

Family

ID=51299075

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480019844.9A Pending CN105209410A (zh) 2013-02-06 2014-02-06 自由基轨道转换

Country Status (7)

Country Link
US (1) US20160075732A1 (https=)
EP (1) EP2953916A4 (https=)
JP (1) JP2016508488A (https=)
CN (1) CN105209410A (https=)
AU (1) AU2014214532B2 (https=)
CA (1) CA2900272A1 (https=)
WO (1) WO2014121327A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112955416A (zh) * 2018-10-29 2021-06-11 根特大学 用于水泥胶结材料以影响水泥胶结材料的流变性质的外掺料
CN113707226A (zh) * 2021-08-24 2021-11-26 西安热工研究院有限公司 一种建立木糖-木酮糖相互转化时微观动力学模型的方法
CN118609730A (zh) * 2024-06-13 2024-09-06 中国长城科技集团股份有限公司 锂电池正极材料的钴酸锂性能分析方法及相关设备

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110265646B (zh) * 2019-06-25 2022-09-16 西南大学 一种氮掺杂类石墨烯活性碳材料及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2757865B1 (fr) * 1996-12-26 1999-04-02 Atochem Elf Sa Procede de polymerisation ou copolymerisation radicalaire controlee de monomeres (meth)acryliques, vinyliques, vinylideniques et dieniques et (co)polymeres obtenus
TW593347B (en) * 1997-03-11 2004-06-21 Univ Carnegie Mellon Improvements in atom or group transfer radical polymerization
SE0101153D0 (sv) * 2001-03-30 2001-03-30 Zipat Ab New material
JP2003096054A (ja) * 2001-09-25 2003-04-03 Nof Corp アルコキシアミンおよびその製造方法
CN102083863B (zh) * 2008-03-07 2014-10-22 卡内基梅隆大学 改进的受控自由基聚合方法
CN102746515B (zh) * 2012-07-16 2013-09-18 浙江大学 一种嵌段共聚物的制备方法

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ASHUTOSH GUPTA等: "Electron Attachment to the Guanine−Cytosine Nucleic Acid Base Pair and the Effects of Monohydration and Proton Transfer", 《J. PHYS. CHEM. B 》 *
BENJAMIN B. KIRK: "irect Observation of the Gas Phase Reaction of the Cyclohexyl Radical with Dioxygen Using a Distonic Radical Ion Approach", 《J. PHYS. CHEM. A》 *
GANNA GRYN’OVA，MICHELLE L. COOTE: "Origin and Scope of Long-Range Stabilizing Interactions and Associated SOMO−HOMO Conversion in Distonic Radical Anions", 《J.AM.CHEM.SOC. 》 *
GANNA GRYN’OVA等: "Switching radical stability by pH-induced orbital conversion", 《NATURE CHEMISTRY》 *
JIANDE GU等: "Electron Attachment to a Hydrated DNA Duplex: The Dinucleoside Phosphate Deoxyguany -lyl-3’,5’-Deoxycytidine", 《CHEM.EUR.J.》 *
MARIYA V. EDELEVA等: "pH-Sensitive C-ON Bond Homolysis of Alkoxyamines of Imidazoline Series with Multiple Ionizable Groups As an Approach for Control of Nitroxide Mediated Polymerization", 《J.ORG.CHEM.》 *
MINTU POREL等: "Interaction between Encapsulated Excited Organic Molecules andFree Nitroxides: Communication Across a Molecular Wall", 《LANGMUIR》 *
SAMIR ATIK,LAWRENCE A.: "Fluorescence quenching by nitroxyl radicals in micellar environments. A useful probe for studying micelle-substrate interactions", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》 *
YASAR AKDOGAN等: "The solvation of nitroxide radicals in ionic liquids studied by high-field EPR spectroscopy", 《PHYS. CHEM. CHEM. PHYS.》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112955416A (zh) * 2018-10-29 2021-06-11 根特大学 用于水泥胶结材料以影响水泥胶结材料的流变性质的外掺料
CN112955416B (zh) * 2018-10-29 2023-07-21 根特大学 用于水泥胶结材料以影响水泥胶结材料的流变性质的外掺料
CN113707226A (zh) * 2021-08-24 2021-11-26 西安热工研究院有限公司 一种建立木糖-木酮糖相互转化时微观动力学模型的方法
CN118609730A (zh) * 2024-06-13 2024-09-06 中国长城科技集团股份有限公司 锂电池正极材料的钴酸锂性能分析方法及相关设备

Also Published As

Publication number Publication date
AU2014214532A1 (en) 2015-08-20
EP2953916A4 (en) 2016-10-26
EP2953916A1 (en) 2015-12-16
US20160075732A1 (en) 2016-03-17
CA2900272A1 (en) 2014-08-14
AU2014214532B2 (en) 2018-02-22
JP2016508488A (ja) 2016-03-22
WO2014121327A1 (en) 2014-08-14

Similar Documents

Publication Publication Date Title
US20250224411A1 (en) Molecular hopper
Spiegel et al. Modeling anticancer drug–DNA interactions via mixed QM/MM molecular dynamics simulations
Schalley Molecular recognition and supramolecular chemistry in the gas phase
TW309512B (https=)
CN105209410A (zh) 自由基轨道转换
WO2012080735A1 (en) Ask1 inhibiting pyrrolopyrimidine derivatives
US8906852B2 (en) Inhibitors of protein tyrosine kinase activity
CN109111446B (zh) 一种具有药物活性的杂芳基化合物
Chandra et al. Potential inhibitors of DNA topoisomerase II: ruthenium (II) poly-pyridyl and pyridyl-azine complexes
Lehmann et al. Triple‐Helix Formation by Pyrimidine Oligonucleotides Containing Nonnatural Nucleosides with Extended Aromatic Nucleobases: Intercalation from the major groove as a method for recognizing C· G and T· A base pairs
Tintaru et al. Conformational sensitivity of conjugated poly (ethylene oxide)-poly (amidoamine) molecules to cations adducted upon electrospray ionization–A mass spectrometry, ion mobility and molecular modeling study
Huang et al. Uv–vis photodissociation action spectroscopy reveals cytosine–guanine hydrogen transfer in dna tetranucleotide cation radicals upon one-electron reduction
Thapa et al. Computational study of the formation of C8, C5, and C4 guanine: lysine adducts via oxidation of guanine by sulfate radical anion
Ponikvar-Svet et al. Interplay of thermochemistry and Structural Chemistry, the journal (volume 22, 2011, issues 4–6) and the discipline
Sheha et al. Brain delivery of HIV protease inhibitors
Carvalho et al. Recognition of dicarboxylate anions by a ditopic hexaazamacrocycle containing bis-p-xylyl spacers
Raczyńska et al. Application of FT-ICR-MS for the study of proton-transfer reactions involving biomolecules
Nakatani et al. Charge transport in duplex DNA containing modified nucleotide bases
Mora et al. The role of H-bonding in the structure of the 4-piperidinecarboxylic acid monohydrate
JP2010535202A (ja) ５’−置換アデノシン、その製造、及び、ｓ−アデノシルメチオニン脱炭酸酵素の阻害剤としての使用
Caswell et al. Intramolecular aminolysis of esters. O-Acetylserine and. gamma.-esters of glutamic acid
Wang et al. Construction the switch binding pattern of cyclofructan 6
Xu et al. Identification of an unknown trace-level impurity in bulk drug of Seroquel by high-performance liquid chromatography combined with mass spectrometry
US10442871B2 (en) Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof
TW201006811A (en) Preparation of protected alpha-keto beta-amino esters and amides

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20151230

RJ01 Rejection of invention patent application after publication